Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoindoles
go back to main search page
Accession:CHEBI:24897 term browser browse the term
Synonyms:xref_mesh: MESH:D054833


show annotations for term's descendants           Sort by:
 
isoindoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alg12 ALG12, alpha-1,6-mannosyltransferase affects response to substance ISO ALG12 gene SNP affects the susceptibility to Isoindoles analog CTD PMID:25622337 NCBI chr 7:129,798,663...129,812,677
Ensembl chr 7:129,798,663...129,812,388
JBrowse link
G Ksr2 kinase suppressor of ras 2 affects response to substance ISO KSR2 gene SNP affects the susceptibility to Isoindoles analog CTD PMID:25622337 NCBI chr12:44,531,376...44,911,835
Ensembl chr12:44,536,293...44,911,147
JBrowse link
G Mrps27 mitochondrial ribosomal protein S27 affects response to substance ISO MRPS27 gene SNP affects the susceptibility to Isoindoles analog CTD PMID:25622337 NCBI chr 2:29,598,344...29,666,711
Ensembl chr 2:29,598,344...29,666,724
JBrowse link
G Nebl nebulette affects response to substance ISO NEBL gene SNP affects the susceptibility to Isoindoles analog CTD PMID:25622337 NCBI chr17:84,141,014...84,247,038
Ensembl chr17:84,140,489...84,488,601
JBrowse link
4,5-dianilinophthalimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions EXP 4,5-dianilinophthalimide inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone] CTD PMID:11751714 NCBI chr 2:68,820,616...68,895,537 JBrowse link
captafol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 decreases activity ISO captafol results in decreased activity of DIO1 protein CTD PMID:29228274, PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO captafol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO captafol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO hexylglutathione inhibits the reaction [captafol results in decreased activity of GSTP1 protein] CTD PMID:8678907 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP captafol results in increased expression of PCNA protein
Cysteine inhibits the reaction [captafol results in increased expression of PCNA protein]
CTD PMID:9022123 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO captafol results in decreased activity of TOP1 protein CTD PMID:12113771 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO captafol results in decreased activity of TOP2A protein CTD PMID:12113771 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
captan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA CTD PMID:32745781 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA CTD PMID:32745781 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA CTD PMID:32736067 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein CTD PMID:19883720 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA CTD PMID:32736067 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA CTD PMID:32736067 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA CTD PMID:32736067, PMID:32745781 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B9 mRNA CTD PMID:32745781 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA CTD PMID:32736067 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA CTD PMID:32745781 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
multiple interactions
ISO Captan results in decreased activity of DIO1 protein
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA
CTD PMID:29228274, PMID:32745781 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA CTD PMID:32736067 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Captan binds to ESR1 protein CTD PMID:15253041 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein CTD PMID:32736067 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO hexylglutathione inhibits the reaction [Captan results in decreased activity of GSTP1 protein] CTD PMID:8678907 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA CTD PMID:32745781 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein CTD PMID:19883720 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram] CTD PMID:29950287 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein CTD PMID:32736067 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA CTD PMID:32745781 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA CTD PMID:32745781 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA CTD PMID:32745781 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA] CTD PMID:32745781 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Captan results in decreased activity of TOP2A protein CTD PMID:12113771 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 affects response to substance ISO TSC22D1 gene SNP affects the susceptibility to Captan CTD PMID:25622337 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]
CTD PMID:18040759 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]
CTD PMID:18040759 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP chaetoglobosins results in increased phosphorylation of MAPK1 protein CTD PMID:18040759 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP chaetoglobosins results in increased phosphorylation of MAPK3 protein CTD PMID:18040759 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation EXP chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
chlorisondamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A multiple interactions ISO Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter] CTD PMID:12799369 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA] CTD PMID:1714554 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions EXP Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA] CTD PMID:1714554 NCBI chr10:86,340,893...86,342,501
Ensembl chr10:86,340,940...86,342,858
JBrowse link
G Ren renin multiple interactions EXP Chlorisondamine inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
EXP Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]
Chlorisondamine results in increased expression of TH mRNA
CTD PMID:1714554 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
chlorthalidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases expression EXP Chlorthalidone results in decreased expression of FGFR3 mRNA CTD PMID:20625077 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Nrp2 neuropilin 2 decreases expression EXP Chlorthalidone results in decreased expression of NRP2 mRNA CTD PMID:20625077 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Ren renin increases expression
increases activity
ISO Chlorthalidone results in increased expression of REN protein modified form
Chlorthalidone results in increased activity of REN protein
CTD PMID:796642, PMID:1116335, PMID:3319646 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Chlorthalidone results in decreased expression of TGFB3 mRNA CTD PMID:20625077 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression
increases expression
EXP Chlorthalidone results in decreased expression of VEGFC mRNA; Chlorthalidone results in decreased expression of VEGFC protein
Chlorthalidone results in increased expression of VEGFC protein
CTD PMID:20625077 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
cytochalasin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in increased expression of BAX protein] CTD PMID:27640744 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in decreased expression of BCL2 protein] CTD PMID:27640744 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C5 complement C5 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP3 protein CTD PMID:27640744 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP9 protein CTD PMID:27640744 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Cytochalasin B results in decreased expression of CCNB1 protein CTD PMID:27640744 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Cytochalasin B results in decreased expression of CDK1 protein CTD PMID:27640744 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Cytochalasin B results in increased expression of CDKN1A protein CTD PMID:27640744 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Cytochalasin B results in increased expression of CDKN1B protein CTD PMID:27640744 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin B inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Epo erythropoietin multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Cytochalasin B results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Cytochalasin B results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin B inhibits the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]] CTD PMID:9698594, PMID:17404311 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Lpl lipoprotein lipase decreases activity ISO Cytochalasin B results in decreased activity of LPL protein CTD PMID:9414485 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18776917 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18776917 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects folding
affects binding
multiple interactions
ISO Cytochalasin B affects the folding of SLC2A1 protein
Cytochalasin B binds to SLC2A1 protein
Cytochalasin B inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]
oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]
CTD PMID:8457197, PMID:19686715, PMID:22363641 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects binding
ISO
EXP
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]
Cytochalasin B binds to SLC2A2 protein
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [Cytochalasin B binds to SLC2A2 protein]
CTD PMID:8457197, PMID:10825458 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cytochalasin B results in increased expression of TP53 protein CTD PMID:27640744 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
cytochalasin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Cytochalasin D results in increased expression of ACTA2 mRNA
CTD PMID:11035001, PMID:23517783 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]
Cytochalasin D results in increased expression of CDH1 mRNA; Cytochalasin D results in increased expression of CDH1 protein
CTD PMID:25756282 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:23517783 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA] CTD PMID:23517783 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein] CTD PMID:11145710 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein] CTD PMID:11145710 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:25858758 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO Cytochalasin D affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of IKBKB protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [titanium dioxide results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187, PMID:18403674, PMID:18604214, PMID:24158569, PMID:24760326, PMID:30320338 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Cytochalasin D results in decreased chemical synthesis of IL6 protein
Cytochalasin D results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases response to substance ISO IVNS1ABP gene mutant form results in increased susceptibility to Cytochalasin D CTD PMID:15485691 NCBI chr13:68,702,970...68,722,472
Ensembl chr13:68,702,820...68,722,472
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr 7:122,233,196...122,403,661
Ensembl chr 7:122,234,012...122,403,667
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Cytochalasin D results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of NFKBIA protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 decreases activity ISO Cytochalasin D results in decreased activity of P2RX1 protein CTD PMID:21757694 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Cytochalasin D results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein] CTD PMID:25756282 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO Cytochalasin D results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:35,749,957...35,777,243
Ensembl chr  X:35,749,957...35,777,243
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Smad1 SMAD family member 1 affects localization ISO Cytochalasin D affects the localization of SMAD1 protein CTD PMID:25756282 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad2 SMAD family member 2 affects localization ISO Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 affects localization ISO Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization ISO Cytochalasin D affects the localization of SNAI1 protein CTD PMID:25756282 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tagln transgelin increases expression EXP Cytochalasin D results in increased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:8409756, PMID:12799187, PMID:15034928, PMID:17560598 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] CTD PMID:22961094 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO Cytochalasin D affects the localization of UPF1 protein
Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:76,176,379...76,287,246
Ensembl chr17:76,175,643...76,287,186
JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr  X:123,713,327...123,731,431
Ensembl chr  X:123,713,339...123,731,385
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
indoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Indoprofen results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
lenalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions EXP Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] CTD PMID:30660605 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Crbn cereblon multiple interactions
affects binding
increases response to substance
ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
lenalidomide binds to [CRBN protein binds to DDB1 protein]; lenalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to lenalidomide
CTD PMID:25043012, PMID:25108355, PMID:26186254, PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of CSNK1A1 protein CTD PMID:30067223 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 affects binding ISO lenalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO lenalidomide results in decreased expression of F2R mRNA; lenalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 protein CTD PMID:23696885 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:121,889,157...121,918,772
Ensembl chr 7:121,889,157...121,918,772
JBrowse link
G Faslg Fas ligand multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA] CTD PMID:16510725 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Lenalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Lenalidomide results in decreased expression of FGFR2 mRNA; Lenalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO Lenalidomide results in decreased expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Il12b interleukin 12B multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA] CTD PMID:16510725 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:16510725, PMID:30660605 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO lenalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO lenalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO lenalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:73,888,968...73,963,209
Ensembl chr14:73,889,213...73,963,202
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO lenalidomide binds to [SALL4 protein binds to CRBN protein]
lenalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tek TEK receptor tyrosine kinase decreases expression ISO lenalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO lenalidomide results in decreased expression of TGFBR1 mRNA; lenalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
CTD PMID:16510725, PMID:30660605 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO lenalidomide results in decreased expression of TNFRSF1A mRNA CTD PMID:15618473 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO lenalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Zfp827 zinc finger protein 827 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of ZNF827 protein CTD PMID:30067223 NCBI chr19:32,396,155...32,616,648
Ensembl chr19:32,401,661...32,528,965
JBrowse link
phosmet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Phosmet results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Il13 interleukin 13 increases expression ISO Phosmet results in increased expression of IL13 mRNA CTD PMID:22265773 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A increases expression ISO Phosmet results in increased expression of IL17A mRNA CTD PMID:22265773 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Phosmet results in increased secretion of TNF mRNA; Phosmet results in increased secretion of TNF protein CTD PMID:22265773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
phthalimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor decreases expression
increases expression
ISO phthalimide analog results in decreased expression of TNF protein
phthalimide analog results in increased expression of TNF protein
CTD PMID:12729831 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
pomalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 multiple interactions ISO pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein CTD PMID:29928335 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO pomalidomide results in increased secretion of CCL2 protein CTD PMID:15292067 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO pomalidomide results in increased expression of CEBPA mRNA CTD PMID:15292067 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO pomalidomide results in increased expression of CEBPD mRNA CTD PMID:15292067 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon increases expression ISO pomalidomide results in increased expression of CEBPE mRNA CTD PMID:15292067 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
JBrowse link
G Crbn cereblon multiple interactions
affects binding
increases response to substance
ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide
CTD PMID:25043012, PMID:26186254, PMID:29928335, PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
G Csf2 colony stimulating factor 2 decreases secretion ISO pomalidomide results in decreased secretion of CSF2 protein CTD PMID:15292067 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO pomalidomide results in increased secretion of CSF3 protein CTD PMID:15292067 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation ISO CYP2C19 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases oxidation ISO CYP2J2 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Dtwd1 DTW domain containing 1 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein CTD PMID:30067223 NCBI chr 3:118,427,790...118,443,003
Ensembl chr 3:118,430,511...118,442,098
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:29928335 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:121,889,157...121,918,772
Ensembl chr 7:121,889,157...121,918,772
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO pomalidomide results in decreased expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO pomalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein] CTD PMID:29928335 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gata1 GATA binding protein 1 decreases expression ISO pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 decreases expression ISO pomalidomide results in decreased expression of GATA2 mRNA CTD PMID:15292067 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor increases expression ISO pomalidomide results in increased expression of GFI1 mRNA CTD PMID:15292067 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor decreases expression ISO pomalidomide results in decreased expression of GFI1B mRNA CTD PMID:15292067 NCBI chr 3:7,190,721...7,203,444
Ensembl chr 3:7,190,722...7,203,420
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO pomalidomide results in increased expression of ID1 mRNA CTD PMID:15292067 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO pomalidomide results in increased expression of ID2 mRNA CTD PMID:15292067 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein] CTD PMID:29928335 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein] CTD PMID:29928335 NCBI chr10:86,420,757...86,509,454
Ensembl chr10:86,421,582...86,509,454
JBrowse link
G Il10 interleukin 10 increases secretion ISO pomalidomide results in increased secretion of IL10 protein CTD PMID:15292067 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 decreases secretion ISO pomalidomide results in decreased secretion of IL13 protein CTD PMID:15292067 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il5 interleukin 5 decreases secretion ISO pomalidomide results in decreased secretion of IL5 protein CTD PMID:15292067 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein CTD PMID:29928335 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO pomalidomide results in decreased expression of JUND mRNA CTD PMID:15292067 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Klf1 Kruppel like factor 1 decreases expression ISO pomalidomide results in decreased expression of KLF1 mRNA CTD PMID:15292067 NCBI chr19:26,016,289...26,019,557
Ensembl chr19:26,016,382...26,019,553
JBrowse link
G Lmo2 LIM domain only 2 decreases expression ISO pomalidomide results in decreased expression of LMO2 mRNA CTD PMID:15292067 NCBI chr 3:93,909,156...93,931,888
Ensembl chr 3:93,909,156...93,931,871
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Nfe2 nuclear factor, erythroid 2 decreases expression ISO pomalidomide results in decreased expression of NFE2 mRNA CTD PMID:15292067 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
G Prkcq protein kinase C, theta multiple interactions ISO pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein] CTD PMID:16241859 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:73,888,968...73,963,209
Ensembl chr14:73,889,213...73,963,202
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940
JBrowse link
G Spi1 Spi-1 proto-oncogene increases expression
decreases expression
ISO pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein
CTD PMID:15292067, PMID:16373662 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301
JBrowse link
G Wiz WIZ zinc finger multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of WIZ protein CTD PMID:30067223 NCBI chr 7:14,374,358...14,402,647
Ensembl chr 7:14,374,358...14,402,010
JBrowse link
G Zbtb39 zinc finger and BTB domain containing 39 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein CTD PMID:30067223 NCBI chr 7:71,036,581...71,044,057
Ensembl chr 7:71,036,565...71,044,045
JBrowse link
G Zfp653 zinc finger protein 653 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein CTD PMID:30067223 NCBI chr 8:23,066,576...23,085,502
Ensembl chr 8:23,066,576...23,084,879
JBrowse link
G Zfp91 zinc finger protein 91 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein CTD PMID:30067223 NCBI chr 1:229,602,499...229,640,906
Ensembl chr 1:229,602,499...229,639,187
JBrowse link
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
ISO tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008, PMID:16621434 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Brca1 BRCA1, DNA repair associated affects binding ISO tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases metabolic processing
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Folh1 folate hydrolase 1 decreases expression ISO tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224, PMID:2460452, PMID:2539779 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157, PMID:2539779 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G S100g S100 calcium binding protein G decreases expression
multiple interactions
EXP tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO tetramethrin results in increased expression of TMPRSS2 mRNA CTD PMID:12711008 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
thalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression ISO Thalidomide results in decreased expression of AADAT mRNA CTD PMID:26217789 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases response to substance ISO ABCA1 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity
ISO Thalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 protein
Thalidomide results in decreased activity of ABCB1 protein
CTD PMID:15920492, PMID:19840843 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression
increases activity
EXP Thalidomide results in increased expression of ABCB1B protein
Thalidomide results in increased activity of ABCB1B protein
CTD PMID:19840843 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 protein CTD PMID:16079895 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP [Thalidomide co-treated with Dimethylnitrosamine] results in decreased expression of ACTA2 protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Thalidomide results in decreased expression of ACTA2 protein
CTD PMID:16604421, PMID:16943688, PMID:17030452, PMID:17174718 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Thalidomide results in decreased expression of ACTN2 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Actr6 actin related protein 6 decreases expression ISO Thalidomide results in decreased expression of ACTR6 mRNA CTD PMID:26217789 NCBI chr 7:30,377,369...30,397,922
Ensembl chr 7:30,377,360...30,397,930
JBrowse link
G Adssl1 adenylosuccinate synthase like 1 decreases expression ISO Thalidomide results in decreased expression of ADSSL1 mRNA CTD PMID:26217789 NCBI chr 6:137,184,818...137,206,694
Ensembl chr 6:137,184,820...137,206,693
JBrowse link
G Aff2 AF4/FMR2 family, member 2 decreases expression ISO Thalidomide results in decreased expression of AFF2 mRNA CTD PMID:26217789 NCBI chr  X:153,539,951...154,051,022
Ensembl chr  X:153,539,668...154,051,181
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases activity
increases phosphorylation
ISO Thalidomide analog results in decreased phosphorylation of AKT1 protein
Thalidomide results in decreased activity of AKT1 protein
Thalidomide analog results in increased phosphorylation of AKT1 protein
CTD PMID:15067094, PMID:15858615 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Thalidomide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Alpi alkaline phosphatase, intestinal increases expression ISO Thalidomide results in increased expression of ALPI mRNA CTD PMID:26217789 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Thalidomide results in decreased expression of AMACR mRNA CTD PMID:26217789 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Angpt2 angiopoietin 2 affects expression ISO Thalidomide affects the expression of ANGPT2 mRNA CTD PMID:15939924 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Thalidomide results in decreased expression of ANKRD37 mRNA CTD PMID:26217789 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Anxa2 annexin A2 decreases expression ISO Thalidomide results in decreased expression of ANXA2 mRNA; Thalidomide results in decreased expression of ANXA2 protein CTD PMID:19954599 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apip APAF1 interacting protein decreases expression ISO Thalidomide results in decreased expression of APIP mRNA CTD PMID:26217789 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Apln apelin decreases expression ISO Thalidomide results in decreased expression of APLN mRNA CTD PMID:26217789 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Thalidomide results in increased expression of AQP4 mRNA CTD PMID:26217789 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Aqp5 aquaporin 5 increases expression ISO Thalidomide results in increased expression of AQP5 mRNA CTD PMID:26217789 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Thalidomide results in increased expression of ARHGDIA mRNA CTD PMID:26217789 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 decreases expression ISO Thalidomide results in decreased expression of ARPC4 mRNA CTD PMID:26217789 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984
JBrowse link
G Arx aristaless related homeobox increases expression ISO Thalidomide results in increased expression of ARX mRNA CTD PMID:26217789 NCBI chr  X:62,363,757...62,376,139
Ensembl chr  X:62,363,757...62,376,143
JBrowse link
G Asb12 ankyrin repeat and SOCS box-containing 12 decreases expression ISO Thalidomide results in decreased expression of ASB12 mRNA CTD PMID:26217789 NCBI chr  X:64,714,337...64,800,662
Ensembl chr  X:64,714,335...64,800,435
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thalidomide analog results in increased expression of ATF3 mRNA CTD PMID:20525221 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA CTD PMID:18720364 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Thalidomide results in increased expression of BAX mRNA CTD PMID:18291259 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression ISO Thalidomide results in decreased expression of BCAP29 mRNA CTD PMID:26217789 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein
Thalidomide results in decreased expression of BCL2 protein
CTD PMID:15867202, PMID:15982930 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Thalidomide results in decreased expression of BCL2L1 protein CTD PMID:15986355 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] CTD PMID:16039549 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein] CTD PMID:19567134 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bnipl BCL2 interacting protein like increases expression ISO Thalidomide results in increased expression of BNIPL mRNA CTD PMID:26217789 NCBI chr 2:196,415,736...196,425,727
Ensembl chr 2:196,415,738...196,425,727
JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 decreases expression ISO Thalidomide results in decreased expression of BOD1 mRNA CTD PMID:26217789 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Thalidomide results in decreased expression of BST2 mRNA CTD PMID:26217789 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA CTD PMID:18720364 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G C3 complement C3 decreases expression ISO Thalidomide results in decreased expression of C3 protein CTD PMID:2985516 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression ISO Thalidomide results in decreased expression of CACNA1C mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Calb1 calbindin 1 decreases expression ISO Thalidomide results in decreased expression of CALB1 mRNA CTD PMID:24154490 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Casp3 caspase 3 decreases activity
increases expression
increases activity
ISO
EXP
Thalidomide results in decreased activity of CASP3 protein
Thalidomide results in increased expression of CASP3 mRNA
Thalidomide results in increased activity of CASP3 protein
CTD PMID:14682394, PMID:15067094, PMID:18291259 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
ISO Thalidomide analog results in increased cleavage of CASP8 protein
Thalidomide results in decreased expression of CASP8 mRNA
CTD PMID:15858615, PMID:26217789 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases activity ISO Thalidomide results in decreased activity of CASP9 protein CTD PMID:15067094 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 decreases expression ISO Thalidomide results in decreased expression of CASTOR1 mRNA CTD PMID:26217789 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein] CTD PMID:16616857 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 decreases expression ISO Thalidomide results in decreased expression of CBR1 mRNA CTD PMID:26217789 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccdc130 coiled-coil domain containing 130 decreases expression ISO Thalidomide results in decreased expression of CCDC130 mRNA CTD PMID:26217789 NCBI chr19:25,367,552...25,378,993
Ensembl chr19:25,367,543...25,378,974
JBrowse link
G Ccdc141 coiled-coil domain containing 141 decreases expression ISO Thalidomide results in decreased expression of CCDC141 mRNA CTD PMID:26217789 NCBI chr 3:63,865,240...64,024,208
Ensembl chr 3:63,863,951...64,024,205
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Thalidomide analog results in decreased expression of CCL2 mRNA CTD PMID:20525221 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Thalidomide results in increased expression of CCL3 mRNA CTD PMID:16549389 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA CTD PMID:18720364 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA CTD PMID:18720364 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thalidomide analog results in decreased expression of CCND1 mRNA CTD PMID:20525221 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccno cyclin O increases expression ISO Thalidomide results in increased expression of CCNO mRNA CTD PMID:26217789 NCBI chr 2:44,857,043...44,860,317
Ensembl chr 2:44,857,213...44,860,315
JBrowse link
G Cd24 CD24 molecule affects expression ISO Thalidomide affects the expression of CD24A mRNA CTD PMID:26006729 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA CTD PMID:18720364 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Thalidomide results in decreased expression of CDC42EP5 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 1:73,717,207...73,719,600
Ensembl chr 1:73,719,005...73,719,529
JBrowse link
G Cdh10 cadherin 10 decreases expression ISO Thalidomide results in decreased expression of CDH10 mRNA CTD PMID:26217789 NCBI chr 2:69,415,174...69,636,849
Ensembl chr 2:69,415,057...69,637,524
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA CTD PMID:18720364 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cenpa centromere protein A multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA CTD PMID:18720364 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cenpf centromere protein F multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA CTD PMID:18720364 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist decreases expression ISO Thalidomide results in decreased expression of CER1 mRNA CTD PMID:26217789 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Thalidomide results in decreased expression of CFLAR protein CTD PMID:15986355 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein] CTD PMID:16604421 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CHURC1 mRNA CTD PMID:26217789 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576
JBrowse link
G Cldn4 claudin 4 increases expression ISO Thalidomide results in increased expression of CLDN4 mRNA CTD PMID:26217789 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cldnd1 claudin domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CLDND1 mRNA CTD PMID:26217789 NCBI chr11:43,986,352...43,992,703
Ensembl chr11:43,986,386...43,992,598
JBrowse link
G Clec9a C-type lectin domain containing 9A decreases expression ISO Thalidomide results in decreased expression of CLEC9A mRNA CTD PMID:26217789 NCBI chr 4:163,173,593...163,189,532
Ensembl chr 4:163,174,487...163,189,530
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein] CTD PMID:26221080 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA] CTD PMID:16604421 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Crbn cereblon multiple interactions
affects binding
affects response to substance
ISO Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
Thalidomide binds to [CRBN protein binds to DDB1 protein]
CRBN gene SNP affects the susceptibility to Thalidomide
Thalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN protein
CTD PMID:25043012, PMID:25108355, PMID:27751757, PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO Thalidomide analog results in increased expression of CREBRF mRNA CTD PMID:20525221 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205
JBrowse link
G Crp C-reactive protein decreases expression ISO Thalidomide results in decreased expression of CRP protein CTD PMID:11339241 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 decreases activity ISO Thalidomide results in decreased activity of CSF2 protein CTD PMID:17557286 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases activity ISO Thalidomide results in decreased activity of CSF3 protein CTD PMID:17557286 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 decreases expression ISO Thalidomide results in decreased expression of CSGALNACT2 mRNA CTD PMID:26217789 NCBI chr 4:150,148,626...150,185,062
Ensembl chr 4:150,153,844...150,185,044
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Thalidomide results in increased expression of CXCL10 CTD PMID:17089043 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO Thalidomide results in decreased expression of CXCR1 protein CTD PMID:16344495 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Thalidomide results in decreased expression of CXCR2 protein CTD PMID:16344495 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Thalidomide results in increased expression of CYCS protein CTD PMID:15982930 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Thalidomide results in increased expression of CYP2B6 mRNA CTD PMID:24460184, PMID:28496040 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation
multiple interactions
increases oxidation
ISO CYP2C19 protein results in increased hydroxylation of Thalidomide
[CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide
CTD PMID:20443640, PMID:24350712 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases metabolic processing
increases expression
increases hydroxylation
ISO [CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A5 protein results in increased metabolism of Thalidomide
Thalidomide results in increased expression of CYP3A5 mRNA
CTD PMID:20443640, PMID:28496040, PMID:28745489 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyth3 cytohesin 3 decreases expression ISO Thalidomide results in decreased expression of CYTH3 mRNA CTD PMID:26217789 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192
JBrowse link
G Daam2 dishevelled associated activator of morphogenesis 2 decreases expression ISO Thalidomide results in decreased expression of DAAM2 mRNA CTD PMID:26217789 NCBI chr 9:13,444,883...13,493,154
Ensembl chr 9:13,446,896...13,490,669
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 decreases expression ISO Thalidomide results in decreased expression of DBT mRNA CTD PMID:26217789 NCBI chr 2:219,563,783...219,592,651
Ensembl chr 2:219,563,783...219,592,650
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 affects binding ISO Thalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thalidomide analog results in increased expression of DDIT3 mRNA CTD PMID:20525221 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Defa10 defensin alpha 10 increases expression ISO Thalidomide results in increased expression of DEFA3 mRNA CTD PMID:26217789 NCBI chr16:75,498,236...75,499,012
Ensembl chr16:75,498,236...75,499,012
JBrowse link
G Defb15 defensin beta 15 increases expression ISO Thalidomide results in increased expression of DEFB15 mRNA CTD PMID:26217789 NCBI chr16:75,105,290...75,107,931
Ensembl chr16:75,105,290...75,107,931
Ensembl chr16:75,105,290...75,107,931
JBrowse link
G Des desmin multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of DES protein] CTD PMID:17030452 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dexi Dexi homolog increases expression ISO Thalidomide results in increased expression of DEXI mRNA CTD PMID:26217789 NCBI chr10:5,199,226...5,211,913
Ensembl chr10:5,199,226...5,211,913
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO Thalidomide results in decreased expression of DLGAP5 mRNA CTD PMID:26217789 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Thalidomide results in decreased expression of DLK1 mRNA CTD PMID:26217789 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Thalidomide analog results in increased expression of DNAJB1 mRNA CTD PMID:20525221 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Thalidomide analog results in increased expression of DNAJB4 mRNA CTD PMID:20525221 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Thalidomide analog results in increased expression of DNAJB9 mRNA CTD PMID:20525221 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Thalidomide results in decreased expression of DNAJC19 mRNA CTD PMID:26217789 NCBI chr 2:120,503,093...120,531,782
Ensembl chr 2:120,504,130...120,531,782
JBrowse link
G Dus4l dihydrouridine synthase 4-like decreases expression ISO Thalidomide results in decreased expression of DUS4L mRNA CTD PMID:26217789 NCBI chr 6:50,925,987...50,943,546
Ensembl chr 6:50,928,397...50,943,488
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Thalidomide analog results in increased expression of DUSP1 mRNA CTD PMID:20525221 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Thalidomide analog results in increased expression of DUSP10 mRNA CTD PMID:20525221 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Thalidomide analog results in increased expression of DUSP8 mRNA CTD PMID:20525221 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Thalidomide results in decreased expression of EEF1E1 mRNA CTD PMID:26217789 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Efcab2 EF-hand calcium binding domain 2 decreases expression ISO Thalidomide results in decreased expression of EFCAB2 mRNA CTD PMID:26217789 NCBI chr13:96,303,578...96,414,404
Ensembl chr13:96,303,703...96,414,404
JBrowse link
G Eif1b eukaryotic translation initiation factor 1B decreases expression ISO Thalidomide results in decreased expression of EIF1B mRNA CTD PMID:26217789 NCBI chr 8:129,158,112...129,160,726
Ensembl chr 8:129,158,103...129,160,757
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E decreases expression EXP Thalidomide results in decreased expression of EIF4E protein CTD PMID:18291259 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] CTD PMID:11302825 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Emc8 ER membrane protein complex subunit 8 decreases expression ISO Thalidomide results in decreased expression of EMC8 mRNA CTD PMID:26217789 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esd esterase D decreases expression ISO Thalidomide results in decreased expression of ESD mRNA CTD PMID:26217789 NCBI chr15:56,756,848...56,776,348
Ensembl chr15:56,756,661...56,776,348
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Thalidomide results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO Thalidomide results in decreased expression of F2R mRNA; Thalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Thalidomide results in decreased expression of FABP5 mRNA CTD PMID:26217789 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO Thalidomide affects the expression of FABP7 mRNA CTD PMID:26217789 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fam122a family with sequence similarity 122A decreases expression ISO Thalidomide results in decreased expression of FAM122A mRNA CTD PMID:26217789 NCBI chr 1:242,372,458...242,373,764
Ensembl chr 1:242,372,458...242,373,764
JBrowse link
G Fam174b family with sequence similarity 174, member B decreases expression ISO Thalidomide results in decreased expression of FAM174B mRNA CTD PMID:26217789 NCBI chr 1:135,081,596...135,180,266
Ensembl chr 1:135,083,974...135,162,685
JBrowse link
G Fas Fas cell surface death receptor decreases expression
increases expression
ISO
EXP
Thalidomide results in decreased expression of FAS protein
Thalidomide results in increased expression of FAS mRNA
CTD PMID:16531263, PMID:18291259 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]
Thalidomide results in decreased expression of FASLG protein
CTD PMID:16510725, PMID:16531263 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA CTD PMID:18720364 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fgd3 FYVE, RhoGEF and PH domain containing 3 increases expression ISO Thalidomide results in increased expression of FGD3 mRNA CTD PMID:26217789 NCBI chr17:15,737,962...15,800,403
Ensembl chr17:15,749,978...15,800,401
JBrowse link
G Fgf2 fibroblast growth factor 2 increases response to substance
decreases expression
multiple interactions
decreases activity
affects secretion
affects expression
ISO
EXP
FGF2 protein results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of FGF2 protein
[temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein
Thalidomide results in decreased activity of FGF2 protein
Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide affects the secretion of FGF2 protein
Thalidomide affects the expression of FGF2 mRNA; Thalidomide affects the expression of FGF2 protein
CTD PMID:11555579, PMID:12644816, PMID:14558594, PMID:15863203, PMID:15939924, PMID:16327979, PMID:17557286 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Thalidomide results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Thalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Thalidomide results in decreased expression of FGFR2 mRNA; Thalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO Thalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of FOS mRNA CTD PMID:20525221 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of FOSB mRNA CTD PMID:20525221 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Thalidomide results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Foxred1 FAD-dependent oxidoreductase domain containing 1 decreases expression ISO Thalidomide results in decreased expression of FOXRED1 mRNA CTD PMID:26217789 NCBI chr 8:36,401,317...36,410,589
Ensembl chr 8:36,403,493...36,410,612
JBrowse link
G Fzd8 frizzled class receptor 8 decreases expression ISO Thalidomide results in decreased expression of FZD8 mRNA CTD PMID:24154490 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA] CTD PMID:15797874 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Galm galactose mutarotase decreases expression ISO Thalidomide results in decreased expression of GALM mRNA CTD PMID:26217789 NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744
JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Thalidomide results in increased expression of GATA3 protein CTD PMID:19428696 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) decreases expression ISO Thalidomide results in decreased expression of GCNT2 mRNA CTD PMID:26217789 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Gemin2 gem (nuclear organelle) associated protein 2 decreases expression ISO Thalidomide results in decreased expression of GEMIN2 mRNA CTD PMID:26217789 NCBI chr 6:80,108,751...80,122,382
Ensembl chr 6:80,108,655...80,122,365
JBrowse link
G Gfra2 GDNF family receptor alpha 2 decreases expression ISO Thalidomide results in decreased expression of GFRA2 mRNA CTD PMID:26217789 NCBI chr15:52,557,004...52,648,984
Ensembl chr15:52,557,607...52,648,972
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Thalidomide results in increased expression of GOT1 mRNA CTD PMID:26217789 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gp2 glycoprotein 2 increases expression ISO Thalidomide results in increased expression of GP2 mRNA CTD PMID:26217789 NCBI chr 1:189,166,735...189,182,306
Ensembl chr 1:189,166,399...189,182,306
JBrowse link
G Gpatch4 G patch domain containing 4 decreases expression ISO Thalidomide results in decreased expression of GPATCH4 mRNA CTD PMID:26217789 NCBI chr 2:187,404,731...187,424,047
Ensembl chr 2:187,415,262...187,424,045
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein] CTD PMID:17030452 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx8 glutathione peroxidase 8 decreases expression ISO Thalidomide results in decreased expression of GPX8 mRNA CTD PMID:26217789 NCBI chr 2:44,903,337...44,907,046
Ensembl chr 2:44,903,337...44,907,030
JBrowse link
G Gtf2e1 general transcription factor IIE subunit 1 decreases expression ISO Thalidomide results in decreased expression of GTF2E1 mRNA CTD PMID:26217789 NCBI chr11:66,078,786...66,111,394
Ensembl chr11:66,078,820...66,110,848
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Thalidomide results in decreased expression of GULP1 mRNA CTD PMID:26217789 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Thalidomide results in decreased expression of H2BC12 mRNA CTD PMID:26217789 NCBI chr17:44,527,421...44,527,801
Ensembl chr17:44,527,421...44,527,801
JBrowse link
G H2bu1 H2B.U histone 1 decreases expression ISO Thalidomide results in decreased expression of H2BU2 mRNA CTD PMID:26217789 NCBI chr10:45,296,638...45,297,385
Ensembl chr10:45,296,638...45,297,385
JBrowse link
G H3f3c H3 histone family member 3C decreases expression ISO Thalidomide results in decreased expression of H3C15 mRNA CTD PMID:26217789 NCBI chr 7:94,777,659...94,778,656
Ensembl chr 7:94,777,702...94,778,696
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 decreases expression ISO Thalidomide results in decreased expression of HCN1 mRNA CTD PMID:26217789 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Thalidomide analog results in increased expression of HERPUD1 mRNA CTD PMID:20525221 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hgf hepatocyte growth factor affects expression
affects secretion
decreases activity
ISO Thalidomide affects the expression of HGF mRNA; Thalidomide affects the expression of HGF protein
Thalidomide affects the secretion of HGF protein
Thalidomide results in decreased activity of HGF protein
CTD PMID:15939924, PMID:17557286 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hirip3 HIRA interacting protein 3 decreases expression ISO Thalidomide results in decreased expression of HIRIP3 mRNA CTD PMID:26217789 NCBI chr 1:198,298,138...198,301,164
Ensembl chr 1:198,298,138...198,301,161
JBrowse link
G Hist1h2af histone cluster 1 H2A family member F decreases expression ISO Thalidomide results in decreased expression of H2AC15 mRNA CTD PMID:26217789 NCBI chr17:43,627,237...43,627,629
Ensembl chr17:43,627,237...43,627,629
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Thalidomide results in decreased expression of H2BC4 mRNA CTD PMID:26217789 NCBI chr17:44,736,184...44,738,393
Ensembl chr17:44,737,950...44,738,330
Ensembl chr17:44,737,950...44,738,330
JBrowse link
G Hist2h3c2 histone cluster 2 H3 family member C2 decreases expression ISO Thalidomide results in decreased expression of H3C1 mRNA CTD PMID:26217789 NCBI chr 2:198,390,024...198,418,075
Ensembl chr 2:198,417,619...198,418,029
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO Thalidomide results in decreased expression of H4C11 mRNA CTD PMID:26217789 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 decreases expression ISO Thalidomide results in decreased expression of HMGN5 mRNA CTD PMID:26217789 NCBI chr  X:80,134,557...80,142,902
Ensembl chr  X:80,134,557...80,142,902
JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Thalidomide results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Thalidomide results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression ISO Thalidomide results in decreased expression of HSD11B2 mRNA CTD PMID:26217789 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of HSF1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Thalidomide results in decreased expression of HSPB1 mRNA CTD PMID:26217789 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Thalidomide analog results in increased expression of HSPH1 mRNA CTD PMID:20525221 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases response to substance
decreases expression
ISO
EXP
ICAM1 gene SNP results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of ICAM1 mRNA; Thalidomide results in decreased expression of ICAM1 protein
CTD PMID:17174718, PMID:21245421 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idnk Idnk, gluconokinase decreases expression ISO Thalidomide results in decreased expression of IDNK mRNA CTD PMID:26217789 NCBI chr17:6,885,323...6,892,603
Ensembl chr17:6,885,221...6,892,497
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases expression
affects expression
ISO
EXP
[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
Thalidomide results in decreased expression of IFNG protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IFNG protein]
Thalidomide results in increased expression of IFNG; Thalidomide results in increased expression of IFNG protein
Thalidomide affects the expression of IFNG mRNA
CTD PMID:15588918, PMID:16078585, PMID:16454849, PMID:16514283, PMID:16815871, PMID:17089043 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ift27 intraflagellar transport 27 decreases expression ISO Thalidomide results in decreased expression of IFT27 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 7:119,393,384...119,409,710
Ensembl chr 7:119,393,384...119,409,710
JBrowse link
G Ift74 intraflagellar transport 74 decreases expression ISO Thalidomide results in decreased expression of IFT74 mRNA CTD PMID:26217789 NCBI chr 5:113,579,065...113,682,485
Ensembl chr 5:113,592,919...113,682,484
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO Thalidomide affects the expression of IGF1 mRNA CTD PMID:15939924 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression
decreases expression
ISO Thalidomide affects the expression of IGFBP3 mRNA
Thalidomide results in decreased expression of IGFBP3 mRNA
CTD PMID:15939924, PMID:26217789 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 affects expression
decreases expression
ISO Thalidomide affects the expression of IL10 mRNA
Thalidomide results in decreased expression of IL10 protein
CTD PMID:16454849, PMID:16514283 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:11788559 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]
CTD PMID:11788559, PMID:16510725 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il18 interleukin 18 increases expression ISO Thalidomide results in increased expression of IL18 CTD PMID:17089043 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Thalidomide results in decreased expression of IL1B protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IL1B protein]
CTD PMID:15863203, PMID:16815871, PMID:23510834, PMID:25478868 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Thalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO
EXP
[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
Thalidomide inhibits the reaction [irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [irinotecan results in decreased expression of IL2 protein]
Thalidomide results in decreased expression of IL2 protein
CTD PMID:15588918, PMID:16815871 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression EXP Thalidomide results in increased expression of IL4 protein CTD PMID:16078585 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
decreases activity
ISO
EXP
Thalidomide analog results in decreased secretion of IL6 protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]
Thalidomide results in decreased activity of IL6 protein
CTD PMID:15858615, PMID:16815871, PMID:17557286, PMID:23510834, PMID:25478868, PMID:26221080 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO Thalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Ing3 inhibitor of growth family, member 3 increases expression ISO Thalidomide analog results in increased expression of ING3 mRNA CTD PMID:20525221 NCBI chr 4:49,017,235...49,044,450
Ensembl chr 4:49,017,311...49,042,990
JBrowse link
G Ipp intracisternal A particle-promoted polypeptide decreases expression ISO Thalidomide results in decreased expression of IPP mRNA CTD PMID:26217789 NCBI chr 5:135,351,767...135,390,363
Ensembl chr 5:135,351,816...135,388,083
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of JUN mRNA CTD PMID:20525221 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kif2c kinesin family member 2C multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA CTD PMID:18720364 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Klhl4 kelch-like family member 4 decreases expression ISO Thalidomide results in decreased expression of KLHL4 mRNA CTD PMID:26217789 NCBI chr  X:86,125,929...86,229,565
Ensembl chr  X:86,126,157...86,229,563
JBrowse link
G Klk1 kallikrein 1 decreases expression ISO Thalidomide results in decreased expression of KLK1 mRNA CTD PMID:26217789 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Krtap1-1 keratin associated protein 1-1 increases expression ISO Thalidomide results in increased expression of KRTAP1-4 mRNA CTD PMID:26217789 NCBI chr10:87,502,950...87,503,578
Ensembl chr10:87,502,817...87,503,591
JBrowse link
G Lats2 large tumor suppressor kinase 2 increases expression ISO Thalidomide analog results in increased expression of LATS2 mRNA CTD PMID:20525221 NCBI chr15:37,943,609...37,995,175
Ensembl chr15:37,943,609...37,983,882
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like increases expression ISO Thalidomide results in increased expression of H2-Q1 mRNA CTD PMID:26217789 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like increases expression ISO Thalidomide results in increased expression of USP17LE mRNA CTD PMID:26217789 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G LOC100910669 paired immunoglobulin-like type 2 receptor alpha-like decreases expression ISO Thalidomide results in decreased expression of PILRA mRNA CTD PMID:26217789 NCBI chr12:21,678,550...21,689,821
Ensembl chr12:21,678,580...21,690,678
JBrowse link
G LOC100910887 olfactory receptor 6C4-like decreases expression ISO Thalidomide results in decreased expression of OLFR820 mRNA CTD PMID:26217789 NCBI chr13:9,479,995...9,480,933
Ensembl chr13:9,479,995...9,480,933
JBrowse link
G LOC100912290 histone H4-like decreases expression ISO Thalidomide results in decreased expression of H4C4 mRNA CTD PMID:26217789 NCBI chr 4:170,092,457...170,117,607 JBrowse link
G LOC102548682 histone H4-like decreases expression ISO Thalidomide results in decreased expression of H4C14 mRNA CTD PMID:26217789 NCBI chr17:43,616,218...43,673,659
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr17:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
Ensembl chr 2:43,791,657...43,792,067
JBrowse link
G LOC102553760 zinc finger protein 59-like decreases expression ISO Thalidomide results in decreased expression of ZFP780B mRNA CTD PMID:26217789 NCBI chr 1:84,719,744...84,739,532 JBrowse link
G LOC103689988 2'-5'-oligoadenylate synthase 1A-like decreases expression ISO Thalidomide results in decreased expression of OAS1G mRNA CTD PMID:26217789 NCBI chr12:42,367,110...42,376,531
Ensembl chr12:42,367,535...42,376,426
JBrowse link
G LOC103690022 protein N-terminal asparagine amidohydrolase decreases expression ISO Thalidomide results in decreased expression of NTAN1 mRNA CTD PMID:26217789 NCBI chr10:3,218,408...3,235,229
Ensembl chr10:3,218,466...3,235,229
JBrowse link
G LOC501406 similar to regulator of sex-limitation candidate 1 decreases expression ISO Thalidomide results in decreased expression of ZFP273 mRNA CTD PMID:26217789 NCBI chr 1:38,581,867...38,597,702
Ensembl chr 1:38,582,629...38,586,563
JBrowse link
G LOC687082 similar to olfactory receptor 508 increases expression ISO Thalidomide results in increased expression of OLFR508 mRNA CTD PMID:26217789 NCBI chr 1:172,860,666...172,861,690
Ensembl chr 1:172,860,797...172,861,597
JBrowse link
G Lrr1 leucine rich repeat protein 1 decreases expression ISO Thalidomide results in decreased expression of LRR1 mRNA CTD PMID:26217789 NCBI chr 6:91,463,205...91,472,308
Ensembl chr 6:91,463,308...91,472,308
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] CTD PMID:11302825 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Ly96 lymphocyte antigen 96 decreases expression ISO Thalidomide results in decreased expression of LY96 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 5:1,972,212...1,989,448 JBrowse link
G Lyrm2 LYR motif containing 2 decreases expression ISO Thalidomide results in decreased expression of LYRM2 mRNA CTD PMID:26217789 NCBI chr 5:48,047,913...48,050,191
Ensembl chr 5:48,047,913...48,050,187
JBrowse link
G Lyrm4 LYR motif containing 4 decreases expression ISO Thalidomide results in decreased expression of LYRM4 mRNA CTD PMID:26217789 NCBI chr17:29,439,042...29,552,773
Ensembl chr17:29,438,980...29,552,790
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein] CTD PMID:19567134 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK1 protein CTD PMID:15858615 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK14 protein CTD PMID:15858615 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK3 protein CTD PMID:15858615 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Thalidomide analog results in decreased expression of MCL1 protein CTD PMID:15858615 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm5 minichromosome maintenance complex component 5 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA CTD PMID:18720364 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Thalidomide results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 decreases expression ISO Thalidomide results in decreased expression of MESP2 mRNA CTD PMID:31711903 NCBI chr 1:141,550,633...141,553,239
Ensembl chr 1:141,550,633...141,553,230
JBrowse link
G Mettl5 methyltransferase like 5 decreases expression ISO Thalidomide results in decreased expression of METTL5 mRNA CTD PMID:26217789 NCBI chr 3:56,101,597...56,113,823
Ensembl chr 3:56,101,580...56,113,857
JBrowse link
G Mir301b microRNA 301b increases expression ISO Thalidomide results in increased expression of MIR301B mRNA CTD PMID:26217789 NCBI chr11:88,129,426...88,129,503
Ensembl chr11:88,129,426...88,129,503
JBrowse link
G Mir30e microRNA 30e decreases expression ISO Thalidomide results in decreased expression of MIR30E mRNA CTD PMID:26217789 NCBI chr 5:139,702,872...139,702,963
Ensembl chr 5:139,702,872...139,702,963
JBrowse link
G Mir449c microRNA 449c increases expression ISO Thalidomide results in increased expression of MIR449C mRNA CTD PMID:26217789 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164
JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression ISO Thalidomide results in decreased expression of MIXL1 mRNA CTD PMID:26217789 NCBI chr13:97,278,258...97,282,299
Ensembl chr13:98,973,041...98,975,426
Ensembl chr13:98,973,041...98,975,426
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA CTD PMID:18720364 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mlf2 myeloid leukemia factor 2 decreases expression ISO Thalidomide results in decreased expression of MLF2 mRNA CTD PMID:26217789 NCBI chr 4:157,452,578...157,457,254
Ensembl chr 4:157,452,607...157,457,249
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Thalidomide results in decreased expression of MME mRNA CTD PMID:26217789 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased expression of MMP2 protein
CTD PMID:14558594, PMID:15863203 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Thalidomide results in decreased expression of MMP9 protein CTD PMID:15863203 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 decreases expression ISO Thalidomide results in decreased expression of MOXD1 mRNA CTD PMID:26217789 NCBI chr 1:22,124,498...22,206,565
Ensembl chr 1:22,124,495...22,206,505
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:15138204, PMID:25478868 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mpp1 membrane palmitoylated protein 1 decreases expression ISO Thalidomide results in decreased expression of MPP1 mRNA CTD PMID:26217789 NCBI chr 1:148,450,213...148,458,945 JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 decreases expression ISO Thalidomide results in decreased expression of MRPL32 mRNA CTD PMID:26217789 NCBI chr17:53,102,534...53,105,400
Ensembl chr17:53,102,534...53,105,400
JBrowse link
G Mrpl34 mitochondrial ribosomal protein L34 decreases expression ISO Thalidomide results in decreased expression of MRPL34 mRNA CTD PMID:26217789 NCBI chr16:19,874,034...19,874,769
Ensembl chr16:19,874,034...19,874,768
JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 decreases expression ISO Thalidomide results in decreased expression of MRPL47 mRNA CTD PMID:26217789 NCBI chr 2:119,128,311...119,139,451
Ensembl chr 2:119,128,309...119,139,451
JBrowse link
G Mrpl52 mitochondrial ribosomal protein L52 decreases expression ISO Thalidomide results in decreased expression of MRPL52 mRNA CTD PMID:26217789 NCBI chr15:33,069,479...33,072,777
Ensembl chr15:33,069,382...33,072,777
JBrowse link
G Mrps21 mitochondrial ribosomal protein S21 decreases expression ISO Thalidomide results in decreased expression of MRPS21 mRNA CTD PMID:26217789 NCBI chr 2:197,974,758...197,982,385
Ensembl chr 2:197,974,761...197,982,385
JBrowse link
G Mtfr2 mitochondrial fission regulator 2 decreases expression ISO Thalidomide results in decreased expression of MTFR2 mRNA CTD PMID:26217789 NCBI chr 1:15,834,779...15,850,424
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions
decreases phosphorylation
decreases activity
ISO CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]
Thalidomide results in decreased phosphorylation of MYB protein
CTD PMID:16616857 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybpc3 myosin binding protein C3 decreases expression ISO Thalidomide results in decreased expression of MYBPC3 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression ISO Thalidomide results in decreased expression of MYD88 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Myh6 myosin heavy chain 6 affects expression ISO Thalidomide affects the expression of MYH6 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myl3 myosin light chain 3 affects expression
decreases expression
ISO Thalidomide affects the expression of MYL3 mRNA
Thalidomide results in decreased expression of MYL3 mRNA
CTD PMID:26006729, PMID:26217789 NCBI chr 8:119,030,852...119,036,996
Ensembl chr 8:119,030,875...119,036,996
JBrowse link
G Myl7 myosin light chain 7 decreases expression ISO Thalidomide results in decreased expression of MYL7 mRNA CTD PMID:26217789 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553
JBrowse link
G Mylk myosin light chain kinase increases expression ISO Thalidomide results in increased expression of MYLK mRNA CTD PMID:26217789 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Myom1 myomesin 1 decreases expression ISO Thalidomide results in decreased expression of MYOM1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 9:119,353,840...119,469,196
Ensembl chr 9:119,353,840...119,468,715
JBrowse link
G Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit decreases expression ISO Thalidomide results in decreased expression of NAA20 mRNA CTD PMID:26217789 NCBI chr 3:140,106,723...140,125,047
Ensembl chr 3:140,106,766...140,125,220
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Thalidomide results in decreased expression of NANOG mRNA CTD PMID:26217789 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Naxe NAD(P)HX epimerase decreases expression ISO Thalidomide results in decreased expression of NAXE mRNA CTD PMID:26217789 NCBI chr 2:187,424,319...187,426,410
Ensembl chr 2:187,424,327...187,426,375
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Thalidomide results in decreased expression of NDUFB8 mRNA CTD PMID:26217789 NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762
JBrowse link
G Nebl nebulette decreases expression ISO Thalidomide results in decreased expression of NEBL mRNA CTD PMID:26217789 NCBI chr17:84,141,014...84,247,038
Ensembl chr17:84,140,489...84,488,601
JBrowse link
G Neurod4 neuronal differentiation 4 increases expression ISO Thalidomide results in increased expression of NEUROD4 mRNA CTD PMID:26217789 NCBI chr 7:9,699,964...9,712,067
Ensembl chr 7:9,699,961...9,711,928
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Thalidomide results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein] CTD PMID:25579023 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression
ISO
EXP
[resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]
Thalidomide results in decreased expression of NFKB1 protein
CTD PMID:16333628, PMID:17164350 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO
EXP
Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Thalidomide results in increased expression of NFKBIA protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:15687330, PMID:16288038, PMID:16604421, PMID:16943688, PMID:17174718 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nhlh1 nescient helix loop helix 1 increases expression ISO Thalidomide results in increased expression of NHLH1 mRNA CTD PMID:26217789 NCBI chr13:90,437,956...90,443,157
Ensembl chr13:90,437,956...90,443,157
JBrowse link
G NMS neuromedin S increases expression ISO Thalidomide results in increased expression of NMS mRNA CTD PMID:26217789 NCBI chr 9:45,605,552...45,616,912
Ensembl chr 9:45,605,552...45,616,912
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of NOS2 mRNA] CTD PMID:16604421 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein CTD PMID:18414984 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 decreases expression ISO Thalidomide results in decreased expression of NQO2 mRNA CTD PMID:26217789 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Thalidomide results in increased expression of NR1I2 mRNA CTD PMID:28496040 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Thalidomide analog results in increased expression of NR4A1 mRNA CTD PMID:20525221 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Thalidomide analog results in increased expression of NR4A2 mRNA CTD PMID:20525221 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Nt5c3a 5'-nucleotidase, cytosolic IIIA decreases expression ISO Thalidomide results in decreased expression of NT5C3 mRNA CTD PMID:26217789 NCBI chr 4:87,238,325...87,281,234
Ensembl chr 4:87,237,949...87,281,157
JBrowse link
G Nt5e 5' nucleotidase, ecto decreases expression ISO Thalidomide results in decreased expression of NT5E mRNA CTD PMID:26217789 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nudt14 nudix hydrolase 14 decreases expression ISO Thalidomide results in decreased expression of NUDT14 mRNA CTD PMID:26217789 NCBI chr 6:137,738,150...137,745,143
Ensembl chr 6:137,738,124...137,745,127
JBrowse link
G Nudt22 nudix hydrolase 22 decreases expression ISO Thalidomide results in decreased expression of NUDT22 mRNA CTD PMID:26217789 NCBI chr 1:222,247,500...222,251,053
Ensembl chr 1:222,247,502...222,250,980
JBrowse link
G Nup62cl nucleoporin 62 C-terminal like decreases expression ISO Thalidomide results in decreased expression of NUP62CL mRNA CTD PMID:26217789 NCBI chr  X:111,333,274...111,390,023
Ensembl chr  X:111,334,252...111,365,849
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA CTD PMID:18720364 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Ocln occludin multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of OCLN protein] CTD PMID:16680017 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 increases expression ISO Thalidomide results in increased expression of OLIG2 mRNA CTD PMID:26217789 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Thalidomide results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
G Olr1194 olfactory receptor 1194 decreases expression ISO Thalidomide results in decreased expression of OLFR160 mRNA CTD PMID:26217789 NCBI chr 8:40,191,902...40,192,831
Ensembl chr 8:40,191,902...40,192,831
JBrowse link
G Olr1235 olfactory receptor 1235 increases expression ISO Thalidomide results in increased expression of OLFR147 mRNA CTD PMID:26217789 NCBI chr 4:1,470,716...1,471,657
Ensembl chr 4:1,470,716...1,471,657
JBrowse link
G Olr137 olfactory receptor 137 increases expression ISO Thalidomide results in increased expression of OLFR635 mRNA CTD PMID:26217789 NCBI chr 1:169,153,297...169,154,262
Ensembl chr 1:169,153,297...169,154,262
JBrowse link
G Olr1394 olfactory receptor 1394 increases expression ISO Thalidomide results in increased expression of OLFR1385 mRNA CTD PMID:26217789 NCBI chr10:34,672,726...34,673,655
Ensembl chr10:34,672,726...34,673,655
JBrowse link
G Olr1519 olfactory receptor 1519 increases expression ISO Thalidomide results in increased expression of OLFR412 mRNA CTD PMID:26217789 NCBI chr10:61,160,125...61,161,060
Ensembl chr10:61,160,125...61,161,060
Ensembl chr10:61,160,125...61,161,060
JBrowse link
G Olr217 olfactory receptor 217 increases expression ISO Thalidomide results in increased expression of OLFR705 mRNA CTD PMID:26217789 NCBI chr 1:170,915,109...170,916,059
Ensembl chr 1:170,915,109...170,916,059
JBrowse link
G Olr374 olfactory receptor 374 increases expression ISO Thalidomide results in increased expression of OLFR1494 mRNA CTD PMID:26217789 NCBI chr 1:230,576,298...230,577,254
Ensembl chr 1:230,576,298...230,577,254
JBrowse link
G Olr588 olfactory receptor 588 increases expression ISO Thalidomide results in increased expression of OLFR152 mRNA CTD PMID:26217789 NCBI chr 3:75,936,795...75,937,739
Ensembl chr 3:75,936,795...75,937,739
JBrowse link
G Ostf1 osteoclast stimulating factor 1 decreases expression ISO Thalidomide results in decreased expression of OSTF1 mRNA CTD PMID:26217789 NCBI chr 1:234,749,568...234,796,739
Ensembl chr 1:234,749,568...234,796,739
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein
Thalidomide analog results in increased cleavage of PARP1 protein
CTD PMID:15858615, PMID:19372569 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pax3 paired box 3 decreases expression ISO Thalidomide results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Pax6 paired box 6 increases expression ISO Thalidomide results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pdcd10 programmed cell death 10 decreases expression ISO Thalidomide results in decreased expression of PDCD10 mRNA CTD PMID:26217789 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression ISO Thalidomide results in decreased expression of PDLIM3 mRNA CTD PMID:26217789 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression EXP Thalidomide results in decreased expression of PECAM1 protein CTD PMID:18291259 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pfdn6 prefoldin subunit 6 decreases expression ISO Thalidomide results in decreased expression of PFDN6 mRNA CTD PMID:26217789 NCBI chr20:5,455,974...5,457,448
Ensembl chr20:5,455,974...5,457,444
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Thalidomide results in decreased expression of PILRA mRNA CTD PMID:26217789 NCBI chr12:21,412,598...21,418,621
Ensembl chr12:21,412,538...21,420,169
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO Thalidomide results in decreased expression of PIM1 protein CTD PMID:16616857 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Thalidomide results in decreased expression of PLAU protein CTD PMID:16288038 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
decreases expression
ISO Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]
Thalidomide results in decreased expression of PLAUR protein
CTD PMID:16288038 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pltp phospholipid transfer protein decreases expression ISO Thalidomide results in decreased expression of PLTP mRNA CTD PMID:26217789 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289
JBrowse link
G Polr2k RNA polymerase II, I and III subunit K decreases expression ISO Thalidomide results in decreased expression of POLR2K mRNA CTD PMID:26217789 NCBI chr 7:74,939,010...74,992,594
Ensembl chr 7:74,989,223...74,992,582
JBrowse link
G Popdc2 popeye domain containing 2 decreases expression ISO Thalidomide results in decreased expression of POPDC2 mRNA CTD PMID:26217789 NCBI chr11:64,915,041...64,954,704
Ensembl chr11:64,936,692...64,952,687
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases response to substance ISO PPARD gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 decreases expression ISO Thalidomide results in decreased expression of PPP1R11 mRNA CTD PMID:26217789 NCBI chr20:2,094,931...2,098,438
Ensembl chr20:2,094,931...2,098,433
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Thalidomide analog results in increased expression of PPP1R15A mRNA CTD PMID:20525221 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression ISO Thalidomide results in decreased expression of PPP1R1A mRNA CTD PMID:26217789 NCBI chr 7:145,146,480...145,154,131
Ensembl chr 7:145,146,481...145,154,131
JBrowse link
G Prelid2 PRELI domain containing 2 decreases expression ISO Thalidomide results in decreased expression of PRELID2 mRNA CTD PMID:26217789 NCBI chr18:36,198,522...36,286,217
Ensembl chr18:36,194,778...36,285,444
JBrowse link
G Prf1 perforin 1 increases expression ISO Thalidomide results in increased expression of PRF1 CTD PMID:17089043 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression ISO Thalidomide results in decreased expression of PRKG1 mRNA CTD PMID:26217789 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prr5 proline rich 5 decreases expression ISO Thalidomide results in decreased expression of PRR5 mRNA CTD PMID:26217789 NCBI chr 7:125,569,791...125,609,340
Ensembl chr 7:125,576,327...125,613,114
JBrowse link
G Prxl2a peroxiredoxin like 2A decreases expression ISO Thalidomide results in decreased expression of PRXL2A mRNA CTD PMID:26217789 NCBI chr16:17,494,000...17,513,781
Ensembl chr16:17,493,953...17,513,870
JBrowse link
G Psme2 proteasome activator subunit 2 increases expression ISO Thalidomide results in increased expression of PSME2 mRNA CTD PMID:26217789 NCBI chr15:34,265,552...34,269,851
Ensembl chr15:34,265,557...34,269,851
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Thalidomide results in increased expression of PTEN protein CTD PMID:19567134 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases degradation
decreases stability
multiple interactions
decreases expression
ISO
EXP
Thalidomide results in increased degradation of PTGS2 protein
Thalidomide results in decreased stability of PTGS2 mRNA
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
Thalidomide results in decreased expression of PTGS2 protein
CTD PMID:11705847, PMID:15982930, PMID:17638016 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rab2b RAB2B, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB2B mRNA CTD PMID:26006729, PMID:26217789 NCBI chr15:28,675,504...28,696,192
Ensembl chr15:28,677,055...28,696,122
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB8A mRNA CTD PMID:26006729 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAP1B mRNA CTD PMID:26006729 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Rassf9 Ras association domain family member 9 decreases expression ISO Thalidomide results in decreased expression of RASSF9 mRNA CTD PMID:26217789 NCBI chr 7:44,146,345...44,178,179
Ensembl chr 7:44,146,237...44,181,201
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO
EXP
[irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [irinotecan co-treated with Thalidomide] results in increased expression of RELA protein; [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat affects the localization of RELA protein]
Thalidomide results in decreased expression of RELA protein
[Thalidomide co-treated with Dimethylnitrosamine] results in decreased transport of RELA protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]
CTD PMID:15687330, PMID:16078585, PMID:16333628, PMID:16604421, PMID:16685529, PMID:16943688, PMID:17030452, PMID:17164350, PMID:17174718, PMID:23510834, PMID:26051520 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Thalidomide analog results in increased expression of RELB mRNA CTD PMID:20525221 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA CTD PMID:18720364 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G Rhoa ras homolog family member A affects expression ISO Thalidomide affects the expression of RHOA mRNA CTD PMID:26006729 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rnaseh2c ribonuclease H2, subunit C decreases expression ISO Thalidomide results in decreased expression of RNASEH2C mRNA CTD PMID:26217789 NCBI chr 1:220,966,626...220,967,717
Ensembl chr 1:220,966,655...220,967,825
JBrowse link
G Rnf138 ring finger protein 138 decreases expression ISO Thalidomide results in decreased expression of RNF138 mRNA CTD PMID:26217789 NCBI chr18:15,146,925...15,167,361 JBrowse link
G Rnf166 ring finger protein 166 multiple interactions ISO Thalidomide results in increased degradation of and results in decreased expression of RNF166 protein CTD PMID:30067223 NCBI chr19:55,290,563...55,300,403
Ensembl chr19:55,290,563...55,300,403
JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO Thalidomide results in increased expression of RPS15 mRNA CTD PMID:26217789 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 decreases expression ISO Thalidomide results in decreased expression of RPS6KA2 mRNA CTD PMID:26217789 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
JBrowse link
G Rras RAS related decreases expression ISO Thalidomide results in decreased expression of RRAS mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 1:101,012,822...101,016,720
Ensembl chr 1:101,012,822...101,016,720
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA CTD PMID:18720364 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Thalidomide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Rtn2 reticulon 2 decreases expression ISO Thalidomide results in decreased expression of RTN2 mRNA CTD PMID:26217789 NCBI chr 1:80,195,594...80,208,449
Ensembl chr 1:80,195,532...80,208,448
JBrowse link
G Ryr2 ryanodine receptor 2 decreases expression ISO Thalidomide results in decreased expression of RYR2 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Sall4 spalt-like transcription factor 4 increases expression
affects binding
multiple interactions
ISO Thalidomide results in increased expression of SALL4 mRNA
Thalidomide binds to [SALL4 protein binds to CRBN protein]
Bortezomib inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; MLN7243 inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; pevonedistat inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940
JBrowse link
G Sap30 Sin3A associated protein 30 decreases expression ISO Thalidomide results in decreased expression of SAP30 mRNA CTD PMID:26217789 NCBI chr16:36,115,942...36,121,310
Ensembl chr16:36,116,258...36,121,097
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 decreases expression ISO Thalidomide results in decreased expression of SAT1 mRNA CTD PMID:26217789 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 decreases expression ISO Thalidomide results in decreased expression of SCN7A mRNA CTD PMID:26217789 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907
JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Thalidomide results in decreased expression of SDHAF1 mRNA CTD PMID:26217789 NCBI chr 1:88,779,476...88,780,425
Ensembl chr 1:90,948,976...90,949,332
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C decreases expression ISO Thalidomide results in decreased expression of SDHC mRNA CTD PMID:26217789 NCBI chr13:89,498,047...89,518,979
Ensembl chr13:89,498,048...89,518,939
JBrowse link
G Selenos selenoprotein S decreases expression ISO Thalidomide results in decreased expression of SELENOS mRNA CTD PMID:26006729 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Sell selectin L decreases expression ISO Thalidomide results in decreased expression of SELL protein CTD PMID:16344495 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Serpinb2 serpin family B member 2 increases response to substance ISO SERPINB2 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 increases expression ISO Thalidomide results in increased expression of SFRP2 mRNA CTD PMID:26217789 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Sh3bgr SH3 domain binding glutamate-rich protein decreases expression ISO Thalidomide results in decreased expression of SH3BGR mRNA CTD PMID:26217789 NCBI chr11:36,555,354...36,579,537
Ensembl chr11:36,555,416...36,579,535
JBrowse link
G Slc12a6 solute carrier family 12, member 6 increases response to substance ISO SLC12A6 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 3:103,752,213...103,852,686
Ensembl chr 3:103,753,238...103,852,686
JBrowse link
G Slc13a4 solute carrier family 13 member 4 decreases expression ISO Thalidomide results in decreased expression of SLC13A4 mRNA CTD PMID:26217789 NCBI chr 4:62,796,732...62,841,053
Ensembl chr 4:62,797,677...62,840,357
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thalidomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO Thalidomide results in decreased expression of SLC25A20 mRNA CTD PMID:26217789 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression ISO Thalidomide results in decreased expression of SLC25A30 mRNA CTD PMID:26217789 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Thalidomide results in increased expression of SLC2A3 mRNA CTD PMID:26217789 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc44a3 solute carrier family 44, member 3 decreases expression ISO Thalidomide results in decreased expression of SLC44A3 mRNA CTD PMID:26217789 NCBI chr 2:225,038,261...225,112,859
Ensembl chr 2:225,038,582...225,107,283
JBrowse link
G Slc8a1 solute carrier family 8 member A1 decreases expression ISO Thalidomide results in decreased expression of SLC8A1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 decreases expression ISO Thalidomide results in decreased expression of SLCO4C1 mRNA CTD PMID:26217789 NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308
JBrowse link
G Smim4 small integral membrane protein 4 decreases expression ISO Thalidomide results in decreased expression of SMIM4 mRNA CTD PMID:26217789 NCBI chr16:7,206,632...7,210,518 JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Smyd1 SET and MYND domain containing 1 decreases expression ISO Thalidomide results in decreased expression of SMYD1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 4:99,071,122...99,125,143
Ensembl chr 4:99,074,535...99,125,111
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression EXP Thalidomide results in increased expression of SNAP25 mRNA; Thalidomide results in increased expression of SNAP25 protein CTD PMID:27693314 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide decreases expression ISO Thalidomide results in decreased expression of SNRPD1 mRNA CTD PMID:26217789 NCBI chr18:1,866,066...1,876,613
Ensembl chr18:1,866,080...1,876,613
JBrowse link
G Snx16 sorting nexin 16 increases expression ISO Thalidomide analog results in increased expression of SNX16 mRNA CTD PMID:20525221 NCBI chr 2:93,518,796...93,541,056
Ensembl chr 2:93,518,806...93,540,328
JBrowse link
G Snx24 sorting nexin 24 decreases expression ISO Thalidomide results in decreased expression of SNX24 mRNA CTD PMID:26217789 NCBI chr18:48,201,653...48,355,701
Ensembl chr18:48,201,728...48,355,699
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]
CTD PMID:16510725, PMID:17030452 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sox1 SRY-box transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of SOX1 mRNA CTD PMID:26217789
G Sox17 SRY-box transcription factor 17 decreases localization ISO Thalidomide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sp1 Sp1 transcription factor decreases activity ISO Thalidomide results in decreased activity of SP1 protein CTD PMID:10533722 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Thalidomide results in decreased expression of SP5 mRNA CTD PMID:26217789 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression ISO Thalidomide results in decreased expression of SPA17 mRNA CTD PMID:26217789 NCBI chr 8:40,066,954...40,078,131
Ensembl chr 8:40,067,076...40,078,165
JBrowse link
G Spag5 sperm associated antigen 5 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA CTD PMID:18720364 NCBI chr10:65,552,780...65,585,773
Ensembl chr10:65,566,171...65,585,760
Ensembl chr10:65,566,171...65,585,760
JBrowse link
G Sphkap SPHK1 interactor, AKAP domain containing decreases expression ISO Thalidomide results in decreased expression of SPHKAP mRNA CTD PMID:26217789 NCBI chr 9:89,050,405...89,195,435
Ensembl chr 9:89,050,381...89,195,273
JBrowse link
G Srrd SRR1 domain containing decreases expression ISO Thalidomide results in decreased expression of SRRD mRNA CTD PMID:26217789 NCBI chr12:50,315,876...50,321,488
Ensembl chr12:50,315,933...50,321,144
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
ISO Thalidomide analog results in decreased phosphorylation of STAT3 protein
[resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; Thalidomide promotes the reaction [Capsaicin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:15858615, PMID:17164350, PMID:17505005 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stmn2 stathmin 2 decreases expression ISO Thalidomide results in decreased expression of STMN2 mRNA CTD PMID:26217789 NCBI chr 2:95,424,251...95,471,900
Ensembl chr 2:95,424,251...95,472,115
JBrowse link
G Swsap1 SWIM-type zinc finger 7 associated protein 1 decreases expression ISO Thalidomide results in decreased expression of SWSAP1 mRNA CTD PMID:26217789 NCBI chr 8:22,966,752...22,969,280
Ensembl chr 8:22,966,561...22,969,459
JBrowse link
G Synj2bp synaptojanin 2 binding protein decreases expression ISO Thalidomide results in decreased expression of SYNJ2BP mRNA CTD PMID:26006729 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549
JBrowse link
G Tc2n tandem C2 domains, nuclear decreases expression ISO Thalidomide results in decreased expression of TC2N mRNA CTD PMID:26217789 NCBI chr 6:125,437,767...125,601,408
Ensembl chr 6:125,437,775...125,590,049
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Thalidomide results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Tdg thymine-DNA glycosylase decreases expression ISO Thalidomide results in decreased expression of TDG mRNA CTD PMID:26217789 NCBI chr 7:27,194,000...27,213,676
Ensembl chr 7:27,193,998...27,214,236
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 decreases expression ISO Thalidomide results in decreased expression of TDGF1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Tefm transcription elongation factor, mitochondrial decreases expression ISO Thalidomide results in decreased expression of TEFM mRNA CTD PMID:26217789 NCBI chr10:67,476,006...67,478,830
Ensembl chr10:67,475,968...67,479,077
JBrowse link
G Tek TEK receptor tyrosine kinase decreases expression ISO Thalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tex16-ps1 testis expressed 16, pseudogene 1 decreases expression ISO Thalidomide results in decreased expression of TEX16 mRNA CTD PMID:26217789
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]
Thalidomide results in decreased expression of TGFB1 mRNA
Thalidomide results in decreased expression of TGFB1 mRNA; Thalidomide results in decreased expression of TGFB1 protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
CTD PMID:15464241, PMID:16288038, PMID:16510725, PMID:16549389, PMID:16604421, PMID:17030452, PMID:18291259, PMID:26006729, PMID:26217789, PMID:26221080 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression ISO Thalidomide results in decreased expression of TGFBI mRNA CTD PMID:26006729, PMID:26217789 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Thalidomide results in decreased expression of TGFBR1 mRNA; Thalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA] CTD PMID:15464241, PMID:17030452 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA] CTD PMID:15464241 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 decreases expression ISO Thalidomide results in decreased expression of TINAGL1 mRNA CTD PMID:26217789 NCBI chr 5:148,382,702...148,392,729
Ensembl chr 5:148,382,706...148,392,697
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein] CTD PMID:16680017 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tm2d3 TM2 domain containing 3 decreases expression ISO Thalidomide results in decreased expression of TM2D3 mRNA CTD PMID:26217789 NCBI chr 1:126,573,474...126,595,778
Ensembl chr 1:126,586,543...126,595,603
JBrowse link
G Tmem138 transmembrane protein 138 decreases expression ISO Thalidomide results in decreased expression of TMEM138 mRNA CTD PMID:26217789 NCBI chr 1:226,623,861...226,630,911
Ensembl chr 1:226,623,861...226,630,900
JBrowse link
G Tmem176a transmembrane protein 176A decreases expression ISO Thalidomide results in decreased expression of TMEM176A mRNA CTD PMID:26217789 NCBI chr 4:78,458,735...78,462,415
Ensembl chr 4:78,458,625...78,462,423
JBrowse link
G Tmpo thymopoietin multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA CTD PMID:18720364 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases degradation
increases expression
ISO
EXP
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide results in decreased expression of TNF protein
Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein
Thalidomide results in increased degradation of TNF mRNA
Thalidomide results in increased expression of TNF mRNA
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein]
Thalidomide results in increased expression of TNF protein
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
CTD PMID:9068814, PMID:9623511, PMID:10496904, PMID:10720640, PMID:11367517, PMID:11592764, PMID:11788559, PMID:12411981, PMID:12422154, PMID:14617101, PMID:14687169, PMID:15060740, PMID:15464241, PMID:15687330, PMID:15863203, PMID:15982930, PMID:16078585, PMID:16454849, PMID:16510725, PMID:16549389, PMID:16597438, PMID:16604421, PMID:16680017, PMID:16815871, PMID:16943688, PMID:18291259, PMID:19050852, PMID:23510834, PMID:25478868, PMID:26051520, PMID:26221080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression ISO Thalidomide results in decreased expression of TNFRSF10A protein CTD PMID:16531263 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO Thalidomide results in decreased expression of TNFRSF1A mRNA; Thalidomide results in decreased expression of TNFRSF1A protein CTD PMID:15618473, PMID:16344495 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO Thalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Thalidomide results in decreased expression of TNFSF10 protein CTD PMID:16531263 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein CTD PMID:16079895 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type decreases expression ISO Thalidomide results in decreased expression of TNNC1 mRNA CTD PMID:26006729, PMID:26217789 NCBI chr16:7,292,207...7,295,238
Ensembl chr16:7,292,096...7,295,465
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA CTD PMID:18720364 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Thalidomide analog results in increased expression of TP53 mRNA CTD PMID:20525221 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 decreases expression ISO Thalidomide results in decreased expression of TRAM1L1 mRNA CTD PMID:26217789 NCBI chr 2:228,544,418...228,546,599
Ensembl chr 2:228,544,418...228,546,599
JBrowse link
G Trappc2l trafficking protein particle complex 2-like decreases expression ISO Thalidomide results in decreased expression of TRAPPC2L mRNA CTD PMID:26217789 NCBI chr19:55,423,350...55,428,551
Ensembl chr19:55,423,350...55,427,036
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Thalidomide analog results in increased expression of TRIB3 mRNA CTD PMID:20525221 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim55 tripartite motif-containing 55 decreases expression ISO Thalidomide results in decreased expression of TRIM55 mRNA CTD PMID:26217789 NCBI chr 2:104,416,972...104,459,117
Ensembl chr 2:104,416,972...104,459,107
JBrowse link
G Tspan33 tetraspanin 33 decreases expression ISO Thalidomide results in decreased expression of TSPAN33 mRNA CTD PMID:26217789 NCBI chr 4:56,981,283...57,005,866
Ensembl chr 4:56,981,283...57,004,792
JBrowse link
G Ttc30a1 tetratricopeptide repeat domain 30A1 decreases expression ISO Thalidomide results in decreased expression of TTC30A1 mRNA CTD PMID:26217789 NCBI chr 3:62,800,932...62,803,373
Ensembl chr 3:62,800,935...62,803,373
JBrowse link
G Ttc32 tetratricopeptide repeat domain 32 decreases expression ISO Thalidomide results in decreased expression of TTC32 mRNA CTD PMID:26217789 NCBI chr 6:34,154,973...34,161,857
Ensembl chr 6:34,155,017...34,161,171
JBrowse link
G Ttk Ttk protein kinase multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA CTD PMID:18720364 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Ttn titin decreases expression ISO Thalidomide results in decreased expression of TTN mRNA CTD PMID:26006729, PMID:26217789 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA CTD PMID:18720364 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ubxn1 UBX domain protein 1 decreases expression ISO Thalidomide results in decreased expression of UBXN1 mRNA CTD PMID:26217789 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 decreases expression ISO Thalidomide results in decreased expression of UCHL3 mRNA CTD PMID:26217789 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
JBrowse link
G Uncx UNC homeobox decreases expression ISO Thalidomide results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679
JBrowse link
G Upp1 uridine phosphorylase 1 decreases expression ISO Thalidomide results in decreased expression of UPP1 mRNA CTD PMID:26217789 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Thalidomide results in decreased expression of VCAM1 mRNA; Thalidomide results in decreased expression of VCAM1 protein CTD PMID:17174718 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
multiple interactions
decreases expression
increases expression
decreases activity
decreases secretion
affects secretion
ISO
EXP
Thalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA protein
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA
[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA
[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNA
Thalidomide results in increased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased activity of VEGFA protein
Thalidomide analog results in decreased secretion of VEGFA protein
Thalidomide affects the secretion of VEGFA protein
CTD PMID:15858615, PMID:15863203, PMID:15939924, PMID:15982930, PMID:16313753, PMID:16327979, PMID:17557286, PMID:18291259, PMID:21539454, PMID:24154490, PMID:29699374 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B multiple interactions
decreases expression
ISO [Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFB mRNA
Thalidomide results in decreased expression of VEGFB mRNA
CTD PMID:29699374 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vegfc vascular endothelial growth factor C affects expression ISO Thalidomide affects the expression of VEGFC mRNA CTD PMID:29699374 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions
decreases expression
ISO [Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFD mRNA
Thalidomide results in decreased expression of VEGFD mRNA
CTD PMID:29699374 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Vtn vitronectin decreases expression ISO Thalidomide results in decreased expression of VTN mRNA CTD PMID:26217789 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
G Wnt5b Wnt family member 5B decreases expression ISO Thalidomide results in decreased expression of WNT5B mRNA CTD PMID:24154490 NCBI chr 4:151,500,962...151,516,894
Ensembl chr 4:151,500,957...151,516,894
JBrowse link
G Wnt8a Wnt family member 8A decreases expression ISO Thalidomide results in decreased expression of WNT8A mRNA CTD PMID:26217789 NCBI chr18:27,331,236...27,336,829
Ensembl chr18:27,331,236...27,336,829
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Thalidomide analog results in decreased expression of XIAP protein CTD PMID:15858615 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zcchc17 zinc finger CCHC-type containing 17 increases expression ISO Thalidomide results in increased expression of ZCCHC17 mRNA CTD PMID:26217789 NCBI chr 5:148,535,519...148,577,315
Ensembl chr 5:148,535,519...148,577,292
JBrowse link
G Zfp692 zinc finger protein 692 multiple interactions ISO Thalidomide results in increased degradation of and results in decreased expression of ZNF692 protein CTD PMID:30067223 NCBI chr10:43,740,739...43,752,713
Ensembl chr10:43,744,731...43,752,242
JBrowse link
G Zfpl1 zinc finger protein-like 1 decreases expression ISO Thalidomide results in decreased expression of ZFPL1 mRNA CTD PMID:26217789 NCBI chr 1:221,444,588...221,448,555
Ensembl chr 1:221,443,901...221,448,570
JBrowse link
G Zkscan5 zinc finger with KRAB and SCAN domains 5 decreases expression ISO Thalidomide results in decreased expression of ZKSCAN5 mRNA CTD PMID:26217789 NCBI chr12:11,154,807...11,176,002
Ensembl chr12:11,154,794...11,176,106
JBrowse link
G Zmat5 zinc finger, matrin type 5 decreases expression ISO Thalidomide results in decreased expression of ZMAT5 mRNA CTD PMID:26217789 NCBI chr14:84,937,843...84,968,898
Ensembl chr14:84,953,786...84,969,116
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression ISO Thalidomide results in decreased expression of ZNRD2 mRNA CTD PMID:26217789 NCBI chr 1:221,087,803...221,089,586
Ensembl chr 1:221,087,803...221,089,586
JBrowse link
G Zscan12 zinc finger and SCAN domain containing 12 decreases expression ISO Thalidomide results in decreased expression of ZSCAN12 mRNA CTD PMID:26217789 NCBI chr17:45,279,171...45,285,069
Ensembl chr17:45,279,162...45,285,060
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          nitrogen atom 18542
            nitrogen molecular entity 18542
              organonitrogen compound 18312
                organonitrogen heterocyclic compound 17461
                  benzopyrrole 9340
                    isoindoles 544
                      (3R)-3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione 0
                      (3R,3'R,4'S,5'R)-5'-[2-[4-(2-hydroxyethyl)-1-triazolyl]ethyl]-4'-[(4-methoxyphenyl)-dimethylsilyl]-3'-methyl-5-(2-oxo-1-benzo[cd]indolyl)-1-prop-2-enyl-2-spiro[indole-3,2'-oxolane]one 0
                      (3S,3'S,4'R,5'S)-5'-[2-[4-(2-hydroxyethyl)-1-triazolyl]ethyl]-4'-[(4-methoxyphenyl)-dimethylsilyl]-3'-methyl-5-(2-oxo-1-benzo[cd]indolyl)-1-prop-2-enyl-2-spiro[indole-3,2'-oxolane]one 0
                      1-ethyl-2-benzo[cd]indolone 0
                      2-(1,3-benzodioxol-5-ylmethyl)-3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3H-isoindol-1-one 0
                      2-(2-ethoxyphenyl)-5,6-dimethyl-1,3-dihydroisoindole 0
                      2-(2-furanylmethyl)-3-[[2-(3-pyridinyl)-3H-benzimidazol-5-yl]amino]-3H-isoindol-1-one 0
                      2-(2-methoxyethyl)-7-[oxo-(4-propyl-1-piperazinyl)methyl]-3H-isoindol-1-one 0
                      2-(2-methylphenyl)-3H-isoindol-1-one 0
                      2-(2-oxo-1-benzo[cd]indolyl)-N-(2-oxolanylmethyl)acetamide 0
                      2-(3-\{(2-chloro-4-fluorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino\}propyl)-1H-isoindole-1,3(2H)-dione 0
                      2-(3-amino-1-isoindolylidene)-2-cyano-N-(2-methoxyethyl)acetamide 0
                      2-(4-Hydroxybenzyl)isoindole-1,3-dione 0
                      2-(4-methylphenyl)-1,9b-dihydropyrazolo[1,5-b]isoindol-5-one 0
                      2-(4-oxo-6,8-dioxabicyclo[3.2.1]octan-2-yl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione 0
                      2-(5-chloro-2-pyridinyl)-3-(4-ethoxyanilino)-3H-isoindol-1-one 0
                      2-(5H-[1,2,4]triazolo[5,1-a]isoindol-2-yl)ethanethioamide 0
                      2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                      2-amino-7-cyclohexyl-6,8-dioxo-4,5,5a,8a-tetrahydrothieno[2,3-e]isoindole-3-carboxylic acid ethyl ester 0
                      3-(2-ethoxyanilino)-2-(2-furanylmethyl)-3H-isoindol-1-one 0
                      3-(4-ethylphenyl)imino-1-isoindolamine 0
                      3-[(5-chloro-2-pyridinyl)amino]-2-(2-pyridinyl)-3H-isoindol-1-one 0
                      3-[[2-(2-furanylmethyl)-3-oxo-1H-isoindol-1-yl]amino]benzoic acid ethyl ester 0
                      4-(dimethylsulfamoyl)-N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide 0
                      4-[3-oxo-1-(3,4,5-trimethoxyanilino)-1H-isoindol-2-yl]-1-piperidinecarboxylic acid ethyl ester 0
                      4-[4-[[[1-(2-methylpropyl)-3-pyrrolidinyl]methylamino]-oxomethyl]-3-oxo-1H-isoindol-2-yl]-1-piperidinecarboxylic acid ethyl ester 0
                      4-[[3-oxo-2-(3-pyridinyl)-1H-isoindol-1-yl]amino]benzoic acid ethyl ester 0
                      4-[[[(1-ethyl-2-oxo-6-benzo[cd]indolyl)amino]-oxomethyl]amino]benzoic acid ethyl ester 0
                      4-[[[2-(4-methoxyphenyl)-3-oxo-1H-isoindol-4-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester 0
                      4-chloro-2-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydroisoindole 0
                      5-(2,2-diferuloylethen-1-yl)thalidomide 0
                      5-[2-(feruloyl)ethen-1-yl]thalidomide 0
                      6,7-dimethoxy-2-(2-thiazolyl)-3H-isoindol-1-one 0
                      8'-amino-1,1,4a,6-tetramethylspiro[3,4,6,7,8,8a-hexahydro-2H-naphthalene-5,2'-3,6-dihydrofuro[2,3-e]isoindole]-2,4'-diol 0
                      Captan GlcA 0
                      Captan SO3 0
                      Dialifor 0
                      Ditalimfos 0
                      LSM-17324 0
                      LSM-17343 0
                      LSM-19109 0
                      LSM-19437 0
                      LSM-20631 0
                      LSM-21149 0
                      LSM-25805 0
                      LSM-28383 0
                      LSM-32057 0
                      LSM-33609 0
                      LSM-36632 0
                      LSM-4844 0
                      MGK 264 0
                      N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide 0
                      N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamide 0
                      N-(2-furanylmethyl)-3-(2-furanylmethylimino)-1-isoindolamine 0
                      N-(4-bromophenyl)-2-\{4-[(4-bromophenyl)carbamoyl]phenyl\}-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide 0
                      N-(p-Nitrobenzyl)phthalimide 0
                      N-Benzylphthalimide 0