Moxd1 (monooxygenase, DBH-like 1) - Rat Genome Database

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Gene: Moxd1 (monooxygenase, DBH-like 1) Rattus norvegicus
Analyze
Symbol: Moxd1
Name: monooxygenase, DBH-like 1
RGD ID: 1310033
Description: Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in extracellular space and secretory granule membrane. Orthologous to human MOXD1 (monooxygenase DBH like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DBH-like monooxygenase protein 1; LOC294119
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,075,124 - 21,165,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,075,122 - 21,161,779 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0122,124,498 - 22,206,565 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,124,495 - 22,206,505 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,604,654 - 23,686,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,599,942 - 21,686,543 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,603,599 - 21,688,511 (-)NCBI
Celera119,826,681 - 19,913,152 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15337741  


Genomics

Comparative Map Data
Moxd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,075,124 - 21,165,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,075,122 - 21,161,779 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0122,124,498 - 22,206,565 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,124,495 - 22,206,505 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,604,654 - 23,686,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,599,942 - 21,686,543 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,603,599 - 21,688,511 (-)NCBI
Celera119,826,681 - 19,913,152 (-)NCBICelera
Cytogenetic Map1p12NCBI
MOXD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386132,296,055 - 132,401,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6132,296,055 - 132,401,475 (-)EnsemblGRCh38hg38GRCh38
GRCh376132,617,194 - 132,722,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,658,887 - 132,764,357 (-)NCBINCBI36Build 36hg18NCBI36
Build 346132,658,900 - 132,737,897NCBI
Celera6133,364,075 - 133,469,523 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6130,192,320 - 130,297,382 (-)NCBIHuRef
CHM1_16132,880,907 - 132,986,340 (-)NCBICHM1_1
T2T-CHM13v2.06133,491,085 - 133,596,465 (-)NCBIT2T-CHM13v2.0
Moxd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,099,415 - 24,178,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,099,415 - 24,178,688 (+)EnsemblGRCm39 Ensembl
GRCm381024,223,517 - 24,302,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,223,517 - 24,302,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv371023,943,323 - 24,022,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361023,912,933 - 23,992,199 (+)NCBIMGSCv36mm8
Celera1025,156,513 - 25,235,667 (+)NCBICelera
Cytogenetic Map10A4NCBI
Moxd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,818,375 - 12,872,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,818,375 - 12,872,229 (-)NCBIChiLan1.0ChiLan1.0
MOXD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16134,182,129 - 134,285,995 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6134,179,412 - 134,285,995 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06130,073,802 - 130,177,753 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MOXD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,018,452 - 25,114,028 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,018,509 - 25,112,478 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,404,602 - 26,499,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,328,412 - 25,423,166 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,327,253 - 25,423,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,374,169 - 25,468,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,271,493 - 25,367,112 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,535,032 - 25,630,566 (-)NCBIUU_Cfam_GSD_1.0
Moxd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,553,333 - 120,634,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936560332,718 - 413,559 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936560334,294 - 413,559 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOXD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,282,506 - 31,367,779 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,282,491 - 31,367,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2134,802,968 - 34,888,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOXD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,138,661 - 41,271,779 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604013,329,004 - 13,453,440 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Moxd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247536,377,330 - 6,471,085 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247536,379,583 - 6,471,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Moxd1
519 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:231
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000061234
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat

Markers in Region
RH131733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,075,341 - 21,075,547 (+)MAPPERmRatBN7.2
Rnor_6.0122,124,716 - 22,124,921NCBIRnor6.0
Rnor_5.0123,604,875 - 23,605,080UniSTSRnor5.0
RGSC_v3.4121,600,163 - 21,600,368UniSTSRGSC3.4
Celera119,826,899 - 19,827,104UniSTS
RH 3.4 Map1208.7UniSTS
Cytogenetic Map1p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13 18 21 7
Low 2 14 20 10 19 10 1 1 61 4 15 4 1
Below cutoff 1 16 24 18 18 6 6 10 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061234   ⟹   ENSRNOP00000057945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,075,122 - 21,161,779 (-)Ensembl
Rnor_6.0 Ensembl122,124,495 - 22,206,505 (-)Ensembl
RefSeq Acc Id: XM_220095   ⟹   XP_220095
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2121,075,124 - 21,165,348 (-)NCBI
Rnor_6.0122,124,498 - 22,206,565 (-)NCBI
Rnor_5.0123,604,654 - 23,686,707 (-)NCBI
RGSC_v3.4121,599,942 - 21,686,543 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_220095 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91331 (Get FASTA)   NCBI Sequence Viewer  
  EDL87769 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_220095   ⟸   XM_220095
- Sequence:
RefSeq Acc Id: ENSRNOP00000057945   ⟸   ENSRNOT00000061234
Protein Domains
Cu2_monoox_C   Cu2_monooxygen   DOMON

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9S5-F1-model_v2 AlphaFold G3V9S5 1-613 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310033 AgrOrtholog
BioCyc Gene G2FUF-62105 BioCyc
Ensembl Genes ENSRNOG00000015321 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057945 ENTREZGENE
  ENSRNOP00000057945.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061234 ENTREZGENE
  ENSRNOT00000061234.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.230 UniProtKB/TrEMBL
  2.60.120.310 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314319 IMAGE-MGC_LOAD
InterPro Cu2_ascorb_mOase-like_C UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N_sf UniProtKB/TrEMBL
  Cu2_monoox_C UniProtKB/TrEMBL
  DBH-like UniProtKB/TrEMBL
  DOH_DOMON UniProtKB/TrEMBL
  DOMON_domain UniProtKB/TrEMBL
  MOXD1 UniProtKB/TrEMBL
  PHM/PNGase_F_dom UniProtKB/TrEMBL
  Tbh/DBH UniProtKB/TrEMBL
KEGG Report rno:294119 UniProtKB/TrEMBL
MGC_CLONE MGC:109321 IMAGE-MGC_LOAD
NCBI Gene 294119 ENTREZGENE
PANTHER PTHR10157 UniProtKB/TrEMBL
  PTHR10157:SF28 UniProtKB/TrEMBL
Pfam Cu2_monoox_C UniProtKB/TrEMBL
  Cu2_monooxygen UniProtKB/TrEMBL
PhenoGen Moxd1 PhenoGen
PRINTS DBMONOXGNASE UniProtKB/TrEMBL
PROSITE DOMON UniProtKB/TrEMBL
SMART DoH UniProtKB/TrEMBL
Superfamily-SCOP PHM_PNGase_F UniProtKB/TrEMBL
UniProt G3V9S5_RAT UniProtKB/TrEMBL
  Q5BJU1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Moxd1  monooxygenase, DBH-like 1  Moxd1_predicted  monooxygenase, DBH-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Moxd1_predicted  monooxygenase, DBH-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED