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Gene: Tm2d3 (TM2 domain containing 3) Rattus norvegicus

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Symbol:

Tm2d3

Name:

TM2 domain containing 3

RGD ID:

1564929

Description:

Predicted to be involved in lateral inhibition. Predicted to be located in membrane. Orthologous to human TM2D3 (TM2 domain containing 3); INTERACTS WITH 4,4'-sulfonyldiphenol; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC292995; RGD1564929; similar to BBP-like protein 2; TM2 domain-containing protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TM2D3 (TM2 domain containing 3)	HGNC	Ensembl, HomoloGene, NCBI, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Tm2d3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tm2d3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TM2D3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TM2D3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tm2d3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TM2D3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TM2D3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tm2d3 (TM2 domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tm2d3 (TM2 domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TM2D3 (TM2 domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tm2d3 (TM2 domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C41D11.9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	amx	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tm2d3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI		GRCr8
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	119,264,576 - 119,277,099 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	127,253,172 - 127,265,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	134,424,597 - 134,437,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	127,238,468 - 127,250,985 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	126,573,474 - 126,595,778 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	126,586,543 - 126,595,603 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	127,666,050 - 127,679,269 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	120,102,507 - 120,117,091 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	111,480,377 - 111,492,584 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

frontotemporal dementia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

bortezomib (ISO)

buspirone (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

flutamide (EXP)

formaldehyde (ISO)

lead(0) (ISO)

leflunomide (ISO)

menadione (ISO)

nefazodone (EXP)

nimesulide (EXP)

p-toluidine (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

stigmasterol (ISO)

sunitinib (ISO)

thalidomide (ISO)

thapsigargin (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lateral inhibition (ISO)

Cellular Component

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Tm2d3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI		GRCr8
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	119,264,576 - 119,277,099 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	127,253,172 - 127,265,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	134,424,597 - 134,437,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	127,238,468 - 127,250,985 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	126,573,474 - 126,595,778 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	126,586,543 - 126,595,603 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	127,666,050 - 127,679,269 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	120,102,507 - 120,117,091 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	111,480,377 - 111,492,584 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

TM2D3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	101,632,977 - 101,652,381 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	101,621,444 - 101,652,391 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	102,173,180 - 102,192,584 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	99,999,572 - 100,010,117 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	78,595,626 - 78,606,219 (-)	NCBI		Celera
Cytogenetic Map	15	q26.3	NCBI
HuRef	15	78,305,847 - 78,316,388 (-)	NCBI		HuRef
CHM1_1	15	102,023,180 - 102,033,724 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	99,378,569 - 99,410,385 (-)	NCBI		T2T-CHM13v2.0

Tm2d3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	65,343,204 - 65,351,650 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	65,340,917 - 65,351,661 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	65,693,417 - 65,701,913 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	65,691,169 - 65,701,913 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	72,838,303 - 72,846,799 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	65,570,121 - 65,580,857 (+)	NCBI		MGSCv36	mm8
Celera	7	63,106,694 - 63,115,960 (+)	NCBI		Celera
Cytogenetic Map	7	C	NCBI
cM Map	7	35.26	NCBI

Tm2d3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	28,499,634 - 28,507,867 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	28,499,077 - 28,507,907 (-)	NCBI	ChiLan1.0	ChiLan1.0

TM2D3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	91,237,996 - 91,259,824 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	94,923,661 - 94,958,955 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	80,357,201 - 80,392,500 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	99,655,558 - 99,666,052 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	99,647,402 - 99,666,445 (-)	Ensembl	panpan1.1		panPan2

TM2D3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	39,421,763 - 39,434,014 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	39,421,549 - 39,511,268 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	42,112,514 - 42,124,783 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	39,813,890 - 39,826,164 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	39,813,684 - 39,832,756 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	39,347,671 - 39,359,930 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	39,584,388 - 39,596,648 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	39,785,917 - 39,798,199 (+)	NCBI		UU_Cfam_GSD_1.0

Tm2d3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	144,114,733 - 144,123,558 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	2,210,913 - 2,220,399 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	2,210,949 - 2,219,345 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TM2D3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	145,359,731 - 145,384,212 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	145,359,693 - 145,371,218 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	311,079,780 - 311,091,270 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TM2D3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	20,094,911 - 20,104,639 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	20,094,275 - 20,104,642 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	26,435,092 - 26,445,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tm2d3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	3,184,107 - 3,191,980 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	3,184,034 - 3,210,477 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	171
Count of miRNA genes:	135
Interacting mature miRNAs:	145
Transcripts:	ENSRNOT00000015287
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	176289080	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
631684	Bp117	Blood pressure QTL 117	8.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	120082258	165082258	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	112521556	157521556	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	128019551	173019551	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
631569	Bp93	Blood pressure QTL 93		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	131244255	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	112521556	157521556	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	124975316	152612788	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	111949780	160574007	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	97582336	142582336	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	116099376	191260518	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	111404407	142582336	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001419455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001419456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001419457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001419458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015287 ⟹ ENSRNOP00000015287

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	119,267,143 - 119,277,092 (+)	Ensembl
Rnor_6.0 Ensembl	1	126,586,543 - 126,595,603 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094329 ⟹ ENSRNOP00000091784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	119,264,576 - 119,277,099 (+)	Ensembl

RefSeq Acc Id:

NM_001106267 ⟹ NP_001099737

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI
Rnor_6.0	1	126,573,474 - 126,595,778 (+)	NCBI
Rnor_5.0	1	127,666,050 - 127,679,269 (+)	NCBI
RGSC_v3.4	1	120,102,507 - 120,117,091 (+)	RGD
Celera	1	111,480,377 - 111,492,584 (+)	RGD

Sequence:

show sequence

TGGTTGGTGAAAAGGAAAAGCTAAACAATTCAGTAAATGTGCGAACAAGAGACAACAAAATTCA
TGGAGAAATATCAATAACTTCAGTCATTGAAAAATTGAAGAACCTCAAAAAATCACGCTGTGGT
GAAACCTAAGGCAGGAGTCCTGGGTCCTGGTGCGTGGGACTCCGTGCTCTTGGAGCTACTTCCC
TTGCTGCCTGGATCAGCGGAACTAAAATGGGCTAACGACATCGGATCATAACCGTCCCCCAGAC
TCCCATTGGAAAGAGAGGGGTATCTCTTCAAAGGCAGTAAGGGCTATTCTGGTCCGAGCTACCT
CCTGCTGCTGCGGAGCCCCAGCTCCACTCACTTTCCCTGGCCAACAGCACTCTAAATGCAGCGA
CAGAGAAACCACCCTACCTCCTAGCCGGGAAGCACGGTCGTCTGCTGGCGGAGCCCAGCAACAG
TGCGCCTGCGGGCGCCCGGACACGCCCTCTTCGGCGCGCCCCCCATAGTCCCGCCTCCTGGCCC
GGAAGTGCGCACGCGCACCGGCAAGATGGAGGCTGCGGCCGAGCCGCTGCGGTCTGTCCGCCAC
CTGTCCCGCGTGCTGCTCTTCCTGTCCCAGTGCTACATTCTGTCGGGCGATGGATCCTTAAATT
TAGACCATTCGCAGCCGCTGGCTCAGTCAATAAAGGATCCGGGCCCAACACGTATATTCATAGT
AGTTCCCAGGGCAGCAGAGAATCAGCTGTTCTCTCACCTCACAGAAAGTACTGAGATCCCTCCT
TACATGATGAAGTGTCCAAGCAATGGCTTATGTAGCAGACTTCCTGCAGACTGCATAGAGTGTG
CGACCAATGCCTCCTGTACTTATGGGAAGCCTGTCACGTTTGACTGCACGGTGAAACCCTCTGT
TACCTGTGTCGATCAAGACCTCAGGCCCCAGAGGAACTTCGTCATCAACATGACTTGCAGGTTT
TGCTGGCAGCTTCCTGAGACAGACTATGAGTGTTCAAATTCCACCACCTGCATGACCGTGGCCT
GCCCTCGGCAGCGCTACTTTGCCAACTGCACTGTGCGCGACCACATTCATTGCTTGGGTAACCG
GACTTTCCCTAAACTGCTGTACTGCAACTGGACTGGAGGCTACAAGTGGTCGACGGCTCTGGCT
CTGAGCATCACCCTTGGGGGCTTTGGAGCGGATCGCTTCTACCTGGGCCAGTGGCGTGAAGGCC
TCGGCAAGCTCTTCAGCTTTGGTGGTCTGGGAATATGGACCCTAATCGACGTCTTGCTGATTGG
AGTTGGCTATGTGGGGCCAGCGGATGGCTCTTTGTACATTTAGTGTGGTTATGTGCTTCAGAGA
GCAGTGCGTAGAGTCCTTTGTGCGAGGTGGACATGGTGTAAGAGGGGTATTTATGTTTTTAATG
TACAGCATCTGTACTTGGCTTGCCTTGATGAAGGTAAAATAAAGAAATGGAACACTGAACCACA

hide sequence

RefSeq Acc Id:

NM_001419455 ⟹ NP_001406384

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI

RefSeq Acc Id:

NM_001419456 ⟹ NP_001406385

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI

RefSeq Acc Id:

NM_001419457 ⟹ NP_001406386

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI

RefSeq Acc Id:

NM_001419458 ⟹ NP_001406387

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	128,677,680 - 128,687,580 (+)	NCBI
mRatBN7.2	1	119,267,194 - 119,277,094 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099737	(Get FASTA)	NCBI Sequence Viewer
	NP_001406384	(Get FASTA)	NCBI Sequence Viewer
	NP_001406385	(Get FASTA)	NCBI Sequence Viewer
	NP_001406386	(Get FASTA)	NCBI Sequence Viewer
	NP_001406387	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM08410	(Get FASTA)	NCBI Sequence Viewer
	EDM08411	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015287.8
	ENSRNOP00000091784.1

RefSeq Acc Id:	NP_001099737 ⟸ NM_001106267
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I6ACD9 (UniProtKB/TrEMBL), A6JBN3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEAAAEPLRSVRHLSRVLLFLSQCYILSGDGSLNLDHSQPLAQSIKDPGPTRIFIVVPRAAENQ LFSHLTESTEIPPYMMKCPSNGLCSRLPADCIECATNASCTYGKPVTFDCTVKPSVTCVDQDLR PQRNFVINMTCRFCWQLPETDYECSNSTTCMTVACPRQRYFANCTVRDHIHCLGNRTFPKLLYC NWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPAD GSLYI hide sequence

Ensembl Acc Id:

ENSRNOP00000015287 ⟸ ENSRNOT00000015287

Ensembl Acc Id:

ENSRNOP00000091784 ⟸ ENSRNOT00000094329

RefSeq Acc Id:	NP_001406384 ⟸ NM_001419455
- Peptide Label:	isoform 2

RefSeq Acc Id:	NP_001406385 ⟸ NM_001419456
- Peptide Label:	isoform 3

RefSeq Acc Id:	NP_001406386 ⟸ NM_001419457
- Peptide Label:	isoform 4
- UniProtKB:	D3ZQU1 (UniProtKB/TrEMBL), A6JBN4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001406387 ⟸ NM_001419458
- Peptide Label:	isoform 5

Protein Domains

TM2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQU1-F1-model_v2	AlphaFold	D3ZQU1	1-258	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690100

Promoter ID:

EPDNEW_R624

Type:

multiple initiation site

Name:

Tm2d3_1

Description:

TM2 domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	126,586,526 - 126,586,586	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564929	AgrOrtholog
BioCyc Gene	G2FUF-59036	BioCyc
Ensembl Genes	ENSRNOG00000011290	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015287.8	UniProtKB/TrEMBL
	ENSRNOT00000094329.1	UniProtKB/TrEMBL
InterPro	TM2	UniProtKB/TrEMBL
	TM2_domain	UniProtKB/TrEMBL
KEGG Report	rno:292995	UniProtKB/TrEMBL
NCBI Gene	292995	ENTREZGENE
PANTHER	BETA-AMYLOID BINDING PROTEIN-RELATED	UniProtKB/TrEMBL
	TM2 DOMAIN-CONTAINING PROTEIN 3	UniProtKB/TrEMBL
Pfam	TM2	UniProtKB/TrEMBL
PhenoGen	Tm2d3	PhenoGen
RatGTEx	ENSRNOG00000011290	RatGTEx
UniProt	A0A8I6ACD9	ENTREZGENE, UniProtKB/TrEMBL
	A6JBN3	ENTREZGENE, UniProtKB/TrEMBL
	A6JBN4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZQU1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Tm2d3	TM2 domain containing 3	Tm2d3_predicted	TM2 domain containing 3 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Tm2d3_predicted	TM2 domain containing 3 (predicted)	RGD1564929_predicted	similar to BBP-like protein 2 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1564929_predicted	similar to BBP-like protein 2 (predicted)	LOC292995	similar to BBP-like protein 2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC292995	similar to BBP-like protein 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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