mitomycin C - Ontology Report - Rat Genome Database

mitomycin C - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	mitomycin C	go back to main search page
Accession:	CHEBI:27504	browse the term
Definition:	A mitomycin that has formula C15H18N4O5.
Synonyms:	exact_synonym:	[(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
	related_synonym:	7-Amino-9alpha-methoxymitosane; Ametycine; Formula=C15H18N4O5; InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1; InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N; MMC; Mitocin-C; Mitomycin; Mutamycin; SMILES=[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
	alt_id:	CHEBI:25356; CHEBI:6953
	xref:	Beilstein:3570056; CAS:50-07-7; DrugBank:DB00305; Drug_Central:1819; KEGG:C06681; KEGG:D00208; KNApSAcK:C00018668; LINCS:LSM-6310
	xref_mesh:	MESH:D016685
	xref:	PMID:36194168; PMID:36453313; PMID:36473690; Wikipedia:Mitomycin
	cyclic_relationship:	is_conjugate_acid_of CHEBI:194095

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Genes (418)

mitomycin C

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

Mitomycin results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

decreases expression

Mitomycin results in decreased expression of ABCB1B mRNA; Mitomycin results in decreased expression of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to Mitomycin

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

Mitomycin results in increased expression of ABHD4 mRNA

NCBI chr15:31,674,090...31,686,051
Ensembl chr15:27,704,113...27,716,966

G

actin-binding LIM protein 1

affects response to substance

ABLIM1 protein affects the susceptibility to Mitomycin

NCBI chr 1:266,088,868...266,377,169
Ensembl chr 1:256,084,297...256,371,969

G

aconitase 1

affects response to substance

ACO1 protein affects the susceptibility to Mitomycin

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA thioesterase 2

affects response to substance

ACOT2 protein affects the susceptibility to Mitomycin

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA synthetase long-chain family member 1

affects response to substance

ACSL1 protein affects the susceptibility to Mitomycin

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitomycin

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627

G

adhesion G protein-coupled receptor G1

affects response to substance

ADGRG1 protein affects the susceptibility to Mitomycin

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,003,975...10,041,108

G

adenosylhomocysteinase-like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitomycin

NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:195,294,153...195,345,815

G

A-kinase anchoring protein 12

affects response to substance

AKAP12 protein affects the susceptibility to Mitomycin

NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:40,730,123...40,819,886

G

akirin 2

decreases expression

Mitomycin results in decreased expression of AKIRIN2 mRNA

NCBI chr 5:53,897,792...53,918,873
Ensembl chr 5:49,108,220...49,122,568

G

AKT serine/threonine kinase 1

decreases expression
multiple interactions

Mitomycin results in decreased expression of AKT1 protein modified form
AKT1 protein affects the reaction [Mitomycin results in increased activity of GLB1 protein]; AKT1 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]

PMID:16186332 PMID:34624459

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

affects response to substance

ALCAM protein affects the susceptibility to Mitomycin

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 3 family, member A1

affects response to substance

ALDH3A1 protein affects the susceptibility to Mitomycin

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681

G

aldehyde oxidase 1

affects response to substance

AOX1 protein affects the susceptibility to Mitomycin

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:59,579,649...59,658,770

G

apoptotic peptidase activating factor 1

increases expression

Mitomycin results in increased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

acylaminoacyl-peptide hydrolase

affects response to substance

APEH protein affects the susceptibility to Mitomycin

NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:108,773,794...108,782,933

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

APEX1 protein results in increased reduction of and results in increased susceptibility to Mitomycin
[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin

PMID:10190555 PMID:21357694

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor protein

increases expression

Mitomycin results in increased expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

Rho GTPase activating protein 19

decreases expression

Mitomycin results in decreased expression of ARHGAP19 mRNA

NCBI chr 1:250,519,703...250,566,705
Ensembl chr 1:240,580,871...240,617,287

G

ariadne RBR E3 ubiquitin protein ligase 1

increases response to substance

ARIH1 mutant form results in increased susceptibility to Mitomycin

NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245

G

ARL6 interacting reticulophagy regulator 1

decreases expression

Mitomycin results in decreased expression of ARL6IP1 mRNA

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:172,430,489...172,439,994

G

N-acylsphingosine amidohydrolase 1

affects response to substance

ASAH1 protein affects the susceptibility to Mitomycin

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:50,966,229...51,008,233

G

achaete-scute family bHLH transcription factor 2

increases expression

Mitomycin results in increased expression of ASCL2 mRNA

NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406

G

activating transcription factor 4

increases expression
decreases expression

Mitomycin results in increased expression of ATF4 mRNA
Mitomycin results in decreased expression of ATF4 mRNA

PMID:12760830 PMID:25270620

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

ATPase Na+/K+ transporting subunit alpha 1

affects response to substance

ATP1A1 protein affects the susceptibility to Mitomycin

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837

G

attractin like 1

decreases expression

Mitomycin results in decreased expression of ATRNL1 mRNA

NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:256,670,627...257,213,197

G

ATRX, chromatin remodeler

affects response to substance

ATRX protein affects the susceptibility to Mitomycin

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

ataxin 1

decreases expression

Mitomycin results in decreased expression of ATXN1 mRNA

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:18,737,533...19,142,360

G

aurora kinase A

decreases expression

Mitomycin results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

arginine vasopressin-induced 1

affects response to substance

AVPI1 protein affects the susceptibility to Mitomycin

NCBI chr 1:250,879,530...250,885,448
Ensembl chr 1:240,930,236...240,936,154

G

beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitomycin

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546

G

BCL2-associated agonist of cell death

increases expression

Mitomycin results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BMP and activin membrane-bound inhibitor

affects response to substance

BAMBI protein affects the susceptibility to Mitomycin

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

affects localization
decreases expression
multiple interactions
increases expression

Mitomycin affects the localization of BAX protein
Mitomycin results in decreased expression of BAX mRNA
silybin inhibits the reaction [Mitomycin affects the localization of BAX protein]; Tamoxifen promotes the reaction [Mitomycin results in decreased expression of BAX mRNA]
Mitomycin results in increased expression of BAX mRNA; Mitomycin results in increased expression of BAX protein

PMID:11867586 PMID:15120327 PMID:18615204 PMID:19757172 PMID:19834285

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

affects expression
increases expression
multiple interactions

Mitomycin affects the expression of BCL2
Mitomycin results in increased expression of BCL2 mRNA; Mitomycin results in increased expression of BCL2 protein
Silybin inhibits the reaction [Mitomycin affects the expression of BCL2]; Tamoxifen promotes the reaction [Mitomycin results in increased expression of BCL2 mRNA]

PMID:11867586 PMID:15793875 PMID:19757172 PMID:19834285

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
increases expression

Mitomycin results in decreased expression of BCL2L1 mRNA
Mitomycin results in increased expression of BCL2L1 protein

PMID:11867586 PMID:18615204

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

bridging integrator 3

affects response to substance

BIN3 protein affects the susceptibility to Mitomycin

NCBI chr15:51,583,474...51,622,329
Ensembl chr15:45,173,732...45,212,604

G

baculoviral IAP repeat-containing 2

affects response to substance

BIRC2 protein affects the susceptibility to Mitomycin

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

increases expression

Mitomycin results in increased expression of BIRC5 mRNA; Mitomycin results in increased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BLM RecQ like helicase

decreases expression

Mitomycin results in decreased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:134,409,857...134,484,312

G

biogenesis of lysosomal organelles complex-1, subunit 2

increases expression

Mitomycin results in increased expression of BLOC1S2 mRNA

NCBI chr 1:252,973,818...252,980,873
Ensembl chr 1:243,024,614...243,031,653

G

basic helix-loop-helix ARNT like 1

decreases expression

Mitomycin results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 2

decreases expression

Mitomycin results in decreased expression of BMP2 mRNA

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

decreases expression

Mitomycin results in decreased expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

BRCA1, DNA repair associated

increases response to substance

BRCA1 protein mutant form results in increased susceptibility to Mitomycin

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BSCL2 lipid droplet biogenesis associated, seipin

increases expression

Mitomycin results in increased expression of BSCL2 mRNA

NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421

G

BTG anti-proliferation factor 2

increases expression

Mitomycin results in increased expression of BTG2 mRNA

PMID:21382384 PMID:25270620

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

decreases expression

Mitomycin results in decreased expression of BTG3 mRNA

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:17,030,160...17,046,170

G

calcium dependent secretion activator 2

affects response to substance

CADPS2 protein affects the susceptibility to Mitomycin

NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:51,781,053...52,309,829

G

caspase 3

multiple interactions
increases cleavage
increases activity

[Mitomycin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]]; Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]; Mitomycin promotes the reaction [CASP3 protein results in increased cleavage of PRKCD protein]
Mitomycin results in increased cleavage of CASP3 protein

PMID:10960761 PMID:15120327 PMID:15905168 PMID:16019139 PMID:16186332 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Mitomycin results in increased cleavage of and results in increased activity of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases cleavage
increases activity

Mitomycin results in increased cleavage of and results in increased activity of CASP8 protein
Mitomycin results in increased cleavage of CASP8 protein
Mitomycin results in increased activity of CASP8 protein

PMID:10960761 PMID:12181741 PMID:16019139 PMID:17021654 PMID:17094455 More...

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

Mitomycin promotes the reaction [CASP9 protein results in increased secretion of CYCS protein]; Mitomycin results in increased cleavage of and results in increased activity of CASP9 protein
Mitomycin results in increased activity of CASP9 protein

PMID:10960761 PMID:12181741 PMID:16186332 PMID:17094455 PMID:17530733 More...

Ensembl chr 5:154,109,046...154,126,626

G

coiled-coil domain containing 51

decreases expression

Mitomycin results in decreased expression of CCDC51 mRNA

NCBI chr 8:118,601,002...118,619,943
Ensembl chr 8:109,722,557...109,741,472

G

C-C motif chemokine ligand 2

multiple interactions
increases expression
increases secretion

Dexamethasone inhibits the reaction [Mitomycin results in increased expression of CCL2 mRNA]; Dexamethasone inhibits the reaction [Mitomycin results in increased secretion of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

cyclin B1

multiple interactions
increases expression
decreases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of CCNB1 mRNA]
Mitomycin results in increased expression of CCNB1 mRNA
Mitomycin results in decreased expression of CCNB1 mRNA

PMID:12760830 PMID:18647660 PMID:25270620

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin G1

increases expression

Mitomycin results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641

G

CD59b molecule

increases mutagenesis

Mitomycin results in increased mutagenesis of CD59 protein

NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847

G

CD9 molecule

affects response to substance

CD9 protein affects the susceptibility to Mitomycin

NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:158,256,328...158,289,222

G

cytidine deaminase

multiple interactions

CDA protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:150,556,615...150,583,231

G

cell division cycle 20

decreases expression

Mitomycin results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

CDC42 binding protein kinase gamma

increases expression

Mitomycin results in increased expression of CDC42BPG mRNA

NCBI chr 1:213,037,603...213,057,764
Ensembl chr 1:203,608,574...203,628,502

G

cell division cycle 6

decreases expression

Mitomycin results in decreased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase 1

decreases expression

Mitomycin results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

affects response to substance

CDK2 protein affects the susceptibility to Mitomycin

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[Mitomycin co-treated with Resveratrol] results in increased expression of CDKN1A; [Mitomycin results in increased stability of TP53 protein] which results in increased expression of CDKN1A mRNA; AKT1 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]; baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]]; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; GSK3B protein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; Mitomycin promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; perifosine inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]
Mitomycin results in increased expression of CDKN1A mRNA; Mitomycin results in increased expression of CDKN1A protein

PMID:15905168 PMID:18647660 PMID:20536192 PMID:24211769 PMID:25270620 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

affects response to substance

CDKN1B protein affects the susceptibility to Mitomycin

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein gamma

decreases expression

Mitomycin results in decreased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:87,684,019...87,694,569

G

centromere protein F

decreases expression

Mitomycin results in decreased expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:101,184,127...101,229,669

G

centrosomal protein 57

affects response to substance

CEP57 protein affects the susceptibility to Mitomycin

NCBI chr 8:18,951,179...18,971,205
Ensembl chr 8:10,669,590...10,689,249

G

centrosomal protein 89

decreases expression

Mitomycin results in decreased expression of CEP89 mRNA

NCBI chr 1:97,195,116...97,237,015
Ensembl chr 1:88,058,227...88,100,112

G

ceramide synthase 4

increases expression

Mitomycin results in increased expression of CERS4 mRNA

NCBI chr12:2,851,784...2,890,244
Ensembl chr12:2,851,784...2,886,828

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

Mitomycin results in decreased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:106,342,302...106,345,526

G

chromatin assembly factor 1 subunit A

decreases expression

Mitomycin results in decreased expression of CHAF1A mRNA

NCBI chr 9:961,225...987,825
Ensembl chr 9:874,051...900,654

G

chromatin assembly factor 1 subunit B

decreases expression

Mitomycin results in decreased expression of CHAF1B mRNA

NCBI chr11:46,670,560...46,690,739
Ensembl chr11:33,200,981...33,221,070

G

checkpoint kinase 1

increases phosphorylation

Mitomycin results in increased phosphorylation of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

increases phosphorylation

Mitomycin results in increased phosphorylation of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

cysteine-rich hydrophobic domain 2

affects response to substance

CHIC2 protein affects the susceptibility to Mitomycin

NCBI chr14:33,157,669...33,192,015
Ensembl chr14:33,157,537...33,191,895

G

cytoskeleton associated protein 2

increases expression

Mitomycin results in increased expression of CKAP2 mRNA

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:69,839,630...69,864,913

G

cytoskeleton associated protein 2-like

decreases expression

Mitomycin results in decreased expression of CKAP2L mRNA

NCBI chr 3:136,950,390...136,977,503
Ensembl chr 3:116,498,022...116,524,366

G

creatine kinase, mitochondrial 1

affects response to substance

CKMT1B protein affects the susceptibility to Mitomycin

NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:108,330,705...108,335,758

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Mitomycin results in decreased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519

G

calmegin

affects response to substance

CLGN protein affects the susceptibility to Mitomycin

NCBI chr19:41,601,568...41,633,207
Ensembl chr19:24,696,875...24,728,758

G

cytochrome c oxidase assembly factor 7

decreases expression

Mitomycin results in decreased expression of COA7 mRNA

NCBI chr 5:128,298,084...128,308,935
Ensembl chr 5:123,069,371...123,080,199

G

cordon-bleu WH2 repeat protein

decreases expression

Mitomycin results in decreased expression of COBL mRNA

NCBI chr14:91,041,721...91,274,272
Ensembl chr14:86,828,139...87,060,800

G

cochlin

affects response to substance

COCH protein affects the susceptibility to Mitomycin

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:69,031,167...69,045,109

G

collagen type IV alpha 2 chain

affects response to substance

COL4A2 protein affects the susceptibility to Mitomycin

NCBI chr16:84,749,672...84,885,520
Ensembl chr16:78,047,602...78,183,839

G

collagen type IX alpha 3 chain

affects response to substance

COL9A3 protein affects the susceptibility to Mitomycin

NCBI chr 3:188,089,337...188,112,034
Ensembl chr 3:167,711,840...167,734,465

G

COMM domain containing 3

increases expression

Mitomycin results in increased expression of COMMD3 mRNA

NCBI chr17:86,235,863...86,239,610
Ensembl chr17:81,327,405...81,331,177

G

cytochrome c oxidase copper chaperone COX17

affects response to substance

COX17 protein affects the susceptibility to Mitomycin

NCBI chr11:75,906,245...75,912,036

G

cytoplasmic polyadenylated homeobox 1

decreases expression

Mitomycin results in decreased expression of CPHX1 mRNA

NCBI chr16:1,540,653...1,544,288
Ensembl chr16:1,528,440...1,537,082

G

carbamoyl-phosphate synthase 1

affects response to substance

CPS1 protein affects the susceptibility to Mitomycin

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:68,614,153...68,737,033

G

carnitine palmitoyltransferase 2

decreases expression

Mitomycin results in decreased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095

G

cysteine-rich protein 2

increases expression

Mitomycin results in increased expression of CRIP2 mRNA

NCBI chr 6:138,042,175...138,047,121
Ensembl chr 6:132,221,082...132,226,065

G

cryptochrome circadian regulator 1

decreases expression

Mitomycin results in decreased expression of CRY1 mRNA

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:18,529,823...18,594,091

G

CTD small phosphatase like

affects response to substance

CTDSPL protein affects the susceptibility to Mitomycin

NCBI chr 8:127,520,478...127,644,999
Ensembl chr 8:118,642,672...118,767,117

G

catenin alpha 1

affects response to substance

CTNNA1 protein affects the susceptibility to Mitomycin

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,728,485...26,860,910

G

cytochrome c, somatic

multiple interactions
increases secretion

Mitomycin promotes the reaction [CASP9 protein results in increased secretion of CYCS protein]
Mitomycin results in increased secretion of CYCS protein

PMID:10960761 PMID:16186332

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

Mitomycin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Mitomycin affects the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]

NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity

Mitomycin results in decreased activity of CYP2C11 protein

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily d, polypeptide 1

decreases activity

Mitomycin results in decreased activity of CYP2D1 protein

NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:113,908,947...113,922,084

G

death associated protein kinase 1

increases expression

Mitomycin results in increased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991

G

DBF4-CDC7 kinase regulatory subunit

decreases expression

Mitomycin results in decreased expression of DBF4 mRNA

NCBI chr 4:26,631,491...26,656,080
Ensembl chr 4:25,676,634...25,701,066

G

DDB1 and CUL4 associated factor 4

increases expression

Mitomycin results in increased expression of DCAF4 mRNA

NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982

G

DNA cross-link repair 1C

decreases response to substance

DCLRE1C results in decreased susceptibility to Mitomycin

NCBI chr17:79,684,988...79,718,399
Ensembl chr17:74,776,935...74,809,186

G

dopachrome tautomerase

affects response to substance

DCT protein affects the susceptibility to Mitomycin

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836

G

damage specific DNA binding protein 2

multiple interactions
increases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of DDB2 mRNA]
Mitomycin results in increased expression of DDB2 mRNA

NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:77,185,109...77,207,631

G

DNA damage-induced apoptosis suppressor

increases expression

Mitomycin results in increased expression of DDIAS mRNA

NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:146,906,154...146,930,462

G

DNA-damage-inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitomycin

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

DNA-damage-inducible transcript 4-like

increases expression

Mitomycin results in increased expression of DDIT4L mRNA

NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:226,128,276...226,131,375

G

discoidin domain receptor tyrosine kinase 1

affects response to substance

DDR1 protein affects the susceptibility to Mitomycin

NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,044,320...3,064,468

G

disco-interacting protein 2 homolog C

decreases expression

Mitomycin results in decreased expression of DIP2C mRNA

NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305

G

dickkopf WNT signaling pathway inhibitor 3

affects response to substance

DKK3 protein affects the susceptibility to Mitomycin

NCBI chr 1:175,672,834...175,715,867
Ensembl chr 1:166,238,238...166,280,590

G

dystrophin

affects response to substance

DMD protein affects the susceptibility to Mitomycin

NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

Mitomycin results in increased expression of DNAJB5 mRNA

NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:57,176,845...57,185,490

G

DnaJ heat shock protein family (Hsp40) member C9

increases expression

Mitomycin results in increased expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

DNA methyltransferase 1

decreases expression

Mitomycin results in decreased expression of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases expression

Mitomycin results in decreased expression of DNMT3A protein

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687

G

Dr1 associated protein 1

affects response to substance

DRAP1 protein affects the susceptibility to Mitomycin

NCBI chr 1:212,161,107...212,163,833
Ensembl chr 1:202,731,788...202,734,425

G

dermatan sulfate epimerase

affects response to substance

DSE protein affects the susceptibility to Mitomycin

NCBI chr20:26,661,326...26,740,011
Ensembl chr20:26,118,196...26,196,992

G

dual specificity phosphatase 4

affects response to substance

DUSP4 protein affects the susceptibility to Mitomycin

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138

G

E2F transcription factor 1

decreases expression

Mitomycin results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

embryonal Fyn-associated substrate

increases expression

Mitomycin results in increased expression of EFS mRNA

NCBI chr15:32,362,401...32,374,490
Ensembl chr15:28,392,187...28,401,902

G

epidermal growth factor

multiple interactions

Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

early growth response 1

affects response to substance
increases expression

EGR1 protein affects the susceptibility to Mitomycin
Mitomycin results in increased expression of EGR1 mRNA

PMID:12760830 PMID:16217747

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 5B

affects response to substance

EIF5B protein affects the susceptibility to Mitomycin

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:40,222,898...40,277,482

G

ETS transcription factor ELK3

affects response to substance

ELK3 protein affects the susceptibility to Mitomycin

NCBI chr 7:29,655,676...29,718,163
Ensembl chr 7:27,768,599...27,804,084

G

epithelial membrane protein 2

affects response to substance

EMP2 protein affects the susceptibility to Mitomycin

NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,360,073...5,394,733

G

Eph receptor A2

decreases expression

Mitomycin results in decreased expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117

G

epoxide hydrolase 1

increases expression

Mitomycin results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 3

affects response to substance

ERBB3 protein affects the susceptibility to Mitomycin

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525

G

ELKS/RAB6-interacting/CAST family member 2

decreases expression

Mitomycin results in decreased expression of ERC2 mRNA

NCBI chr16:2,819,399...3,680,258
Ensembl chr16:2,848,620...3,670,776

G

ERCC excision repair 5, endonuclease

increases expression

Mitomycin results in increased expression of ERCC5 mRNA

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:46,309,389...46,354,472

G

endogenous retrovirus group FRD member 1, envelope

affects response to substance

ERVFRD-1 protein affects the susceptibility to Mitomycin

NCBI chr12:27,787,680...27,794,732
Ensembl chr12:22,151,211...22,158,264

G

exocyst complex component 4

increases expression

Mitomycin results in increased expression of EXOC4 mRNA

NCBI chr 4:62,774,896...63,551,541
Ensembl chr 4:61,807,761...62,585,723

G

coagulation factor II (thrombin) receptor

affects response to substance

F2R protein affects the susceptibility to Mitomycin

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870

G

family with sequence similarity 171, member A1

affects response to substance

FAM171A1 protein affects the susceptibility to Mitomycin

NCBI chr17:79,933,742...80,057,495
Ensembl chr17:75,024,575...75,150,255

G

FANCD2 and FANCI associated nuclease 1

decreases response to substance
increases response to substance

FAN1 protein results in decreased susceptibility to Mitomycin
FAN1 gene mutant form results in increased susceptibility to Mitomycin

PMID:21115814 PMID:22772369

NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:117,917,099...117,944,977

G

FA complementation group D2

multiple interactions
increases ubiquitination

[arsenic trioxide results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin; [monomethylarsonic acid results in decreased activity of FANCD2 protein] which results in increased susceptibility to Mitomycin; Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; Mitomycin results in increased expression of and results in increased ubiquitination of FANCD2 protein; Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Mitomycin results in increased ubiquitination of FANCD2 protein

PMID:24124520 PMID:25092648 PMID:26208482

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group I

multiple interactions

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]; Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]; Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]; Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:133,327,297...133,383,640

G

Fas cell surface death receptor

affects splicing
multiple interactions
increases expression

Mitomycin affects the splicing of FAS gene
Mitomycin results in increased expression of and results in increased secretion of FAS protein alternative form
Mitomycin results in increased expression of FAS mRNA; Mitomycin results in increased expression of FAS protein

PMID:11867586 PMID:16186332 PMID:16957513 PMID:18571879

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Mitomycin results in increased expression of FASLG; Mitomycin results in increased expression of FASLG mRNA; Mitomycin results in increased expression of FASLG protein

PMID:16019139 PMID:16186332 PMID:16957513

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

FAT atypical cadherin 1

affects response to substance

FAT1 protein affects the susceptibility to Mitomycin

NCBI chr16:53,909,759...54,029,175
Ensembl chr16:47,177,248...47,296,107

G

fibrillarin

affects localization

Mitomycin analog affects the localization of FBL protein

NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:83,469,832...83,478,932

G

farnesyl diphosphate farnesyl transferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitomycin

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287

G

fibroblast growth factor 2

increases expression

Mitomycin results in increased expression of FGF2 protein

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

fragile histidine triad diadenosine triphosphatase

decreases expression

Mitomycin results in decreased expression of FHIT mRNA

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:13,934,995...15,442,340

G

four and a half LIM domains 1

affects response to substance

FHL1 protein affects the susceptibility to Mitomycin

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:134,555,479...134,614,928

G

fission, mitochondrial 1

affects response to substance

FIS1 protein affects the susceptibility to Mitomycin

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377

G

Fos proto-oncogene, AP-1 transcription factor subunit

affects response to substance

FOS protein affects the susceptibility to Mitomycin

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box J1

increases expression

Mitomycin results in increased expression of FOXJ1 mRNA

NCBI chr10:102,065,163...102,069,945
Ensembl chr10:101,566,304...101,570,237

G

forkhead box J2

decreases expression

Mitomycin results in decreased expression of FOXJ2 mRNA

NCBI chr 4:157,718,990...157,745,468
Ensembl chr 4:156,046,969...156,073,518

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitomycin

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 1

decreases expression

Mitomycin results in decreased expression of FZD1 mRNA

NCBI chr 4:30,265,074...30,269,472
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643

G

G0/G1switch 2

affects response to substance

G0S2 protein affects the susceptibility to Mitomycin

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of GADD45A mRNA]
Mitomycin results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

GTP cyclohydrolase 1

decreases expression

Mitomycin results in decreased expression of GCH1 mRNA

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698

G

growth differentiation factor 15

increases expression

Mitomycin results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

galactosidase, beta 1

increases activity
multiple interactions

Mitomycin results in increased activity of GLB1 protein
AKT1 protein affects the reaction [Mitomycin results in increased activity of GLB1 protein]; baicalein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]; GSK3B protein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]; perifosine inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]; TP53 protein affects the reaction [Mitomycin results in increased activity of GLB1 protein]

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:114,085,508...114,158,127

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

decreases expression

Mitomycin results in decreased expression of GPIHBP1 mRNA

NCBI chr 7:109,166,334...109,169,448
Ensembl chr 7:107,285,654...107,288,702

G

G-protein signaling modulator 2

affects response to substance
decreases expression

GPSM2 protein affects the susceptibility to Mitomycin
Mitomycin results in decreased expression of GPSM2 mRNA

PMID:16217747 PMID:25270620

NCBI chr 2:199,015,250...199,063,788
Ensembl chr 2:196,327,149...196,375,154

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

Mitomycin results in increased expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096

G

GrpE-like 1, mitochondrial

decreases expression

Mitomycin results in decreased expression of GRPEL1 mRNA

NCBI chr14:78,517,049...78,522,868
Ensembl chr14:74,292,023...74,298,200

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

Mitomycin results in increased phosphorylation of GSK3B protein
baicalein inhibits the reaction [Mitomycin results in increased phosphorylation of GSK3B protein]; GSK3B protein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]; GSK3B protein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase mu 4

affects response to substance

GSTM4 protein affects the susceptibility to Mitomycin

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase pi 1

increases response to substance
multiple interactions

GSTP1 mRNA results in increased susceptibility to Mitomycin
Mitomycin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

PMID:15239142 PMID:23769903

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

H1.0 linker histone

decreases expression

Mitomycin results in decreased expression of H1F0 mRNA

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694

G

H2A.X variant histone

increases phosphorylation
increases expression

Mitomycin results in increased phosphorylation of H2AX protein
Mitomycin results in increased expression of H2AX protein; Mitomycin results in increased expression of H2AX protein modified form

PMID:21386838 PMID:29928969 PMID:32087850 PMID:32482060 PMID:34510228

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hepcidin antimicrobial peptide

decreases expression

Mitomycin results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891

G

HMG-box transcription factor 1

decreases expression

Mitomycin results in decreased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:48,529,372...48,555,787

G

hematopoietic cell specific Lyn substrate 1

affects response to substance

HCLS1 protein affects the susceptibility to Mitomycin

NCBI chr11:77,322,873...77,346,333
Ensembl chr11:63,817,476...63,841,014

G

histone deacetylase 9

affects response to substance

HDAC9 protein affects the susceptibility to Mitomycin

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:50,763,590...51,625,333

G

hes-related family bHLH transcription factor with YRPW motif 1

affects response to substance

HEY1 protein affects the susceptibility to Mitomycin

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312

G

hematopoietically expressed homeobox

affects response to substance

HHEX protein affects the susceptibility to Mitomycin

NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:235,190,455...235,196,042

G

high mobility group 20 B

affects response to substance

HMG20B protein affects the susceptibility to Mitomycin

NCBI chr 7:9,019,670...9,024,382
Ensembl chr 7:8,368,990...8,373,640

G

high mobility group AT-hook 1

affects response to substance

HMGA1 protein affects the susceptibility to Mitomycin

NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752

G

high mobility group AT-hook 2

affects response to substance

HMGA2 protein affects the susceptibility to Mitomycin

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784

G

hippocalcin-like 1

increases expression

Mitomycin results in increased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:40,478,208...40,584,687

G

heat shock protein family A (Hsp70) member 8

multiple interactions
increases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of HSPA8 mRNA]
Mitomycin results in increased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259

G

isoprenylcysteine carboxyl methyltransferase

affects response to substance

ICMT protein affects the susceptibility to Mitomycin

NCBI chr 5:168,084,487...168,097,519
Ensembl chr 5:162,804,368...162,811,128

G

inhibitor of DNA binding 4

affects response to substance

ID4 protein affects the susceptibility to Mitomycin

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,389,387...16,392,470

G

interferon-related developmental regulator 1

decreases expression

Mitomycin results in decreased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:57,269,384...57,288,990

G

immunoglobulin superfamily, DCC subclass, member 4

increases expression

Mitomycin results in increased expression of IGDCC4 mRNA

NCBI chr 8:74,517,082...74,552,834
Ensembl chr 8:65,621,897...65,657,648

G

interleukin 18

decreases expression

Mitomycin results in decreased expression of IL18; Mitomycin results in decreased expression of IL18 protein

PMID:16019139 PMID:17021654

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

increases expression

Mitomycin results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

affects response to substance
multiple interactions

IL1B protein affects the susceptibility to Mitomycin
Mitomycin affects the reaction [IL1B protein results in increased uptake of Zinc]

PMID:1502195 PMID:16217747

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Mitomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

decreases response to substance
increases expression

IL6 protein results in decreased susceptibility to Mitomycin
Mitomycin results in increased expression of IL6 mRNA

PMID:7834629 PMID:34624459

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases response to substance

IL6R protein results in decreased susceptibility to Mitomycin

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536

G

inositol monophosphatase 2

affects response to substance

IMPA2 protein affects the susceptibility to Mitomycin

NCBI chr18:63,104,113...63,135,232
Ensembl chr18:60,834,246...60,865,641

G

inner centromere protein

decreases expression

Mitomycin results in decreased expression of INCENP mRNA

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:206,523,380...206,553,265

G

inka box actin regulator 2

increases expression

Mitomycin results in increased expression of INKA2 mRNA

NCBI chr 2:195,873,617...195,888,983
Ensembl chr 2:193,185,275...193,200,642

G

integrator complex subunit 15

decreases expression

Mitomycin results in decreased expression of INTS15 mRNA

NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166

G

interferon stimulated exonuclease gene 20-like 2

decreases expression

Mitomycin results in decreased expression of ISG20L2 mRNA

NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:173,396,780...173,406,614

G

Janus kinase 1

decreases phosphorylation

Mitomycin results in decreased phosphorylation of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

decreases phosphorylation

Mitomycin results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

jumonji domain containing 1C

affects response to substance

JMJD1C protein affects the susceptibility to Mitomycin

NCBI chr20:21,330,990...21,508,580
Ensembl chr20:21,332,147...21,463,122

G

KN motif and ankyrin repeat domains 1

affects response to substance

KANK1 protein affects the susceptibility to Mitomycin

NCBI chr 1:232,381,720...232,500,834
Ensembl chr 1:222,877,622...223,074,514

G

kazrin, periplakin interacting protein

affects response to substance

KAZN protein affects the susceptibility to Mitomycin

NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:154,392,793...154,779,074

G

potassium voltage-gated channel subfamily E regulatory subunit 3

decreases expression

Mitomycin results in decreased expression of KCNE3 mRNA

NCBI chr 1:163,936,035...163,942,998
Ensembl chr 1:154,523,830...154,532,020

G

kinesin family member 20A

decreases expression

Mitomycin results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 23

affects response to substance
decreases expression

KIF23 protein affects the susceptibility to Mitomycin
Mitomycin results in decreased expression of KIF23 mRNA

PMID:16217747 PMID:25270620

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:62,397,948...62,425,072

G

KLF transcription factor 6

decreases expression

Mitomycin results in decreased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:64,531,463...64,588,570

G

kynurenine aminotransferase 3

affects response to substance

KYAT3 protein affects the susceptibility to Mitomycin

NCBI chr 2:234,362,306...234,407,646
Ensembl chr 2:231,701,963...231,747,227

G

L1 cell adhesion molecule

affects response to substance

L1CAM protein affects the susceptibility to Mitomycin

NCBI chr X:156,748,597...156,775,116
Ensembl chr X:151,597,277...151,623,857

G

galectin 3

affects response to substance

LGALS3 protein affects the susceptibility to Mitomycin

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025

G

LIM homeobox 2

decreases expression

Mitomycin results in decreased expression of LHX2 mRNA

NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:22,126,007...22,143,908

G

DNA ligase 1

decreases expression

Mitomycin results in decreased expression of LIG1 mRNA

NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:74,165,842...74,204,413

G

LIM and calponin homology domains 1

affects response to substance

LIMCH1 protein affects the susceptibility to Mitomycin

NCBI chr14:41,466,433...41,779,477
Ensembl chr14:41,114,803...41,425,191

G

lipopolysaccharide-induced TNF factor

affects response to substance

LITAF protein affects the susceptibility to Mitomycin

NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763

G

lamin A/C

affects response to substance

LMNA protein affects the susceptibility to Mitomycin

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423

G

lipin 1

increases expression

Mitomycin results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:39,312,748...39,417,097

G

leucine rich repeat containing 47

decreases expression

Mitomycin results in decreased expression of LRRC47 mRNA

NCBI chr 5:169,852,926...169,862,598
Ensembl chr 5:164,570,435...164,580,174

G

latent transforming growth factor beta binding protein 2

affects response to substance

LTBP2 protein affects the susceptibility to Mitomycin

NCBI chr 6:110,161,029...110,261,586
Ensembl chr 6:104,429,947...104,526,208

G

mago homolog, exon junction complex subunit

affects response to substance

MAGOH protein affects the susceptibility to Mitomycin

NCBI chr 5:127,868,044...127,875,423
Ensembl chr 5:122,639,308...122,646,617

G

mitogen activated protein kinase kinase 1

multiple interactions

MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243

G

microtubule-associated protein 7

affects response to substance

MAP7 protein affects the susceptibility to Mitomycin

NCBI chr 1:16,730,000...16,857,173
Ensembl chr 1:14,910,551...15,037,574

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]
Mitomycin results in decreased phosphorylation of MAPK1 protein

PMID:21810436 PMID:34624459 PMID:38642817

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

Dexamethasone inhibits the reaction [Mitomycin results in increased activity of and results in increased phosphorylation of MAPK14 protein]; Mitomycin results in increased activity of and results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
decreases phosphorylation

Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]
Mitomycin results in decreased phosphorylation of MAPK3 protein

PMID:21810436 PMID:34624459 PMID:38642817

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Mitomycin results in increased activity of and results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

MAPK activated protein kinase 3

increases expression

Mitomycin results in increased expression of MAPKAPK3 mRNA

NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:107,929,762...107,963,568

G

microtubule-associated protein, RP/EB family, member 1

increases expression

Mitomycin results in increased expression of MAPRE1 mRNA

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:142,212,955...142,246,983

G

matrilin 2

affects response to substance

MATN2 protein affects the susceptibility to Mitomycin

NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:65,494,834...65,645,113

G

myelin basic protein

affects response to substance

MBP protein affects the susceptibility to Mitomycin

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404

G

melanoma cell adhesion molecule

increases expression

Mitomycin results in increased expression of MCAM mRNA

NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:44,479,376...44,487,571

G

minichromosome maintenance 10 replication initiation factor

decreases expression

Mitomycin results in decreased expression of MCM10 mRNA

NCBI chr17:78,172,049...78,197,644
Ensembl chr17:73,266,095...73,287,364

G

midkine

affects response to substance

MDK protein affects the susceptibility to Mitomycin

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:77,901,158...77,903,130

G

MDM2 proto-oncogene

multiple interactions
increases expression

[Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA
Mitomycin results in increased expression of MDM2 protein
Mitomycin results in increased expression of MDM2 mRNA

PMID:18096571 PMID:20536192 PMID:25270620

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

methyl CpG binding protein 2

increases expression

Mitomycin results in increased expression of MECP2 protein

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:151,789,930...151,844,689

G

O-6-methylguanine-DNA methyltransferase

multiple interactions
increases response to substance

Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]; Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 34a

multiple interactions

[[MIR34A binds to MAGEA12 3' UTR] which results in decreased expression of MAGEA12 protein] which results in increased susceptibility to Mitomycin; [[MIR34A binds to MAGEA3 3' UTR] which results in decreased expression of MAGEA3 protein] which results in increased susceptibility to Mitomycin; [[MIR34A binds to MAGEA6 3' UTR] which results in decreased expression of MAGEA6 protein] which results in increased susceptibility to Mitomycin

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103

G

MIS18 binding protein 1

decreases expression

Mitomycin results in decreased expression of MIS18BP1 mRNA

NCBI chr 6:88,918,743...88,968,225
Ensembl chr 6:83,182,499...83,231,383

G

malectin

increases expression

Mitomycin results in increased expression of MLEC mRNA

NCBI chr12:47,118,918...47,133,598
Ensembl chr12:41,458,231...41,468,708

G

membrane metallo-endopeptidase

affects response to substance

MME protein affects the susceptibility to Mitomycin

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 14

decreases expression

Mitomycin results in decreased expression of MMP14 mRNA

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864

G

multimerin 2

increases expression

Mitomycin results in increased expression of MMRN2 mRNA

NCBI chr16:9,712,181...9,733,653
Ensembl chr16:9,705,892...9,727,405

G

MOK protein kinase

affects response to substance

MOK protein affects the susceptibility to Mitomycin

NCBI chr 6:129,823,794...129,854,669
Ensembl chr 6:129,823,795...129,854,700

G

myelin protein zero-like 1

decreases expression

Mitomycin results in decreased expression of MPZL1 mRNA

NCBI chr13:80,385,454...80,422,315
Ensembl chr13:77,852,467...77,896,616

G

mitochondrial rRNA methyltransferase 2

decreases expression

Mitomycin results in decreased expression of MRM2 mRNA

NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118

G

mutS homolog 6

decreases expression

Mitomycin results in decreased expression of MSH6 mRNA

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956

G

metallothionein 1, pseudogene 3

affects response to substance

MT1E protein affects the susceptibility to Mitomycin

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135

G

MX dynamin like GTPase 1

increases response to substance

MX1 protein results in increased susceptibility to Mitomycin

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507

G

myosin regulatory light chain interacting protein

affects response to substance

MYLIP protein affects the susceptibility to Mitomycin

NCBI chr17:19,492,826...19,514,490
Ensembl chr17:19,286,650...19,308,295

G

myosin X

affects response to substance

MYO10 protein affects the susceptibility to Mitomycin

NCBI chr 2:77,831,532...78,036,137
Ensembl chr 2:76,100,987...76,303,030

G

neural precursor cell expressed, developmentally down-regulated 9

affects response to substance

NEDD9 protein affects the susceptibility to Mitomycin

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,282,326...23,468,019

G

nuclear factor, interleukin 3 regulated

decreases expression

Mitomycin results in decreased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858

G

nuclear transcription factor Y subunit alpha

increases expression
affects response to substance

Mitomycin results in increased expression of NFYA mRNA
NFYA protein affects the susceptibility to Mitomycin

PMID:12760830 PMID:16217747

NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:12,586,259...12,613,898

G

niban apoptosis regulator 1

affects response to substance

NIBAN1 protein affects the susceptibility to Mitomycin

NCBI chr13:66,224,219...66,377,728
Ensembl chr13:63,674,171...63,827,729

G

N-myristoyltransferase 2

affects response to substance

NMT2 protein affects the susceptibility to Mitomycin

NCBI chr17:79,826,999...79,874,088
Ensembl chr17:74,917,833...74,961,080

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases response to substance
affects response to substance
increases metabolic processing
increases reduction

[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Oxygen deficiency co-treated with Mitomycin] results in decreased activity of NQO1 protein; [Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of NQO1 protein; [Tetrachlorodibenzodioxin co-treated with Mitomycin] results in decreased activity of NQO1 protein; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin]; NQO1 protein results in increased metabolism of and results in increased susceptibility to Mitomycin
NQO1 mRNA results in increased susceptibility to Mitomycin; NQO1 protein results in increased susceptibility to Mitomycin
NQO1 protein affects the susceptibility to Mitomycin
NQO1 protein results in increased reduction of Mitomycin

PMID:1701346 PMID:9865924 PMID:15239142 PMID:15655414 PMID:16217747 More...

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Mitomycin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Mitomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 3, group C, member 1

increases expression

Mitomycin results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

NRAS proto-oncogene, GTPase

decreases expression

Mitomycin results in decreased expression of NRAS protein

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:190,582,918...190,591,626

G

nuclear respiratory factor 1

decreases expression

Mitomycin results in decreased expression of NRF1 mRNA

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitomycin

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:14,895,553...14,981,761

G

nucleolar and spindle associated protein 1

decreases expression

Mitomycin results in decreased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624

G

obscurin like cytoskeletal adaptor 1

increases expression

Mitomycin results in increased expression of OBSL1 mRNA

NCBI chr 9:84,416,447...84,442,415
Ensembl chr 9:76,974,253...76,993,560

G

8-oxoguanine DNA glycosylase

decreases expression

Mitomycin results in decreased expression of OGG1 protein

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766

G

ORAI calcium release-activated calcium modulator 3

decreases expression

Mitomycin results in decreased expression of ORAI3 mRNA

NCBI chr 1:191,811,671...191,816,530
Ensembl chr 1:182,344,293...182,386,052

G

partner and localizer of BRCA2

decreases expression

Mitomycin results in decreased expression of PALB2 mRNA

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:176,665,076...176,688,990

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases activity
increases cleavage
decreases response to substance

CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]; Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]
PARP1 protein results in decreased susceptibility to Mitomycin

PMID:15905168 PMID:24124520 PMID:28757444

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

PDZ binding kinase

affects response to substance

PBK protein affects the susceptibility to Mitomycin

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:40,023,002...40,034,014

G

polycomb group ring finger 3

increases expression

Mitomycin results in increased expression of PCGF3 mRNA

NCBI chr14:1,381,976...1,436,709
Ensembl chr14:1,233,947...1,291,793

G

proliferating cell nuclear antigen

multiple interactions
increases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of PCNA mRNA]
Mitomycin results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

PDS5 cohesin associated factor A

affects response to substance

PDS5A protein affects the susceptibility to Mitomycin

NCBI chr14:42,905,734...43,004,740
Ensembl chr14:42,552,647...42,648,669

G

pelota mRNA surveillance and ribosome rescue factor

decreases expression

Mitomycin results in decreased expression of PELO mRNA

NCBI chr 2:48,530,902...48,532,670
Ensembl chr 2:46,797,853...46,799,746

G

p53 apoptosis effector related to PMP22

increases expression

Mitomycin results in increased expression of PERP mRNA

NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:13,542,067...13,554,511

G

pleckstrin homology-like domain, family A, member 3

increases expression

Mitomycin results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335

G

pirin

affects response to substance

PIR protein affects the susceptibility to Mitomycin

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:30,108,538...30,219,218

G

cAMP-dependent protein kinase inhibitor alpha

affects response to substance

PKIA protein affects the susceptibility to Mitomycin

NCBI chr 2:96,306,181...96,380,959
Ensembl chr 2:94,398,869...94,414,282

G

plasminogen activator, urokinase

affects response to substance

PLAU protein affects the susceptibility to Mitomycin

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

polo-like kinase 1

decreases expression

Mitomycin results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400

G

proteolipid protein 1

affects response to substance

PLP1 protein affects the susceptibility to Mitomycin

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:100,185,767...100,201,032

G

premelanosome protein

affects response to substance

PMEL protein affects the susceptibility to Mitomycin

NCBI chr 7:1,721,948...1,733,248
Ensembl chr 7:1,138,586...1,148,746

G

peripheral myelin protein 22

affects response to substance

PMP22 protein affects the susceptibility to Mitomycin

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:47,795,709...47,825,714

G

proline-rich nuclear receptor coactivator 2

decreases expression

Mitomycin results in decreased expression of PNRC2 mRNA

NCBI chr 5:148,103,966...148,106,950
Ensembl chr 5:148,095,699...148,107,242
Ensembl chr 5:148,095,699...148,107,242

G

DNA polymerase beta

decreases response to substance

POLB results in decreased susceptibility to Mitomycin

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:69,379,400...69,404,812

G

DNA polymerase kappa

multiple interactions

POLK protein inhibits the reaction [Mitomycin results in increased mutagenesis of TK1 gene]

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:27,822,679...27,882,313

G

DNA polymerase theta

decreases response to substance

POLQ results in decreased susceptibility to Mitomycin

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878

G

cytochrome p450 oxidoreductase

increases response to substance

POR mRNA results in increased susceptibility to Mitomycin; POR protein results in increased susceptibility to Mitomycin

PMID:15239142 PMID:21386838

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245

G

protein phosphatase 2, regulatory subunit B, alpha

decreases response to substance

PPP2R2A protein results in decreased susceptibility to Mitomycin

NCBI chr15:45,380,142...45,439,428
Ensembl chr15:41,204,200...41,263,924

G

protein phosphatase 2, regulatory subunit B', gamma

increases response to substance

PPP2R5C protein results in increased susceptibility to Mitomycin

NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:129,461,648...129,598,346

G

protein phosphatase 2 regulatory subunit B', epsilon

decreases response to substance

PPP2R5E protein results in decreased susceptibility to Mitomycin

NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:94,168,846...94,317,872

G

protein regulator of cytokinesis 1

decreases expression

Mitomycin results in decreased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:134,250,081...134,271,765

G

protein kinase C, delta

multiple interactions

Mitomycin promotes the reaction [CASP3 protein results in increased cleavage of PRKCD protein]

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, zeta

increases cleavage

Mitomycin results in increased cleavage of PRKCZ protein

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367

G

prion protein

increases expression

Mitomycin results in increased expression of PRNP mRNA

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937

G

proline-rich coiled-coil 2C

affects response to substance

PRRC2C protein affects the susceptibility to Mitomycin

NCBI chr13:77,537,226...77,606,926
Ensembl chr13:75,004,010...75,073,643

G

PSMC3 interacting protein

decreases expression

Mitomycin results in decreased expression of PSMC3IP mRNA

NCBI chr10:86,524,546...86,527,764
Ensembl chr10:86,023,950...86,027,423

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Mitomycin results in increased expression of PTGS2 protein
Sulindac inhibits the reaction [Mitomycin results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 11

decreases phosphorylation

Mitomycin results in decreased phosphorylation of PTPN11 protein

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 6

decreases phosphorylation

Mitomycin results in decreased phosphorylation of PTPN6 protein

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984

G

pseudouridine synthase 3

decreases expression

Mitomycin results in decreased expression of PUS3 mRNA

NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714

G

RAB17, member RAS oncogene family

affects response to substance

RAB17 protein affects the susceptibility to Mitomycin

NCBI chr 9:99,001,044...99,014,340
Ensembl chr 9:91,553,464...91,566,451

G

RAB18, member RAS oncogene family

decreases expression

Mitomycin results in decreased expression of RAB18 protein

NCBI chr17:59,639,264...59,670,653
Ensembl chr17:54,943,955...54,976,043

G

RAB20, member RAS oncogene family

affects response to substance

RAB20 protein affects the susceptibility to Mitomycin

NCBI chr16:84,721,427...84,745,610
Ensembl chr16:78,019,337...78,043,529

G

RAB8A, member RAS oncogene family

decreases expression

Mitomycin results in decreased expression of RAB8A protein

NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,654,034...17,675,678

G

RAD51 recombinase

multiple interactions
increases expression

[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD51 paralog C

increases response to substance
decreases response to substance
decreases expression

RAD51C gene mutant form results in increased susceptibility to Mitomycin
RAD51C results in decreased susceptibility to Mitomycin
Mitomycin results in decreased expression of RAD51C mRNA

PMID:20400963 PMID:20471405 PMID:24211769

NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248

G

RAP1B, member of RAS oncogene family

decreases expression

Mitomycin results in decreased expression of RAP1B protein

NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:53,423,130...53,456,370

G

RAP2B, member of RAS oncogene family

decreases expression

Mitomycin results in decreased expression of RAP2B mRNA

NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:145,599,116...145,603,069

G

Ras association domain family member 1

increases response to substance

RASSF1 protein results in increased susceptibility to Mitomycin

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:108,225,023...108,236,164

G

RB transcriptional corepressor 1

decreases expression

Mitomycin results in decreased expression of RB1 protein modified form

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RB binding protein 7, chromatin remodeling factor

increases expression

Mitomycin results in increased expression of RBBP7 mRNA

NCBI chr X:35,544,873...35,563,030
Ensembl chr X:31,913,081...31,931,226

G

RNA binding motif protein 34

decreases expression

Mitomycin results in decreased expression of RBM34 mRNA

NCBI chr19:71,832,189...71,854,038
Ensembl chr19:54,936,531...54,956,715

G

RNA binding protein, mRNA processing factor

decreases expression

Mitomycin results in decreased expression of RBPMS mRNA

NCBI chr16:64,942,159...65,098,504
Ensembl chr16:58,239,474...58,395,426

G

RELA proto-oncogene, NF-kB subunit

increases expression

Mitomycin results in increased expression of RELA

PMID:16019139 PMID:17021654

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

replication factor C subunit 1

decreases expression

Mitomycin results in decreased expression of RFC1 mRNA

NCBI chr14:43,319,768...43,395,028
Ensembl chr14:42,966,324...43,041,370

G

replication factor C subunit 3

affects response to substance

RFC3 protein affects the susceptibility to Mitomycin

NCBI chr12:5,836,546...5,847,331
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 4

decreases expression

Mitomycin results in decreased expression of RFC4 mRNA

NCBI chr11:91,254,273...91,268,727
Ensembl chr11:77,749,638...77,764,122

G

regulator of G-protein signaling 16

decreases expression

Mitomycin results in decreased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857

G

rhomboid 5 homolog 2

increases expression

Mitomycin results in increased expression of RHBDF2 mRNA

NCBI chr10:102,331,991...102,359,117
Ensembl chr10:101,833,157...101,860,283

G

ring finger protein 113A1

decreases expression

Mitomycin results in decreased expression of RNF113A mRNA

NCBI chr X:121,293,621...121,294,844
Ensembl chr X:116,427,684...116,433,762

G

ribosomal protein S3a

increases expression

Mitomycin results in increased expression of RPS3A mRNA

NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:171,524,500...171,529,055

G

rhotekin

increases expression

Mitomycin results in increased expression of RTKN mRNA

NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:115,640,774...115,657,952

G

RUNX family transcription factor 3

increases response to substance

RUNX3 protein results in increased susceptibility to Mitomycin

NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156

G

S100 calcium binding protein A10

affects response to substance

S100A10 protein affects the susceptibility to Mitomycin

NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium binding protein A11

affects response to substance

S100A11 protein affects the susceptibility to Mitomycin

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium-binding protein A4

affects response to substance

S100A4 protein affects the susceptibility to Mitomycin

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254

G

spermidine/spermine N1-acetyl transferase 1

affects response to substance

SAT1 protein affects the susceptibility to Mitomycin

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813

G

secretogranin V

affects response to substance

SCG5 protein affects the susceptibility to Mitomycin

NCBI chr 3:120,998,420...121,042,881
Ensembl chr 3:100,544,099...100,588,463

G

synthesis of cytochrome C oxidase 1

decreases expression

Mitomycin results in decreased expression of SCO1 mRNA

NCBI chr10:52,243,664...52,256,250
Ensembl chr10:51,744,656...51,757,237

G

succinate dehydrogenase complex assembly factor 1

decreases expression

Mitomycin results in decreased expression of SDHAF1 mRNA

NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366
Ensembl chr 1:85,576,041...85,577,366

G

serpin family B member 2

affects response to substance

SERPINB2 protein affects the susceptibility to Mitomycin

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:23,541,400...23,550,408

G

serpin family E member 1

affects response to substance
increases expression

SERPINE1 protein affects the susceptibility to Mitomycin
Mitomycin results in increased expression of SERPINE1 protein

PMID:16217747 PMID:34624459

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

serum/glucocorticoid regulated kinase 1

increases expression
multiple interactions
decreases expression

Mitomycin results in increased expression of SGK1 mRNA
Mitomycin promotes the reaction [TP53 protein results in increased expression of SGK1 mRNA]
Mitomycin results in decreased expression of SGK1 mRNA

PMID:18647660 PMID:24211769

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

SH3-domain binding protein 5

affects response to substance

SH3BP5 protein affects the susceptibility to Mitomycin

NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975

G

SIVA1, apoptosis-inducing factor

increases expression

Mitomycin results in increased expression of SIVA1 mRNA

NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:131,705,323...131,709,690

G

stem-loop histone mRNA binding protein

decreases expression

Mitomycin results in decreased expression of SLBP mRNA

NCBI chr14:81,295,479...81,306,446
Ensembl chr14:77,071,632...77,081,906

G

solute carrier family 16, member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitomycin

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 1

affects response to substance

SLC1A1 protein affects the susceptibility to Mitomycin

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 1 member 4

decreases expression

Mitomycin results in decreased expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 1 member 5

decreases expression

Mitomycin results in decreased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 27 member 3

affects response to substance

SLC27A3 protein affects the susceptibility to Mitomycin

NCBI chr 2:178,150,835...178,155,503
Ensembl chr 2:175,853,241...175,857,909

G

solute carrier family 7 member 11

decreases expression

Mitomycin results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

sphingomyelin phosphodiesterase, acid-like 3A

affects response to substance

SMPDL3A protein affects the susceptibility to Mitomycin

NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,132,592...37,155,567

G

superoxide dismutase 1

increases expression

Mitomycin results in increased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

affects response to substance

SOD2 protein affects the susceptibility to Mitomycin

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitomycin

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169

G

sortilin 1

affects response to substance

SORT1 protein affects the susceptibility to Mitomycin

NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:195,924,099...196,002,354

G

SPC25 component of NDC80 kinetochore complex

increases expression

Mitomycin results in increased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959

G

serglycin

affects response to substance

SRGN protein affects the susceptibility to Mitomycin

NCBI chr20:30,985,508...31,022,296
Ensembl chr20:30,442,813...30,457,406

G

serine and arginine rich splicing factor 1

affects response to substance

SRSF1 protein affects the susceptibility to Mitomycin

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:72,839,274...72,845,336

G

sulfiredoxin 1

increases expression

Mitomycin results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448

G

ST14 transmembrane serine protease matriptase

increases expression

Mitomycin results in increased expression of ST14 mRNA

NCBI chr 8:37,798,994...37,839,881
Ensembl chr 8:29,540,811...29,581,517

G

suppression of tumorigenicity 7

affects response to substance

ST7 protein affects the susceptibility to Mitomycin

NCBI chr 4:46,041,655...46,289,745
Ensembl chr 4:46,042,236...46,289,740

G

signal transducer and activator of transcription 2

decreases phosphorylation

Mitomycin results in decreased phosphorylation of STAT2 protein

NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967

G

signal transducer and activator of transcription 3

decreases phosphorylation

Mitomycin results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

decreases phosphorylation

Mitomycin results in decreased phosphorylation of STAT6 protein

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495

G

starch binding domain 1

decreases expression

Mitomycin results in decreased expression of STBD1 mRNA

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,469,582...15,477,443

G

stanniocalcin 2

affects response to substance

STC2 protein affects the susceptibility to Mitomycin

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973

G

SUB1 regulator of transcription

increases expression

Mitomycin results in increased expression of SUB1 mRNA

NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436

G

syntabulin

affects response to substance

SYBU protein affects the susceptibility to Mitomycin

NCBI chr 7:77,731,662...77,833,413
Ensembl chr 7:75,847,003...75,948,828

G

TBC1 domain family, member 8

increases expression

Mitomycin results in increased expression of TBC1D8 mRNA

NCBI chr 9:49,147,109...49,257,140
Ensembl chr 9:41,651,395...41,761,409

G

tudor domain containing 3

affects response to substance

TDRD3 protein affects the susceptibility to Mitomycin

NCBI chr15:69,748,754...69,911,605
Ensembl chr15:63,341,235...63,476,110

G

terminal nucleotidyltransferase 4A

decreases expression

Mitomycin results in decreased expression of TENT4A mRNA

NCBI chr 1:35,594,380...35,627,836
Ensembl chr 1:33,765,672...33,799,433

G

terminal nucleotidyltransferase 5A

affects response to substance

TENT5A protein affects the susceptibility to Mitomycin

NCBI chr 8:95,102,349...95,109,100
Ensembl chr 8:86,225,357...86,229,045

G

telomerase reverse transcriptase

decreases expression

Mitomycin results in decreased expression of TERT protein

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor AP-2 alpha

affects response to substance

TFAP2A protein affects the susceptibility to Mitomycin

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,024,432...24,047,507

G

transcription factor EC

decreases expression

Mitomycin results in decreased expression of TFEC mRNA

NCBI chr 4:46,072,093...46,146,200
Ensembl chr 4:45,107,641...45,180,236

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitomycin

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054

G

tissue factor pathway inhibitor

affects response to substance

TFPI protein affects the susceptibility to Mitomycin

NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880

G

tissue factor pathway inhibitor 2

affects response to substance

TFPI2 protein affects the susceptibility to Mitomycin

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:31,982,178...31,986,600

G

TDP-glucose 4,6-dehydratase

affects response to substance

TGDS protein affects the susceptibility to Mitomycin

NCBI chr15:101,581,765...101,602,779
Ensembl chr15:95,174,608...95,195,554

G

transforming growth factor, beta 1

increases expression

Mitomycin results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

decreases expression

Mitomycin results in decreased expression of TGFBI mRNA; Mitomycin results in decreased expression of TGFBI protein

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,955,603...7,985,240

G

transglutaminase 2

affects response to substance

TGM2 protein affects the susceptibility to Mitomycin

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:146,772,687...146,801,981

G

timeless interacting protein

decreases expression

Mitomycin results in decreased expression of TIPIN mRNA

NCBI chr 8:73,676,020...73,696,620
Ensembl chr 8:64,780,828...64,801,352
Ensembl chr 9:64,780,828...64,801,352

G

thymidine kinase 1

increases mutagenesis
multiple interactions

Mitomycin results in increased mutagenesis of TK1 gene
POLK protein inhibits the reaction [Mitomycin results in increased mutagenesis of TK1 gene]

PMID:19237551 PMID:28077981 PMID:30103639 PMID:32087850

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920

G

transmembrane BAX inhibitor motif containing 4

increases expression

Mitomycin results in increased expression of TMBIM4 mRNA

NCBI chr 7:57,604,275...57,618,861
Ensembl chr 7:55,718,699...55,742,773

G

transmembrane protein 156

affects response to substance

TMEM156 protein affects the susceptibility to Mitomycin

NCBI chr14:43,568,131...43,606,109
Ensembl chr14:43,223,381...43,252,449

G

transmembrane protein 185B

decreases expression

Mitomycin results in decreased expression of TMEM185B mRNA

NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858

G

transmembrane protein 19

increases expression

Mitomycin results in increased expression of TMEM19 mRNA

NCBI chr 7:52,844,985...52,871,708
Ensembl chr 7:50,958,888...50,986,809

G

transmembrane protein 97

affects response to substance

TMEM97 protein affects the susceptibility to Mitomycin

NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730

G

TNF superfamily member 10

multiple interactions

[Mitomycin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

torsin family 1, member A

decreases expression

Mitomycin results in decreased expression of TOR1A mRNA

NCBI chr 3:34,648,421...34,655,453
Ensembl chr 3:14,250,676...14,257,691

G

tumor protein p53

increases expression
affects response to substance
multiple interactions
increases stability
affects activity
affects localization

Mitomycin results in increased expression of TP53; Mitomycin results in increased expression of TP53 mRNA; Mitomycin results in increased expression of TP53 protein; Mitomycin results in increased expression of TP53 protein modified form
TP53 protein affects the susceptibility to Mitomycin
[Mitomycin results in increased stability of TP53 protein] which results in increased expression of CDKN1A mRNA; [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA; Mitomycin promotes the reaction [TP53 protein results in increased expression of CCNB1 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of DDB2 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of GADD45A mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of HSPA8 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of PCNA mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of SGK1 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of TP53I3 mRNA]; Mitomycin promotes the reaction [TP53 protein results in increased expression of TRIAP1 mRNA]; Mitomycin results in increased phosphorylation of and results in increased activity of TP53 protein; Silybin inhibits the reaction [Mitomycin results in increased expression of TP53]; TP53 protein affects the reaction [Mitomycin results in increased activity of GLB1 protein]; TP53 protein affects the reaction [Mitomycin results in increased expression of CDKN1A protein]; TRP53 protein affects the reaction [Mitomycin results in increased expression of TRP73 protein]
Mitomycin affects the activity of TP53 protein
Mitomycin affects the localization of TP53 protein

PMID:12082016 PMID:15182437 PMID:16186332 PMID:17530733 PMID:18647660 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 inducible protein 3

multiple interactions
increases expression

Mitomycin promotes the reaction [TP53 protein results in increased expression of TP53I3 mRNA]
Mitomycin results in increased expression of TP53I3 mRNA

NCBI chr 6:33,537,779...33,545,204

G

tumor protein p73

increases expression
multiple interactions

Mitomycin results in increased expression of TRP73 protein
TRP53 protein affects the reaction [Mitomycin results in increased expression of TRP73 protein]

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitomycin

NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622

G

TPX2, microtubule nucleation factor

decreases expression

Mitomycin results in decreased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:141,318,455...141,360,468

G

TP53 regulated inhibitor of apoptosis 1

increases expression
multiple interactions

Mitomycin results in increased expression of TRIAP1 mRNA
Mitomycin promotes the reaction [TP53 protein results in increased expression of TRIAP1 mRNA]

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:41,267,549...41,270,042

G

tribbles pseudokinase 2

affects response to substance

TRIB2 protein affects the susceptibility to Mitomycin

NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:38,545,975...38,569,370

G

tribbles pseudokinase 3

decreases expression

Mitomycin results in decreased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitomycin

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:169,500,634...169,652,927

G

tripartite motif-containing 26

decreases expression

Mitomycin results in decreased expression of TRIM26 mRNA

NCBI chr20:1,711,564...1,736,389
Ensembl chr20:1,709,788...1,731,120

G

tripartite motif-containing 32

decreases expression

Mitomycin results in decreased expression of TRIM32 mRNA

NCBI chr 5:84,020,604...84,031,483
Ensembl chr 5:78,999,389...79,022,018

G

tripartite motif containing 38

decreases expression

Mitomycin results in decreased expression of TRIM38 mRNA

NCBI chr17:41,774,419...41,787,709

G

thioredoxin reductase 1

multiple interactions

[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein; Glutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

thymidine phosphorylase

multiple interactions
decreases expression

TYMP protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]
Mitomycin results in decreased expression of TYMP mRNA

PMID:16568373 PMID:18728667

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

thymidylate synthetase

increases expression

Mitomycin results in increased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin-like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitomycin

NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitomycin

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

uridine monophosphate synthetase

decreases expression

Mitomycin results in decreased expression of UMPS mRNA

NCBI chr11:80,311,269...80,321,678
Ensembl chr11:66,806,045...66,821,903

G

uracil-DNA glycosylase

decreases response to substance

UNG results in decreased susceptibility to Mitomycin

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:42,485,276...42,494,206

G

UTP3, small subunit processome component

decreases expression

Mitomycin results in decreased expression of UTP3 mRNA

NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396

G

WD repeat domain, phosphoinositide interacting 1

affects response to substance

WIPI1 protein affects the susceptibility to Mitomycin

NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846

G

Wnt family member 5A

affects response to substance

WNT5A protein affects the susceptibility to Mitomycin

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234

G

Wnt family member 9A

increases expression

Mitomycin results in increased expression of WNT9A mRNA

NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,094,140...44,121,133

G

WT1 associated protein

affects response to substance

WTAP protein affects the susceptibility to Mitomycin

NCBI chr 1:50,070,973...50,096,074
Ensembl chr 1:47,665,965...47,691,065

G

xanthine dehydrogenase

multiple interactions
decreases activity

[Oxygen deficiency co-treated with Mitomycin] results in decreased activity of XDH protein; [Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of XDH protein
Mitomycin results in decreased activity of XDH protein

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

G

X-linked inhibitor of apoptosis

affects response to substance

XIAP protein affects the susceptibility to Mitomycin

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

XPA, DNA damage recognition and repair factor

decreases response to substance

XPA protein results in decreased susceptibility to Mitomycin

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:60,431,673...60,475,726

G

X-ray repair cross complementing 4

decreases response to substance

XRCC4 results in decreased susceptibility to Mitomycin

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808

G

zinc finger and BTB domain containing 24

decreases expression

Mitomycin results in decreased expression of ZBTB24 mRNA

NCBI chr20:46,525,982...46,546,363
Ensembl chr20:44,947,297...44,963,963

G

zinc finger DHHC-type palmitoyltransferase 14

decreases expression

Mitomycin results in decreased expression of ZDHHC14 mRNA

NCBI chr 1:48,473,860...48,746,201
Ensembl chr 1:46,069,127...46,330,488

G

zinc finger protein 202

decreases expression

Mitomycin results in decreased expression of ZNF202 mRNA

NCBI chr 8:49,439,849...49,460,117
Ensembl chr 8:40,542,701...40,563,118

G

zinc finger protein 281

affects response to substance

ZNF281 protein affects the susceptibility to Mitomycin

NCBI chr13:50,647,750...50,655,912
Ensembl chr13:48,037,286...48,104,888

G

zinc finger protein 365

increases expression

Mitomycin results in increased expression of ZFP365 mRNA

NCBI chr20:20,665,122...20,688,607
Ensembl chr20:20,666,240...20,691,238

G

zinc finger protein 36, C3H type-like 1

decreases expression

Mitomycin results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:104,663,396...104,669,815
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 94

decreases expression

Mitomycin results in decreased expression of ZNF45 mRNA

NCBI chr 1:88,986,094...89,007,584
Ensembl chr 1:79,859,180...79,879,612

G

zinc finger, MYND-type containing 11

decreases expression

Mitomycin results in decreased expression of ZMYND11 mRNA

NCBI chr17:65,226,907...65,323,278
Ensembl chr17:60,543,077...60,631,902

BMY-25067

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

decreases expression

N-7-(2-(nitrophenyldithio)ethyl)mitomycin C results in decreased expression of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
application	19697
pharmaceutical	19534
drug	19534
antineoplastic agent	17832
mitomycin C	418
BMY-25067	1
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
p-block element atom	19824
carbon group element atom	19763
carbon atom	19760
organic molecular entity	19760
heteroorganic entity	19521
organochalcogen compound	19282
organooxygen compound	19197
carbonyl compound	18927
ketone	17266
cyclic ketone	15917
quinone	9912
p-quinones	8574
mitomycin	418
mitomycin C	418
BMY-25067	1

paths to the root