Gene: Hdac9 (histone deacetylase 9) Rattus norvegicus
Analyze
Symbol:
Hdac9
Name:
histone deacetylase 9
RGD ID:
1310748
Description:
Predicted to have several functions, including enzyme binding activity; histone deacetylase activity (H4-K16 specific); and transcription corepressor activity. Involved in neuron differentiation and response to amphetamine. Localizes to nucleus. Biomarker of middle cerebral artery infarction. Orthologous to human HDAC9 (histone deacetylase 9); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC314040; LOC500642; RGD1310748; RGD1563092; similar to histone deacetylase 9 isoform 5; similar to histone deacetylase-related protein; similar to histone decetylase 9b
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 53,487,367 - 54,358,694 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 53,488,883 - 54,059,119 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 63,109,688 - 63,978,416 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 53,066,308 - 53,114,402 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera 6 49,930,173 - 50,491,018 (-) NCBI Celera Cytogenetic Map 6 q16 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
pleomorphic xanthoastrocytoma ISO RGD:1353912 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358
Imported Annotations - CTD
Osteoarthritis, Hip ISO RGD:1353912 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30374069 Stroke ISO RGD:1353912 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22306652
(-)-demecolcine decreases expression ISO RGD:1353912 6480464 Demecolcine results in decreased expression of HDAC9 mRNA CTD PMID:23649840 17beta-estradiol multiple interactions ISO RGD:1353912 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of HDAC9 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDAC9 mRNA CTD PMID:22493514 , PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1614254 6480464 Tetrachlorodibenzodioxin results in decreased expression of HDAC9 mRNA CTD PMID:19933214 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:32119087 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:1614254 6480464 tetrabromobisphenol A results in decreased expression of HDAC9 mRNA CTD PMID:25172293 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1614254 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of HDAC9 mRNA CTD PMID:26251327 3,5-diethoxycarbonyl-1,4-dihydrocollidine increases expression ISO RGD:1614254 6480464 Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA CTD PMID:18098314 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO RGD:1614254 6480464 S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 5-aza-2'-deoxycytidine decreases expression ISO RGD:1614254 6480464 Decitabine results in decreased expression of HDAC9 mRNA CTD PMID:27915011 5-fluorouracil increases expression ISO RGD:1353912 6480464 Fluorouracil results in increased expression of HDAC9 mRNA CTD PMID:24737281 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HDAC9 mRNA CTD PMID:24780913 acetamide increases expression EXP 6480464 acetamide results in increased expression of HDAC9 mRNA CTD PMID:31881176 acrylamide decreases expression ISO RGD:1614254 6480464 Acrylamide results in decreased expression of HDAC9 mRNA CTD PMID:30807115 aflatoxin B1 decreases methylation ISO RGD:1353912 6480464 Aflatoxin B1 results in decreased methylation of HDAC9 gene CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:1353912 6480464 Aflatoxin B1 results in increased methylation of HDAC9 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:1353912 6480464 Tretinoin results in decreased expression of HDAC9 mRNA CTD PMID:21934132 antirheumatic drug increases expression ISO RGD:1353912 6480464 Antirheumatic Agents results in increased expression of HDAC9 mRNA CTD PMID:24449571 benzo[a]pyrene affects methylation ISO RGD:1353912 6480464 Benzo(a)pyrene affects the methylation of HDAC9 intron, Benzo(a)pyrene affects the methylation of HDAC9 promoter CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases expression ISO RGD:1353912 6480464 Benzo(a)pyrene results in increased expression of HDAC9 mRNA CTD PMID:32234424 benzo[a]pyrene increases methylation ISO RGD:1614254 6480464 Benzo(a)pyrene results in increased methylation of HDAC9 intron CTD PMID:27901495 benzo[e]pyrene decreases methylation ISO RGD:1353912 6480464 benzo(e)pyrene results in decreased methylation of HDAC9 intron CTD PMID:30157460 berberine decreases expression ISO RGD:1353912 6480464 Berberine results in decreased expression of HDAC9 mRNA CTD PMID:27311644 berberine increases expression ISO RGD:1353912 6480464 Berberine results in increased expression of HDAC9 mRNA CTD PMID:27311644 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1614254 6480464 Mustard Gas results in decreased expression of HDAC9 mRNA CTD PMID:26392148 bisphenol A decreases expression ISO RGD:1353912 6480464 bisphenol A results in decreased expression of HDAC9 mRNA CTD PMID:22576693 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HDAC9 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HDAC9 mRNA CTD PMID:25181051 cadmium atom multiple interactions ISO RGD:1614254 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of HDAC9 mRNA CTD PMID:31904401 cadmium dichloride multiple interactions ISO RGD:1614254 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of HDAC9 mRNA CTD PMID:31904401 chloroprene decreases expression ISO RGD:1614254 6480464 Chloroprene results in decreased expression of HDAC9 mRNA CTD PMID:23125180 cisplatin multiple interactions ISO RGD:1353912 6480464 Cisplatin promotes the reaction [jinfukang results in decreased expression of HDAC9 mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of HDAC9 mRNA] CTD PMID:27392435 dorsomorphin multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1353912 6480464 Doxorubicin results in decreased expression of HDAC9 mRNA CTD PMID:29803840 entinostat multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:1353912 6480464 entinostat results in decreased expression of HDAC9 mRNA CTD PMID:26272509 ethyl methanesulfonate decreases expression ISO RGD:1353912 6480464 Ethyl Methanesulfonate results in decreased expression of HDAC9 mRNA CTD PMID:23649840 folic acid decreases expression ISO RGD:1614254 6480464 Folic Acid results in decreased expression of HDAC9 mRNA CTD PMID:25629700 gemcitabine increases expression ISO RGD:1353912 6480464 gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 genistein decreases expression ISO RGD:1614254 6480464 Genistein results in decreased expression of HDAC9 mRNA CTD PMID:32186404 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of HDAC9 mRNA CTD PMID:24915197 hydroquinone increases expression ISO RGD:1353912 6480464 hydroquinone results in increased expression of HDAC9 mRNA CTD PMID:31256213 indometacin increases expression ISO RGD:1353912 6480464 Indomethacin results in increased expression of HDAC9 mRNA CTD PMID:24737281 lead diacetate increases expression ISO RGD:1614254 6480464 lead acetate results in increased expression of HDAC9 mRNA CTD PMID:20542052 lipopolysaccharide decreases expression ISO RGD:1614254 6480464 Lipopolysaccharides results in decreased expression of HDAC9 mRNA CTD PMID:25890327 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of HDAC9 mRNA CTD PMID:25452209 methapyrilene decreases methylation ISO RGD:1353912 6480464 Methapyrilene results in decreased methylation of HDAC9 intron CTD PMID:30157460 methyl methanesulfonate decreases expression ISO RGD:1353912 6480464 Methyl Methanesulfonate results in decreased expression of HDAC9 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1353912 6480464 methylmercuric chloride results in decreased expression of HDAC9 mRNA CTD PMID:28001369 mitomycin C affects response to substance ISO RGD:1353912 6480464 HDAC9 protein affects the susceptibility to Mitomycin CTD PMID:16217747 paclitaxel increases response to substance ISO RGD:1353912 6480464 HDAC9 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 panobinostat decreases expression ISO RGD:1353912 6480464 Panobinostat results in decreased expression of HDAC9 mRNA CTD PMID:30481203 paracetamol increases expression ISO RGD:1353912 6480464 Acetaminophen results in increased expression of HDAC9 mRNA CTD PMID:29067470 PD 0325901 decreases expression ISO RGD:1353912 6480464 PD 0325901 results in decreased expression of HDAC9 mRNA CTD PMID:25119042 PD 0325901 multiple interactions ISO RGD:1353912 6480464 [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HDAC9 mRNA CTD PMID:25119042 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1614254 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of HDAC9 mRNA CTD PMID:31904401 pirfenidone decreases expression ISO RGD:1353912 6480464 pirfenidone results in decreased expression of HDAC9 mRNA CTD PMID:30481203 resveratrol increases expression ISO RGD:1353912 6480464 Resveratrol results in increased expression of HDAC9 mRNA CTD PMID:30481203 S-adenosyl-L-methioninate multiple interactions ISO RGD:1614254 6480464 S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 S-adenosyl-L-methionine multiple interactions ISO RGD:1614254 6480464 S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 SB 431542 multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1353912 6480464 Silicon Dioxide results in increased expression of HDAC9 mRNA CTD PMID:22300531 , PMID:25351596 silver atom decreases expression ISO RGD:1614254 6480464 Silver results in decreased expression of HDAC9 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1614254 6480464 Silver results in decreased expression of HDAC9 mRNA CTD PMID:27131904 sodium arsenite increases expression ISO RGD:1353912 6480464 sodium arsenite results in increased expression of HDAC9 mRNA CTD PMID:16966095 succimer multiple interactions ISO RGD:1353912 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HDAC9 mRNA CTD PMID:26378955 sulforaphane decreases expression ISO RGD:1353912 6480464 sulforafan results in decreased expression of HDAC9 mRNA CTD PMID:26833863 sunitinib decreases expression ISO RGD:1353912 6480464 Sunitinib results in decreased expression of HDAC9 mRNA CTD PMID:31533062 tetrachloromethane increases expression ISO RGD:1614254 6480464 Carbon Tetrachloride results in increased expression of HDAC9 mRNA CTD PMID:27396813 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of HDAC9 mRNA CTD PMID:31150632 topotecan affects response to substance ISO RGD:1353912 6480464 HDAC9 protein affects the susceptibility to Topotecan CTD PMID:16217747 trichostatin A decreases expression ISO RGD:1353912 6480464 trichostatin A results in decreased expression of HDAC9 mRNA CTD PMID:22723015 more ... trichostatin A multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:1353912 6480464 Triclosan results in decreased expression of HDAC9 mRNA CTD PMID:30510588 valproic acid decreases expression ISO RGD:1353912 6480464 Valproic Acid results in decreased expression of HDAC9 mRNA CTD PMID:24383497 , PMID:26272509 valproic acid increases methylation ISO RGD:1353912 6480464 Valproic Acid results in increased methylation of HDAC9 gene CTD PMID:29501571 valproic acid affects expression ISO RGD:1353912 6480464 Valproic Acid affects the expression of HDAC9 mRNA CTD PMID:29501571 valproic acid multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC9 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1353912 6480464 Valproic Acid results in increased expression of HDAC9 mRNA CTD PMID:23179753 , PMID:27188386 valsartan multiple interactions ISO RGD:1353912 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA] CTD PMID:19225232 vincristine decreases expression ISO RGD:1353912 6480464 Vincristine results in decreased expression of HDAC9 mRNA CTD PMID:23649840 vorinostat multiple interactions ISO RGD:1353912 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:23891734 , PMID:27188386 vorinostat increases expression ISO RGD:1353912 6480464 vorinostat results in increased expression of HDAC9 mRNA CTD PMID:27188386 zoledronic acid increases expression ISO RGD:1353912 6480464 zoledronic acid results in increased expression of HDAC9 mRNA CTD PMID:24714768
Biological Process cellular response to insulin stimulus ISO RGD:1353912 1624291 (PMID:19303849) RGD PMID:19303849 cholesterol homeostasis ISO RGD:1353912 1624291 (PMID:28855441) RGD PMID:28855441 determination of adult lifespan ISO RGD:1614254 1624291 MGI:1890508 (MGI:5139938 , PMID:21746928) RGD MGI:5139938 , PMID:21746928 DNA repair ISO RGD:1614254 1624291 MGI:1890508 (MGI:5139938 , PMID:21746928) RGD MGI:5139938 , PMID:21746928 heart development ISO RGD:1614254 1624291 MGI:1333784 (MGI:3055619 , PMID:15367668) RGD MGI:3055619 , PMID:15367668 histone deacetylation ISO RGD:1353912 1624291 (PMID:11535832) RGD PMID:11535832 histone H3 deacetylation ISO RGD:1353912 1624291 (PMID:12590135) RGD PMID:12590135 histone H4 deacetylation ISO RGD:1353912 1624291 (PMID:12590135) RGD PMID:12590135 histone H4-K16 deacetylation ISO RGD:1353912 1624291 (PMID:28855441) RGD PMID:28855441 negative regulation of cytokine production ISO RGD:1353912 1624291 (PMID:28855441) RGD PMID:28855441 negative regulation of lipoprotein lipase activity ISO RGD:1353912 1624291 (PMID:28855441) RGD PMID:28855441 negative regulation of transcription by RNA polymerase II ISO RGD:1353912 1624291 (PMID:10655483), (PMID:11535832) RGD PMID:10655483 , PMID:11535832 negative regulation of transcription by RNA polymerase II ISO RGD:1614254 1624291 (MGI:2136109 more ... RGD MGI:2136109 more ... negative regulation of transcription, DNA-templated ISO RGD:1353912 1624291 (PMID:10655483), (PMID:11535832) RGD PMID:10655483 , PMID:11535832 negative regulation of transcription, DNA-templated ISO RGD:1614254 1624291 (MGI:1931108 more ... RGD MGI:1931108 more ... neuron differentiation IEP 704464 RGD peptidyl-lysine deacetylation ISO RGD:1353912 1624291 (PMID:11535832) RGD PMID:11535832 positive regulation of cell migration involved in sprouting angiogenesis ISO RGD:1353912 1624291 (PMID:19351956) RGD PMID:19351956 regulation of skeletal muscle fiber development ISO RGD:1614254 1624291 MGI:1333784 more ... RGD MGI:3763703 , PMID:17786239 regulation of striated muscle cell differentiation ISO RGD:1614254 1624291 MGI:1333784 more ... RGD MGI:3763703 , PMID:17786239 response to amphetamine IEP 9681719 RGD Cellular Component cytoplasm ISO RGD:1353912 1624291 (PMID:12590135), (PMID:20188095) RGD PMID:12590135 , PMID:20188095 histone deacetylase complex IEA UniRule:UR000135806 1600115 GO_REF:0000104 UniProt GO_REF:0000104 histone methyltransferase complex ISO RGD:1614254 1624291 (MGI:4359370, PMID:12242305) RGD MGI:4359370 , PMID:12242305 nucleus IDA 9588273 RGD nucleus ISO RGD:1353912 1624291 (PMID:12590135), (PMID:20188095) RGD PMID:12590135 , PMID:20188095 transcription regulator complex ISO RGD:1353912 1624291 (PMID:15567413), (PMID:19303849) RGD PMID:15567413 , PMID:19303849 Molecular Function histone deacetylase activity NOT ISO RGD:1353912 1624291 (PMID:10655483) RGD PMID:10655483 histone deacetylase activity ISO RGD:1353912 1624291 (PMID:11535832) RGD PMID:11535832 histone deacetylase activity (H4-K16 specific) ISO RGD:1353912 1624291 (PMID:28855441) RGD PMID:28855441 histone deacetylase binding ISO RGD:1353912 1624291 UniProtKB:O15379 more ... RGD PMID:10655483 , PMID:12590135 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 molecular_function ND 1598407 04/2009: no relevant rat data RGD protein binding ISO RGD:1353912 1624291 UniProtKB:P41182 more ... RGD PMID:12590135 more ... protein binding ISO RGD:1614254 1624291 PR:O88712 more ... RGD MGI:2136109 more ... protein deacetylase activity ISO RGD:1353912 1624291 (PMID:11535832) RGD PMID:11535832 protein kinase C binding ISO RGD:1353912 1624291 UniProtKB:Q16512 (PMID:20188095) RGD PMID:20188095 repressing transcription factor binding ISO RGD:1353912 1624291 UniProtKB:Q9BZS1 (PMID:12590135), (PMID:17360565) RGD PMID:12590135 , PMID:17360565 repressing transcription factor binding ISO RGD:1614254 1624291 UniProtKB:Q61686 (MGI:4359370 , PMID:12242305) RGD MGI:4359370 , PMID:12242305 transcription corepressor activity ISO RGD:1614254 1624291 (MGI:1931108, PMID:11022042) RGD MGI:1931108 , PMID:11022042 transcription factor binding ISO RGD:1353912 1624291 UniProtKB:P22415 more ... RGD PMID:10748098 more ...
Gene-Chemical Interaction Annotations
