Cers4 (ceramide synthase 4) - Rat Genome Database

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Gene: Cers4 (ceramide synthase 4) Rattus norvegicus
Analyze
Symbol: Cers4
Name: ceramide synthase 4
RGD ID: 1309303
Description: Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CERS4 (ceramide synthase 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; Lass4; LOC304208; longevity assurance homolog 4; longevity assurance homolog 4 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,649,610 - 7,688,066 (+)NCBIGRCr8
mRatBN7.2122,851,784 - 2,890,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,851,784 - 2,886,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,499,944 - 3,534,889 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0124,123,536 - 4,158,481 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,887,342 - 2,922,582 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,439,750 - 4,474,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,439,750 - 4,474,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0126,568,235 - 6,602,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,256,396 - 1,291,578 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,257,772 - 1,290,757 (-)NCBI
Celera124,665,718 - 4,700,469 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12912983   PMID:15823095   PMID:17977534   PMID:29632068  


Genomics

Comparative Map Data
Cers4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,649,610 - 7,688,066 (+)NCBIGRCr8
mRatBN7.2122,851,784 - 2,890,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,851,784 - 2,886,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,499,944 - 3,534,889 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0124,123,536 - 4,158,481 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,887,342 - 2,922,582 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,439,750 - 4,474,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,439,750 - 4,474,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0126,568,235 - 6,602,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,256,396 - 1,291,578 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,257,772 - 1,290,757 (-)NCBI
Celera124,665,718 - 4,700,469 (+)NCBICelera
Cytogenetic Map12p12NCBI
CERS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,209,370 - 8,262,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,206,736 - 8,262,421 (+)EnsemblGRCh38hg38GRCh38
GRCh37198,274,254 - 8,327,305 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,180,257 - 8,233,302 (+)NCBINCBI36Build 36hg18NCBI36
Build 34198,180,256 - 8,233,302NCBI
Celera198,145,624 - 8,198,703 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,944,374 - 7,996,205 (+)NCBIHuRef
CHM1_1198,273,682 - 8,326,785 (+)NCBICHM1_1
T2T-CHM13v2.0198,210,805 - 8,263,817 (+)NCBIT2T-CHM13v2.0
Cers4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,542,863 - 4,579,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,543,026 - 4,581,680 (+)EnsemblGRCm39 Ensembl
GRCm3884,492,818 - 4,529,603 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,493,026 - 4,531,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,493,405 - 4,526,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,493,504 - 4,525,757 (+)NCBIMGSCv36mm8
Celera84,687,834 - 4,720,521 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.04NCBI
Cers4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,100,787 - 1,124,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,100,410 - 1,105,662 (-)NCBIChiLan1.0ChiLan1.0
CERS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,890,575 - 12,944,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,007,769 - 12,065,077 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,509,213 - 7,562,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,364,569 - 8,415,345 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,364,569 - 8,415,345 (+)Ensemblpanpan1.1panPan2
CERS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,829,482 - 52,860,783 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,829,316 - 52,860,803 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,630,184 - 52,662,189 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,356,351 - 53,388,350 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,357,348 - 53,388,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,559,172 - 52,591,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,004,363 - 53,036,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,235,869 - 53,267,895 (+)NCBIUU_Cfam_GSD_1.0
Cers4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,706,004 - 212,713,170 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365885,107,663 - 5,131,140 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365885,121,645 - 5,128,774 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,004,420 - 71,048,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,004,418 - 71,047,968 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,405,245 - 71,448,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CERS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366608179,409 - 171,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cers4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,074,942 - 1,092,647 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248281,074,920 - 1,092,607 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cers4
252 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:504
Count of miRNA genes:279
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000001418
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat

Markers in Region
RH133755  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map120.0UniSTS
Cytogenetic Map12p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 15 4 16 4 74 27 34 11
Low 3 42 37 3 37 8 11 8 6 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001418   ⟹   ENSRNOP00000001418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,851,784 - 2,886,828 (+)Ensembl
Rnor_6.0 Ensembl124,439,750 - 4,474,729 (-)Ensembl
RefSeq Acc Id: NM_001107117   ⟹   NP_001100587
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,649,610 - 7,684,653 (+)NCBI
mRatBN7.2122,851,784 - 2,886,828 (+)NCBI
Rnor_6.0124,439,750 - 4,474,729 (-)NCBI
Rnor_5.0126,568,235 - 6,602,867 (-)NCBI
RGSC_v3.4121,256,396 - 1,291,578 (-)RGD
Celera124,665,718 - 4,700,469 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248804   ⟹   XP_006248866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,649,739 - 7,688,066 (+)NCBI
mRatBN7.2122,852,019 - 2,890,244 (+)NCBI
Rnor_6.0124,439,952 - 4,474,470 (-)NCBI
Rnor_5.0126,568,235 - 6,602,867 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100587 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248866 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001418
  ENSRNOP00000001418.5
Reference Protein Sequences
RefSeq Acc Id: NP_001100587   ⟸   NM_001107117
- UniProtKB: D3ZU86 (UniProtKB/TrEMBL),   A6KQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248866   ⟸   XM_006248804
- Peptide Label: isoform X1
- UniProtKB: D3ZU86 (UniProtKB/TrEMBL),   A6KQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001418   ⟸   ENSRNOT00000001418
Protein Domains
Homeobox   TLC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU86-F1-model_v2 AlphaFold D3ZU86 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698387
Promoter ID:EPDNEW_R8911
Type:multiple initiation site
Name:Cers4_1
Description:ceramide synthase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,474,299 - 4,474,359EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309303 AgrOrtholog
BioCyc Gene G2FUF-20336 BioCyc
Ensembl Genes ENSRNOG00000001072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001418 ENTREZGENE
  ENSRNOT00000001418.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Longevity_assurance_LAG1_LAC1 UniProtKB/TrEMBL
  TLC-dom UniProtKB/TrEMBL
KEGG Report rno:304208 UniProtKB/TrEMBL
NCBI Gene 304208 ENTREZGENE
PANTHER CERAMIDE SYNTHASE 4 UniProtKB/TrEMBL
  PTHR12560 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PhenoGen Cers4 PhenoGen
PIRSF LAG1_LAC1 UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001072 RatGTEx
SMART HOX UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6KQ80 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Cers4  ceramide synthase 4  Lass4  LAG1 homolog, ceramide synthase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Lass4  LAG1 homolog, ceramide synthase 4  Lass4_predicted  longevity assurance homolog 4 (S. cerevisiae) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Lass4_predicted  longevity assurance homolog 4 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED