Tdrd3 (tudor domain containing 3)

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Gene: Tdrd3 (tudor domain containing 3) Rattus norvegicus

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Symbol:

Tdrd3

Name:

tudor domain containing 3

RGD ID:

1310126

Description:

Predicted to enable chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in chromatin organization and positive regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of DNA topoisomerase III-beta-TDRD3 complex and exon-exon junction complex. Predicted to be active in nucleus. Orthologous to human TDRD3 (tudor domain containing 3); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC306066; tudor domain-containing protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TDRD3 (tudor domain containing 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Tdrd3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tdrd3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TDRD3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TDRD3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tdrd3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TDRD3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TDRD3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tdrd3 (tudor domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TDRD3 (tudor domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tdrd3 (tudor domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tdrd3 (tudor domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y50D4C.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Tdrd3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tdrd3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	69,748,754 - 69,911,605 (+)	NCBI		GRCr8
mRatBN7.2	15	63,340,531 - 63,497,208 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	63,341,235 - 63,476,110 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	67,449,294 - 67,576,546 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	68,534,799 - 68,662,049 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	65,431,929 - 65,566,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	70,732,164 - 70,864,855 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	70,790,125 - 70,859,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	74,335,410 - 74,468,101 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	69,605,244 - 69,739,566 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	69,621,023 - 69,755,345 (+)	NCBI
Celera	15	62,845,891 - 62,979,450 (+)	NCBI		Celera
Cytogenetic Map	15	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 13q14 deletion syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,6-dinitrotoluene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chrysene (ISO)

cisplatin (ISO)

coumarin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

etoposide (ISO)

formaldehyde (ISO)

FR900359 (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methoxychlor (EXP)

mitomycin C (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamibarotene (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

topotecan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin organization (IEA)

positive regulation of DNA-templated transcription (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

DNA topoisomerase III-beta-TDRD3 complex (ISO)

exon-exon junction complex (IEA,ISO,ISS)

Golgi apparatus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

chromatin binding (IEA,ISO,ISS)

methylated histone binding (IEA,ISO,ISS)

protein binding (ISO)

transcription coactivator activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Tudor: a versatile family of histone methylation 'readers'.	Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Perceiving the epigenetic landscape through histone readers.	Musselman CA, etal., Nat Struct Mol Biol. 2012 Dec;19(12):1218-27. doi: 10.1038/nsmb.2436.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:20930030	PMID:21172665	PMID:22658674	PMID:22681889	PMID:25931508

Genomics

Comparative Map Data

Tdrd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	69,748,754 - 69,911,605 (+)	NCBI		GRCr8
mRatBN7.2	15	63,340,531 - 63,497,208 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	63,341,235 - 63,476,110 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	67,449,294 - 67,576,546 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	68,534,799 - 68,662,049 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	65,431,929 - 65,566,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	70,732,164 - 70,864,855 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	70,790,125 - 70,859,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	74,335,410 - 74,468,101 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	69,605,244 - 69,739,566 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	69,621,023 - 69,755,345 (+)	NCBI
Celera	15	62,845,891 - 62,979,450 (+)	NCBI		Celera
Cytogenetic Map	15	q12	NCBI

TDRD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	60,395,533 - 60,573,879 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	60,396,457 - 60,573,878 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	60,970,591 - 61,148,013 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	59,911,823 - 60,046,012 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	59,869,122 - 60,046,012	NCBI
Celera	13	41,929,733 - 42,107,133 (+)	NCBI		Celera
Cytogenetic Map	13	q21.2	NCBI
HuRef	13	41,662,317 - 41,839,768 (+)	NCBI		HuRef
CHM1_1	13	60,938,267 - 61,115,685 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	59,615,225 - 59,793,547 (+)	NCBI		T2T-CHM13v2.0

Tdrd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	87,647,598 - 87,782,944 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	87,654,075 - 87,782,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	87,416,178 - 87,545,508 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	87,416,639 - 87,545,504 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	87,816,390 - 87,945,315 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	86,248,429 - 86,377,251 (+)	NCBI		MGSCv36	mm8
Celera	14	84,929,172 - 85,068,169 (+)	NCBI		Celera
Cytogenetic Map	14	E1	NCBI
cM Map	14	44.17	NCBI

Tdrd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	44,328,795 - 44,457,784 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	44,329,159 - 44,457,958 (-)	NCBI	ChiLan1.0	ChiLan1.0

TDRD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	61,913,781 - 62,095,454 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	60,505,859 - 60,687,137 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	41,568,080 - 41,750,288 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	60,289,702 - 60,470,245 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	60,290,518 - 60,470,245 (+)	Ensembl	panpan1.1		panPan2

TDRD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	16,287,721 - 16,449,842 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	16,288,473 - 16,444,635 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	16,265,095 - 16,427,920 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	16,524,378 - 16,687,132 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	16,525,132 - 16,687,126 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	16,224,234 - 16,386,787 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	16,249,914 - 16,412,810 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	16,264,401 - 16,386,815 (+)	NCBI		UU_Cfam_GSD_1.0

Tdrd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	135,830,370 - 135,931,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936511	11,258,898 - 11,348,522 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TDRD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	33,258,063 - 33,440,123 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	33,257,556 - 33,440,131 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	34,988,674 - 35,171,255 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TDRD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	38,174,141 - 38,361,626 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	38,174,990 - 38,361,622 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	5,331,867 - 5,524,367 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tdrd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624748	21,656,003 - 21,815,589 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tdrd3
302 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	145
Count of miRNA genes:	117
Interacting mature miRNAs:	124
Transcripts:	ENSRNOT00000012440
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	53806152	98806152	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat
61477	Aia4	Adjuvant induced arthritis QTL 4	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	15	55596089	91365858	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
724545	Niddm54	Non-insulin dependent diabetes mellitus QTL 54		0.02	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	50794494	73699215	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
631516	Gluco31	Glucose level QTL 31	7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	55596089	95018120	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2317050	Aia24	Adjuvant induced arthritis QTL 24	2.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	52847908	73690657	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
2313080	Bss65	Bone structure and strength QTL 65	3.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	15	60990468	73690657	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat

Markers in Region

RH132759

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	63,446,011 - 63,446,191 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	70,834,287 - 70,834,466	NCBI	Rnor6.0
Rnor_5.0	15	74,437,533 - 74,437,712	UniSTS	Rnor5.0
RGSC_v3.4	15	69,708,829 - 69,709,008	UniSTS	RGSC3.4
RGSC_v3.4	15	69,928,252 - 69,928,431	UniSTS	RGSC3.4
Celera	15	63,091,098 - 63,091,277	UniSTS
Celera	15	62,949,353 - 62,949,532	UniSTS
Cytogenetic Map	15	q12	UniSTS

BE119407

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	63,426,170 - 63,426,322 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	70,816,222 - 70,816,373	NCBI	Rnor6.0
Rnor_5.0	15	74,419,468 - 74,419,619	UniSTS	Rnor5.0
Celera	15	62,930,012 - 62,930,163	UniSTS
RH 3.4 Map	15	385.47	UniSTS
Cytogenetic Map	15	q12	UniSTS

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_197221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_197222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005493732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005493733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012440 ⟹ ENSRNOP00000012440

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	63,341,268 - 63,476,094 (+)	Ensembl
Rnor_6.0 Ensembl	15	70,790,125 - 70,859,185 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110490 ⟹ ENSRNOP00000083043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	63,341,235 - 63,476,097 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117994 ⟹ ENSRNOP00000077267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	63,341,268 - 63,476,094 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119103 ⟹ ENSRNOP00000086500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	63,341,235 - 63,476,110 (+)	Ensembl

RefSeq Acc Id:

NM_001012043 ⟹ NP_001012043

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,749,830 - 69,884,657 (+)	NCBI
mRatBN7.2	15	63,341,268 - 63,476,097 (+)	NCBI
Rnor_6.0	15	70,732,164 - 70,864,855 (+)	NCBI
Rnor_5.0	15	74,335,410 - 74,468,101 (+)	NCBI
RGSC_v3.4	15	69,605,244 - 69,739,566 (+)	RGD
Celera	15	62,845,891 - 62,979,450 (+)	RGD

Sequence:

show sequence

CACAGTCGAACAGAGGAGTTTTTTTTCTTTTTCTTTTCTTTCTTCTTTTTTCTCTCTTTCTTCT
TTTTCTTTTTTCTGGGTCTCCAGCAGGAGGCCTGTCCCCCACCCTCAGTTCAGACCCCCGCCGT
CCCCGAGCCTGAGCAGCTAACCATGGCCGAGGTGTCCGGCGCCGCGTTGTCCCAGGCGGGTTGG
TATCTTTCAGATGAAGGCATTGAAGCTTGTACAAGCTCTCCTGGGAAAGTCAATATAAATGACA
TCATCCTGATTGCTCTCAATATTTGAGAACAATTGGCAAGAAGTTCCTCCCCAGTGACATCAGC
GGTGGAAAGGTAGAAAAGCTCGAAGGTCCATGTGTTTTACAAATTCAGAAGGTCCGCAATGTGG
CTGCGCCGAGGGATAATGAGGAGTCCCAAGCTGCGCCAAGGATGCTGCGTGTGCAGATGACGGA
CGGGCACACGAGTTGTACTGCAGTAGAATTCAGTTACATTTCAAAGATAAGCCTGAACACACCA
CCTGGCACAAAAGTGAAGCTCTCCGGCACTGTGGACATAAAGAACGGATTCCTGCTGTTAAGTG
ACTCTAATACCACAGTTCTTGGTGGTGAAGTGGAACACCTAATTGACAAGTGGGCGTTACAGAG
AAGCTTACTAAAACACAACAGAAGCAATATTGGAGCTGAAGGTGGCCCGCCTCCTTTTTTACCT
TTCGGACAGAAATGTGCATCTACTGTCCAAGTGGATAGCAGAGAACTTGATCGAAGAAAGACAT
TACAAGTTTCATTGCCTGCCAAACCTACAAATGATAATGATGAGTTTGAAAAGCAAAGGACTGC
TGCCATTGCAGAGGTCGCAAAGAGCAAAGAGACCAAGACATTTGGAGGAGGTGGAGGTGGAGTC
AGAAGTCATCTCAATATTGGTGCTGGCGGGCACCGAAATCGGGAGGTTTCACAGAAGGAAAAGG
CTTCCAAGTCAGAGAGCAAAAATGAAGGTGTCTATAGAGAACTGGTTGATGAGAAAGCGCTGAA
GCACATAACGGAAATGGGCTTCAGTAAGGAGGCGTCGAGGCAAGCACTGATGGATAATGCCAAC
AACCTAGAGGCAGCCTTGAACGTACTTCTGAACAGCAGTAAACAGAAGCCTGTCGTGGGTCCTC
CTCCCAGAGGTAGAGGGAAAGGCAGGGGGCGAGTACGATCAGAAGATGAAGAAGACCTAGGAAA
CGCAAGACCGTCAGCACCAAGCACATTATTTGATTTCTTGGAGTCTAAAATGGGAACTCTGAAT
ATGGAAGAACCTAGGTCACAGCCACAGCACCTTTATCAAGGACAGCACAGAGTATCGAATACTG
AGCAAAATGGGATAAAGGATGGCAATCAATCAAGACATCTTCCTCGGAACGACCCCAGGCAGCC
GAGAAATGAGAAACCTCCTCGCTTTCAAAGAGACACCCCCAATTTGAAGTCAGCCTTAGAAAAC
AGCGTATTATCTAGAAATAGAGGCTCCGAAAGACCAAGCAGTTCTTCAGGTTCTGATGTGTGGG
CAGAAGAGAGGATCAAGTGTGATAGGCCGTATTCTAGATATGACAGAACTAAAGACGCTTCGTA
TCCTTTAGGTTTTCAGCACAATGATGGTGCTTTTAAAAGGAGAGATAACTCTATGCAAAACAGA
TCAGGAAGAGGCCCGTTGTATGCAGAGGCAAAAGAAAACCCACATCCTTCAGAATTTGTAGATT
ATAATAATCAAAAACGTGGGAAAAGAGAAAACCAAACCAGTAATCCTGATCATTTTTATGACAG
GAAATCACGAACAATGAATAGTGAAGCGTTTAGTGGTCTAAAAATTGAAAAACATTTTAGTGCA
AATACTGATTATCAGAATCCTGTCCAAAGTAATAGTTTTGTTGGTGTTCCAAATGGAGAAACAG
ATATGCCTATGAAAGGAAGACGAGTAGGACCAATTAAGCCAGCAGGACCTGTCACAGCTGTGCC
CTACGATGATAAAATATTTTATAATAGTGGGCCCAAAAGAAGATCTGGGCCAATTAAGCCTGAA
AAGGTGATAGAATCATCTATTCCTGTGGAGTATGCAAAAATGTGGAAACCTGGAGATGAATGTT
TTGCACTTTATTGGGAAGACAACAAGTTTTACCGAGCAGAAGTTGAAGCCCTGCATTCTTCGGG
CATGACAGCGGTTGTGAAGTTCACGGACTACGGAAACTACGAAGAGGTGCTTCTAAGCAACATC
AAGCCTGTTCAGACAGAGGCATGGGAAGAAGAGGGTACCTATGATCACACCATTGAGTTCCGGA
GAGGGGGTGACGGACAGCCTCGAAGGTCCACTCGGCCAACACAGCAGTTTTACCAGCCTCCTCG
AGCTCGGAACTAATGTGAAAGGGTTTTTGTGAAGGAAGAACCACTGACTGAAAGATCCTGGCAG
CCCATTCATAGATTTCCACTTCTTCAGACTGTGACTCAACGTGCTGGATATGATTTTTAGAGAA
AGAAAAAAAAAATAAGGAAATTTTAGGGGAAAGATTCAACCTACACAAAGCAAGGGGGGAAATA
CTGAGTCTGATAGAGCAAATATCTTTACAATGGAAAACTTTTCTTCTGCCATCAATAAAACCAG
TGTGTTATTATAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039093361 ⟹ XP_038949289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,756 - 69,884,657 (+)	NCBI
mRatBN7.2	15	63,340,532 - 63,476,099 (+)	NCBI

RefSeq Acc Id:

XM_039093362 ⟹ XP_038949290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,755 - 69,911,605 (+)	NCBI
mRatBN7.2	15	63,340,531 - 63,497,208 (+)	NCBI

RefSeq Acc Id:

XM_039093365 ⟹ XP_038949293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,756 - 69,884,657 (+)	NCBI
mRatBN7.2	15	63,340,532 - 63,476,099 (+)	NCBI

RefSeq Acc Id:

XM_063274315 ⟹ XP_063130385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,754 - 69,878,996 (+)	NCBI

RefSeq Acc Id:

XR_005493732

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,757 - 69,878,995 (+)	NCBI
mRatBN7.2	15	63,340,533 - 63,470,435 (+)	NCBI

RefSeq Acc Id:

XR_005493733

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	69,748,757 - 69,863,237 (+)	NCBI
mRatBN7.2	15	63,340,533 - 63,454,661 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012043	(Get FASTA)	NCBI Sequence Viewer
	NP_001418403	(Get FASTA)	NCBI Sequence Viewer
	NP_001418404	(Get FASTA)	NCBI Sequence Viewer
	NP_001418405	(Get FASTA)	NCBI Sequence Viewer
	NP_001418406	(Get FASTA)	NCBI Sequence Viewer
	NP_001418407	(Get FASTA)	NCBI Sequence Viewer
	XP_038949289	(Get FASTA)	NCBI Sequence Viewer
	XP_038949290	(Get FASTA)	NCBI Sequence Viewer
	XP_038949293	(Get FASTA)	NCBI Sequence Viewer
	XP_063130385	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81929	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012440.6
	ENSRNOP00000077267.1
	ENSRNOP00000083043.1
	ENSRNOP00000086500.1
GenBank Protein	Q66HC1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012043 ⟸ NM_001012043

- UniProtKB:

Q66HC1 (UniProtKB/Swiss-Prot), A0A096MIS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRVQMTDGHTSCTAVEFSYISKISLNTPPGTKVKLSGTVDIKNGFLLLSDSNTTVLGGEVEHL
IDKWALQRSLLKHNRSNIGAEGGPPPFLPFGQKCASTVQVDSRELDRRKTLQVSLPAKPTNDND
EFEKQRTAAIAEVAKSKETKTFGGGGGGVRSHLNIGAGGHRNREVSQKEKASKSESKNEGVYRE
LVDEKALKHITEMGFSKEASRQALMDNANNLEAALNVLLNSSKQKPVVGPPPRGRGKGRGRVRS
EDEEDLGNARPSAPSTLFDFLESKMGTLNMEEPRSQPQHLYQGQHRVSNTEQNGIKDGNQSRHL
PRNDPRQPRNEKPPRFQRDTPNLKSALENSVLSRNRGSERPSSSSGSDVWAEERIKCDRPYSRY
DRTKDASYPLGFQHNDGAFKRRDNSMQNRSGRGPLYAEAKENPHPSEFVDYNNQKRGKRENQTS
NPDHFYDRKSRTMNSEAFSGLKIEKHFSANTDYQNPVQSNSFVGVPNGETDMPMKGRRVGPIKP
AGPVTAVPYDDKIFYNSGPKRRSGPIKPEKVIESSIPVEYAKMWKPGDECFALYWEDNKFYRAE
VEALHSSGMTAVVKFTDYGNYEEVLLSNIKPVQTEAWEEEGTYDHTIEFRRGGDGQPRRSTRPT
QQFYQPPRARN

hide sequence

Ensembl Acc Id:

ENSRNOP00000012440 ⟸ ENSRNOT00000012440

RefSeq Acc Id:	XP_038949290 ⟸ XM_039093362
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZYD3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949289 ⟸ XM_039093361
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZYD3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949293 ⟸ XM_039093365
- Peptide Label:	isoform X3
- UniProtKB:	Q66HC1 (UniProtKB/Swiss-Prot), A0A096MIS7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000086500 ⟸ ENSRNOT00000119103

Ensembl Acc Id:

ENSRNOP00000083043 ⟸ ENSRNOT00000110490

Ensembl Acc Id:

ENSRNOP00000077267 ⟸ ENSRNOT00000117994

RefSeq Acc Id:	XP_063130385 ⟸ XM_063274315
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZYD3 (UniProtKB/TrEMBL), A0A8I6A6B7 (UniProtKB/TrEMBL)

Protein Domains

Tudor UBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HC1-F1-model_v2	AlphaFold	Q66HC1	1-651	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310126	AgrOrtholog
BioCyc Gene	G2FUF-12928	BioCyc
Ensembl Genes	ENSRNOG00000009034	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012440.8	UniProtKB/TrEMBL
	ENSRNOT00000110490.1	UniProtKB/TrEMBL
	ENSRNOT00000117994.1	UniProtKB/Swiss-Prot
	ENSRNOT00000119103.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.30.140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.50.770	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113366	IMAGE-MGC_LOAD
InterPro	RMI1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RMI1_N_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor_TDRD3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA_TDRD3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:306066	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93931	IMAGE-MGC_LOAD
NCBI Gene	306066	ENTREZGENE
PANTHER	SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUDOR DOMAIN-CONTAINING PROTEIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RMI1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUDOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tdrd3	PhenoGen
PROSITE	TUDOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009034	RatGTEx
SMART	DUF1767	UniProtKB/TrEMBL
	TUDOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46934	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tudor/PWWP/MBT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A096MIS7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZYD3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6B7	ENTREZGENE, UniProtKB/TrEMBL
	Q66HC1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Tdrd3	tudor domain containing 3	Tdrd3_predicted	tudor domain containing 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Tdrd3_predicted	tudor domain containing 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

RGD Manual Annotations