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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylparaben
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Accession:CHEBI:31575 term browser browse the term
Definition:An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,
Synonyms:exact_synonym: ethyl 4-hydroxybenzoate
 related_synonym: 4-hydroxybenzoic acid ethyl ester;   E-214;   E214;   Ethyl parahydroxybenzoate;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3;   InChIKey=NUVBSKCKDOMJSU-UHFFFAOYSA-N;   SMILES=C(=O)(C1=CC=C(C=C1)O)OCC;   ethyl p-hydroxybenzoate;   ethyl paraben;   p-Oxybenzoesaeureaethylester;   p-hydroxybenzoic acid ethyl ester
 alt_id: CHEBI:86616
 xref: CAS:120-47-8;   Drug_Central:4773;   HMDB:HMDB0032573;   KEGG:D01647;   KNApSAcK:C00033837
 xref_mesh: MESH:C012313
 xref: PDBeChem:E4B;   PMID:26901724;   PMID:27106519;   PMID:27377865;   Reaxys:1101972;   Wikipedia:Ethylparaben


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ethylparaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of ADIPOQ mRNA CTD PMID:22956630 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ar androgen receptor multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of CEBPA mRNA CTD PMID:22956630 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP1A1 protein CTD PMID:27432241 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2E1 protein CTD PMID:27432241 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO
EXP		 ethyl-p-hydroxybenzoate binds to and results in increased activity of ESR1 protein
ethyl-p-hydroxybenzoate results in increased activity of ESR1 protein
ethyl-p-hydroxybenzoate binds to ESR1 protein		 CTD PMID:11193391 PMID:20132880 PMID:23567241 PMID:25012808 PMID:29162470 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO
EXP		 ethyl-p-hydroxybenzoate binds to ESR2 protein
ethyl-p-hydroxybenzoate binds to and results in increased activity of ESR2 protein		 CTD PMID:11193391 PMID:20132880 PMID:23567241 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of FABP4 mRNA CTD PMID:22956630 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of GREB1 mRNA CTD PMID:35307500 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Lep leptin decreases expression ISO ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mir375 microRNA 375 affects expression ISO ethyl-p-hydroxybenzoate affects the expression of MIR375 CTD PMID:30481674 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO
EXP		 ethyl-p-hydroxybenzoate results in increased expression of NR1I2 mRNA CTD PMID:31472229 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of PGR mRNA CTD PMID:35307500 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of PPARG mRNA CTD PMID:22956630 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO ethyl-p-hydroxybenzoate binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tyr tyrosinase affects response to substance ISO TYR protein affects the susceptibility to ethyl-p-hydroxybenzoate CTD PMID:19944085 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        antimicrobial agent 17945
          antifungal agent 16379
            ethylparaben 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        aromatic carboxylic acid 11830
                                          benzoic acids 11805
                                            benzoic acid 4374
                                              hydroxybenzoic acid 3784
                                                monohydroxybenzoic acid 1484
                                                  4-hydroxybenzoic acid 630
                                                    4-hydroxybenzoate ester 625
                                                      paraben 625
                                                        ethylparaben 23
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