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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylparaben
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Accession:CHEBI:31575 term browser browse the term
Definition:An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,
Synonyms:exact_synonym: ethyl 4-hydroxybenzoate
 related_synonym: 4-hydroxybenzoic acid ethyl ester;   E-214;   E214;   Ethyl parahydroxybenzoate;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3;   InChIKey=NUVBSKCKDOMJSU-UHFFFAOYSA-N;   SMILES=C(=O)(C1=CC=C(C=C1)O)OCC;   ethyl p-hydroxybenzoate;   ethyl paraben;   p-Oxybenzoesaeureaethylester;   p-hydroxybenzoic acid ethyl ester
 alt_id: CHEBI:86616
 xref: CAS:120-47-8;   Drug_Central:4773;   HMDB:HMDB0032573;   KEGG:D01647;   KNApSAcK:C00033837
 xref_mesh: MESH:C012313
 xref: PDBeChem:E4B;   PMID:26901724;   PMID:27106519;   PMID:27377865;   Reaxys:1101972;   Wikipedia:Ethylparaben


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ethylparaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of ADIPOQ mRNA CTD PMID:22956630 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ar androgen receptor multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of CEBPA mRNA CTD PMID:22956630 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP1A1 protein CTD PMID:27432241 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP2E1 protein CTD PMID:27432241 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP ethyl-p-hydroxybenzoate results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding
ISO
EXP
ethyl-p-hydroxybenzoate binds to and results in increased activity of ESR1 protein
ethyl-p-hydroxybenzoate results in increased activity of ESR1 protein
ethyl-p-hydroxybenzoate binds to ESR1 protein
CTD PMID:11193391, PMID:20132880, PMID:23567241, PMID:25012808, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
ISO
EXP
ethyl-p-hydroxybenzoate binds to ESR2 protein
ethyl-p-hydroxybenzoate binds to and results in increased activity of ESR2 protein
CTD PMID:11193391, PMID:20132880, PMID:23567241 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of FABP4 mRNA CTD PMID:22956630 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Lep leptin decreases expression ISO ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mir375 microRNA 375 affects expression ISO ethyl-p-hydroxybenzoate affects the expression of MIR375 CTD PMID:30481674 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO
EXP
ethyl-p-hydroxybenzoate results in increased expression of NR1I2 mRNA CTD PMID:31472229 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO ethyl-p-hydroxybenzoate results in increased expression of PPARG mRNA CTD PMID:22956630 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO ethyl-p-hydroxybenzoate binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tyr tyrosinase affects response to substance ISO TYR protein affects the susceptibility to ethyl-p-hydroxybenzoate CTD PMID:19944085 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antifungal agent 14870
            ethylparaben 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            benzoic acid 3839
                                              hydroxybenzoic acid 3227
                                                monohydroxybenzoic acid 1264
                                                  4-hydroxybenzoic acid 619
                                                    4-hydroxybenzoate ester 614
                                                      paraben 614
                                                        ethylparaben 20
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