Gdf5 (growth differentiation factor 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gdf5 (growth differentiation factor 5) Rattus norvegicus
Analyze
Symbol: Gdf5
Name: growth differentiation factor 5
RGD ID: 620102
Description: Enables signaling receptor binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; ossification involved in bone remodeling; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and bone disease (multiple). Orthologous to human GDF5 (growth differentiation factor 5); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cartilage-derived morphogenetic protein 1; Cdmp1; growth/differentiation factor 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,914,401 - 164,918,593 (-)NCBIGRCr8
mRatBN7.23144,454,316 - 144,458,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,454,338 - 144,458,612 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,319,762 - 148,323,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,937,031 - 156,941,212 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,676,561 - 154,680,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,482,672 - 151,487,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,483,249 - 151,486,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,849,749 - 157,853,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3143,176,803 - 143,181,254 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel insertion mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene underlies Grebe-type chondrodysplasia in a consanguineous Pakistani family. Basit S, etal., BMC Med Genet. 2008 Nov 27;9:102. doi: 10.1186/1471-2350-9-102.
2. Mutations in GDF5 presenting as semidominant brachydactyly A1. Byrnes AM, etal., Hum Mutat. 2010 Oct;31(10):1155-62. doi: 10.1002/humu.21338.
3. Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease. Costello DJ, etal., J Cell Mol Med. 2012 Oct;16(10):2451-60. doi: 10.1111/j.1582-4934.2012.01562.x.
4. Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study. Dai J, etal., Arthritis Res Ther. 2008;10(5):R126. doi: 10.1186/ar2540. Epub 2008 Oct 24.
5. GDF5 is a second locus for multiple-synostosis syndrome. Dawson K, etal., Am J Hum Genet. 2006 Apr;78(4):708-12. Epub 2006 Feb 24.
6. Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome. Degenkolbe E, etal., Bone. 2015 Apr;73:111-9. doi: 10.1016/j.bone.2014.12.017. Epub 2014 Dec 24.
7. The effect of growth differentiation factor-5-coated sutures on tendon repair in a rat model. Dines JS, etal., J Shoulder Elbow Surg. 2007 Sep-Oct;16(5 Suppl):S215-21. Epub 2007 May 15.
8. Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome). Faiyaz-Ul-Haque M, etal., Clin Genet. 2002 Jun;61(6):454-8.
9. Grebe-type chondrodysplasia: a novel missense mutation in a conserved cysteine of the growth differentiation factor 5. Faiyaz-Ul-Haque M, etal., J Bone Miner Metab. 2008;26(6):648-52. doi: 10.1007/s00774-008-0853-5. Epub 2008 Nov 1.
10. Characterization of a novel missense mutation in the prodomain of GDF5, which underlies brachydactyly type C and mild Grebe type chondrodysplasia in a large Pakistani family. Farooq M, etal., Hum Genet. 2013 Nov;132(11):1253-64. doi: 10.1007/s00439-013-1330-3. Epub 2013 Jun 29.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. 6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo. Gavin AM, etal., Neurosci Lett. 2014 Feb 21;561:176-81. doi: 10.1016/j.neulet.2013.12.046. Epub 2013 Dec 25.
13. Growth of severely hypoplastic phalanges and metacarpals in symbrachydactyly: an experimental study in mice. Kanauchi Y, etal., J Hand Surg Am. 2008 Nov;33(9):1589-96. doi: 10.1016/j.jhsa.2008.05.015.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro. O'Keeffe GW, etal., J Neurocytol. 2004 Sep;33(5):479-88.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. Sato M, etal., J Bone Miner Res. 1999 Jul;14(7):1084-95.
24. Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1. Schwabe GC, etal., Am J Med Genet A. 2004 Feb 1;124A(4):356-63.
25. Gene expression of growth differentiation factors in the developing periodontium of rat molars. Sena K, etal., J Dent Res 2003 Mar;82(3):166-71.
26. Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C. Stange K, etal., J Mol Biol. 2014 Sep 23;426(19):3221-31. doi: 10.1016/j.jmb.2014.07.029. Epub 2014 Aug 1.
27. Effect of GDF-5 on ligament healing. Tashiro T, etal., J Orthop Res. 2006 Jan;24(1):71-9.
Additional References at PubMed
PMID:8145850   PMID:9885252   PMID:9950587   PMID:15246706   PMID:15542031   PMID:17085896   PMID:17118748   PMID:18363966   PMID:18569021   PMID:21976273   PMID:24098149   PMID:24682653  
PMID:25174448   PMID:26010756   PMID:37310547  


Genomics

Comparative Map Data
Gdf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,914,401 - 164,918,593 (-)NCBIGRCr8
mRatBN7.23144,454,316 - 144,458,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,454,338 - 144,458,612 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,319,762 - 148,323,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,937,031 - 156,941,212 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,676,561 - 154,680,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,482,672 - 151,487,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,483,249 - 151,486,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,849,749 - 157,853,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3143,176,803 - 143,181,254 (-)NCBICelera
Cytogenetic Map3q42NCBI
GDF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,433,347 - 35,454,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,433,347 - 35,454,746 (-)EnsemblGRCh38hg38GRCh38
GRCh372034,021,145 - 34,042,571 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,484,563 - 33,489,441 (-)NCBINCBI36Build 36hg18NCBI36
Build 342033,484,562 - 33,489,441NCBI
Celera2030,769,772 - 30,774,651 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,798,624 - 30,803,509 (-)NCBIHuRef
CHM1_12033,922,579 - 33,927,457 (-)NCBICHM1_1
T2T-CHM13v2.02037,154,208 - 37,175,640 (-)NCBIT2T-CHM13v2.0
Gdf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,782,943 - 155,787,204 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,782,943 - 155,787,287 (-)EnsemblGRCm39 Ensembl
GRCm382155,941,023 - 155,945,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,941,023 - 155,945,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,766,759 - 155,771,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,632,468 - 155,636,808 (-)NCBIMGSCv36mm8
Celera2161,874,286 - 161,878,600 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Gdf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542225,992,081 - 25,997,122 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542225,992,081 - 25,997,122 (+)NCBIChiLan1.0ChiLan1.0
GDF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22141,166,285 - 41,174,274 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12041,159,388 - 41,167,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,761,199 - 31,766,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,882,094 - 32,903,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,882,094 - 32,886,899 (-)Ensemblpanpan1.1panPan2
GDF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,395,699 - 24,400,302 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,395,263 - 24,399,928 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,041,515 - 24,046,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,088,106 - 25,092,591 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2425,088,006 - 25,092,220 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,374,851 - 24,379,335 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,469,869 - 24,474,354 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,908,900 - 24,913,385 (-)NCBIUU_Cfam_GSD_1.0
Gdf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,399,611 - 173,406,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,343,038 - 5,347,721 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,343,038 - 5,347,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,792,187 - 38,797,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,792,854 - 38,796,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,913,724 - 43,917,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,340,371 - 56,346,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,340,933 - 56,345,053 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,491,489 - 2,496,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248423,959,617 - 3,963,020 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248423,958,814 - 3,963,713 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf5
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:126
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000071099, ENSRNOT00000073736
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
U08337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,454,464 - 144,454,586 (+)MAPPERmRatBN7.2
Rnor_6.03151,482,879 - 151,483,000NCBIRnor6.0
Rnor_5.03157,849,400 - 157,849,521UniSTSRnor5.0
Celera3143,177,010 - 143,177,131UniSTS
UniSTS:143190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,454,319 - 144,454,861 (+)MAPPERmRatBN7.2
Rnor_6.03151,482,734 - 151,483,275NCBIRnor6.0
Rnor_5.03157,849,255 - 157,849,796UniSTSRnor5.0
Celera3143,176,865 - 143,177,406UniSTS
UniSTS:496658  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,458,285 - 144,458,489 (+)MAPPERmRatBN7.2
Rnor_6.03151,486,709 - 151,486,912NCBIRnor6.0
Rnor_5.03157,852,921 - 157,853,124UniSTSRnor5.0
Celera3143,180,834 - 143,181,037UniSTS
REN57716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,455,253 - 144,455,478 (+)MAPPERmRatBN7.2
Rnor_6.03151,483,668 - 151,483,892NCBIRnor6.0
Rnor_5.03157,850,189 - 157,850,413UniSTSRnor5.0
Celera3143,177,799 - 143,178,023UniSTS
REN57733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,458,454 - 144,458,696 (+)MAPPERmRatBN7.2
Rnor_6.03151,486,878 - 151,487,119NCBIRnor6.0
Rnor_5.03157,853,090 - 157,853,331UniSTSRnor5.0
Celera3143,181,003 - 143,181,244UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 3 2 6 5 42 16 27
Below cutoff 22 11 3 12 3 6 8 28 18 12 9 6

Sequence


RefSeq Acc Id: ENSRNOT00000071099   ⟹   ENSRNOP00000063921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3151,483,844 - 151,486,693 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073736   ⟹   ENSRNOP00000066703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,454,338 - 144,458,612 (-)Ensembl
Rnor_6.0 Ensembl3151,483,249 - 151,486,693 (-)Ensembl
RefSeq Acc Id: NM_001398661   ⟹   NP_001385590
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,914,401 - 164,918,593 (-)NCBI
mRatBN7.23144,454,316 - 144,458,508 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385590 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC02713 (Get FASTA)   NCBI Sequence Viewer  
  BAD83809 (Get FASTA)   NCBI Sequence Viewer  
  EDL85884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066703
  ENSRNOP00000066703.1
RefSeq Acc Id: ENSRNOP00000063921   ⟸   ENSRNOT00000071099
RefSeq Acc Id: ENSRNOP00000066703   ⟸   ENSRNOT00000073736
RefSeq Acc Id: NP_001385590   ⟸   NM_001398661
- Peptide Label: preproprotein
- UniProtKB: M0RAY4 (UniProtKB/TrEMBL),   A6KI71 (UniProtKB/TrEMBL)
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAY4-F1-model_v2 AlphaFold M0RAY4 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620102 AgrOrtholog
BioCyc Gene G2FUF-47113 BioCyc
Ensembl Genes ENSRNOG00000050123 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073736 ENTREZGENE
  ENSRNOT00000073736.4 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_N UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report rno:252835 UniProtKB/TrEMBL
NCBI Gene 252835 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 5 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PhenoGen Gdf5 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050123 RatGTEx
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A6KI71 ENTREZGENE, UniProtKB/TrEMBL
  M0RAY4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gdf5  growth differentiation factor 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gdf5  growth differentiation factor 5      Symbol and Name status set to provisional 70820 PROVISIONAL