Slc26a5 (solute carrier family 26 member 5) - Rat Genome Database

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Gene: Slc26a5 (solute carrier family 26 member 5) Rattus norvegicus
Analyze
Symbol: Slc26a5
Name: solute carrier family 26 member 5
RGD ID: 69334
Description: Enables identical protein binding activity. Involved in several processes, including chloride transmembrane transport; positive regulation of cell size; and response to ischemia. Located in basolateral plasma membrane; cytoplasm; and lateral plasma membrane. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Pres; prestin; prestin (motor protein); solute carrier family 26 (anion exchanger), member 5; solute carrier family 26, member 5; solute carrier family 26, member 5 (prestin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2413,210,260 - 13,249,289 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
Rnor_6.049,795,811 - 9,860,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,822,682 - 9,861,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,657,314 - 8,697,539 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.148,657,313 - 8,697,539 (+)NCBI
Celera48,801,513 - 8,840,481 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Bostjancic W, etal., Dtsch Med Wochenschr 1977 Aug 19;102(33):1175-7, 1185.
2. Chambard JM and Ashmore JF, J Physiol. 2003 Aug 1;550(Pt 3):667-77.
3. Chambard JM and Ashmore JF, Pflugers Arch. 2005 Apr;450(1):34-44. Epub 2005 Jan 20.
4. Cheatham MA, etal., J Physiol. 2004 Nov 1;560(Pt 3):821-30. Epub 2004 Aug 19.
5. Chen GD Hear Res. 2006 Dec;222(1-2):54-61. Epub 2006 Sep 26.
6. Chen GD, etal., Hear Res. 2009 Feb;248(1-2):39-47. doi: 10.1016/j.heares.2008.11.010. Epub 2008 Dec 10.
7. Detro-Dassen S, etal., J Biol Chem. 2008 Feb 15;283(7):4177-88. Epub 2007 Dec 11.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Gross J, etal., Hear Res. 2005 Jun;204(1-2):183-90.
10. Gross J, etal., Hear Res. 2010 Mar;261(1-2):9-21. doi: 10.1016/j.heares.2009.12.017. Epub 2009 Dec 16.
11. Lewis MA, etal., Nat Genet. 2009 May;41(5):614-8. doi: 10.1038/ng.369. Epub 2009 Apr 12.
12. Liu XZ, etal., Hum Mol Genet. 2003 May 15;12(10):1155-62.
13. Lu Y, etal., J Biomed Res. 2011 Sep;25(5):309-18. doi: 10.1016/S1674-8301(11)60042-0.
14. Ludwig J, etal., Proc Natl Acad Sci U S A 2001 Mar 27;98(7):4178-83.
15. Mahendrasingam S, etal., Eur J Neurosci. 2010 May;31(9):1595-605. doi: 10.1111/j.1460-9568.2010.07182.x.
16. Mazurek B, etal., Neurosci Lett. 2011 Jul 15;499(1):52-6. doi: 10.1016/j.neulet.2011.05.031. Epub 2011 May 20.
17. MGD data from the GO Consortium
18. Mio K, etal., J Biol Chem. 2008 Jan 11;283(2):1137-45. Epub 2007 Nov 12.
19. Mustapha M, etal., J Neurosci. 2009 Jan 28;29(4):1212-23. doi: 10.1523/JNEUROSCI.4957-08.2009.
20. Nagy I, etal., Hear Res. 2005 Jun;204(1-2):216-22.
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Oliver D, etal., Science. 2001 Jun 22;292(5525):2340-3.
23. OMIM Disease Annotation Pipeline
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Schanzler M and Fahlke C, J Physiol. 2012 Jan 15;590(Pt 2):259-72. doi: 10.1113/jphysiol.2011.209577. Epub 2011 Nov 7.
28. Tang HY, etal., BMC Med Genet. 2005 Aug 8;6:30.
29. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Weber T, etal., Proc Natl Acad Sci U S A 2002 Mar 5;99(5):2901-6.
31. Winter H, etal., Histochem Cell Biol. 2007 Jul;128(1):65-75. Epub 2007 May 23.
32. Xia A, etal., PLoS One. 2013 Dec 20;8(12):e82602. doi: 10.1371/journal.pone.0082602. eCollection 2013.
33. Yang K, etal., Int J Audiol. 2009 Jan;48(1):18-23. doi: 10.1080/14992020802327998.
Additional References at PubMed
PMID:11125015   PMID:12584604   PMID:14553901   PMID:15649974   PMID:16803873   PMID:17120772   PMID:18226918   PMID:18796539   PMID:20418376   PMID:21344672   PMID:21614551   PMID:22890707  
PMID:23542924   PMID:24303013   PMID:24603188   PMID:26635354   PMID:27636386   PMID:28097024   PMID:30529910   PMID:33667636  


Genomics

Comparative Map Data
Slc26a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2413,210,260 - 13,249,289 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
Rnor_6.049,795,811 - 9,860,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,822,682 - 9,861,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,657,314 - 8,697,539 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.148,657,313 - 8,697,539 (+)NCBI
Celera48,801,513 - 8,840,481 (+)NCBICelera
Cytogenetic Map4q11NCBI
SLC26A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,352,730 - 103,446,207 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7103,352,730 - 103,446,207 (-)EnsemblGRCh38hg38GRCh38
GRCh377102,993,177 - 103,086,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,780,413 - 102,873,834 (-)NCBINCBI36hg18NCBI36
Celera797,800,386 - 97,892,942 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef797,355,533 - 97,447,053 (-)NCBIHuRef
CHM1_17102,926,169 - 103,019,937 (-)NCBICHM1_1
T2T-CHM13v2.07104,667,171 - 104,760,648 (-)NCBI
CRA_TCAGchr7v27102,353,543 - 102,447,443 (-)NCBI
Slc26a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,013,999 - 22,070,602 (-)NCBIGRCm39mm39
GRCm39 Ensembl522,015,653 - 22,070,602 (-)Ensembl
GRCm38521,809,001 - 21,865,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,810,655 - 21,865,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,316,473 - 21,371,422 (-)NCBIGRCm37mm9NCBIm37
MGSCv36521,322,479 - 21,377,428 (-)NCBImm8
Celera518,781,281 - 18,837,517 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Slc26a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,358,786 - 8,414,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,358,780 - 8,414,145 (-)NCBIChiLan1.0ChiLan1.0
SLC26A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17108,088,197 - 108,178,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,088,197 - 108,178,578 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0795,363,028 - 95,437,527 (-)NCBIMhudiblu_PPA_v0panPan3
SLC26A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,783,795 - 16,841,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,788,759 - 16,839,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1816,426,732 - 16,484,887 (+)NCBI
ROS_Cfam_1.01817,074,350 - 17,132,490 (+)NCBI
ROS_Cfam_1.0 Ensembl1817,079,270 - 17,131,472 (+)Ensembl
UMICH_Zoey_3.11816,839,580 - 16,897,324 (+)NCBI
UNSW_CanFamBas_1.01816,777,413 - 16,835,901 (+)NCBI
UU_Cfam_GSD_1.01817,046,210 - 17,104,115 (+)NCBI
Slc26a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,980,819 - 59,021,086 (+)NCBI
SpeTri2.0NW_00493647920,104,625 - 20,145,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,378,776 - 103,453,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,382,558 - 103,420,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,990,590 - 114,062,746 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC26A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,347,276 - 72,418,311 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,347,792 - 72,393,765 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604231,608,735 - 31,657,804 (+)NCBIVero_WHO_p1.0
Slc26a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,930,221 - 25,995,828 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473925,925,835 - 25,998,410 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:79
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000015733
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 6
Below cutoff 22 9 3 3 3 2 2 49 2 14 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015733   ⟹   ENSRNOP00000015733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114029   ⟹   ENSRNOP00000085244
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
RefSeq Acc Id: NM_030840   ⟹   NP_110467
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2413,210,260 - 13,249,289 (+)NCBI
Rnor_6.049,821,541 - 9,860,571 (+)NCBI
Rnor_5.049,822,682 - 9,861,708 (+)NCBI
RGSC_v3.448,657,314 - 8,697,539 (+)RGD
Celera48,801,513 - 8,840,481 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110467 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG30297 (Get FASTA)   NCBI Sequence Viewer  
  CAC21555 (Get FASTA)   NCBI Sequence Viewer  
  CAD21439 (Get FASTA)   NCBI Sequence Viewer  
  EDL99408 (Get FASTA)   NCBI Sequence Viewer  
  Q9EPH0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_110467   ⟸   NM_030840
- UniProtKB: Q9EPH0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015733   ⟸   ENSRNOT00000015733
RefSeq Acc Id: ENSRNOP00000085244   ⟸   ENSRNOT00000114029
Protein Domains
STAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPH0-F1-model_v2 AlphaFold Q9EPH0 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69334 AgrOrtholog
BioCyc Gene G2FUF-45989 BioCyc
Ensembl Genes ENSRNOG00000011616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000015733 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015733 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.750.24 UniProtKB/Swiss-Prot
InterPro Prestin UniProtKB/Swiss-Prot
  S04_transporter_CS UniProtKB/Swiss-Prot
  SLC26A/SulP_dom UniProtKB/Swiss-Prot
  SLC26A/SulP_fam UniProtKB/Swiss-Prot
  STAS_dom UniProtKB/Swiss-Prot
  STAS_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:83819 UniProtKB/Swiss-Prot
NCBI Gene 83819 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot
  PTHR11814:SF32 UniProtKB/Swiss-Prot
Pfam STAS UniProtKB/Swiss-Prot
  Sulfate_transp UniProtKB/Swiss-Prot
PhenoGen Slc26a5 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot
  STAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52091 UniProtKB/Swiss-Prot
TIGR TC226893
TIGRFAMs sulP UniProtKB/Swiss-Prot
UniProt Q9EPH0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9ERC6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc26a5  solute carrier family 26 member 5  Slc26a5  solute carrier family 26 (anion exchanger), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc26a5  solute carrier family 26 (anion exchanger), member 5  Slc26a5  solute carrier family 26, member 5 (prestin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc26a5  solute carrier family 26, member 5 (prestin)  Slc26a5  solute carrier family 26, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc26a5  solute carrier family 26, member 5  Pres  prestin (motor protein)  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pres  prestin (motor protein)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the lateral membrane before the onset of hearing but was localized to the entire OHC membrane in hypothyroid rats 70328
gene_domains contains a TRE (thyroid hormone response element) in the second intron upstream of the ATG start site, which binds thyroid hormone receptors 68832
gene_domains contains a TRE (thyroid hormone response element) in the second intron upstream of the ATG start site, which binds thyroid hormone receptors 70328
gene_expression expressed in the apical cell pole of cochlear outer hair cells 68832
gene_expression expressed in the apical cell pole of cochlear outer hair cells 70328
gene_function cochlear motor protein 68832
gene_function cochlear motor protein 70328
gene_regulation transcription is stimulated by thyroid hormone 68832
gene_regulation transcription is stimulated by thyroid hormone 70328