Dleu7 (deleted in lymphocytic leukemia, 7) - Rat Genome Database

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Gene: Dleu7 (deleted in lymphocytic leukemia, 7) Rattus norvegicus
Analyze
Symbol: Dleu7
Name: deleted in lymphocytic leukemia, 7
RGD ID: 1305071
Description: Orthologous to human DLEU7 (deleted in lymphocytic leukemia 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukemia-associated protein 7; LOC290308; RGD1305071; similar to hypothetical protein MGC47306
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,655,563 - 40,671,759 (-)NCBIGRCr8
mRatBN7.21536,479,533 - 36,495,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,479,534 - 36,495,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1538,355,897 - 38,372,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01539,506,524 - 39,522,722 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,940,213 - 37,956,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01545,360,505 - 45,378,840 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,360,503 - 45,376,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,135,923 - 49,151,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,493,066 - 41,509,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11541,508,758 - 41,524,943 (-)NCBI
Celera1536,169,809 - 36,185,961 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Dleu7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,655,563 - 40,671,759 (-)NCBIGRCr8
mRatBN7.21536,479,533 - 36,495,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,479,534 - 36,495,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1538,355,897 - 38,372,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01539,506,524 - 39,522,722 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,940,213 - 37,956,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01545,360,505 - 45,378,840 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,360,503 - 45,376,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,135,923 - 49,151,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,493,066 - 41,509,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11541,508,758 - 41,524,943 (-)NCBI
Celera1536,169,809 - 36,185,961 (-)NCBICelera
Cytogenetic Map15p12NCBI
DLEU7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,711,026 - 50,843,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1350,519,364 - 50,843,939 (-)EnsemblGRCh38hg38GRCh38
GRCh371351,285,162 - 51,418,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,184,760 - 50,315,886 (-)NCBINCBI36Build 36hg18NCBI36
Celera1332,335,784 - 32,466,889 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,075,797 - 32,206,867 (-)NCBIHuRef
CHM1_11351,254,317 - 51,385,437 (-)NCBICHM1_1
T2T-CHM13v2.01349,925,974 - 50,058,890 (-)NCBIT2T-CHM13v2.0
Dleu7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,513,678 - 62,530,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,513,680 - 62,530,496 (-)EnsemblGRCm39 Ensembl
GRCm381462,276,229 - 62,292,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,276,231 - 62,293,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv371462,895,066 - 62,911,816 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,230,339 - 61,247,073 (-)NCBIMGSCv36mm8
Celera1460,045,477 - 60,062,544 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.19NCBI
Dleu7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,204,901 - 4,220,311 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554314,205,391 - 4,220,305 (-)NCBIChiLan1.0ChiLan1.0
DLEU7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,137,546 - 52,285,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11350,781,012 - 50,929,914 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01331,834,182 - 31,982,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11350,705,421 - 50,726,780 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1350,706,111 - 50,726,445 (-)Ensemblpanpan1.1panPan2
Dleu7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,222,483 - 160,238,776 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365653,706,538 - 3,722,802 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365653,706,566 - 3,722,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLEU7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,972,554 - 16,989,488 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11116,970,802 - 16,990,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21117,077,502 - 17,094,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLEU7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1328,606,670 - 28,731,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl328,710,019 - 28,731,258 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605715,126,386 - 15,148,508 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dleu7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247483,449,405 - 3,469,197 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247483,448,977 - 3,479,958 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dleu7
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:188
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000065838
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
D15Got38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21536,494,654 - 36,494,827 (+)MAPPERmRatBN7.2
Rnor_6.01545,375,434 - 45,375,606NCBIRnor6.0
Rnor_5.01549,150,854 - 49,151,026UniSTSRnor5.0
RGSC_v3.41541,508,177 - 41,508,348RGDRGSC3.4
RGSC_v3.41541,508,178 - 41,508,350UniSTSRGSC3.4
RGSC_v3.11541,523,877 - 41,524,048RGD
Celera1536,184,921 - 36,185,091UniSTS
RH 3.4 Map15248.7UniSTS
RH 3.4 Map15248.7RGD
RH 2.0 Map15249.3RGD
Cytogenetic Map15p12UniSTS
RH144272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21536,479,650 - 36,479,857 (+)MAPPERmRatBN7.2
Rnor_6.01545,360,621 - 45,360,827NCBIRnor6.0
Rnor_5.01549,136,041 - 49,136,247UniSTSRnor5.0
RGSC_v3.41541,493,175 - 41,493,381UniSTSRGSC3.4
Celera1536,169,918 - 36,170,124UniSTS
RH 3.4 Map15252.6UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 29
Low 2 26 14 6 14 45 35 33
Below cutoff 2 21 8 6 8 6 5 5 6 5 5

Sequence


RefSeq Acc Id: ENSRNOT00000065838   ⟹   ENSRNOP00000063653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,479,542 - 36,495,697 (-)Ensembl
Rnor_6.0 Ensembl1545,360,512 - 45,376,476 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076969   ⟹   ENSRNOP00000068182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,479,534 - 36,495,545 (-)Ensembl
Rnor_6.0 Ensembl1545,360,503 - 45,376,324 (-)Ensembl
RefSeq Acc Id: NM_001400998   ⟹   NP_001387927
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,655,563 - 40,671,759 (-)NCBI
mRatBN7.21536,479,533 - 36,495,730 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387927 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58601 (Get FASTA)   NCBI Sequence Viewer  
  EDL85286 (Get FASTA)   NCBI Sequence Viewer  
  EDL85287 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063653.1
  ENSRNOP00000068182
  ENSRNOP00000068182.1
RefSeq Acc Id: ENSRNOP00000063653   ⟸   ENSRNOT00000065838
RefSeq Acc Id: ENSRNOP00000068182   ⟸   ENSRNOT00000076969
RefSeq Acc Id: NP_001387927   ⟸   NM_001400998
- UniProtKB: B0BMX5 (UniProtKB/TrEMBL),   A0A096MJM2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVY5-F1-model_v2 AlphaFold D3ZVY5 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305071 AgrOrtholog
BioCyc Gene G2FUF-13464 BioCyc
Ensembl Genes ENSRNOG00000009181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065838.2 UniProtKB/TrEMBL
  ENSRNOT00000076969 ENTREZGENE
  ENSRNOT00000076969.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130710 IMAGE-MGC_LOAD
InterPro DLEU7 UniProtKB/TrEMBL
KEGG Report rno:290308 UniProtKB/TrEMBL
MGC_CLONE MGC:187450 IMAGE-MGC_LOAD
NCBI Gene 290308 ENTREZGENE
PANTHER LEUKEMIA-ASSOCIATED PROTEIN 7 UniProtKB/TrEMBL
  PTHR36961 UniProtKB/TrEMBL
Pfam DLEU7 UniProtKB/TrEMBL
PhenoGen Dleu7 PhenoGen
RatGTEx ENSRNOG00000009181 RatGTEx
UniProt A0A096MJM2 ENTREZGENE, UniProtKB/TrEMBL
  B0BMX5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVY5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dleu7  deleted in lymphocytic leukemia, 7   Dleu7_predicted  deleted in lymphocytic leukemia, 7 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Dleu7_predicted  deleted in lymphocytic leukemia, 7 (predicted)  RGD1305071_predicted  similar to hypothetical protein MGC47306 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305071_predicted  similar to hypothetical protein MGC47306 (predicted)  LOC290308_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290308_predicted  similar to hypothetical protein MGC47306 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL