Adgrg3 (adhesion G protein-coupled receptor G3) - Rat Genome Database

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Gene: Adgrg3 (adhesion G protein-coupled receptor G3) Rattus norvegicus
Analyze
Symbol: Adgrg3
Name: adhesion G protein-coupled receptor G3
RGD ID: 1305674
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including B cell differentiation; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in plasma membrane. Orthologous to human ADGRG3 (adhesion G protein-coupled receptor G3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 97; Gpr97; LOC291854; probable G-protein coupled receptor 97
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,978,450 - 10,007,145 (-)NCBIGRCr8
mRatBN7.2199,972,425 - 10,001,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,972,430 - 10,001,123 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01910,392,001 - 10,422,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,392,004 - 10,421,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,371,082 - 10,402,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,407,270 - 10,435,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,412,095 - 10,440,214 (-)NCBI
Celera199,860,063 - 9,890,543 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22575658   PMID:24113187   PMID:24178298  


Genomics

Comparative Map Data
Adgrg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,978,450 - 10,007,145 (-)NCBIGRCr8
mRatBN7.2199,972,425 - 10,001,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,972,430 - 10,001,123 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01910,392,001 - 10,422,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,392,004 - 10,421,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,371,082 - 10,402,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,407,270 - 10,435,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,412,095 - 10,440,214 (-)NCBI
Celera199,860,063 - 9,890,543 (-)NCBICelera
Cytogenetic Map19p13NCBI
ADGRG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,665,629 - 57,689,378 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,668,277 - 57,689,378 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,702,218 - 57,723,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,259,672 - 56,280,791 (+)NCBINCBI36Build 36hg18NCBI36
Build 341656,259,671 - 56,280,789NCBI
Celera1642,203,376 - 42,231,241 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,569,798 - 43,590,888 (+)NCBIHuRef
CHM1_11659,110,213 - 59,131,348 (+)NCBICHM1_1
T2T-CHM13v2.01663,460,829 - 63,484,584 (+)NCBIT2T-CHM13v2.0
Adgrg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,743,742 - 95,771,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,744,320 - 95,771,878 (+)EnsemblGRCm39 Ensembl
GRCm38895,017,113 - 95,045,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,017,692 - 95,045,250 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,541,592 - 97,569,150 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,906,861 - 97,934,378 (+)NCBIMGSCv36mm8
Celera899,344,524 - 99,371,230 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map847.12NCBI
Adgrg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,290,394 - 15,319,361 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,290,538 - 15,317,020 (+)NCBIChiLan1.0ChiLan1.0
ADGRG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,139,535 - 67,160,521 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,060,393 - 73,081,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,945,248 - 37,966,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,077,366 - 57,098,456 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,077,429 - 57,098,456 (+)Ensemblpanpan1.1panPan2
ADGRG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,780,800 - 58,805,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,781,680 - 58,802,534 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,409,759 - 55,432,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,316,968 - 59,341,019 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,319,163 - 59,340,923 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,150,076 - 56,172,684 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,157,558 - 57,180,173 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,049,476 - 58,073,530 (-)NCBIUU_Cfam_GSD_1.0
Adgrg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934949,879,028 - 49,899,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,685,960 - 9,707,251 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,699,703 - 9,707,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,574,530 - 19,599,080 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,573,080 - 19,599,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,680,262 - 17,699,296 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,598,868 - 43,619,611 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,599,185 - 43,620,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,577,307 - 32,599,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,412,193 - 28,436,946 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,411,293 - 28,439,124 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrg3
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:96
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000020062
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 15 32 24 19 24 39 30 35 11
Below cutoff 26 20 12 12 8 10 30 5 5 8

Sequence


RefSeq Acc Id: ENSRNOT00000020062   ⟹   ENSRNOP00000020062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl199,972,430 - 10,001,123 (-)Ensembl
Rnor_6.0 Ensembl1910,392,004 - 10,421,010 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105448   ⟹   ENSRNOP00000078552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl199,972,431 - 9,983,294 (-)Ensembl
RefSeq Acc Id: XM_006255126   ⟹   XP_006255188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,978,450 - 10,007,145 (-)NCBI
mRatBN7.2199,972,425 - 10,001,118 (-)NCBI
Rnor_6.01910,392,001 - 10,422,606 (-)NCBI
Rnor_5.01910,371,082 - 10,402,917 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255127   ⟹   XP_006255189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,978,450 - 10,007,145 (-)NCBI
mRatBN7.2199,972,425 - 10,001,118 (-)NCBI
Rnor_6.01910,392,001 - 10,422,606 (-)NCBI
Rnor_5.01910,371,082 - 10,402,917 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098148   ⟹   XP_038954076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,978,450 - 10,007,054 (-)NCBI
mRatBN7.2199,972,425 - 10,001,034 (-)NCBI
RefSeq Acc Id: XM_039098149   ⟹   XP_038954077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,978,450 - 10,007,054 (-)NCBI
mRatBN7.2199,972,425 - 10,001,034 (-)NCBI
RefSeq Acc Id: XP_006255189   ⟸   XM_006255127
- Peptide Label: isoform X4
- UniProtKB: A6JY31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255188   ⟸   XM_006255126
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000020062   ⟸   ENSRNOT00000020062
RefSeq Acc Id: XP_038954077   ⟸   XM_039098149
- Peptide Label: isoform X3
- UniProtKB: A6JY31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954076   ⟸   XM_039098148
- Peptide Label: isoform X1
- UniProtKB: A6JY31 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078552   ⟸   ENSRNOT00000105448
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JSN6-F1-model_v2 AlphaFold A0A0G2JSN6 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305674 AgrOrtholog
BioCyc Gene G2FUF-6522 BioCyc
Ensembl Genes ENSRNOG00000014896 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020062.8 UniProtKB/TrEMBL
  ENSRNOT00000105448.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_orphan_rcpt_GPR56 UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
KEGG Report rno:291854 UniProtKB/TrEMBL
NCBI Gene 291854 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR G3 UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
PhenoGen Adgrg3 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
  GPR56ORPHANR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014896 RatGTEx
SMART GPS UniProtKB/TrEMBL
UniProt A0A0G2JSN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL74_RAT UniProtKB/TrEMBL
  A6JY31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrg3  adhesion G protein-coupled receptor G3  Gpr97  G protein-coupled receptor 97  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gpr97  G protein-coupled receptor 97   Gpr97_predicted  G protein-coupled receptor 97 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr97_predicted  G protein-coupled receptor 97 (predicted)      Symbol and Name status set to approved 70820 APPROVED