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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305674
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adgrg3
Name: adhesion G protein-coupled receptor G3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adgrg3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ADGRG3 mRNAPMID:32109520
Adgrg3affects expressionISOAdgrg3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ADGRG3 mRNAPMID:26377647
Adgrg3increases expressionISOAdgrg3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ADGRG3 mRNAPMID:21889950 PMID:25975270 PMID:26290441 PMID:28922406
Adgrg3multiple interactionsISOAdgrg3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ADGRG3 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADGRG3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ADGRG3 mRNAPMID:16214954 PMID:17942748 PMID:25975270
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