Prmt8 (protein arginine methyltransferase 8) - Rat Genome Database

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Gene: Prmt8 (protein arginine methyltransferase 8) Rattus norvegicus
Analyze
Symbol: Prmt8
Name: protein arginine methyltransferase 8
RGD ID: 1587677
Description: Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; protein homodimerization activity; and protein-arginine N-methyltransferase activity. Predicted to be involved in histone methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; and protein homooligomerization. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human PRMT8 (protein arginine methyltransferase 8); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688502; protein arginine N-methyltransferase 8; similar to Protein arginine N-methyltransferase 4 (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24160,535,813 - 160,618,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4160,535,813 - 160,617,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,765,769 - 166,847,117 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04162,548,690 - 162,630,028 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04161,182,745 - 161,264,101 (-)NCBIRnor_WKY
Rnor_6.04160,253,409 - 160,334,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4160,253,073 - 160,334,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,280,525 - 231,361,024 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44164,136,859 - 164,217,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4149,248,571 - 149,293,076 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16051612   PMID:16189514   PMID:17925405   PMID:18320585   PMID:19060904   PMID:23455924   PMID:25416956   PMID:26876602  


Genomics

Comparative Map Data
Prmt8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24160,535,813 - 160,618,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4160,535,813 - 160,617,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,765,769 - 166,847,117 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04162,548,690 - 162,630,028 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04161,182,745 - 161,264,101 (-)NCBIRnor_WKY
Rnor_6.04160,253,409 - 160,334,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4160,253,073 - 160,334,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,280,525 - 231,361,024 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44164,136,859 - 164,217,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4149,248,571 - 149,293,076 (-)NCBICelera
Cytogenetic Map4q42NCBI
PRMT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,381,349 - 3,593,973 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl123,381,349 - 3,593,973 (+)EnsemblGRCh38hg38GRCh38
GRCh37123,490,515 - 3,703,139 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,470,686 - 3,573,400 (+)NCBINCBI36Build 36hg18NCBI36
Celera125,214,206 - 5,316,768 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef123,346,677 - 3,558,964 (+)NCBIHuRef
CHM1_1123,489,578 - 3,702,173 (+)NCBICHM1_1
T2T-CHM13v2.0123,387,867 - 3,600,523 (+)NCBIT2T-CHM13v2.0
Prmt8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,665,972 - 127,746,430 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,665,974 - 127,746,435 (-)EnsemblGRCm39 Ensembl
GRCm386127,689,009 - 127,769,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,689,011 - 127,769,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv376127,639,029 - 127,718,747 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,654,630 - 127,734,348 (-)NCBIMGSCv36mm8
Celera6129,363,916 - 129,443,847 (-)NCBICelera
Cytogenetic Map6F3NCBI
Prmt8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554131,323,356 - 1,409,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554131,323,436 - 1,409,188 (+)NCBIChiLan1.0ChiLan1.0
PRMT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1123,446,338 - 3,634,513 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,429,458 - 3,634,507 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0123,614,041 - 3,710,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRMT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12741,245,480 - 41,338,437 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2741,246,287 - 41,430,680 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,332,728 - 5,436,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02741,603,291 - 41,707,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2741,603,291 - 41,788,308 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12741,540,528 - 41,644,916 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02741,515,992 - 41,619,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,694,493 - 4,798,960 (+)NCBIUU_Cfam_GSD_1.0
Prmt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945105,319,816 - 105,372,136 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366063,811,975 - 3,864,394 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366063,812,030 - 3,864,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRMT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,667,899 - 66,838,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,667,695 - 66,754,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,944,977 - 69,060,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRMT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,548,026 - 3,646,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,547,803 - 3,646,239 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660634,599,425 - 4,698,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prmt8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860751,360 - 831,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624860751,366 - 831,680 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prmt8
273 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:63
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000006878
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
27.MMHAP24FLA6.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24160,562,536 - 160,562,667 (+)MAPPERmRatBN7.2
Rnor_6.04160,280,124 - 160,280,254NCBIRnor6.0
Rnor_5.04231,334,179 - 231,334,309UniSTSRnor5.0
RGSC_v3.44164,162,759 - 164,162,889UniSTSRGSC3.4
Celera4149,275,296 - 149,275,426UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 72
Low 31 19 3 16 3 1 1 2 8 29 9 1
Below cutoff 3 12 13 13 2 13 7 8 13 11 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086772   ⟹   ENSRNOP00000071703
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4160,535,813 - 160,617,930 (-)Ensembl
Rnor_6.0 Ensembl4160,253,073 - 160,334,910 (-)Ensembl
RefSeq Acc Id: NM_001271385   ⟹   NP_001258314
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24160,535,813 - 160,617,176 (-)NCBI
Rnor_6.04160,253,409 - 160,334,647 (-)NCBI
Rnor_5.04231,280,525 - 231,361,024 (+)NCBI
Celera4149,248,571 - 149,293,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108363   ⟹   XP_038964291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24160,550,523 - 160,618,193 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001258314 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964291 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM01802 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258314   ⟸   NM_001271385
- UniProtKB: F1LWG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071703   ⟸   ENSRNOT00000086772
RefSeq Acc Id: XP_038964291   ⟸   XM_039108363
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWG2-F1-model_v2 AlphaFold F1LWG2 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587677 AgrOrtholog
BioCyc Gene G2FUF-42927 BioCyc
Ensembl Genes ENSRNOG00000053804 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071703 ENTREZGENE
  ENSRNOP00000071703.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086772 ENTREZGENE
  ENSRNOT00000086772.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Arg_MeTrfase UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:688502 UniProtKB/TrEMBL
NCBI Gene 688502 ENTREZGENE
PANTHER PTHR11006 UniProtKB/TrEMBL
PhenoGen Prmt8 PhenoGen
PROSITE SAM_MT_PRMT UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt F1LWG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Prmt8  protein arginine methyltransferase 8  LOC688502  similar to Protein arginine N-methyltransferase 4 (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC688502  similar to Protein arginine N-methyltransferase 4 (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)  LOC683275  similar to heterogeneous nuclear ribonucleoprotein methyltransferase-like 4  Data Merged 1643240 APPROVED
2006-11-19 LOC688502  similar to Protein arginine N-methyltransferase 4 (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683275  similar to heterogeneous nuclear ribonucleoprotein methyltransferase-like 4      Symbol and Name status set to provisional 70820 PROVISIONAL