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Gene: Nalf2 (NALCN channel auxiliary factor 2) Rattus norvegicus

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Symbol:

Nalf2

Name:

NALCN channel auxiliary factor 2

RGD ID:

1584125

Description:

Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be active in plasma membrane. Orthologous to human NALF2 (NALCN channel auxiliary factor 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fam155b; family with sequence similarity 155, member B; LOC688841; similar to transmembrane protein 28; Tmem28l; transmembrane protein 28-like; transmembrane protein FAM155B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NALF2 (NALCN channel auxiliary factor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Nalf2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nalf2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NALF2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NALF2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nalf2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NALF2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NALF2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nalf2 (NALCN channel auxiliary factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LY6G6C (lymphocyte antigen 6 family member G6C)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NALF2 (NALCN channel auxiliary factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nalf2 (NALCN channel auxiliary factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fam155b (family with sequence similarity 155 member B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mid1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	nalf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	68,965,327 - 68,991,201 (+)	NCBI		GRCr8
mRatBN7.2	X	64,925,100 - 64,951,074 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	64,925,051 - 64,951,077 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	69,579,968 - 69,605,032 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	69,580,015 - 69,605,032 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	70,452,229 - 70,477,252 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	87,823,433 - 87,845,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	65,289,397 - 65,314,753 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal hemophilia A (ISO)

factor VIII deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

CGP 52608 (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethylparaben (ISO)

furan (EXP)

hydralazine (ISO)

hydrogen peroxide (ISO)

methapyrilene (ISO)

N-Nitrosopyrrolidine (ISO)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

testosterone (EXP)

Theaflavin 3,3'-digallate (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion import across plasma membrane (IBA)

Cellular Component

membrane (IEA)

plasma membrane (IBA)

Molecular Function

stretch-activated, monoatomic cation-selective, calcium channel activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Nalf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	68,965,327 - 68,991,201 (+)	NCBI		GRCr8
mRatBN7.2	X	64,925,100 - 64,951,074 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	64,925,051 - 64,951,077 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	69,579,968 - 69,605,032 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	69,580,015 - 69,605,032 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	70,452,229 - 70,477,252 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	87,823,433 - 87,845,963 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	65,289,397 - 65,314,753 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

NALF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	69,504,326 - 69,532,508 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	69,504,326 - 69,532,508 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	68,724,169 - 68,752,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	68,641,803 - 68,669,076 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	68,508,098 - 68,535,370	NCBI
Celera	X	69,078,407 - 69,105,680 (+)	NCBI		Celera
Cytogenetic Map	X	q13.1	NCBI
HuRef	X	62,546,646 - 62,572,751 (+)	NCBI		HuRef
CHM1_1	X	68,618,438 - 68,645,717 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	67,937,741 - 67,965,930 (+)	NCBI		T2T-CHM13v2.0

Nalf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	98,863,770 - 98,892,395 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	98,864,627 - 98,892,396 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	99,820,164 - 99,848,789 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	99,821,021 - 99,848,790 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	97,016,408 - 97,041,684 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	96,023,788 - 96,049,064 (+)	NCBI		MGSCv36	mm8
MGSCv36	X	82,660,766 - 82,686,328 (+)	NCBI		MGSCv36	mm8
Celera	X	86,754,906 - 86,780,428 (+)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	43.59	NCBI

Nalf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	9,025,628 - 9,052,438 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	9,024,816 - 9,052,394 (+)	NCBI	ChiLan1.0	ChiLan1.0

NALF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	69,179,357 - 69,207,541 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	69,182,960 - 69,211,144 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	58,770,612 - 58,798,803 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NALF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	53,969,675 - 53,998,274 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	53,969,665 - 53,997,140 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	44,795,303 - 44,823,793 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	54,935,550 - 54,964,053 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	54,935,676 - 54,962,919 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	52,903,387 - 52,931,870 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	54,232,158 - 54,260,634 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	54,156,091 - 54,184,582 (+)	NCBI		UU_Cfam_GSD_1.0

Nalf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	48,090,547 - 48,134,196 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936777	1,116,759 - 1,143,766 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936777	1,100,109 - 1,143,753 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NALF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	55,631,037 - 55,658,303 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	55,631,149 - 55,658,309 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	62,829,412 - 62,856,570 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NALF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	59,343,731 - 59,370,975 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	59,343,823 - 59,368,426 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	1,198,929 - 1,227,061 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nalf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624891	649,561 - 676,976 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624891	649,825 - 677,539 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nalf2
24 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	78
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000057920
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
70221	Bp56	Blood pressure QTL 56	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	57042141	65612192	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	6	26	113	42	41	14	12	14	6	132	60	93	45	60	27

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002727573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000057920 ⟹ ENSRNOP00000054729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	64,925,051 - 64,951,077 (+)	Ensembl
Rnor_6.0 Ensembl	X	69,580,015 - 69,605,032 (+)	Ensembl

RefSeq Acc Id:

NM_001427609 ⟹ NP_001414538

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	68,965,327 - 68,991,201 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414538	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054729
	ENSRNOP00000054729.2

Ensembl Acc Id:

ENSRNOP00000054729 ⟸ ENSRNOT00000057920

RefSeq Acc Id:	NP_001414538 ⟸ NM_001427609
- UniProtKB:	D4A4E6 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A4E6-F1-model_v2	AlphaFold	D4A4E6	1-471	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701865

Promoter ID:

EPDNEW_R12385

Type:

single initiation site

Name:

Fam155b_1

Description:

family with sequence similarity 155, member B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	69,580,107 - 69,580,167	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1584125	AgrOrtholog
BioCyc Gene	G2FUF-2143	BioCyc
Ensembl Genes	ENSRNOG00000038066	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000057920	ENTREZGENE
	ENSRNOT00000057920.4	UniProtKB/TrEMBL
InterPro	NALCN_aux_factor_1/2	UniProtKB/TrEMBL
NCBI Gene	688841	ENTREZGENE
PANTHER	PTHR15819:SF8	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN FAM155	UniProtKB/TrEMBL
PhenoGen	Nalf2	PhenoGen
RatGTEx	ENSRNOG00000038066	RatGTEx
UniProt	D4A4E6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-04-29	Nalf2	NALCN channel auxiliary factor 2	Fam155b	family with sequence similarity 155, member B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-11-06	Fam155b	family with sequence similarity 155, member B	Tmem28l	transmembrane protein 28-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-14	Tmem28l	transmembrane protein 28-like	LOC688841	similar to transmembrane protein 28	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC688841	similar to transmembrane protein 28	LOC684154	similar to transmembrane protein 28	Data merged from RGD:1593901	1643240	APPROVED
2006-11-20	LOC684154	similar to transmembrane protein 28			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC688841	similar to transmembrane protein 28			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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