Pxk (PX domain containing serine/threonine kinase like) - Rat Genome Database

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Gene: Pxk (PX domain containing serine/threonine kinase like) Rattus norvegicus
Analyze
Symbol: Pxk
Name: PX domain containing serine/threonine kinase like (Ensembl:PX domain containing serine/threonine kinase)
RGD ID: 727819
Description: Predicted to enable several functions, including ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; and negative regulation of monoatomic ion transport. Predicted to be located in centriolar satellite; cytosol; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PXK (PX domain containing serine/threonine kinase like); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC114238; modulator of Na,K-ATPase; MONaKA; PX domain containing serine/threonine kinase; PX domain-containing protein kinase-like protein; PX serine/threonine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,190,085 - 19,258,711 (-)NCBIGRCr8
mRatBN7.21516,759,857 - 16,828,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,759,862 - 16,828,444 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1518,934,729 - 19,002,810 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01519,893,192 - 19,961,285 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,148,098 - 18,216,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,548,209 - 18,616,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,548,212 - 18,616,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,515,244 - 22,583,076 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,744,748 - 18,815,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,744,747 - 18,815,195 (-)NCBI
Celera1516,718,088 - 16,763,954 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriolar satellite  (IEA,ISO)
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleus  (ISO)
plasma membrane  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16135750   PMID:16142408   PMID:17606467   PMID:18204446  


Genomics

Comparative Map Data
Pxk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,190,085 - 19,258,711 (-)NCBIGRCr8
mRatBN7.21516,759,857 - 16,828,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,759,862 - 16,828,444 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1518,934,729 - 19,002,810 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01519,893,192 - 19,961,285 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,148,098 - 18,216,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,548,209 - 18,616,617 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,548,212 - 18,616,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,515,244 - 22,583,076 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,744,748 - 18,815,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,744,747 - 18,815,195 (-)NCBI
Celera1516,718,088 - 16,763,954 (-)NCBICelera
Cytogenetic Map15p14NCBI
PXK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,332,892 - 58,426,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,332,880 - 58,426,127 (+)EnsemblGRCh38hg38GRCh38
GRCh37358,318,619 - 58,411,854 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,293,657 - 58,385,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 34358,293,656 - 58,385,918NCBI
Celera358,333,171 - 58,424,771 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,415,213 - 58,507,044 (+)NCBIHuRef
CHM1_1358,268,906 - 58,361,147 (+)NCBICHM1_1
T2T-CHM13v2.0358,373,299 - 58,466,504 (+)NCBIT2T-CHM13v2.0
Pxk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,304,656 - 14,371,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,304,656 - 14,371,562 (-)EnsemblGRCm39 Ensembl
GRCm38148,098,180 - 8,165,117 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl148,098,211 - 8,165,117 (+)EnsemblGRCm38mm10GRCm38
MGSCv37148,930,727 - 8,997,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,890,122 - 6,956,645 (+)NCBIMGSCv36mm8
Celera143,744,197 - 3,788,968 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.7NCBI
Pxk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554301,714,208 - 1,765,102 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554301,714,208 - 1,780,674 (-)NCBIChiLan1.0ChiLan1.0
PXK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,301,066 - 58,397,126 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,305,857 - 58,402,000 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,265,626 - 58,358,247 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,711,754 - 59,774,616 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,711,749 - 59,773,556 (+)Ensemblpanpan1.1panPan2
PXK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,138,320 - 32,272,767 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,193,339 - 32,272,774 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,086,073 - 32,197,776 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,428,953 - 32,540,222 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,460,192 - 32,540,747 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12031,885,521 - 31,997,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,241,546 - 32,353,742 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,413,940 - 32,525,359 (-)NCBIUU_Cfam_GSD_1.0
Pxk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,448,559 - 169,496,492 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,587,990 - 2,635,189 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,587,145 - 2,635,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PXK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1340,074,466 - 40,160,380 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11340,079,238 - 40,160,387 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21344,039,928 - 44,120,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PXK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,622,364 - 19,717,245 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,622,402 - 19,711,127 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,106,915 - 147,203,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pxk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,430,764 - 5,481,539 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,413,558 - 5,481,578 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pxk
385 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:155
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000010763
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
BI297004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21516,760,671 - 16,760,833 (+)MAPPERmRatBN7.2
Rnor_6.01518,549,024 - 18,549,185NCBIRnor6.0
Rnor_5.01522,516,059 - 22,516,220UniSTSRnor5.0
RGSC_v3.41518,745,560 - 18,745,721UniSTSRGSC3.4
Celera1516,718,900 - 16,719,061UniSTS
RH 3.4 Map15137.2UniSTS
Cytogenetic Map15p14UniSTS
RH137973  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21516,769,976 - 16,770,147 (+)MAPPERmRatBN7.2
Rnor_6.01518,558,327 - 18,558,497NCBIRnor6.0
Rnor_5.01522,525,270 - 22,525,440UniSTSRnor5.0
Celera1516,727,695 - 16,727,865UniSTS
RH 3.4 Map15139.7UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001399677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY327408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010763   ⟹   ENSRNOP00000010763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,759,862 - 16,828,444 (-)Ensembl
Rnor_6.0 Ensembl1518,548,212 - 18,616,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094093   ⟹   ENSRNOP00000079956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,793,119 - 16,828,444 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098948   ⟹   ENSRNOP00000084053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,759,862 - 16,828,444 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099957   ⟹   ENSRNOP00000080198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,760,610 - 16,828,444 (-)Ensembl
RefSeq Acc Id: NM_001399677   ⟹   NP_001386606
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,258,671 (-)NCBI
mRatBN7.21516,759,857 - 16,828,442 (-)NCBI
RefSeq Acc Id: NM_182821   ⟹   NP_877973
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,258,671 (-)NCBI
mRatBN7.21516,759,857 - 16,828,442 (-)NCBI
Rnor_6.01518,548,212 - 18,616,589 (-)NCBI
Rnor_5.01522,515,244 - 22,583,076 (-)NCBI
RGSC_v3.41518,744,748 - 18,815,195 (-)RGD
Celera1516,718,088 - 16,763,954 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251776   ⟹   XP_006251838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,175 - 19,258,711 (-)NCBI
mRatBN7.21516,760,925 - 16,828,450 (-)NCBI
Rnor_6.01518,549,314 - 18,616,617 (-)NCBI
Rnor_5.01522,515,244 - 22,583,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770539   ⟹   XP_008768761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,223,595 (-)NCBI
mRatBN7.21516,759,857 - 16,793,384 (-)NCBI
Rnor_6.01518,548,209 - 18,581,736 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599722   ⟹   XP_017455211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,258,711 (-)NCBI
mRatBN7.21516,759,857 - 16,828,450 (-)NCBI
Rnor_6.01518,548,209 - 18,616,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599723   ⟹   XP_017455212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,203,406 - 19,258,711 (-)NCBI
mRatBN7.21516,773,180 - 16,828,451 (-)NCBI
Rnor_6.01518,561,532 - 18,616,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599725   ⟹   XP_017455214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,163 - 19,258,711 (-)NCBI
mRatBN7.21516,760,924 - 16,828,450 (-)NCBI
Rnor_6.01518,549,314 - 18,616,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599726   ⟹   XP_017455215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,175 - 19,258,711 (-)NCBI
mRatBN7.21516,760,925 - 16,828,450 (-)NCBI
Rnor_6.01518,549,314 - 18,616,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599727   ⟹   XP_017455216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,163 - 19,258,711 (-)NCBI
mRatBN7.21516,760,752 - 16,828,450 (-)NCBI
Rnor_6.01518,549,104 - 18,616,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093421   ⟹   XP_038949349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,089 - 19,258,711 (-)NCBI
mRatBN7.21516,760,861 - 16,828,452 (-)NCBI
RefSeq Acc Id: XM_063274362   ⟹   XP_063130432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,258,662 (-)NCBI
RefSeq Acc Id: XM_063274363   ⟹   XP_063130433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,190,085 - 19,258,662 (-)NCBI
RefSeq Acc Id: XM_063274365   ⟹   XP_063130435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,191,089 - 19,258,711 (-)NCBI
RefSeq Acc Id: XR_010057833
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,205,156 - 19,258,711 (-)NCBI
RefSeq Acc Id: NP_877973   ⟸   NM_182821
- Peptide Label: isoform 1
- UniProtKB: A0A140TAA2 (UniProtKB/TrEMBL),   A0A8I5ZY08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251838   ⟸   XM_006251776
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G486 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768761   ⟸   XM_008770539
- Peptide Label: isoform X9
- UniProtKB: A6K0B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455211   ⟸   XM_017599722
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZY08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455216   ⟸   XM_017599727
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017455215   ⟸   XM_017599726
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017455214   ⟸   XM_017599725
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017455212   ⟸   XM_017599723
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000010763   ⟸   ENSRNOT00000010763
RefSeq Acc Id: XP_038949349   ⟸   XM_039093421
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000080198   ⟸   ENSRNOT00000099957
Ensembl Acc Id: ENSRNOP00000084053   ⟸   ENSRNOT00000098948
Ensembl Acc Id: ENSRNOP00000079956   ⟸   ENSRNOT00000094093
RefSeq Acc Id: NP_001386606   ⟸   NM_001399677
- Peptide Label: isoform 2
- UniProtKB: Q4FZZ1 (UniProtKB/Swiss-Prot),   Q7TNZ7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130433   ⟸   XM_063274363
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130432   ⟸   XM_063274362
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130435   ⟸   XM_063274365
- Peptide Label: isoform X10
Protein Domains
Protein kinase   PX   WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZZ1-F1-model_v2 AlphaFold Q4FZZ1 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699590
Promoter ID:EPDNEW_R10113
Type:multiple initiation site
Name:Pxk_1
Description:PX domain containing serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,616,543 - 18,616,603EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727819 AgrOrtholog
BioCyc Gene G2FUF-14287 BioCyc
Ensembl Genes ENSRNOG00000008024 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013508 UniProtKB/Swiss-Prot
  ENSRNOG00060020546 UniProtKB/Swiss-Prot
  ENSRNOG00065008657 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010763 UniProtKB/TrEMBL
  ENSRNOT00000010763.7 UniProtKB/Swiss-Prot
  ENSRNOT00000094093.1 UniProtKB/TrEMBL
  ENSRNOT00000098948.1 UniProtKB/TrEMBL
  ENSRNOT00000099957.1 UniProtKB/TrEMBL
  ENSRNOT00055023182 UniProtKB/Swiss-Prot
  ENSRNOT00060035775 UniProtKB/Swiss-Prot
  ENSRNOT00065013750 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127537 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MONaKA_PX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SortingNexin/PXDomain-PKLike UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114238 IMAGE-MGC_LOAD
NCBI Gene 306203 ENTREZGENE
PANTHER PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX SERINE/THREONINE KINASE PXK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SORTING NEXIN UniProtKB/TrEMBL
  SORTING NEXIN-13 UniProtKB/TrEMBL
Pfam PF00787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pxk PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008024 RatGTEx
  ENSRNOG00055013508 RatGTEx
  ENSRNOG00060020546 RatGTEx
  ENSRNOG00065008657 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPL8_RAT UniProtKB/TrEMBL
  A0A8I5ZY08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G486 ENTREZGENE, UniProtKB/TrEMBL
  A6K0B8 ENTREZGENE, UniProtKB/TrEMBL
  PXK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TNZ7 ENTREZGENE
UniProt Secondary Q7TNZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-10-22 Pxk  PX domain containing serine/threonine kinase like  Pxk  PX domain containing serine/threonine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pxk  PX domain containing serine/threonine kinase    PX serine/threonine kinase  Name updated 1299863 APPROVED