Mip (major intrinsic protein of lens fiber) - Rat Genome Database

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Gene: Mip (major intrinsic protein of lens fiber) Rattus norvegicus
Analyze
Symbol: Mip
Name: major intrinsic protein of lens fiber
RGD ID: 3090
Description: Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in intracellular canaliculus. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aqp0; aquaporin-0; lens fiber major intrinsic protein; major intrinsic protein of eye lens fiber; MIP26; MP26
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,228,089 - 1,237,707 (+)NCBIGRCr8
mRatBN7.27643,502 - 653,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7647,315 - 654,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,405,806 - 3,411,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,281,813 - 5,287,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,583,723 - 5,589,495 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,635,743 - 2,642,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,635,743 - 2,642,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,614,619 - 2,621,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,509,023 - 1,516,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,509,073 - 1,514,815 (+)NCBI
Celera7525,859 - 533,134 (+)NCBICelera
RH 3.4 Map10194.71RGD
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. Berry V, etal., Nat Genet. 2000 May;25(1):15-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. Huebert RC, etal., J Biol Chem 2002 Jun 21;277(25):22710-7.
5. Nucleotide and derived amino-acid sequence of the major intrinsic protein of rat eye-lens. Kent NA and Shiels A, Nucleic Acids Res 1990 Jul 25;18(14):4256.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:3174458   PMID:7333462   PMID:7530250   PMID:7848273   PMID:9369468   PMID:9405233   PMID:9620080   PMID:9806845   PMID:9829975   PMID:10067969  
PMID:10318966   PMID:10510269   PMID:10564231   PMID:11001937   PMID:11034202   PMID:11076974   PMID:11573934   PMID:11773604   PMID:11852078   PMID:11852079   PMID:12084581   PMID:12835653  
PMID:14701836   PMID:15223838   PMID:15948717   PMID:16596446   PMID:17178220   PMID:17377981   PMID:17881123   PMID:18056999   PMID:18202181   PMID:18501347   PMID:18511455   PMID:18523655  
PMID:18762715   PMID:19281766   PMID:21251984   PMID:22020074   PMID:23226368   PMID:24120416  


Genomics

Comparative Map Data
Mip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,228,089 - 1,237,707 (+)NCBIGRCr8
mRatBN7.27643,502 - 653,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7647,315 - 654,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,405,806 - 3,411,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,281,813 - 5,287,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,583,723 - 5,589,495 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,635,743 - 2,642,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,635,743 - 2,642,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,614,619 - 2,621,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,509,023 - 1,516,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,509,073 - 1,514,815 (+)NCBI
Celera7525,859 - 533,134 (+)NCBICelera
RH 3.4 Map10194.71RGD
Cytogenetic Map7q11NCBI
MIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,449,502 - 56,456,553 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,449,502 - 56,469,166 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,843,286 - 56,848,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,130,151 - 55,134,696 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,131,148 - 55,134,709NCBI
Celera1256,496,656 - 56,501,806 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,882,327 - 53,887,476 (-)NCBIHuRef
CHM1_11256,810,895 - 56,816,045 (-)NCBICHM1_1
T2T-CHM13v2.01256,417,213 - 56,424,265 (-)NCBIT2T-CHM13v2.0
Mip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,061,679 - 128,067,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,061,707 - 128,067,681 (+)EnsemblGRCm39 Ensembl
GRCm3810128,225,810 - 128,231,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,225,838 - 128,231,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,662,894 - 127,668,867 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,628,787 - 127,634,760 (+)NCBIMGSCv36mm8
Celera10133,261,918 - 133,267,869 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
Mip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,030,619 - 4,035,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,030,619 - 4,035,656 (-)NCBIChiLan1.0ChiLan1.0
MIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,876,677 - 37,882,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,873,442 - 37,878,910 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,459,965 - 32,465,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,713,470 - 32,718,026 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,713,470 - 32,718,026 (+)Ensemblpanpan1.1panPan2
MIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110701,385 - 707,005 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10701,387 - 706,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10764,593 - 769,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010710,356 - 715,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10710,358 - 715,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110687,429 - 692,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010930,541 - 935,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,054,262 - 1,059,027 (-)NCBIUU_Cfam_GSD_1.0
Mip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,058,559 - 58,063,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646807,856 - 811,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646806,467 - 811,676 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,787,826 - 21,793,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,789,040 - 21,804,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,334,531 - 23,339,133 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,409,592 - 52,415,752 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,410,325 - 52,413,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,568,279 - 193,573,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,600,405 - 11,603,502 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,600,405 - 11,603,502 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mip
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:53
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000004223
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH94755  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10194.71UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004223   ⟹   ENSRNOP00000004223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7647,315 - 654,400 (+)Ensembl
Rnor_6.0 Ensembl72,635,743 - 2,642,848 (+)Ensembl
RefSeq Acc Id: NM_001105719   ⟹   NP_001099189
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,231,905 - 1,237,707 (+)NCBI
mRatBN7.27647,316 - 653,121 (+)NCBI
Rnor_6.072,635,743 - 2,642,995 (+)NCBI
Rnor_5.072,614,619 - 2,621,871 (+)NCBI
RGSC_v3.471,509,023 - 1,516,275 (+)RGD
Celera7525,859 - 533,134 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078465   ⟹   XP_038934393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,228,089 - 1,237,707 (+)NCBI
mRatBN7.27643,502 - 653,121 (+)NCBI
RefSeq Acc Id: XM_039078466   ⟹   XP_038934394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,229,847 - 1,237,707 (+)NCBI
mRatBN7.27645,286 - 653,121 (+)NCBI
RefSeq Acc Id: NP_001099189   ⟸   NM_001105719
- UniProtKB: P09011 (UniProtKB/Swiss-Prot),   G3V6E0 (UniProtKB/TrEMBL),   A6KSB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004223   ⟸   ENSRNOT00000004223
RefSeq Acc Id: XP_038934393   ⟸   XM_039078465
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934394   ⟸   XM_039078466
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09011-F1-model_v2 AlphaFold P09011 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3090 AgrOrtholog
BioCyc Gene G2FUF-35388 BioCyc
Ensembl Genes ENSRNOG00000003132 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055013605 UniProtKB/Swiss-Prot
  ENSRNOG00060022011 UniProtKB/Swiss-Prot
  ENSRNOG00065013368 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004223 ENTREZGENE
  ENSRNOT00000004223.8 UniProtKB/Swiss-Prot
  ENSRNOT00055023325 UniProtKB/Swiss-Prot
  ENSRNOT00060038139 UniProtKB/Swiss-Prot
  ENSRNOT00065021988 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25480 ENTREZGENE
PANTHER LENS FIBER MAJOR INTRINSIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mip PhenoGen
PRINTS AQUAPORIN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003132 RatGTEx
  ENSRNOG00055013605 RatGTEx
  ENSRNOG00060022011 RatGTEx
  ENSRNOG00065013368 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KSB0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6E0 ENTREZGENE
  K7ZN92_RAT UniProtKB/TrEMBL
  M1UY73_RAT UniProtKB/TrEMBL
  M1VD62_RAT UniProtKB/TrEMBL
  M1VMW4_RAT UniProtKB/TrEMBL
  MIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6E0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Mip  major intrinsic protein of lens fiber  Mip  major intrinsic protein of eye lens fiber  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mip  Major intrinsic protein of eye lens fiber      Symbol and Name status set to approved 70586 APPROVED