Acss1 (acyl-CoA synthetase short-chain family member 1)

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Gene: Acss1 (acyl-CoA synthetase short-chain family member 1) Rattus norvegicus

Analyze

Symbol:

Acss1

Name:

acyl-CoA synthetase short-chain family member 1

RGD ID:

1306246

Description:

Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Acas2l; acetyl-Coenzyme A synthetase 2 (AMP forming)-like; acetyl-coenzyme A synthetase 2-like, mitochondrial; LOC296259

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	139,450,383 - 139,500,325 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,450,383 - 139,500,325 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,346,852 - 143,396,694 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	151,930,593 - 151,980,423 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,678,658 - 149,728,584 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,420,346 - 146,470,293 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,420,346 - 146,470,293 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,779,621 - 152,829,324 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,259,016 - 141,308,871 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	141,164,598 - 141,235,812 (-)	NCBI
Celera	3	138,212,667 - 138,262,509 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Melanoma (ISO)

genetic disease (ISO)

Hypothermia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cocaine (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

D-glucose (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

glucose (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

MeIQx (ISO)

menadione (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium acetate trihydrate (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

sunitinib (ISO)

tebuconazole (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (ISO)

trichloroethene (EXP)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetate biosynthetic process (IDA)

acetyl-CoA biosynthetic process (IBA,ISO)

acetyl-CoA biosynthetic process from acetate (IEA)

propionate biosynthetic process (IDA)

Cellular Component

mitochondrial matrix (ISO)

mitochondrion (IBA)

Molecular Function

acetate-CoA ligase activity (IBA,IDA,ISO)

AMP binding (IEA)

ATP binding (IEA)

propionate-CoA ligase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

disulfiram pharmacodynamics pathway (ISO)

fatty acid beta degradation pathway (ISO)

gluconeogenesis pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

malonic aciduria pathway (ISO)

methylmalonic aciduria, cobalamin-related pathway (ISO)

propanoate metabolic pathway (IEA,ISO)

pyruvate metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues.	Barth C, etal., Biochim Biophys Acta. 1971 Oct 5;248(1):24-33.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	Lakhter AJ, etal., J Biol Chem. 2016 Oct 14;291(42):21869-21879. doi: 10.1074/jbc.M115.712166. Epub 2016 Aug 18.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.	Sakakibara I, etal., Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.
10.	Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.	Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.

Additional References at PubMed

PMID:11150295	PMID:16788062	PMID:16790548	PMID:18614015	PMID:26945066

Genomics

Comparative Map Data

Acss1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	139,450,383 - 139,500,325 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,450,383 - 139,500,325 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,346,852 - 143,396,694 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	151,930,593 - 151,980,423 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,678,658 - 149,728,584 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,420,346 - 146,470,293 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,420,346 - 146,470,293 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,779,621 - 152,829,324 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,259,016 - 141,308,871 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	141,164,598 - 141,235,812 (-)	NCBI
Celera	3	138,212,667 - 138,262,509 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

ACSS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	25,006,237 - 25,058,139 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	25,006,230 - 25,058,980 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	24,986,873 - 25,038,775 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	24,934,873 - 24,987,616 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	24,934,873 - 24,987,616	NCBI
Celera	20	25,060,679 - 25,113,427 (-)	NCBI		Celera
Cytogenetic Map	20	p11.21	NCBI
HuRef	20	24,943,703 - 24,995,659 (-)	NCBI		HuRef
CHM1_1	20	24,987,355 - 25,039,309 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	25,070,421 - 25,122,324 (-)	NCBI		T2T-CHM13v2.0

Acss1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	150,460,031 - 150,510,160 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	150,460,025 - 150,510,420 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	150,618,111 - 150,668,240 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	150,618,105 - 150,668,500 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	150,443,847 - 150,493,976 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	150,309,552 - 150,359,670 (-)	NCBI		MGSCv36	mm8
Celera	2	151,852,988 - 151,903,233 (-)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.74	NCBI

Acss1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,117,303 - 31,154,654 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,117,542 - 31,154,654 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACSS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	25,874,190 - 25,928,929 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	24,946,629 - 25,001,311 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	25,294,186 - 25,348,109 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	25,293,511 - 25,349,017 (-)	Ensembl	panpan1.1		panPan2

ACSS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	1,192,771 - 1,251,724 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	1,184,392 - 1,252,255 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	1,222,892 - 1,281,311 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	1,435,773 - 1,494,208 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	1,435,776 - 1,494,754 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	1,251,020 - 1,309,471 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	1,381,192 - 1,439,604 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	1,364,196 - 1,422,653 (-)	NCBI		UU_Cfam_GSD_1.0

Acss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	147,319,248 - 147,380,019 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936620	739,633 - 800,803 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936620	739,633 - 800,472 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACSS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	30,800,427 - 30,839,742 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	30,800,536 - 30,839,799 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	34,949,412 - 34,988,665 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103247057
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666087	2,048,170 - 2,100,706 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acss1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624939	394,884 - 435,098 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624939	384,003 - 431,485 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acss1
320 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	811
Count of miRNA genes:	294
Interacting mature miRNAs:	391
Transcripts:	ENSRNOT00000009627
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat

Markers in Region

D3Rat148

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	146,426,801 - 146,427,014	NCBI	Rnor6.0
Rnor_5.0	3	152,786,076 - 152,786,289	UniSTS	Rnor5.0
RGSC_v3.4	3	141,265,470 - 141,265,676	RGD	RGSC3.4
RGSC_v3.4	3	141,265,471 - 141,265,676	UniSTS	RGSC3.4
RGSC_v3.1	3	141,171,043 - 141,171,249	RGD
Celera	3	138,219,122 - 138,219,291	UniSTS
SHRSP x BN Map	3	65.2999	UniSTS
SHRSP x BN Map	3	65.2999	RGD
Cytogenetic Map	3	q41	UniSTS

BF389773

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	139,463,124 - 139,463,298 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,433,095 - 146,433,268	NCBI	Rnor6.0
Rnor_5.0	3	152,792,370 - 152,792,543	UniSTS	Rnor5.0
RGSC_v3.4	3	141,271,757 - 141,271,930	UniSTS	RGSC3.4
Celera	3	138,225,372 - 138,225,545	UniSTS
RH 3.4 Map	3	1197.32	UniSTS
Cytogenetic Map	3	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	25	30	22	19	22	7	10	54	33	23	11	7
Low		18	27	19		19	1	1	20	2	18		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009627 ⟹ ENSRNOP00000009627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	139,450,383 - 139,500,325 (-)	Ensembl
Rnor_6.0 Ensembl	3	146,420,346 - 146,470,293 (-)	Ensembl

RefSeq Acc Id:

NM_001106524 ⟹ NP_001099994

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	139,450,383 - 139,500,325 (-)	NCBI
Rnor_6.0	3	146,420,346 - 146,470,293 (-)	NCBI
Rnor_5.0	3	152,779,621 - 152,829,324 (-)	NCBI
RGSC_v3.4	3	141,259,016 - 141,308,871 (-)	RGD
Celera	3	138,212,667 - 138,262,509 (-)	RGD

Sequence:

show sequence

GGCTCCTGCACCCGCGTGGGGCGTCGGGCGAGATGGCGGCGCGCAGCCTCGGCAGCGGTGTGGG
GCGACTGCTGCGTGGCCTGCACGGGCACTCGGGACAATCGGGGTGGTTGCTGAGCCTGTCCCGC
TGGACCACCACCCGATTCCTGGGCAGTGTTCCTGCAGCAGCGCAGCTAGGCTCGTACCCCGCTT
TGAGCGCTCAGGCAGCCCAGGAGCCGGCCGCCTTCTGGGGACCGCTGGCCCGTGACACACTAGT
TTGGGACACTCCTTACCATACTGTCTGGGACTGCGACTTCAGGACGGGCAAGATCGGCTGGTTC
CTGGGAGGCCAGTTGAATGTGTCTGTCAACTGCCTGGACCAGCACGTGCAGAAGTCTCCCGACA
CCATAGCTTTGATTTGGGAGAGAGATGAACCTGGGACAGAAGTGAGGATCACTTACAGGGAGCT
TCTGGAGACCACATGCCGCCTGGCCAACACGCTGAAGAGGCATGGTGTGCACCGAGGGGACCGT
GTGGCCATCTACATGCCTGTGTCCCCACTGGCTGTGGCAGCGATGCTGGCCTGTGCCAGGATTG
GAGCTATCCACACAGTGGTTTTTGCTGGCTTTAGTGCAGAGTCCTTGGCCGGGAGGATCAATGA
TGCCAAGTGCAAGGTTGTTATCACCTTCAACCAAGGACTCCGGGGAGGGCGTGTGGTGGAGCTG
AAGAAAATAGTGGACGAAGCTGTGAAGAACTGCCCAACAGTGCAGCATGTCCTAGTGGCTCACA
GGACGGACACCAAGGTTCCCATGGGGAATCTGGACATCCCCCTTGAGCAGGAGATGGCCAATGA
GGCCCCTGTGTGTACCCCTGAAAGCATGAACAGTGAAGATATGCTCTTCATGCTCTACACGTCT
GGGAGCACTGGGACACCCAAGGGACTCGTTCATACACAGGCAGGCTATCTGCTGTATGCCGCCA
TGACGCACAAGCTCGTGTTTGACTACCATCCAGGTGATGTCTTTGGTTGTGTGGCTGACATCGG
TTGGATCACAGGACACAGCTATGTGGTGTATGGACCCCTCTGCAATGGAGCTACCACGGTCCTT
TTTGAGAGCACCCCAGTTTACCCTGATGCTGGTCGTTACTGGGAGACAGTACAGAGGCTAAAGA
TCAACCAGTTCTATGGTGCCCCGACAGCTGTCCGACTGCTGCTGAAGTTCGGGGATGCCTGGGT
GAAAAAGTATGACCGCTCCTCCCTGCGCACACTGGGGTCAGTGGGAGAGCCCATCAATCATGAG
GCCTGGGAGTGGCTCCACAAAGTGGTGGGTGATGGCAGATGTACCCTGGTGGACACTTGGTGGC
AGACAGAAACTGGAGGCATCTGCATTGCACCACGGCCCTCGGAAGATGGGGCAGAGATCCTCCC
AGGCATGGCCATGAGGCCGTTTTTTGGCATTGTCCCTGCACTCATGGATGAGAAGGGCAATGTT
GTGGAGGGTGGTGATGTCTCTGGGGCCCTGTGTATTTCCCAAGCTTGGCCAGGCATGGCAAGGA
CCATCTACGGTGACCACCAGAGGTTCGTAGATGCCTACTTCAGAACGTACCCAGGTTACTACTT
CACTGGAGATGGAGCTCACCGGACGGAGGGTGGCTATTACCAGATCACAGGGCGCATGGATGAT
GTCATCAACATCAGTGGTCATCGCCTGGGGACTGCAGAGATTGAGGATGCAATGGCTGACCATC
CCGCTGTCCCAGAAACTGCTGTCATTGGGTACCCTCATGACATCAAAGGAGAAGCTGCGTTTGC
CTTCATTGTACTGAAAGATGACGTCCGTGATGCAAACGTGGTGGTAAATGAGCTCAAGTTGGCA
GTGGCCACCAAGATCGCCAAGTATGCTGTGCCTGACCAGATCCTGGTGGTGAAGCGTCTCCCCA
AAACCAGGTCTGGGAAGGTGATGAGGAGGCTGCTGAGGAAGATCATCACCAGCAGGGGGCAGGA
TCTAGGGGACACCACTACCCTGGAGGACCCCAGTGTCATCACGGAGATCATGAGTGCCTTTCGG
GAGTACGAAGAGCAGCGGGCTGCCACCAACTGAGAGGTGCACCTCTGTGTTGCCCAGACAAAGC
CGCACAGGACCCCTGGTCACCCTCAGGGAAAGGAGCTTCAAAGCTGGCTTGTTTCATCTGAGCA
CATGACCCATGTACTGCCCTATTTGCAGCTGAAGCCCCTCTTTCTTTCTCCTGGGGCCTCGAGC
GCTGCCTCTGGAAGGGGAGGCCTTTGTCCTACTTCTGGTTTCCAGAATTAAGTCATAATTGGAA
CTAAACCAGCACGGGGTAACCAGAGGTCTTAGCTCCAGAACTGTCATGTTTTCTCCAGATGTGT
GTAGATACAAAACACAGAATATTTTATTTTTTTGTACTTTTTCTATTTGGGGAGAGTAACAGAA
CATTTGGGTATAATGTGAACATTTAGTTTTGCACGTGCGCGTGCGTATGCACACACACACACAC
ACACACACACACACACACACACACACACACACACACACTGTGGGAAAATATTCTTGCCTCCCCA
GGGATGAGGATAACAGAATGTGCTTTTTTAAAAAAATTATCATTCAGTGTGCTTGAAATTCAAA
CCATAGATGTTTGTGCCTCTGCCACATAACTGTCCCCATCCTACTAATCCAAGTCGCCATATCC
ACCTCCTGTGTCTATTTCATATTTGGTTCACTTGGTTTATTTTGTGATAGAACAGACTGGACGA
TTCTTATATTTACGTTTCGCACCTTAGGGATTGCACTCAGGGCCTCCTGAACACTAGGCAAGCA
CTCTACCTCTGAGCTGCACACCAGCACCTTTAATCCCCAAGAGACGGAGTGAATGTCCTCTCCT
TTACTTGTGAAATCATTTGGGTTCGCTTCTCTAAGCTGTGATCTGGAAGGAGCTTCTTTCCCCA
GGGAATATGACCTCATAGGAGGTCATATTGCTTCAAACGTGTGGTTGTTCGTGGCAACCGGTGA
AAACTCAGGTGTCTTACTAAGGCTCTGGTCCCATTGGGGCTCTTGAAGACTCTGCCTGCCCTTT
CTCTTGTGATTGGGGCAACAAGAGCCACTGTGGTCCAATGACAACACTTGGTGCTCTTGAGCGA
GTTCTCTCTCGATGTGCCTTAAGTCCTCTGGACACTGGTGAGTGTCACAAACCGTGAAGTCTGG
AAAACGTATTCTGTAGCTTGGTTGTGGCTAAGCATGGGAGGGCTTGAAGGGGTGGCAGCTCTGT
GAGCAGGGCCCCTGGGGGCAGAGGAAGATGGTTCTGGCTGGTCCACAGAACTCAGCTCTATGGG
TGTTTCTTAGTTACTGCACACCTACTGTCTGTCCTGACTTCTTGGGTAATGGGGTAAATATTCT
GATACTCCCGGGAGGTGGAGTGGTTGTAGTATGCACAAATATTAATAGTCCTTTGTTACAGTCA
GCGGTAAAGAGCCATGTGATGGATTTACTTGGCTGACTACAGTTACTTTAGGGAATGGCCTAGG
TTTCCAGGTTACTGATAGAACCTATCAGAATGATTTATAGAAATATTCAAATAAAGCTTTATTT
TGTTCAGTGTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099994	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL86149	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001099994 ⟸ NM_001106524

- UniProtKB:

D3ZZN3 (UniProtKB/TrEMBL), A6KHF6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPAAAQLGSYPALSAQAAQEPAA
FWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPDTIALIWERDEP
GTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGF
SAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNL
DIPLEQEMANEAPVCTPESMNSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHP
GDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAV
RLLLKFGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAP
RPSEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQRFVD
AYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGY
PHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILVVKRLPKTRSGKVMRRL
LRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN

hide sequence

RefSeq Acc Id:

ENSRNOP00000009627 ⟸ ENSRNOT00000009627

Protein Domains

Acetyl-coenzyme A synthetase N-terminal AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZN3-F1-model_v2	AlphaFold	D3ZZN3	1-682	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306246	AgrOrtholog
BioCyc Gene	G2FUF-47349	BioCyc
Ensembl Genes	ENSRNOG00000007102	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000009627	ENTREZGENE
	ENSRNOP00000009627.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009627	ENTREZGENE
	ENSRNOT00000009627.6	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/TrEMBL
InterPro	Ac_CoA_lig_AcsA	UniProtKB/TrEMBL
	ACAS_N	UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/TrEMBL
	DUF4009	UniProtKB/TrEMBL
KEGG Report	rno:296259	UniProtKB/TrEMBL
NCBI Gene	296259	ENTREZGENE
PANTHER	ACETYL-COENZYME A SYNTHETASE	UniProtKB/TrEMBL
	ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	ACAS_N	UniProtKB/TrEMBL
	AMP-binding	UniProtKB/TrEMBL
	DUF4009	UniProtKB/TrEMBL
PhenoGen	Acss1	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/TrEMBL
UniProt	A6KHF6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZZN3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Acss1	acyl-CoA synthetase short-chain family member 1	Acss1_predicted	acyl-CoA synthetase short-chain family member 1 (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	Acss1_predicted	acyl-CoA synthetase short-chain family member 1 (predicted)	LOC681886	similar to acetyl-CoA synthetase 2-like	Data Merged	1643240	APPROVED
2006-11-20	LOC681886	similar to acetyl-CoA synthetase 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Acss1_predicted	acyl-CoA synthetase short-chain family member 1 (predicted)	Acas2l_predicted	acetyl-Coenzyme A synthetase 2 (AMP forming)-like (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Acas2l_predicted	acetyl-Coenzyme A synthetase 2 (AMP forming)-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)