Necab2 (N-terminal EF-hand calcium binding protein 2) - Rat Genome Database

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Gene: Necab2 (N-terminal EF-hand calcium binding protein 2) Rattus norvegicus
Analyze
Symbol: Necab2
Name: N-terminal EF-hand calcium binding protein 2
RGD ID: 621844
Description: Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Located in cytoplasm. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2); INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EF hand calcium binding protein 2; Efcbp2; N-terminal EF-hand calcium-binding protein 2; neuronal calcium binding 2; neuronal calcium-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,501,351 - 47,527,722 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1947,501,302 - 47,527,684 (+)Ensembl
Rnor_6.01952,086,325 - 52,112,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,086,325 - 52,112,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,834,865 - 62,861,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,691,466 - 49,718,718 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,696,347 - 49,723,599 (+)NCBI
Celera1946,743,032 - 46,786,775 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA)
cytoplasm  (IBA,IDA)
dendrite  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Sugita S, etal., Neuroscience 2002;112(1):51-63.
Additional References at PubMed
PMID:17689978   PMID:19694902   PMID:25416956   PMID:27107012   PMID:32557241  


Genomics

Comparative Map Data
Necab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21947,501,351 - 47,527,722 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1947,501,302 - 47,527,684 (+)Ensembl
Rnor_6.01952,086,325 - 52,112,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,086,325 - 52,112,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01962,834,865 - 62,861,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,691,466 - 49,718,718 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11949,696,347 - 49,723,599 (+)NCBI
Celera1946,743,032 - 46,786,775 (+)NCBICelera
Cytogenetic Map19q12NCBI
NECAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381683,965,177 - 84,002,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1683,968,244 - 84,002,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371684,001,849 - 84,036,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,559,738 - 82,593,880 (+)NCBINCBI36hg18NCBI36
Build 341682,559,737 - 82,593,878NCBI
Celera1668,304,639 - 68,338,784 (+)NCBI
Cytogenetic Map16q23.3NCBI
HuRef1669,754,045 - 69,790,327 (+)NCBIHuRef
CHM1_11685,413,645 - 85,447,739 (+)NCBICHM1_1
T2T-CHM13v2.01690,034,300 - 90,068,832 (+)NCBI
Necab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,173,431 - 120,199,379 (+)NCBIGRCm39mm39
GRCm39 Ensembl8120,173,458 - 120,199,379 (+)Ensembl
GRCm388119,446,719 - 119,472,640 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,446,719 - 119,472,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv378121,970,619 - 121,996,535 (+)NCBIGRCm37mm9NCBIm37
MGSCv368122,332,696 - 122,358,612 (+)NCBImm8
Celera8123,664,580 - 123,689,964 (+)NCBICelera
Cytogenetic Map8E1NCBI
Necab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564258,222 - 277,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955564257,781 - 279,937 (-)NCBIChiLan1.0ChiLan1.0
NECAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11683,979,108 - 84,013,436 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1683,983,626 - 84,013,436 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01664,636,198 - 64,670,019 (+)NCBIMhudiblu_PPA_v0panPan3
NECAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,313,699 - 68,342,253 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,314,000 - 68,378,311 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,327,774 - 68,357,105 (-)NCBI
ROS_Cfam_1.0568,612,120 - 68,641,500 (-)NCBI
ROS_Cfam_1.0 Ensembl568,612,421 - 68,641,500 (-)Ensembl
UMICH_Zoey_3.1568,559,839 - 68,589,193 (-)NCBI
UNSW_CanFamBas_1.0568,396,250 - 68,425,583 (-)NCBI
UU_Cfam_GSD_1.0568,812,005 - 68,841,393 (-)NCBI
Necab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934928,025,477 - 28,046,190 (-)NCBI
SpeTri2.0NW_0049366413,779,024 - 3,802,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NECAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.164,598,752 - 4,641,450 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NECAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,380,328 - 69,413,985 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660476,360,688 - 6,394,401 (-)NCBIVero_WHO_p1.0
Necab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,552,719 - 3,577,433 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247463,552,719 - 3,574,124 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Rat22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,483,643 - 47,483,996 (+)MAPPERmRatBN7.2
Rnor_6.01952,068,621 - 52,068,973NCBIRnor6.0
Rnor_5.01962,817,161 - 62,817,513UniSTSRnor5.0
RGSC_v3.41949,673,571 - 49,674,008RGDRGSC3.4
RGSC_v3.41949,673,609 - 49,673,961UniSTSRGSC3.4
RGSC_v3.11949,678,490 - 49,678,842RGD
Celera1946,742,921 - 46,743,273UniSTS
RH 3.4 Map19650.9RGD
RH 3.4 Map19650.9UniSTS
RH 2.0 Map19676.2RGD
FHH x ACI Map360.54RGD
Cytogenetic Map19q12UniSTS
AU047953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,491,621 - 47,491,755 (+)MAPPERmRatBN7.2
Rnor_6.01952,076,596 - 52,076,729NCBIRnor6.0
Rnor_5.01962,825,136 - 62,825,269UniSTSRnor5.0
RGSC_v3.41949,681,584 - 49,681,717UniSTSRGSC3.4
Celera1946,750,896 - 46,751,029UniSTS
Cytogenetic Map19q12UniSTS
AI236754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,500,358 - 47,500,491 (+)MAPPERmRatBN7.2
Rnor_6.01952,085,333 - 52,085,465NCBIRnor6.0
Rnor_5.01962,833,873 - 62,834,005UniSTSRnor5.0
RGSC_v3.41949,690,321 - 49,690,453UniSTSRGSC3.4
Celera1946,759,633 - 46,759,765UniSTS
RH 3.4 Map19648.6UniSTS
Cytogenetic Map19q12UniSTS
RH130737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,527,291 - 47,527,471 (+)MAPPERmRatBN7.2
Rnor_6.01952,112,203 - 52,112,382NCBIRnor6.0
Rnor_5.01962,860,697 - 62,860,876UniSTSRnor5.0
Celera1946,786,345 - 46,786,524UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS
BF387455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,515,254 - 47,515,408 (+)MAPPERmRatBN7.2
Rnor_6.01952,100,227 - 52,100,380NCBIRnor6.0
Rnor_5.01962,848,767 - 62,848,920UniSTSRnor5.0
RGSC_v3.41949,706,267 - 49,706,420UniSTSRGSC3.4
RGSC_v3.41949,705,325 - 49,705,478UniSTSRGSC3.4
Celera1946,774,307 - 46,774,460UniSTS
RH 3.4 Map19636.1UniSTS
Cytogenetic Map19q12UniSTS
BF402232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,522,920 - 47,524,135 (+)MAPPERmRatBN7.2
Rnor_6.01952,107,832 - 52,109,046NCBIRnor6.0
Rnor_5.01962,856,326 - 62,857,540UniSTSRnor5.0
RGSC_v3.41949,714,332 - 49,715,546UniSTSRGSC3.4
Celera1946,781,974 - 46,783,188UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:179
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000020341
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 4 4 74 6 24
Low 22 25 10 18 10 1 2 27 17 9 1
Below cutoff 3 15 28 27 1 27 6 8 2 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020341   ⟹   ENSRNOP00000020341
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,501,302 - 47,527,684 (+)Ensembl
Rnor_6.0 Ensembl1952,086,325 - 52,112,629 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106560   ⟹   ENSRNOP00000076965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,501,302 - 47,527,684 (+)Ensembl
RefSeq Acc Id: NM_133415   ⟹   NP_596906
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21947,501,351 - 47,527,722 (+)NCBI
Rnor_6.01952,086,325 - 52,112,633 (+)NCBI
Rnor_5.01962,834,865 - 62,861,130 (+)NCBI
RGSC_v3.41949,691,466 - 49,718,718 (+)RGD
Celera1946,743,032 - 46,786,775 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_596906 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG28413 (Get FASTA)   NCBI Sequence Viewer  
  EDL92668 (Get FASTA)   NCBI Sequence Viewer  
  F1LQY6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_596906   ⟸   NM_133415
- Sequence:
RefSeq Acc Id: ENSRNOP00000020341   ⟸   ENSRNOT00000020341
RefSeq Acc Id: ENSRNOP00000076965   ⟸   ENSRNOT00000106560
Protein Domains
ABM   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQY6-F1-model_v2 AlphaFold F1LQY6 1-389 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701180
Promoter ID:EPDNEW_R11702
Type:single initiation site
Name:Necab2_1
Description:N-terminal EF-hand calcium binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,086,320 - 52,086,380EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621844 AgrOrtholog
BioCyc Gene G2FUF-5517 BioCyc
Ensembl Genes ENSRNOG00000015084 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020341 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000076965.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020341 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000106560.1 UniProtKB/TrEMBL
InterPro ABM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dimeric_a/b-barrel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NECAB1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170928 UniProtKB/Swiss-Prot
NCBI Gene 170928 ENTREZGENE
PANTHER PTHR12178 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Necab2 PhenoGen
PROSITE ABM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5H1ZRU5_RAT UniProtKB/TrEMBL
  A0A8I5YBK3_RAT UniProtKB/TrEMBL
  F1LQY6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9ESB4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Necab2  N-terminal EF-hand calcium binding protein 2  Efcbp2  EF hand calcium binding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Efcbp2  EF hand calcium binding protein 2    neuronal calcium binding 2  Name updated 1299863 APPROVED
2004-09-10 Efcbp2  neuronal calcium binding 2  Necab2    Symbol and Name updated 1299863 APPROVED
2002-08-07 Necab2  neuronal calcium binding 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a single N-terminal EF-hand domain 633497
gene_expression expressed in brain 633497
gene_product member of a family of neuronal Ca2+ binding proteins 633497