Doc2a (double C2 domain alpha) - Rat Genome Database

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Gene: Doc2a (double C2 domain alpha) Rattus norvegicus
Analyze
Symbol: Doc2a
Name: double C2 domain alpha
RGD ID: 620518
Description: Predicted to enable calcium-dependent phospholipid binding activity and metal ion binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion. Located in lysosome. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2A (double C2 domain alpha); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: doc2-alpha; double C2, alpha; double C2-like domain-containing protein alpha; double C2-like domains, alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,887,306 - 190,893,057 (+)NCBIGRCr8
mRatBN7.21181,457,415 - 181,462,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,809,758 - 189,813,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,995,831 - 196,999,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,663,042 - 189,666,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,282,828 - 198,288,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,263,516 - 205,268,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,027,821 - 186,031,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,177,701 - 186,181,341 (+)NCBI
Celera1179,113,629 - 179,117,269 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doc2aRatautism spectrum disorder  ISORGD:7314238554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:18184952|PMID:25255310
Doc2aRatautistic disorder  ISORGD:7314238554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Doc2aRatchromosome 16p11.2 deletion syndrome, 220-kb  ISORGD:7314238554872ClinVar Annotator: match by term: Distal 16p11.2 microdeletion syndromeClinVar 
Doc2aRatchromosome 16p11.2 deletion syndrome, 593-kb  ISORGD:7314238554872ClinVar Annotator: match by term: Proximal 16p11.2 microdeletion syndromeClinVarPMID:25741868|PMID:31690835
Doc2aRatchromosome 16p11.2 duplication syndrome  ISORGD:7314238554872ClinVar Annotator: match by term: Chromosome 16p11.2 duplication syndromeClinVarPMID:31690835
Doc2aRatcoronin-1A deficiency  ISORGD:7314238554872ClinVar Annotator: match by term: Immunodeficiency 8ClinVarPMID:14615364|PMID:18836449|PMID:22515636|PMID:22623405|PMID:22726847|PMID:22744660|PMID:23363396|PMID:24372385|PMID:24811917|PMID:25073507|PMID:2825199|PMID:28492532
Doc2aRatdilated cardiomyopathy  ISORGD:7314238554872ClinVar Annotator: match by term: Dilated Cardiomyopathy, DominantClinVarPMID:28492532
Doc2aRatEpisodic Kinesigenic Dyskinesia  ISORGD:7314238554872ClinVar Annotator: match by term: Episodic kinesigenic dyskinesiaClinVarPMID:14615364|PMID:18836449|PMID:22515636|PMID:22623405|PMID:22726847|PMID:22744660|PMID:23363396|PMID:24372385|PMID:24811917|PMID:25073507|PMID:2825199|PMID:28492532
Doc2aRatepisodic kinesigenic dyskinesia 1  ISORGD:7314238554872ClinVar Annotator: match by term: Paroxysmal kinesigenic dyskinesiaClinVarPMID:14615364|PMID:18836449|PMID:22515636|PMID:22623405|PMID:22726847|PMID:22744660|PMID:23363396|PMID:24372385|PMID:24811917|PMID:25073507|PMID:2825199|PMID:28492532
Doc2aRatGlycogen Storage Disease XII  ISORGD:7314238554872ClinVar Annotator: match by term: Red cell aldolase deficiencyClinVarPMID:14615364|PMID:18836449|PMID:22515636|PMID:22623405|PMID:22726847|PMID:22744660|PMID:23363396|PMID:24372385|PMID:24811917|PMID:25073507|PMID:2825199|PMID:28492532
Doc2aRatNeurodevelopmental Disorders  ISORGD:7314238554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Doc2aRatschizophrenia  ISORGD:7314238554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
Doc2aRatspondylocostal dysostosis 5  ISORGD:7314238554872ClinVar Annotator: match by term: SCOLIOSIS, CONGENITAL, WITH OR WITHOUT RIB ANOMALIES | ClinVar Annotator: more ...ClinVarPMID:23335591|PMID:23806086|PMID:24088041|PMID:25564734|PMID:25741868
Doc2aRatspondylocostal dysostosis 5  ISORGD:7314238554872ClinVar Annotator: match by term: Spondylocostal dysostosis 5ClinVarPMID:23335591|PMID:23806086|PMID:24088041|PMID:25564734
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doc2aRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DOC2A mRNA]CTDPMID:31150632
Doc2aRat1,2-dimethylhydrazine decreases expressionISORGD:73142464804641,2-Dimethylhydrazine results in decreased expression of DOC2A mRNACTDPMID:22206623
Doc2aRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of DOC2A mRNACTDPMID:30723492
Doc2aRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7314246480464Tetrachlorodibenzodioxin affects the expression of DOC2A mRNACTDPMID:21570461
Doc2aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7314246480464Tetrachlorodibenzodioxin results in increased expression of DOC2A mRNACTDPMID:33956508
Doc2aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of DOC2A mRNACTDPMID:32109520
Doc2aRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of DOC2A mRNACTDPMID:32109520
Doc2aRat2-palmitoylglycerol increases expressionISORGD:73142364804642-palmitoylglycerol results in increased expression of DOC2A mRNACTDPMID:37199045
Doc2aRat3,4-methylenedioxymethamphetamine increases expressionISORGD:7314246480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DOC2A mRNACTDPMID:20188158
Doc2aRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of DOC2A mRNACTDPMID:24780913|PMID:30047161
Doc2aRatacetamide increases expressionEXP 6480464acetamide results in increased expression of DOC2A mRNACTDPMID:31881176
Doc2aRatacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of DOC2A mRNACTDPMID:28959563
Doc2aRataflatoxin B1 decreases methylationISORGD:7314236480464Aflatoxin B1 results in decreased methylation of DOC2A exonCTDPMID:30157460
Doc2aRatAflatoxin B2 alpha decreases methylationISORGD:7314236480464aflatoxin B2 results in decreased methylation of DOC2A exon; aflatoxin B2 results in decreased methylation more ...CTDPMID:30157460
Doc2aRatamitrole increases expressionEXP 6480464Amitrole results in increased expression of DOC2A mRNACTDPMID:30047161
Doc2aRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of DOC2A mRNACTDPMID:16483693
Doc2aRatatrazine increases expressionISORGD:7314236480464Atrazine results in increased expression of DOC2A mRNACTDPMID:22378314
Doc2aRatbenzo[a]pyrene affects methylationISORGD:7314236480464Benzo(a)pyrene affects the methylation of DOC2A exon; Benzo(a)pyrene affects the methylation of DOC2A intronCTDPMID:30157460
Doc2aRatbenzo[a]pyrene decreases methylationISORGD:7314236480464Benzo(a)pyrene results in decreased methylation of DOC2A promoterCTDPMID:27901495
Doc2aRatbenzo[e]pyrene decreases methylationISORGD:7314236480464benzo(e)pyrene results in decreased methylation of DOC2A exonCTDPMID:30157460

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doc2aRatcalcium-dependent activation of synaptic vesicle fusion involved_inIBAMGI:109446|MGI:1100497|PANTHER:PTN000001999|RGD:620518|RGD:6205191600115GO_REF:0000033GO_CentralGO_REF:0000033
Doc2aRatcalcium-dependent activation of synaptic vesicle fusion involved_inIEAUniProtKB:Q7TNF0|ensembl:ENSMUSP000000701191600115GO_REF:0000107EnsemblGO_REF:0000107
Doc2aRatcalcium-dependent activation of synaptic vesicle fusion involved_inISORGD:7314241624291 PMID:20150444RGDPMID:20150444
Doc2aRatcalcium-dependent activation of synaptic vesicle fusion involved_inIDA 155230732PMID:22036572SynGO 
Doc2aRatcalcium-dependent activation of synaptic vesicle fusion involved_inIMP 155230732PMID:22036572SynGO 
Doc2aRatexocytosis involved_inIEAUniProtKB-KW:KW-02681600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatneurotransmitter secretion involved_inIEAARBA:ARBA000281861600115GO_REF:0000117UniProtGO_REF:0000117
Doc2aRatpositive regulation of calcium ion-dependent exocytosis involved_inIBAPANTHER:PTN002467273|RGD:6205191600115GO_REF:0000033GO_CentralGO_REF:0000033
Doc2aRatregulation of calcium ion-dependent exocytosis involved_inISORGD:7314231624291 PMID:18354201RGDPMID:18354201
Doc2aRatregulation of calcium ion-dependent exocytosis involved_inIEAUniProtKB:Q7TNF0|ensembl:ENSMUSP000000701191600115GO_REF:0000107EnsemblGO_REF:0000107
Doc2aRatregulation of calcium ion-dependent exocytosis involved_inIEAUniProtKB:Q14183|ensembl:ENSP000003400171600115GO_REF:0000107EnsemblGO_REF:0000107
Doc2aRatregulation of calcium ion-dependent exocytosis involved_inISORGD:7314241624291 PMID:18354201RGDPMID:18354201
Doc2aRatspontaneous neurotransmitter secretion acts_upstream_of_or_withinIEAUniProtKB:Q7TNF0|ensembl:ENSMUSP000000701191600115GO_REF:0000107EnsemblGO_REF:0000107
Doc2aRatspontaneous neurotransmitter secretion acts_upstream_of_or_withinISORGD:7314241624291MGI:102788|MGI:1100497|MGI:1926250 PMID:21521611RGDPMID:21521611
Doc2aRatsynaptic vesicle exocytosis  IEP 1357914 RGD 
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Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doc2aRatcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatextrinsic component of synaptic vesicle membrane is_active_inIDA 1357915PMID:9115738SynGO 
Doc2aRatextrinsic component of synaptic vesicle membrane is_active_inIBAPANTHER:PTN002906461|RGD:6205181600115GO_REF:0000033GO_CentralGO_REF:0000033
Doc2aRatextrinsic component of synaptic vesicle membrane is_active_inIEP 1357915PMID:9115738SynGO 
Doc2aRatglutamatergic synapse is_active_inIDA 155230732PMID:22036572SynGO 
Doc2aRatglutamatergic synapse is_active_inIMP 155230732PMID:22036572SynGO 
Doc2aRatlysosome located_inIEAUniProtKB-KW:KW-04581600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatlysosome located_inIEAUniProtKB-SubCell:SL-01581600115GO_REF:0000044UniProtGO_REF:0000044
Doc2aRatlysosome located_inIDA 8554104PMID:18354201UniProt 
Doc2aRatmembrane located_inIEAInterPro:IPR0015651600115GO_REF:0000002InterProGO_REF:0000002
Doc2aRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatneuron projection located_inIEAUniProtKB-KW:KW-07711600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatsynapse located_inIEAUniProtKB-KW:KW-07701600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatsynapse located_inIEAUniProtKB-SubCell:SL-02581600115GO_REF:0000044UniProtGO_REF:0000044
Doc2aRatsynapse is_active_inIBAPANTHER:PTN000001999|RGD:620073|RGD:620518|RGD:620519|WB:WBGene000043161600115GO_REF:0000033GO_CentralGO_REF:0000033
Doc2aRatsynaptic vesicle membrane located_inIEAUniProtKB-SubCell:SL-02601600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doc2aRatcalcium-dependent phospholipid binding enablesIEAUniProtKB-KW:KW-01111600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Doc2aRatprotein binding enablesISORGD:7314231624291UniProtKB:B2RUP2|UniProtKB:Q8TF42 PMID:18354201, PMID:24722188, PMID:28514442, PMID:32296183, PMID:33961781RGDPMID:18354201|PMID:24722188|PMID:28514442|PMID:32296183|PMID:33961781


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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. Higashio H, etal., J Immunol. 2008 Apr 1;180(7):4774-84.
4. Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development. Korteweg N, etal., Eur J Neurosci 2000 Jan;12(1):165-71.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Naito A, etal., Brain Res Mol Brain Res 1997 Mar;44(2):198-204.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Verhage M, etal., Neuron 1997 Mar;18(3):453-61.
12. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Yao J, etal., Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.
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PMID:9804756   PMID:21521611  



Doc2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,887,306 - 190,893,057 (+)NCBIGRCr8
mRatBN7.21181,457,415 - 181,462,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,809,758 - 189,813,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,995,831 - 196,999,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,663,042 - 189,666,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,282,828 - 198,288,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,263,516 - 205,268,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,027,821 - 186,031,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,177,701 - 186,181,341 (+)NCBI
Celera1179,113,629 - 179,117,269 (+)NCBICelera
Cytogenetic Map1q36NCBI
DOC2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,005,514 - 30,023,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,005,514 - 30,023,270 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,016,835 - 30,024,917 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,924,336 - 29,929,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 341629,924,335 - 29,929,902NCBI
Celera1672,773,320 - 72,778,886 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,677,850 - 27,683,416 (-)NCBIHuRef
CHM1_11631,232,624 - 31,238,190 (-)NCBICHM1_1
T2T-CHM13v2.01630,288,154 - 30,305,880 (-)NCBIT2T-CHM13v2.0
Doc2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,446,525 - 126,451,877 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,446,588 - 126,451,877 (+)EnsemblGRCm39 Ensembl
GRCm387126,846,983 - 126,852,705 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,847,416 - 126,852,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,991,067 - 133,996,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,638,701 - 126,643,853 (+)NCBIMGSCv36mm8
Celera7126,695,691 - 126,700,843 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Doc2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,947,512 - 6,953,835 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,948,089 - 6,953,835 (+)NCBIChiLan1.0ChiLan1.0
DOC2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,755,311 - 30,762,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,463,559 - 35,470,605 (+)NCBINHGRI_mPanPan1
PanPan1.11630,378,922 - 30,385,982 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,378,922 - 30,384,142 (-)Ensemblpanpan1.1panPan2
DOC2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,041,551 - 18,046,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,041,296 - 18,046,265 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,618,518 - 19,623,772 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,175,690 - 18,180,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,175,456 - 18,181,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,974,905 - 17,980,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,890,274 - 17,895,521 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,205,875 - 18,211,122 (-)NCBIUU_Cfam_GSD_1.0
Doc2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,359,243 - 124,365,997 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,458,482 - 12,463,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,458,537 - 12,463,857 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOC2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,210,965 - 18,216,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,211,264 - 18,216,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DOC2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,649,818 - 26,656,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,651,949 - 26,656,075 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,876,676 - 2,883,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Doc2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,217,736 - 13,221,457 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,217,553 - 13,221,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Doc2a
15 total Variants

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:47
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000027022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 85 rows
PMC21657P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,461,236 - 181,461,603 (+)MAPPERmRatBN7.2
Rnor_6.01198,287,320 - 198,287,686NCBIRnor6.0
Rnor_5.01205,267,500 - 205,267,866UniSTSRnor5.0
RGSC_v3.41186,030,668 - 186,031,034UniSTSRGSC3.4
Celera1179,116,476 - 179,116,842UniSTS
Cytogenetic Map1q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 37 113 79 78 47 25 47 6 192 84 93 45 60 31



Ensembl Acc Id: ENSRNOT00000027022   ⟹   ENSRNOP00000027022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)Ensembl
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)Ensembl
RefSeq Acc Id: NM_022937   ⟹   NP_075226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,919 - 190,892,559 (+)NCBI
mRatBN7.21181,458,390 - 181,462,030 (+)NCBI
Rnor_6.01198,284,473 - 198,288,113 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
RGSC_v3.41186,027,821 - 186,031,461 (+)RGD
Celera1179,113,629 - 179,117,269 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230335   ⟹   XP_006230397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,042 - 190,893,057 (+)NCBI
mRatBN7.21181,457,416 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230336   ⟹   XP_006230398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,175 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
Rnor_6.01198,283,720 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230337   ⟹   XP_006230399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,081 - 190,893,057 (+)NCBI
mRatBN7.21181,457,416 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230339   ⟹   XP_006230401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,058 - 190,893,057 (+)NCBI
mRatBN7.21181,457,415 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230340   ⟹   XP_006230402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,174 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
Rnor_6.01198,283,720 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089802   ⟹   XP_038945730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,175 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
RefSeq Acc Id: XM_063272851   ⟹   XP_063128921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,887,306 - 190,893,057 (+)NCBI
RefSeq Acc Id: NP_075226   ⟸   NM_022937
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230397   ⟸   XM_006230335
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230399   ⟸   XM_006230337
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230401   ⟸   XM_006230339
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230398   ⟸   XM_006230336
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
C2

Name Modeler Protein Id AA Range Protein Structure
AF-P70611-F1-model_v2 AlphaFold P70611 1-403 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57412 BioCyc
Ensembl Genes ENSRNOG00000019920 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027022 ENTREZGENE
  ENSRNOT00000027022.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Doc2 UniProtKB/Swiss-Prot
  Rabphilin/DOC2/Noc2 UniProtKB/Swiss-Prot
  Rabphilin_Doc2_C2A UniProtKB/Swiss-Prot
  Synaptotagmin UniProtKB/Swiss-Prot
KEGG Report rno:65031 UniProtKB/Swiss-Prot
NCBI Gene 65031 ENTREZGENE
PANTHER PTHR45729 UniProtKB/Swiss-Prot
  PTHR45729:SF1 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
PhenoGen Doc2a PhenoGen
PIRSF Doc2 UniProtKB/Swiss-Prot
PRINTS C2DOMAIN UniProtKB/Swiss-Prot
  SYNAPTOTAGMN UniProtKB/Swiss-Prot
PROSITE PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019920 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
UniProt A6I9G0 ENTREZGENE, UniProtKB/TrEMBL
  DOC2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Doc2a  double C2 domain alpha  Doc2a  double C2-like domains, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Doc2a  double C2-like domains, alpha  Doc2a  double C2, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Doc2a  double C2, alpha    Doc2A  Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Doc2a  Doc2A      Symbol and Name status set to provisional 70820 PROVISIONAL