Fbxw12 (F-box and WD repeat domain containing 12) - Rat Genome Database

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Gene: Fbxw12 (F-box and WD repeat domain containing 12) Rattus norvegicus
Analyze
Symbol: Fbxw12
Name: F-box and WD repeat domain containing 12
RGD ID: 1307859
Description: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12); INTERACTS WITH vinclozolin; aldehydo-D-glucose (ortholog); arsane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box and WD-40 domain protein 12; F-box/WD repeat-containing protein 12; LOC301015; RGD1307859; similar to RIKEN cDNA E330009P21 gene
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,660,777 - 118,680,565 (-)NCBIGRCr8
mRatBN7.28109,782,315 - 109,802,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,871,409 - 117,890,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,223,248 - 117,243,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,152,906 - 114,173,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,174,950 - 114,193,260 (-)NCBI
Celera8109,072,457 - 109,091,905 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19028597  


Genomics

Comparative Map Data
Fbxw12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,660,777 - 118,680,565 (-)NCBIGRCr8
mRatBN7.28109,782,315 - 109,802,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,871,409 - 117,890,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,223,248 - 117,243,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,152,906 - 114,173,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,174,950 - 114,193,260 (-)NCBI
Celera8109,072,457 - 109,091,905 (-)NCBICelera
Cytogenetic Map8q32NCBI
FBXW12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,372,219 - 48,394,725 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,372,219 - 48,401,259 (+)EnsemblGRCh38hg38GRCh38
GRCh37348,413,709 - 48,436,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,388,713 - 48,411,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 34348,388,712 - 48,411,194NCBI
Celera348,364,476 - 48,386,962 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,468,007 - 48,490,493 (+)NCBIHuRef
CHM1_1348,365,990 - 48,388,474 (+)NCBICHM1_1
T2T-CHM13v2.0348,400,304 - 48,422,793 (+)NCBIT2T-CHM13v2.0
Fbxw13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,008,295 - 109,025,043 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,008,295 - 109,025,043 (-)EnsemblGRCm39 Ensembl
GRCm389109,179,227 - 109,195,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,179,227 - 109,195,975 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,081,741 - 109,098,489 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,036,633 - 109,053,381 (-)NCBIMGSCv36mm8
Celera9108,737,972 - 108,754,720 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
FBXW12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,342,011 - 48,371,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,346,966 - 48,383,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,290,904 - 48,318,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,375,181 - 49,399,598 (+)NCBIpanpan1.1PanPan1.1panPan2
FBXW12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,696,434 - 40,711,177 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,696,502 - 40,710,720 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,610,074 - 40,686,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,177,976 - 41,255,021 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,181,959 - 41,196,209 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,418,762 - 40,495,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,819,973 - 40,896,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,100,712 - 41,177,532 (-)NCBIUU_Cfam_GSD_1.0
Fbxw12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,396,384 - 63,415,071 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936529156,881 - 175,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,771,420 - 9,795,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,772,202 - 9,794,123 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,298,216 - 157,320,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fbxw12
271 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000028113
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system
High
Medium 3
Low 12 12 12 2 14 6
Below cutoff 1 2 12 11 1 11 3 5 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028113   ⟹   ENSRNOP00000028113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)Ensembl
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078885   ⟹   ENSRNOP00000072825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8117,871,445 - 117,887,894 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079879   ⟹   ENSRNOP00000071073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8117,871,445 - 117,890,930 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086509   ⟹   ENSRNOP00000073995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,786,821 - 109,801,813 (-)Ensembl
Rnor_6.0 Ensembl8117,871,445 - 117,890,930 (-)Ensembl
RefSeq Acc Id: XM_039082627   ⟹   XP_038938555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,660,777 - 118,680,565 (-)NCBI
mRatBN7.28109,782,315 - 109,802,086 (-)NCBI
RefSeq Acc Id: XM_063266472   ⟹   XP_063122542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,665,305 - 118,670,696 (-)NCBI
RefSeq Acc Id: XM_063266473   ⟹   XP_063122543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,664,348 - 118,680,565 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038938555 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122542 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122543 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028113.7
  ENSRNOP00000073995
  ENSRNOP00000073995.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000028113   ⟸   ENSRNOT00000028113
RefSeq Acc Id: ENSRNOP00000071073   ⟸   ENSRNOT00000079879
RefSeq Acc Id: ENSRNOP00000073995   ⟸   ENSRNOT00000086509
RefSeq Acc Id: ENSRNOP00000072825   ⟸   ENSRNOT00000078885
RefSeq Acc Id: XP_038938555   ⟸   XM_039082627
- Peptide Label: isoform X2
- UniProtKB: A6I3B7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122543   ⟸   XM_063266473
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122542   ⟸   XM_063266472
- Peptide Label: isoform X1
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A956-F1-model_v2 AlphaFold D4A956 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307859 AgrOrtholog
BioCyc Gene G2FUF-29089 BioCyc
Ensembl Genes ENSRNOG00000020720 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028113.7 UniProtKB/TrEMBL
  ENSRNOT00000086509.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 301015 ENTREZGENE
PANTHER EXPRESSED SEQUENCE C85627-RELATED UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxw12 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020720 RatGTEx
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K6Z0_RAT UniProtKB/TrEMBL
  A6I3B7 ENTREZGENE, UniProtKB/TrEMBL
  D4A956_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fbxw12  F-box and WD repeat domain containing 12  Fbxw12  F-box and WD-40 domain protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fbxw12  F-box and WD-40 domain protein 12  RGD1307859_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307859_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)  LOC301015_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301015_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL