Car8 (carbonic anhydrase 8) - Rat Genome Database

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Gene: Car8 (carbonic anhydrase 8) Rattus norvegicus
Analyze
Symbol: Car8
Name: carbonic anhydrase 8
RGD ID: 1304709
Description: Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within phosphatidylinositol-mediated signaling. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human CA8 (carbonic anhydrase 8); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-VIII; Ca8; carbonic anhydrase VIII; carbonic anhydrase-related protein; CARP; LOC297814; MGC105764
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2521,302,940 - 21,402,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl521,305,383 - 21,402,374 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx523,538,258 - 23,635,134 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0525,125,409 - 25,222,414 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0524,905,671 - 25,002,676 (-)NCBIRnor_WKY
Rnor_6.0521,249,018 - 21,345,810 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl521,249,020 - 21,345,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0526,010,374 - 26,106,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4521,951,255 - 22,049,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1521,951,256 - 22,049,427 (-)NCBI
Celera520,578,323 - 20,675,389 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
hydralazine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12611586   PMID:15489334  


Genomics

Comparative Map Data
Car8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2521,302,940 - 21,402,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl521,305,383 - 21,402,374 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx523,538,258 - 23,635,134 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0525,125,409 - 25,222,414 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0524,905,671 - 25,002,676 (-)NCBIRnor_WKY
Rnor_6.0521,249,018 - 21,345,810 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl521,249,020 - 21,345,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0526,010,374 - 26,106,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4521,951,255 - 22,049,427 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1521,951,256 - 22,049,427 (-)NCBI
Celera520,578,323 - 20,675,389 (-)NCBICelera
Cytogenetic Map5q13NCBI
CA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38860,185,412 - 60,281,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl860,185,412 - 60,281,400 (-)EnsemblGRCh38hg38GRCh38
GRCh37861,097,971 - 61,193,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36861,263,977 - 61,356,508 (-)NCBINCBI36Build 36hg18NCBI36
Build 34861,263,976 - 61,356,508NCBI
Celera857,092,480 - 57,182,989 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef856,589,359 - 56,681,767 (-)NCBIHuRef
CHM1_1861,153,453 - 61,246,009 (-)NCBICHM1_1
T2T-CHM13v2.0860,609,460 - 60,705,474 (-)NCBIT2T-CHM13v2.0
Car8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3948,141,493 - 8,239,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl48,143,362 - 8,239,041 (-)EnsemblGRCm39 Ensembl
GRCm3848,141,493 - 8,239,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl48,143,362 - 8,239,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv3748,068,640 - 8,166,188 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3647,613,848 - 7,709,581 (-)NCBIMGSCv36mm8
MGSCv3648,068,640 - 8,166,188 (-)NCBIMGSCv36mm8
Celera48,024,484 - 8,115,866 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map43.53NCBI
Ca8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544418,413,958 - 18,512,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544418,414,006 - 18,510,800 (+)NCBIChiLan1.0ChiLan1.0
CA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1858,273,696 - 58,367,615 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl858,273,696 - 58,367,615 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0856,606,454 - 56,702,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12910,678,122 - 10,763,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2910,679,038 - 10,764,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2910,989,287 - 11,075,445 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02910,763,585 - 10,849,785 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2910,785,281 - 10,850,629 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12910,765,703 - 10,851,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02910,899,217 - 10,985,514 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02911,167,585 - 11,253,944 (-)NCBIUU_Cfam_GSD_1.0
Ca8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530361,800,602 - 61,889,623 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649612,895,858 - 12,984,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl473,047,847 - 73,141,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1473,047,867 - 73,172,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2479,510,120 - 79,573,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1856,111,149 - 56,203,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl856,131,599 - 56,203,336 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603985,472,882 - 85,568,158 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474431,658,539 - 31,748,022 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474431,659,318 - 31,777,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D5Got135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2521,389,876 - 21,390,062 (+)MAPPERmRatBN7.2
Rnor_6.0521,333,315 - 21,333,500NCBIRnor6.0
Rnor_5.0526,094,361 - 26,094,546UniSTSRnor5.0
RGSC_v3.4522,036,930 - 22,037,117RGDRGSC3.4
RGSC_v3.4522,036,932 - 22,037,117UniSTSRGSC3.4
RGSC_v3.1522,036,930 - 22,037,117RGD
Celera520,662,894 - 20,663,079UniSTS
RH 3.4 Map5110.2UniSTS
RH 3.4 Map5110.2RGD
RH 2.0 Map5115.0RGD
Cytogenetic Map5q13UniSTS
AA923902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2521,305,533 - 21,305,713 (+)MAPPERmRatBN7.2
Rnor_6.0521,249,173 - 21,249,352NCBIRnor6.0
Rnor_5.0526,010,529 - 26,010,708UniSTSRnor5.0
RGSC_v3.4521,951,410 - 21,951,589UniSTSRGSC3.4
Celera520,578,478 - 20,578,657UniSTS
RH 3.4 Map5107.3UniSTS
Cytogenetic Map5q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:353
Count of miRNA genes:208
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000007802
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 45 41 41 44 35 25 11
Low 19 12 19 8 11 30 16 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007802   ⟹   ENSRNOP00000007802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl521,305,383 - 21,402,374 (-)Ensembl
Rnor_6.0 Ensembl521,249,020 - 21,345,810 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081296   ⟹   ENSRNOP00000074141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl521,305,383 - 21,360,666 (-)Ensembl
Rnor_6.0 Ensembl521,282,625 - 21,345,805 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106574   ⟹   ENSRNOP00000077757
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl521,305,383 - 21,358,270 (-)Ensembl
RefSeq Acc Id: NM_001009662   ⟹   NP_001009662
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2521,305,379 - 21,402,374 (-)NCBI
Rnor_6.0521,249,018 - 21,345,810 (-)NCBI
Rnor_5.0526,010,374 - 26,106,856 (-)NCBI
RGSC_v3.4521,951,255 - 22,049,427 (-)RGD
Celera520,578,323 - 20,675,389 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109403   ⟹   XP_038965331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2521,353,318 - 21,402,395 (-)NCBI
RefSeq Acc Id: XM_039109404   ⟹   XP_038965332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2521,302,940 - 21,358,026 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001009662 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965331 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965332 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87586 (Get FASTA)   NCBI Sequence Viewer  
  EDM11644 (Get FASTA)   NCBI Sequence Viewer  
  Q5PPN4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009662   ⟸   NM_001009662
- UniProtKB: Q5PPN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007802   ⟸   ENSRNOT00000007802
RefSeq Acc Id: ENSRNOP00000074141   ⟸   ENSRNOT00000081296
RefSeq Acc Id: XP_038965332   ⟸   XM_039109404
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965331   ⟸   XM_039109403
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000077757   ⟸   ENSRNOT00000106574
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPN4-F1-model_v2 AlphaFold Q5PPN4 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693555
Promoter ID:EPDNEW_R4080
Type:single initiation site
Name:Car8_1
Description:carbonic anhydrase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0521,345,818 - 21,345,878EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304709 AgrOrtholog
BioCyc Gene G2FUF-42063 BioCyc
Ensembl Genes ENSRNOG00000005669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074141.2 UniProtKB/TrEMBL
  ENSRNOP00000077757 ENTREZGENE
  ENSRNOP00000077757.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081296.2 UniProtKB/TrEMBL
  ENSRNOT00000106574 ENTREZGENE
  ENSRNOT00000106574.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7318288 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
  CARP_VIII UniProtKB/Swiss-Prot
KEGG Report rno:297814 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105764 IMAGE-MGC_LOAD
NCBI Gene 297814 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car8 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7B9_RAT UniProtKB/TrEMBL
  A0A8I5Y6A0_RAT UniProtKB/TrEMBL
  CAH8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-18 Car8  carbonic anhydrase 8  Ca8  carbonic anhydrase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca8  carbonic anhydrase 8  Car8  carbonic anhydrase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Car8  carbonic anhydrase 8  Car8_predicted  carbonic anhydrase 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Car8_predicted  carbonic anhydrase 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED