Frmpd3 (FERM and PDZ domain containing 3) - Rat Genome Database

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Gene: Frmpd3 (FERM and PDZ domain containing 3) Rattus norvegicus
Analyze
Symbol: Frmpd3
Name: FERM and PDZ domain containing 3
RGD ID: 1563753
Description: Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Orthologous to human FRMPD3 (FERM and PDZ domain containing 3); INTERACTS WITH Cuprizon; paraquat; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FERM and PDZ domain-containing protein 3; LOC315916; RGD1563753; similar to novel protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,752,511 - 108,902,393 (+)NCBIGRCr8
mRatBN7.2X103,964,168 - 104,113,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,043,194 - 104,111,968 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X111,689,587 - 111,778,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0352,821,331 - 52,908,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X128,160,190 - 128,229,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera343,819,462 - 43,881,625 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoskeleton  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Frmpd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,752,511 - 108,902,393 (+)NCBIGRCr8
mRatBN7.2X103,964,168 - 104,113,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,043,194 - 104,111,968 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X111,689,587 - 111,778,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0352,821,331 - 52,908,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X128,160,190 - 128,229,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera343,819,462 - 43,881,625 (-)NCBICelera
Cytogenetic MapXq32NCBI
FRMPD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X107,449,652 - 107,605,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX107,449,652 - 107,605,255 (+)EnsemblGRCh38hg38GRCh38
GRCh37X106,692,882 - 106,848,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,652,336 - 106,735,135 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX107,237,183 - 107,319,985 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX96,395,418 - 96,423,490 (+)NCBIHuRef
HuRefX96,429,726 - 96,465,594 (+)NCBIHuRef
CHM1_1X106,676,670 - 106,759,452 (+)NCBICHM1_1
T2T-CHM13v2.0X105,886,268 - 106,042,004 (+)NCBIT2T-CHM13v2.0
Frmpd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X139,177,867 - 139,336,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX139,243,012 - 139,336,216 (+)EnsemblGRCm39 Ensembl
GRCm38X140,277,123 - 140,435,467 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX140,342,263 - 140,435,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X136,916,510 - 136,929,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X135,728,335 - 135,740,904 (+)NCBIMGSCv36mm8
CeleraX123,641,137 - 123,653,779 (+)NCBICelera
Cytogenetic MapXF1NCBI
Frmpd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554908,330,703 - 8,369,075 (-)NCBIChiLan1.0ChiLan1.0
FRMPD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X106,927,330 - 107,081,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X106,930,932 - 107,085,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X96,544,115 - 96,698,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X106,990,946 - 107,072,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX106,994,050 - 107,072,027 (+)Ensemblpanpan1.1panPan2
FRMPD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X81,077,242 - 81,137,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX81,110,672 - 81,136,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX67,211,715 - 67,256,270 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X82,738,558 - 82,783,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX82,743,327 - 82,783,965 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X80,199,025 - 80,243,580 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X81,910,705 - 81,955,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X81,702,095 - 81,746,786 (+)NCBIUU_Cfam_GSD_1.0
Frmpd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X80,419,891 - 80,503,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364997,155,505 - 7,220,915 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364997,155,413 - 7,220,876 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRMPD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX87,897,022 - 88,053,073 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X87,980,635 - 88,053,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X102,400,217 - 102,508,895 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FRMPD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X95,303,078 - 95,431,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX95,348,346 - 95,429,748 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606520,427,498 - 20,526,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frmpd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248038,898,580 - 8,978,851 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248038,897,739 - 9,048,090 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Frmpd3
398 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000119738   ⟹   ENSRNOP00000084520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX104,043,194 - 104,111,968 (+)Ensembl
RefSeq Acc Id: XM_039100595   ⟹   XP_038956523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,806,754 - 108,902,393 (+)NCBI
mRatBN7.2X104,018,182 - 104,113,864 (+)NCBI
RefSeq Acc Id: XM_039100596   ⟹   XP_038956524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,752,511 - 108,902,393 (+)NCBI
mRatBN7.2X103,964,168 - 104,113,864 (+)NCBI
RefSeq Acc Id: XM_039100597   ⟹   XP_038956525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,831,858 - 108,902,393 (+)NCBI
mRatBN7.2X104,043,313 - 104,113,864 (+)NCBI
RefSeq Acc Id: XM_039100599   ⟹   XP_038956527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,831,747 - 108,902,393 (+)NCBI
mRatBN7.2X104,043,206 - 104,113,864 (+)NCBI
RefSeq Acc Id: XM_039100600   ⟹   XP_038956528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,752,703 - 108,902,393 (+)NCBI
mRatBN7.2X103,964,171 - 104,113,864 (+)NCBI
RefSeq Acc Id: XM_063280550   ⟹   XP_063136620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,752,703 - 108,902,393 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038956524   ⟸   XM_039100596
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956528   ⟸   XM_039100600
- Peptide Label: isoform X2
- UniProtKB: A6HLS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956523   ⟸   XM_039100595
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956527   ⟸   XM_039100599
- Peptide Label: isoform X2
- UniProtKB: A6HLS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956525   ⟸   XM_039100597
- Peptide Label: isoform X2
- UniProtKB: A6HLS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084520   ⟸   ENSRNOT00000119738
RefSeq Acc Id: XP_063136620   ⟸   XM_063280550
- Peptide Label: isoform X2
Protein Domains
FERM   PDZ   Ras-associating

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563753 AgrOrtholog
BioCyc Gene G2FUF-1544 BioCyc
Ensembl Genes ENSRNOG00000065509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000119738.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FAK1-like_FERM_C UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FRMPD1/3/4_FERM_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene 315916 ENTREZGENE
PANTHER FERM AND PDZ DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam FERM_C_FAK1 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PhenoGen Frmpd3 PhenoGen
PROSITE FERM_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PS50200 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065509 RatGTEx
SMART B41 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5ZZJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HLS1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-30 Frmpd3  FERM and PDZ domain containing 3  RGD1563753  similar to novel protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563753  similar to novel protein   RGD1563753_predicted  similar to novel protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563753_predicted  similar to novel protein (predicted)  LOC315916  similar to novel protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315916  similar to novel protein      Symbol and Name status set to provisional 70820 PROVISIONAL