Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cdkl1 | Rat | 1,1-dichloroethene | decreases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of CDKL1 mRNA | CTD | PMID:26682919 | Cdkl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CDKL1 mRNA | CTD | PMID:21570461 | Cdkl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CDKL1 mRNA | CTD | PMID:33387578 | Cdkl1 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Cdkl1 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CDKL1 mRNA | CTD | PMID:30071829 | Cdkl1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of CDKL1 mRNA | CTD | PMID:36041667 | Cdkl1 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Cdkl1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of CDKL1 gene | CTD | PMID:31683443 | Cdkl1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CDKL1 mRNA | CTD | PMID:28973697 | Cdkl1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CDKL1 mRNA | CTD | PMID:24780913 | Cdkl1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CDKL1 mRNA | CTD | PMID:30047161 | Cdkl1 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CDKL1 mRNA | CTD | PMID:31881176 | Cdkl1 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of CDKL1 mRNA | CTD | PMID:33354967 | Cdkl1 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of CDKL1 mRNA | CTD | PMID:30047161 | Cdkl1 | Rat | benzo[a]pyrene | increases methylation | ISO | CDKL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CDKL1 exon | CTD | PMID:27901495 | Cdkl1 | Rat | benzo[a]pyrene | increases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of CDKL1 mRNA | CTD | PMID:32234424 | Cdkl1 | Rat | bisphenol A | increases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of CDKL1 mRNA | CTD | PMID:29275510 | Cdkl1 | Rat | bisphenol A | increases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CDKL1 mRNA | CTD | PMID:32156529 | Cdkl1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of CDKL1 mRNA | CTD | PMID:36041667 | Cdkl1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CDKL1 mRNA | CTD | PMID:25181051 and PMID:30816183 | Cdkl1 | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of CDKL1 mRNA | CTD | PMID:36041667 | Cdkl1 | Rat | carbon nanotube | decreases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of CDKL1 mRNA | CTD | PMID:25554681 | Cdkl1 | Rat | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of CDKL1 mRNA | CTD | PMID:18500788 | Cdkl1 | Rat | cisplatin | increases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of CDKL1 mRNA | CTD | PMID:27392435 | Cdkl1 | Rat | copper(II) sulfate | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CDKL1 mRNA | CTD | PMID:19549813 | Cdkl1 | Rat | decabromodiphenyl ether | multiple interactions | EXP | | 6480464 | [Flame Retardants co-treated with pentabromodiphenyl ether co-treated with decabromobiphenyl ether co-treated with hexabromocyclododecane] results in decreased expression of CDKL1 mRNA | CTD | PMID:32207525 | Cdkl1 | Rat | dimethylarsinic acid | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of CDKL1 mRNA | CTD | PMID:34876320 | Cdkl1 | Rat | dioxygen | increases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of CDKL1 mRNA | CTD | PMID:22629407 | Cdkl1 | Rat | dioxygen | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of CDKL1 mRNA] | CTD | PMID:22629407 | Cdkl1 | Rat | dorsomorphin | multiple interactions | ISO | CDKL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDKL1 mRNA | CTD | PMID:27188386 | Cdkl1 | Rat | ethylparaben | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in decreased expression of CDKL1 mRNA | CTD | PMID:37690743 | Cdkl1 | Rat | FR900359 | increases phosphorylation | ISO | CDKL1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of CDKL1 protein | CTD | PMID:37730182 | Cdkl1 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of CDKL1 gene | CTD | PMID:22079235 | Cdkl1 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of CDKL1 mRNA | CTD | PMID:25539665 | Cdkl1 | Rat | mercury dichloride | decreases expression | EXP | | 6480464 | Mercuric Chloride results in decreased expression of CDKL1 mRNA | CTD | PMID:16507785 | Cdkl1 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of CDKL1 mRNA | CTD | PMID:30047161 | Cdkl1 | Rat | methylarsonic acid | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of CDKL1 mRNA | CTD | PMID:34876320 | Cdkl1 | Rat | methylseleninic acid | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | methylselenic acid results in decreased expression of CDKL1 mRNA | CTD | PMID:11830524 | Cdkl1 | Rat | N-acetyl-beta-D-glucosamine | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Acetylglucosamine results in decreased expression of CDKL1 mRNA | CTD | PMID:18047607 | Cdkl1 | Rat | N-acetyl-D-glucosamine | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Acetylglucosamine results in decreased expression of CDKL1 mRNA | CTD | PMID:18047607 | Cdkl1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CDKL1 mRNA | CTD | PMID:33387578 | Cdkl1 | Rat | phenylmercury acetate | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of CDKL1 mRNA | CTD | PMID:26272509 | Cdkl1 | Rat | phenylmercury acetate | multiple interactions | ISO | CDKL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDKL1 mRNA | CTD | PMID:27188386 | Cdkl1 | Rat | pioglitazone | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CDKL1 mRNA | CTD | PMID:27935865 | Cdkl1 | Rat | progesterone | decreases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Progesterone results in decreased expression of CDKL1 mRNA | CTD | PMID:17556502 | Cdkl1 | Rat | progesterone | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | NCOA2 protein affects the reaction [Progesterone results in decreased expression of CDKL1 mRNA] | CTD | PMID:17556502 | Cdkl1 | Rat | SB 431542 | multiple interactions | ISO | CDKL1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDKL1 mRNA | CTD | PMID:27188386 | Cdkl1 | Rat | sodium arsenate | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of CDKL1 mRNA | CTD | PMID:34876320 | Cdkl1 | Rat | sodium arsenite | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CDKL1 mRNA | CTD | PMID:38568856 | Cdkl1 | Rat | sodium arsenite | multiple interactions | ISO | Cdkl1 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of CDKL1 mRNA | CTD | PMID:34876320 | Cdkl1 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of CDKL1 mRNA | CTD | PMID:30047161 | Cdkl1 | Rat | sunitinib | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of CDKL1 mRNA | CTD | PMID:31533062 | Cdkl1 | Rat | titanium dioxide | decreases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CDKL1 mRNA | CTD | PMID:23557971 and PMID:29264374 | Cdkl1 | Rat | triphenyl phosphate | affects expression | ISO | CDKL1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CDKL1 mRNA | CTD | PMID:37042841 | Cdkl1 | Rat | urethane | decreases expression | ISO | CDKL1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CDKL1 mRNA | CTD | PMID:28818685 | Cdkl1 | Rat | vancomycin | increases expression | ISO | Cdkl1 (Mus musculus) | 6480464 | Vancomycin results in increased expression of CDKL1 mRNA | CTD | PMID:18930951 | |