CDKL1 (cyclin dependent kinase like 1) - Rat Genome Database

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Gene: CDKL1 (cyclin dependent kinase like 1) Chlorocebus sabaeus
Analyze
Symbol: CDKL1
Name: cyclin dependent kinase like 1
RGD ID: 18454402
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN heart development (ortholog); ASSOCIATED WITH Noonan syndrome 9 (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase-like 1; LOC103228959; uncharacterized LOC103228959
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,401,003 - 27,468,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,396,911 - 27,469,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,723,170 - 15,789,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CDKL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,401,003 - 27,468,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,396,911 - 27,469,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,723,170 - 15,789,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CDKL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,326,265 - 50,397,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1450,326,265 - 50,416,461 (-)EnsemblGRCh38hg38GRCh38
GRCh371450,792,983 - 50,864,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,866,470 - 49,932,367 (-)NCBINCBI36Build 36hg18NCBI36
Build 341449,866,469 - 49,932,367NCBI
Celera1430,663,847 - 30,729,727 (-)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,921,968 - 30,987,930 (-)NCBIHuRef
CHM1_11450,735,355 - 50,801,213 (-)NCBICHM1_1
T2T-CHM13v2.01444,532,486 - 44,603,508 (-)NCBIT2T-CHM13v2.0
Cdkl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,791,944 - 69,838,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,793,622 - 69,838,041 (-)EnsemblGRCm39 Ensembl
GRCm381269,745,167 - 69,791,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,746,848 - 69,791,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv371270,847,835 - 70,891,694 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,665,453 - 70,709,312 (-)NCBIMGSCv36mm8
Celera1270,842,757 - 70,886,848 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.94NCBI
Cdkl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,960,157 - 94,005,207 (-)NCBIGRCr8
mRatBN7.2688,224,154 - 88,273,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,224,143 - 88,270,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,623,989 - 88,667,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,923,441 - 88,967,352 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,363,180 - 88,407,097 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,076,247 - 92,123,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,077,416 - 92,121,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,525,767 - 101,572,007 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,800,976 - 91,869,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,426,823 - 3,447,743 (-)NCBI
Celera686,720,262 - 86,764,060 (-)NCBICelera
Cytogenetic Map6q24NCBI
Cdkl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,419,556 - 12,472,215 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,419,556 - 12,472,215 (+)NCBIChiLan1.0ChiLan1.0
CDKL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21551,467,099 - 51,535,020 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,683,602 - 50,752,380 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,917,602 - 30,987,992 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,213,925 - 49,291,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,223,146 - 49,291,192 (-)Ensemblpanpan1.1panPan2
CDKL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,771,498 - 26,828,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,773,636 - 26,828,270 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,525,498 - 26,581,908 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0826,949,620 - 27,006,081 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,949,620 - 27,006,517 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,604,557 - 26,661,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,676,990 - 26,733,441 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,995,836 - 27,052,284 (-)NCBIUU_Cfam_GSD_1.0
Cdkl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,966,730 - 59,018,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649515,173,643 - 15,228,490 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649515,173,672 - 15,225,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,078,659 - 180,145,054 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,081,385 - 180,145,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,424,327 - 200,440,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cdkl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,490,755 - 18,543,211 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473118,490,780 - 18,543,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013258   ⟹   ENSCSAP00000011264
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2427,396,911 - 27,469,284 (-)Ensembl
RefSeq Acc Id: XM_007986636   ⟹   XP_007984827
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12427,401,003 - 27,468,961 (-)NCBI
Vero_WHO_p1.0NW_02366605315,723,170 - 15,789,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037983939   ⟹   XP_037839867
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605315,724,087 - 15,789,088 (-)NCBI
RefSeq Acc Id: XM_037983940   ⟹   XP_037839868
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605315,724,087 - 15,789,575 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007984827 (Get FASTA)   NCBI Sequence Viewer  
  XP_037839867 (Get FASTA)   NCBI Sequence Viewer  
  XP_037839868 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011264
  ENSCSAP00000011264.1
RefSeq Acc Id: XP_007984827   ⟸   XM_007986636
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RRM5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000011264   ⟸   ENSCSAT00000013258
RefSeq Acc Id: XP_037839868   ⟸   XM_037983940
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037839867   ⟸   XM_037983939
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013258.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103228956 UniProtKB/TrEMBL
NCBI Gene CDKL1 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE-LIKE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RRM5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 CDKL1  cyclin dependent kinase like 1  LOC103228959  uncharacterized LOC103228959  Data merged from RGD:18495100 737654 PROVISIONAL