Matk (megakaryocyte-associated tyrosine kinase) - Rat Genome Database

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Gene: Matk (megakaryocyte-associated tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Matk
Name: megakaryocyte-associated tyrosine kinase
RGD ID: 69058
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and membrane. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Batk; megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase); megakaryocyte-associated tyrosine-protein kinase; MGC105436; non-receptor protein kinase protein; protein kinase BATK; tyrosine-protein kinase CTK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,456,990 - 8,465,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,341,194 - 11,346,217 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,216,677 - 13,221,700 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,084,145 - 11,089,168 (-)NCBIRnor_WKY
Rnor_6.0711,325,246 - 11,334,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,492,654 - 11,498,451 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,940,799 - 9,945,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,940,799 - 9,945,824 (-)NCBI
Celera76,645,321 - 6,650,346 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk. Kuo SS, etal., J Neurosci Res 1994 Aug 15;38(6):705-15.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17999719   PMID:21393838   PMID:30053369  


Genomics

Comparative Map Data
Matk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,456,990 - 8,465,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,341,194 - 11,346,217 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,216,677 - 13,221,700 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,084,145 - 11,089,168 (-)NCBIRnor_WKY
Rnor_6.0711,325,246 - 11,334,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,492,654 - 11,498,451 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,940,799 - 9,945,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,940,799 - 9,945,824 (-)NCBI
Celera76,645,321 - 6,650,346 (-)NCBICelera
Cytogenetic Map7q11NCBI
MATK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,777,973 - 3,801,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,777,970 - 3,802,129 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,777,971 - 3,801,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,728,967 - 3,752,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,728,967 - 3,737,414NCBI
Celera193,715,610 - 3,739,451 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,542,732 - 3,566,615 (-)NCBIHuRef
CHM1_1193,777,602 - 3,801,471 (-)NCBICHM1_1
T2T-CHM13v2.0193,757,233 - 3,781,064 (-)NCBIT2T-CHM13v2.0
Matk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,088,769 - 81,098,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,088,769 - 81,099,199 (+)EnsemblGRCm39 Ensembl
GRCm381081,252,935 - 81,262,985 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,252,935 - 81,263,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,720,290 - 80,725,726 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,660,674 - 80,666,110 (+)NCBIMGSCv36mm8
Celera1082,277,893 - 82,283,329 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Matk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,663,768 - 5,669,654 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,663,768 - 5,670,113 (-)NCBIChiLan1.0ChiLan1.0
MATK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,750,256 - 3,758,272 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,750,256 - 3,757,385 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,800,301 - 2,825,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MATK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,697,377 - 55,704,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,698,350 - 55,704,022 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,422,757 - 55,429,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,357,401 - 56,364,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,357,860 - 56,365,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,413,344 - 55,420,706 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,895,262 - 55,902,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,094,009 - 56,100,857 (+)NCBIUU_Cfam_GSD_1.0
Matk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,689,105 - 215,696,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,137,663 - 2,144,512 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365882,137,987 - 2,144,274 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MATK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,911,143 - 74,918,966 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,911,119 - 74,921,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MATK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,533,363 - 3,542,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,533,236 - 3,542,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,707,784 - 4,716,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Matk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,415,120 - 6,419,822 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,414,859 - 6,420,924 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Matk
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:61
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000027730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
G67866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,458,271 - 8,458,512 (+)MAPPERmRatBN7.2
Rnor_6.0711,326,528 - 11,326,768NCBIRnor6.0
Rnor_5.0711,493,936 - 11,494,176UniSTSRnor5.0
RGSC_v3.479,942,074 - 9,942,314UniSTSRGSC3.4
Celera76,646,596 - 6,646,836UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 52 1 3
Low 3 33 57 41 8 41 8 10 22 35 40 8 8
Below cutoff 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027730   ⟹   ENSRNOP00000027730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)Ensembl
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112957   ⟹   ENSRNOP00000096637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,456,998 - 8,461,774 (-)Ensembl
RefSeq Acc Id: NM_021859   ⟹   NP_068631
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,997 - 8,462,022 (-)NCBI
Rnor_6.0711,325,253 - 11,330,278 (-)NCBI
Rnor_5.0711,492,654 - 11,498,451 (-)NCBI
RGSC_v3.479,940,799 - 9,945,824 (-)RGD
Celera76,645,321 - 6,650,346 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079841   ⟹   XP_038935769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,990 - 8,462,665 (-)NCBI
RefSeq Acc Id: XM_039079842   ⟹   XP_038935770
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,990 - 8,465,947 (-)NCBI
RefSeq Acc Id: XM_039079843   ⟹   XP_038935771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,990 - 8,461,917 (-)NCBI
RefSeq Acc Id: XM_039079844   ⟹   XP_038935772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,990 - 8,462,257 (-)NCBI
RefSeq Acc Id: XM_039079845   ⟹   XP_038935773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,456,990 - 8,462,665 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_068631   ⟸   NM_021859
- UniProtKB: P41243 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027730   ⟸   ENSRNOT00000027730
RefSeq Acc Id: XP_038935770   ⟸   XM_039079842
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935773   ⟸   XM_039079845
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935769   ⟸   XM_039079841
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935772   ⟸   XM_039079844
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935771   ⟸   XM_039079843
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000096637   ⟸   ENSRNOT00000112957
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41243-F1-model_v2 AlphaFold P41243 1-467 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69058 AgrOrtholog
BioCyc Gene G2FUF-35009 BioCyc
Ensembl Genes ENSRNOG00000020431 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027730 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000096637.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027730 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000112957.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320205 IMAGE-MGC_LOAD
InterPro Csk-like_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60450 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105436 IMAGE-MGC_LOAD
NCBI Gene 60450 ENTREZGENE
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Matk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235587
UniProt A0A8I6GLP3_RAT UniProtKB/TrEMBL
  MATK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Matk  megakaryocyte-associated tyrosine kinase      Name updated 70584 APPROVED
2002-02-20 Matk  Megakaryocyte-associated tyrosine kinase      Name updated to reflect Human and Mouse nomenclature 70282 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in regulating brain development 68875