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Gene: Zic4 (Zic family member 4) Rattus norvegicus
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Symbol:
Zic4
Name:
Zic family member 4
RGD ID:
1307298
Description:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZIC4 (Zic family member 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC315882; zinc finger protein of the cerebellum 4; zinc finger protein ZIC 4
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 100,795,860 - 100,816,276 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 8 100,796,102 - 100,816,271 (+) Ensembl GRCr8 mRatBN7.2 8 91,916,356 - 91,936,525 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 91,920,015 - 91,935,368 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 8 97,595,121 - 97,615,263 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 95,794,372 - 95,814,514 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 93,608,259 - 93,628,430 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 98,755,104 - 98,760,737 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 98,745,310 - 98,761,840 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 8 98,246,887 - 98,252,520 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 8 96,335,974 - 96,341,607 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 8 91,456,811 - 91,462,444 (+) NCBI Celera RGSC_v3.1 8 96,341,959 - 96,360,689 (+) NCBI Cytogenetic Map 8 q31 NCBI
JBrowse:
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Only show annotations with direct experimental evidence (0 objects hidden)
Zic4 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Zic4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Zic4 Rat 1,2-dichloroethane increases expression ISO Zic4 (Mus musculus) 6480464 ethylene dichloride results in increased expression of ZIC4 mRNA CTD PMID:28960355 Zic4 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Zic4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Zic4 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Zic4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Zic4 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ZIC4 mRNA CTD PMID:32109520|PMID:33387578 Zic4 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ZIC4 mRNA CTD PMID:32109520 Zic4 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Zic4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Zic4 Rat 4,4'-sulfonyldiphenol decreases expression ISO Zic4 (Mus musculus) 6480464 bisphenol S results in decreased expression of ZIC4 mRNA CTD PMID:30951980 Zic4 Rat 5-aza-2'-deoxycytidine increases expression ISO Zic4 (Mus musculus) 6480464 Decitabine results in increased expression of ZIC4 mRNA CTD PMID:27915011 Zic4 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ZIC4 mRNA CTD PMID:24780913 Zic4 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of ZIC4 mRNA CTD PMID:30047161 Zic4 Rat acetohydrazide decreases expression ISO Zic4 (Mus musculus) 6480464 acetylhydrazine results in decreased expression of ZIC4 mRNA CTD PMID:15282401 Zic4 Rat aflatoxin B1 decreases methylation ISO ZIC4 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of ZIC4 gene CTD PMID:27153756 Zic4 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of ZIC4 mRNA CTD PMID:30047161 Zic4 Rat benzo[a]pyrene affects methylation ISO ZIC4 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of ZIC4 5' UTR CTD PMID:27901495 Zic4 Rat benzo[a]pyrene decreases methylation ISO ZIC4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of ZIC4 3' UTR; Benzo(a)pyrene results in decreased methylation of more ... CTD PMID:27901495 Zic4 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ZIC4 mRNA CTD PMID:25181051 Zic4 Rat bisphenol A decreases expression ISO Zic4 (Mus musculus) 6480464 bisphenol A results in decreased expression of ZIC4 mRNA CTD PMID:30951980|PMID:32156529|PMID:32365465 Zic4 Rat bisphenol F decreases expression ISO Zic4 (Mus musculus) 6480464 bisphenol F results in decreased expression of ZIC4 mRNA CTD PMID:30951980 Zic4 Rat CGP 52608 multiple interactions ISO ZIC4 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to ZIC4 gene] CTD PMID:28238834 Zic4 Rat crocidolite asbestos increases expression ISO Zic4 (Mus musculus) 6480464 Asbestos, Crocidolite results in increased expression of ZIC4 mRNA CTD PMID:19446018 Zic4 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of ZIC4 mRNA CTD PMID:26577399 Zic4 Rat cyclosporin A decreases methylation ISO ZIC4 (Homo sapiens) 6480464 Cyclosporine results in decreased methylation of ZIC4 promoter CTD PMID:27989131 Zic4 Rat dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of ZIC4 mRNA CTD PMID:20032058 Zic4 Rat dexamethasone decreases expression ISO Zic4 (Mus musculus) 6480464 Dexamethasone results in decreased expression of ZIC4 mRNA CTD PMID:22733784 Zic4 Rat dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ZIC4 mRNA] CTD PMID:20032058 Zic4 Rat ethylparaben decreases expression ISO ZIC4 (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in decreased expression of ZIC4 mRNA CTD PMID:37690743 Zic4 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ZIC4 mRNA CTD PMID:33387578 Zic4 Rat lead diacetate increases expression ISO Zic4 (Mus musculus) 6480464 lead acetate results in increased expression of ZIC4 mRNA CTD PMID:22609695 Zic4 Rat lipopolysaccharide decreases expression ISO ZIC4 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of ZIC4 mRNA CTD PMID:35811015 Zic4 Rat lipopolysaccharide multiple interactions ISO ZIC4 (Homo sapiens) 6480464 S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in decreased expression of ZIC4 mRNA] CTD PMID:35811015 Zic4 Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of ZIC4 mRNA CTD PMID:30047161 Zic4 Rat methylazoxymethanol increases expression ISO Zic4 (Mus musculus) 6480464 methylazoxymethanol results in increased expression of ZIC4 mRNA CTD PMID:17107856 Zic4 Rat okadaic acid decreases expression ISO ZIC4 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of ZIC4 mRNA CTD PMID:38832940 Zic4 Rat paracetamol decreases expression ISO ZIC4 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of ZIC4 mRNA CTD PMID:26690555|PMID:29067470 Zic4 Rat PCB138 multiple interactions ISO Zic4 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Zic4 Rat rotenone decreases expression ISO ZIC4 (Homo sapiens) 6480464 Rotenone results in decreased expression of ZIC4 mRNA CTD PMID:29955902 Zic4 Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO ZIC4 (Homo sapiens) 6480464 S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in decreased expression of ZIC4 mRNA] CTD PMID:35811015 Zic4 Rat silver atom decreases expression ISO ZIC4 (Homo sapiens) 6480464 Silver results in decreased expression of ZIC4 mRNA CTD PMID:26551752 Zic4 Rat silver(0) decreases expression ISO ZIC4 (Homo sapiens) 6480464 Silver results in decreased expression of ZIC4 mRNA CTD PMID:26551752 Zic4 Rat sodium arsenite affects methylation ISO ZIC4 (Homo sapiens) 6480464 sodium arsenite affects the methylation of ZIC4 gene CTD PMID:28589171 Zic4 Rat sodium arsenite decreases expression ISO Zic4 (Mus musculus) 6480464 sodium arsenite results in decreased expression of ZIC4 mRNA CTD PMID:37682722 Zic4 Rat Soman decreases expression EXP 6480464 Soman results in decreased expression of ZIC4 mRNA CTD PMID:19281266 Zic4 Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of ZIC4 mRNA CTD PMID:30047161 Zic4 Rat testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ZIC4 mRNA] CTD PMID:20032058 Zic4 Rat titanium dioxide increases methylation ISO Zic4 (Mus musculus) 6480464 titanium dioxide results in increased methylation of ZIC4 gene CTD PMID:35295148 Zic4 Rat titanium dioxide decreases methylation ISO Zic4 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of ZIC4 gene CTD PMID:35295148 Zic4 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of ZIC4 mRNA CTD PMID:33387578 Zic4 Rat valproic acid affects expression ISO Zic4 (Mus musculus) 6480464 Valproic Acid affects the expression of ZIC4 mRNA CTD PMID:17292431 Zic4 Rat valproic acid increases expression ISO ZIC4 (Homo sapiens) 6480464 Valproic Acid results in increased expression of ZIC4 mRNA CTD PMID:23179753 Zic4 Rat valproic acid affects expression ISO ZIC4 (Homo sapiens) 6480464 Valproic Acid affects the expression of ZIC4 mRNA CTD PMID:25979313 Zic4 Rat valproic acid decreases expression ISO Zic4 (Mus musculus) 6480464 Valproic Acid results in decreased expression of ZIC4 mRNA CTD PMID:24896083
QTLs in Region (GRCr8)
12879878 Bw183 Body weight QTL 183 0.001 body mass (VT:0001259) body weight (CMO:0000012) 8 62848139 107848139 Rat 1300177 Cm2 Cardiac mass QTL 2 3.65 heart mass (VT:0007028) heart weight (CMO:0000017) 8 63141536 109261840 Rat 1549909 Stresp11 Stress response QTL 11 6.83 0.0019 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 8 82352698 127352698 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5.5 0 nervous system integrity trait (VT:0010566) logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986) 8 58337123 103337123 Rat 12879879 Cm99 Cardiac mass QTL 99 0.001 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 8 62848139 107848139 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 49849908 118871671 Rat 9590292 Uminl3 Urine mineral level QTL 3 3.62 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 8 80768445 125768445 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 heart mass (VT:0007028) heart wet weight (CMO:0000069) 8 62970527 107970527 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 0.001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 8 39106363 103375781 Rat 12879880 Cm100 Cardiac mass QTL 100 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 8 62848139 107848139 Rat 12879881 Cm101 Cardiac mass QTL 101 0.001 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 8 62848139 107848139 Rat 12879882 Am8 Aortic mass QTL 8 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 8 62848139 107848139 Rat 12879883 Kidm65 Kidney mass QTL 65 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 8 62848139 107848139 Rat 71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 8 66992095 111992095 Rat 8693654 Alc32 Alcohol consumption QTL 32 2 0.755 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) 8 97492344 116428905 Rat 1358912 Bw51 Body weight QTL 51 2.95 body mass (VT:0001259) body weight (CMO:0000012) 8 60248093 105248093 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 0.0001 kidney morphology trait (VT:0002135) organ lesion measurement (CMO:0000677) 8 39106363 103375781 Rat 634332 Pia18 Pristane induced arthritis QTL 18 4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 8 84192326 132782436 Rat 1300171 Bp184 Blood pressure QTL 184 3.66 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) 8 79394435 132782436 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 0.0001 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 8 39106258 103375958 Rat 2313400 Anxrr25 Anxiety related response QTL 25 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 8 98145073 122898010 Rat 631210 Bw3 Body weight QTL3 5.9 mesenteric fat pad mass (VT:0010427) mesenteric fat pad weight to body weight ratio (CMO:0000654) 8 61019838 121662124 Rat 2293697 Bmd39 Bone mineral density QTL 39 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 8 62848139 107848139 Rat 8662823 Vetf5 Vascular elastic tissue fragility QTL 5 1.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 8 63404444 108404444 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 35464071 107982864 Rat 1331837 Bw23 Body weight QTL 23 4.19 0.00007 body mass (VT:0001259) body weight (CMO:0000012) 8 55428416 107963099 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 0.0004 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 8 62963099 107963099 Rat 8694446 Bw170 Body weight QTL 170 12.07 0.001 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 8 80768445 125768445 Rat 631650 Stl6 Serum triglyceride level QTL 6 4 0.0019 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 70041301 121080908 Rat 1331769 Rf39 Renal function QTL 39 3.871 urine output (VT:0003620) timed urine volume (CMO:0000260) 8 50763951 107970527 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 8 68690349 119799881 Rat 10450865 Bw175 Body weight QTL 175 4.1 total fat pad mass (VT:0015008) adipose tissue molecular composition measurement (CMO:0000484) 8 84192326 129192326 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 8 35464071 107982864 Rat 70197 BpQTLcluster8 Blood pressure QTL cluster 8 3.482 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 8 55428333 127966348 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 8 39106363 114525825 Rat 2300181 Bmd55 Bone mineral density QTL 55 5.7 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 8 85348065 130348065 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 8 39106258 103375958 Rat 10402857 Bp380 Blood pressure QTL 380 0.95 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 62848139 107848139 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 8 35464071 107982864 Rat 2301402 Bp316 Blood pressure QTL 316 0.005 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 62848139 107848139 Rat 631664 Hcar3 Hepatocarcinoma resistance QTL 3 2.9 0.0005 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) 8 62982864 107982864 Rat 8694200 Abfw4 Abdominal fat weight QTL 4 9.07 0.001 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) 8 80768445 125768445 Rat 8694392 Bw161 Body weight QTL 161 8.06 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 8 80768445 125768445 Rat 61437 Cia6 Collagen induced arthritis QTL 6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 8 91340911 131690273 Rat