Fmod (fibromodulin) - Rat Genome Database

Name: Fmod
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fmod (fibromodulin) Rattus norvegicus

Analyze

Symbol:

Fmod

Name:

fibromodulin

RGD ID:

619769

Description:

Involved in skin development. Located in collagen-containing extracellular matrix and extracellular region. Biomarker of tendinitis. Orthologous to human FMOD (fibromodulin); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

collagen-binding 59 kDa protein; FM; keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FMOD (fibromodulin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fmod (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fmod (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FMOD (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FMOD (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fmod (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FMOD (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FMOD (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fmod (fibromodulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Fmod (fibromodulin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FMOD (fibromodulin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fmoda (fibromodulin a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fmodb (fibromodulin b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	fmod	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Bp397

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	45,493,517 - 45,504,134 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,493,517 - 45,504,133 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,101,962 - 48,112,556 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,390,009 - 49,400,605 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	46,654,575 - 46,665,165 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	50,874,886 - 50,885,503 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	50,873,605 - 50,885,563 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	55,927,583 - 55,939,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	46,987,714 - 46,998,331 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	47,001,756 - 47,012,373 (+)	NCBI
Celera	13	45,822,144 - 45,832,470 (+)	NCBI		Celera
RH 3.4 Map	13	184.4	RGD
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diabetic Nephropathies (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

gingivitis (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

parathyroid carcinoma (ISO)

periodontitis (ISO)

tendinitis (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

capsaicin (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (ISO)

cobalt atom (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazepam (ISO)

diclofenac (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

fluoxetine (EXP)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

inulin (ISO)

methotrexate (ISO)

monosodium L-glutamate (ISO)

paracetamol (EXP)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenytoin (ISO)

propanal (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium fluoride (EXP,ISO)

T-2 toxin (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

Tungsten carbide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

collagen fibril organization (IEA)

skin development (IEP)

Cellular Component

collagen-containing extracellular matrix (IDA)

extracellular region (IDA)

extracellular space (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

albuminuria (IAGP)

salt-sensitive hypertension (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Female-specific hypertension loci on rat chromosome 13.	Hoffman MJ, etal., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1.
4.	Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice.	Jeansson M, etal., Diabetologia. 2006 Sep;49(9):2200-9. Epub 2006 Jul 26.
5.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6.	Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model.	Lui PP, etal., Rheumatology (Oxford). 2009 Dec 2.
7.	Immunohistochemical localization of fibromodulin in the periodontium during cementogenesis and root formation in the rat molar.	Matias MA, etal., J Periodontal Res. 2003 Oct;38(5):502-7.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Immunohistochemical localization and expression of fibromodulin in adult rat periodontium and inflamed human gingiva.	Qian H, etal., Oral Dis. 2004 Jul;10(4):233-9.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin.	Schaefer L, etal., FASEB J. 2001 Mar;15(3):559-61. Epub 2001 Jan 19.
15.	Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.	Soo C, etal., Am J Pathol. 2000 Aug;157(2):423-33.

Additional References at PubMed

PMID:20551380	PMID:22138190	PMID:23959432	PMID:24006456	PMID:26048315	PMID:26316108	PMID:27068509	PMID:27559042	PMID:27665369

Genomics

Comparative Map Data

Fmod
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	45,493,517 - 45,504,134 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,493,517 - 45,504,133 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,101,962 - 48,112,556 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,390,009 - 49,400,605 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	46,654,575 - 46,665,165 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	50,874,886 - 50,885,503 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	50,873,605 - 50,885,563 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	55,927,583 - 55,939,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	46,987,714 - 46,998,331 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	47,001,756 - 47,012,373 (+)	NCBI
Celera	13	45,822,144 - 45,832,470 (+)	NCBI		Celera
RH 3.4 Map	13	184.4	RGD
Cytogenetic Map	13	q13	NCBI

FMOD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	203,340,628 - 203,351,122 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	203,340,628 - 203,351,758 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	203,309,756 - 203,320,250 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	201,576,375 - 201,586,912 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	200,041,413 - 200,049,060	NCBI
Celera	1	176,439,022 - 176,449,562 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	174,474,902 - 174,485,714 (-)	NCBI		HuRef
CHM1_1	1	204,732,638 - 204,743,449 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	202,603,493 - 202,613,991 (-)	NCBI		T2T-CHM13v2.0

Fmod
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	133,964,992 - 133,976,018 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	133,964,992 - 133,976,015 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	134,037,254 - 134,048,280 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	134,037,254 - 134,048,277 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	135,934,092 - 135,944,854 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	135,853,926 - 135,864,688 (+)	NCBI		MGSCv36	mm8
Celera	1	136,653,909 - 136,670,078 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	58.09	NCBI

Fmod
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	39,328,743 - 39,340,258 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	39,328,743 - 39,340,113 (-)	NCBI	ChiLan1.0	ChiLan1.0

FMOD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	45,993,588 - 46,004,297 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	178,942,472 - 178,953,158 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	183,236,412 - 183,247,057 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	183,238,130 - 183,244,074 (-)	Ensembl	panpan1.1		panPan2

FMOD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	102,106 - 112,267 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	103,230 - 112,154 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	192,095 - 202,277 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	98,889 - 109,072 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	98,893 - 108,988 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	91,412 - 101,593 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	485,490 - 495,671 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	699,365 - 709,547 (-)	NCBI		UU_Cfam_GSD_1.0

Fmod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	72,036,724 - 72,047,975 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	1,271,252 - 1,282,841 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936567	1,271,401 - 1,282,651 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FMOD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	64,063,001 - 64,073,858 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	64,062,995 - 64,073,853 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	70,356,603 - 70,367,308 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FMOD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	25,992,006 - 26,002,909 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	25,992,228 - 26,003,109 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	26,768,097 - 26,779,048 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fmod
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	7,507,449 - 7,518,636 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	7,507,670 - 7,518,076 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fmod
38 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	128
Interacting mature miRNAs:	153
Transcripts:	ENSRNOT00000004382
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	43437904	47841255	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
12879436	Bp395	Blood pressure QTL 395			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	44639182	45700190	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879472	Bp399	Blood pressure QTL 399			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45228358	47841255	Rat

Markers in Region

D13Rat125

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,497,821 - 45,498,068 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	50,879,191 - 50,879,437	NCBI	Rnor6.0
Rnor_5.0	13	55,932,728 - 55,932,974	UniSTS	Rnor5.0
RGSC_v3.4	13	46,992,019 - 46,992,265	UniSTS	RGSC3.4
RGSC_v3.4	13	46,992,018 - 46,992,265	RGD	RGSC3.4
RGSC_v3.1	13	47,005,943 - 47,006,315	RGD
SHRSP x BN Map	13	14.8199	UniSTS
SHRSP x BN Map	13	14.8199	RGD
Cytogenetic Map	13	q13	UniSTS

RH133402

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,503,765 - 45,503,953 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	50,885,135 - 50,885,322	NCBI	Rnor6.0
Rnor_5.0	13	55,938,672 - 55,938,859	UniSTS	Rnor5.0
RGSC_v3.4	13	46,997,963 - 46,998,150	UniSTS	RGSC3.4
Celera	13	45,832,102 - 45,832,289	UniSTS
RH 3.4 Map	13	171.9	UniSTS
Cytogenetic Map	13	q13	UniSTS

RH142446

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,503,702 - 45,503,880 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	50,885,072 - 50,885,249	NCBI	Rnor6.0
Rnor_5.0	13	55,938,609 - 55,938,786	UniSTS	Rnor5.0
RGSC_v3.4	13	46,997,900 - 46,998,077	UniSTS	RGSC3.4
Celera	13	45,832,039 - 45,832,216	UniSTS
RH 3.4 Map	13	184.4	UniSTS
Cytogenetic Map	13	q13	UniSTS

PMC133870P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,496,238 - 45,496,655 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	50,877,608 - 50,878,024	NCBI	Rnor6.0
Rnor_5.0	13	55,931,145 - 55,931,561	UniSTS	Rnor5.0
RGSC_v3.4	13	46,990,436 - 46,990,852	UniSTS	RGSC3.4
Celera	13	45,824,866 - 45,825,282	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	2	2	11	2	6	9	10		33	10	6
Low	1	17	48	32	8	32	2	2	64	35	8	1	2
Below cutoff			7	7		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X82152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004382 ⟹ ENSRNOP00000004382

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	45,493,517 - 45,504,133 (+)	Ensembl
Rnor_6.0 Ensembl	13	50,873,605 - 50,885,563 (+)	Ensembl

RefSeq Acc Id:

NM_080698 ⟹ NP_542429

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	45,493,517 - 45,504,134 (+)	NCBI
Rnor_6.0	13	50,874,886 - 50,885,503 (+)	NCBI
Rnor_5.0	13	55,927,583 - 55,939,041 (+)	NCBI
RGSC_v3.4	13	46,987,714 - 46,998,331 (+)	RGD
Celera	13	45,822,144 - 45,832,470 (+)	RGD

Sequence:

show sequence

GAGGCCAAACAGAAGGACGTGGTCACTCTGAACGGTTCAACCCAAGGGACAACATGCAGTGGGC
CTCCATCCTGCTGCTGCGCGGGCTCTGCTCGCTTTCCCAGGGCCAGTATGAAGAAGACTCTCAC
TGGTGGCTCCAATACCTCCGAAACCAGCAGTCCACCTACTACGACCCCTACGACACTTACCCCT
ACGAGACCTCCGACCCTTACCCCTATGAAGTAGAGGAGGGCCCAGCCTATGCCTATGGTGCCCC
ACCTCCACCAGAGCCCCGTGATTGTCCCCAAGAATGCGACTGTCCCCCCAACTTCCCCACAGCC
ATGTACTGTGACAACCGCAACCTCAAGTACCTGCCCTTTGTGCCCTCCCGCATGAAGTACGTCT
ACTTCCAGAACAACCAGATCGCTGCCATCCAGGAAGGTGTCTTTGACAATGCCACCGGCCTCCT
CTGGATTGCTCTGCATGGCAACCAGATTACCAGTGACAAGATAGGCAGGAAGGTCTTCTCCAAG
CTGAGGCACTTGGAGAGGCTGTACCTGGACCACAACAACCTGACCCGGATGCCCGGACCACTGC
CTCGGTCCCTGAGAGAGCTCCACCTGGACCACAACCAGATCTCTCGGGTCCCCAACAACGCTCT
GGAGGGCCTGGAGAACCTCACAGCATTATATCTCCATCACAATGAGATCCAAGAAGTGGGAAGT
TCCATGAGGGGCCTCCGGTCCCTGATCCTACTAGACCTGAGTTATAACCACCTTCGAAGGGTTC
CCGACGGTCTGCCCTCAGCCCTGGAGCAGCTGTACCTAGAACACAACAACGTCTACACCGTCCC
TGACAGCTACTTCCGGGGCTCACCCAAGCTGCTGTATGTCCGGCTGTCTCACAACAGTCTCACT
AACAATGGCCTTGCTACCAACACCTTCAATTCCAGCAGCCTTCTGGAGCTAGACTTGTCCTACA
ACCAGCTGCAGAAGATCCCTCCCGTCAACACCAACCTGGAGAATCTTTACCTCCAAGGCAACAG
GATCAATGAGTTCTCCATCAGCAGTTTCTGCACGGTGGTGGACGTCATGAACTTCTCCAAGCTG
CAGGTGCTACGCCTGGATGGGAACGAGATCAAGCGCAGCGCTATGCCGGTGGACGCCCCACTCT
GCCTGCGCCTTGCCAGCCTCATCGAGATCTGAGGGGCTTCGCCTTGGGCTCGGGGCTCCGCCTT
GGACTCCGGGCTCCGCCTTGGGATCGGAGATCGGGGCTCAGGGCTCCGGGCTCCGGGCTCCGGG
CACTGGACTCCGGGCTCCAGGCATCGGGTACCGGGCACCGGGGTCCCGGCATATGCCCTGCCAC
CTGCTACACTCAGCTTGAAGGTCTGGTTTGGCTTTTGCTGGATGGTCTGGGACAAGCACGTGAC
AGAAGTCCACAGGATCTTATTCAGTCTCCTTCCGATAGGCAAAGTTAGGTGGGATCAGGGGCCA
GGCCAGTTTCTGCAGGGGATGAAAGTGGTGGTAAAAGAAATGGCCGCAGAGTCTAGCCCCCAAA
TCTTACTATCCCTCAACCCTTCCCCATGACCTAGTCTGGCAGACCATCCCCTTGCTTGGATAAT
AGCATATAACCAGACAATCTGACTTCAGCTGTGCTCACTCAATGGCTTGGCCAGTTGCTTCTGC
AGTCGCTCTGGGCTCCTACTCCTTGCTCCTCAAAACATCAAAACGTACTTCCTGCCCAGCCACT
TCCTCTAGGCCCAGCTCATCCCCTCTGCCCTCTTTCATTGAGGCCTCTTCTAAGGTCTTAGACA
ATCAGGAGACACCCACACCCCAAGGTTGGTGGGGAGCTGTCCAACAACCTGTGGAGGAAGACCA
CACATTATTATCTGAGGTTAAAAGGATATCTAAAACCATCACACACACACACACACACACACAC
ACACACACACACACACACAACGTCACCTGTTTAAAGTCAGCGTATTGAACAGTATAATGGTGAC
TGATAGTCATGACTTAATTACAAGGGGATAACCAGCCCTATAATGGAGGATCCATCAGAGGAGA
GAAGGGTCAAATGCTCATTTTTAGGATCCACAATAAGATGGGGAAGAGTCACACCTCAGAATGG
CAGGACTGAAGGGGCAGCCCCCCTTCCAGCTTCACCTGACCAACATGATCTGTGCCCCTTCTTG
GGCTTTTAGTATCAAAGGGGCCAGTGTGGTTTCCAAACCATGAGAAAGAGCCTCTGCCCATCCT
TGGATCCAGGTATGGAGGTTTGTTACACAGAGGCAGAGGCAGACTGTGCCAGCCGTGGACCCAC
CCACTAACCCAGACAAGGGTGTGATCTCCATAACTGGTTTGTCCCTAAAGCTAGAGTTTAAGGT
ACCAGCTCTTCTGGAGATGGTCACTGGGGTACAGGAAGCCCTAGCCAGGCCCAAGGCTTACCTA
CACTAGACATAGTTTCCTCTGCTTCCACACTGTGGGACCACACCTTATACTGATGGTGCCTGTG
ACGTGTAGCTTGTCTGAGAGCAACCCTGTCTTCTCCTTTTTAAAGGTGATGTTGCCTAGGTACA
GCCATCGGGTTCTCTAGACTCACTGGGAAAGAGCCACGGGTAGCCAGTGGCAAGAACCAGTTGT
GAGATGTTAGCCTGAGGTAGGTCCCTTCCCAGATGCCTTAGACCCATGACTCTGTGTGCACTTA
GGAGCAAGCTTCCCTGAAAAGGACAGGGTGGGGTGGGGTGCTTAGACTGTGCCATGGGTTCCAG
ATCCTGAAATCCACAAAAGCCAAACCAGCTTGTTTGAACCAGGGAGTGCCACATGTGGAGCAAG
GCTGCCCTGCCCAGAGCTCTTGAGAAGCACCTGCATGCAGATACCATCTGGCCTCTATAAAGGG
TCCTCAGCAAGAAGCAAGCATGAGTGGTGGCCAACCTGACCAATAAAGTTATTTTATAAGTGCA
AAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_542429	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA57648	(Get FASTA)	NCBI Sequence Viewer
	EDM09747	(Get FASTA)	NCBI Sequence Viewer
	P50609	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_542429 ⟸ NM_080698
- Peptide Label:	precursor
- UniProtKB:	P50609 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MQWASILLLRGLCSLSQGQYEEDSHWWLQYLRNQQSTYYDPYDTYPYETSDPYPYEVEEGPAYA YGAPPPPEPRDCPQECDCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQNNQIAAIQEGVFDNA TGLLWIALHGNQITSDKIGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVP NNALEGLENLTALYLHHNEIQEVGSSMRGLRSLILLDLSYNHLRRVPDGLPSALEQLYLEHNNV YTVPDSYFRGSPKLLYVRLSHNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYL QGNRINEFSISSFCTVVDVMNFSKLQVLRLDGNEIKRSAMPVDAPLCLRLASLIEI hide sequence

RefSeq Acc Id:

ENSRNOP00000004382 ⟸ ENSRNOT00000004382

Protein Domains

LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50609-F1-model_v2	AlphaFold	P50609	1-376	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619769	AgrOrtholog
BioCyc Gene	G2FUF-18257	BioCyc
Ensembl Genes	ENSRNOG00000003183	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004382	ENTREZGENE
	ENSRNOP00000004382.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004382	ENTREZGENE
	ENSRNOT00000004382.7	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRRNT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64507	UniProtKB/Swiss-Prot
NCBI Gene	64507	ENTREZGENE
PANTHER	AGAP008170-PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45712:SF4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LRR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRRNT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fmod	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LRR_BAC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRRNT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	FMOD_RAT	UniProtKB/Swiss-Prot
	G3V6E7_RAT	UniProtKB/TrEMBL
	P50609	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Fmod	fibromodulin			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Fmod	fibromodulin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype