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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tnn | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNN mRNA] | CTD | PMID:31150632 | Tnn | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNN mRNA | CTD | PMID:34747641 | Tnn | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | ISO | TNN (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | Tnn | Rat | 3-chloropropane-1,2-diol | increases expression | ISO | Tnn (Mus musculus) | 6480464 | alpha-Chlorohydrin results in increased expression of TNN mRNA | CTD | PMID:33187795 | Tnn | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Tnn (Mus musculus) | 6480464 | bisphenol S affects the methylation of TNN exon | CTD | PMID:33297965 | Tnn | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of TNN mRNA | CTD | PMID:24780913 and PMID:25825206 | Tnn | Rat | aflatoxin B1 | increases methylation | ISO | TNN (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TNN gene | CTD | PMID:27153756 | Tnn | Rat | Aflatoxin B2 alpha | increases methylation | ISO | TNN (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of TNN exon | CTD | PMID:30157460 | Tnn | Rat | alpha-Zearalanol | increases expression | EXP | | 6480464 | Zeranol results in increased expression of TNN mRNA | CTD | PMID:35163327 | Tnn | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of TNN mRNA | CTD | PMID:30779732 | Tnn | Rat | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of TNN mRNA | CTD | PMID:36841081 | Tnn | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of TNN gene | CTD | PMID:35440735 | Tnn | Rat | belinostat | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA | CTD | PMID:27188386 | Tnn | Rat | benzo[a]pyrene | increases mutagenesis | ISO | TNN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of TNN gene | CTD | PMID:25435355 | Tnn | Rat | benzo[a]pyrene | affects methylation | ISO | TNN (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TNN 5' UTR and Benzo(a)pyrene affects the methylation of TNN promoter | CTD | PMID:27901495 | Tnn | Rat | benzo[a]pyrene | decreases methylation | ISO | Tnn (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of TNN exon and Benzo(a)pyrene results in decreased methylation of TNN intron | CTD | PMID:27901495 | Tnn | Rat | benzo[a]pyrene | increases methylation | ISO | TNN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TNN 3' UTR | CTD | PMID:27901495 | Tnn | Rat | benzo[e]pyrene | increases methylation | ISO | TNN (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of TNN exon | CTD | PMID:30157460 | Tnn | Rat | Benzo[ghi]perylene | increases expression | ISO | Tnn (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of TNN mRNA | CTD | PMID:26377693 | Tnn | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Tnn (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of TNN mRNA | CTD | PMID:34319233 | Tnn | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TNN mRNA | CTD | PMID:25181051 more ... | Tnn | Rat | cadmium dichloride | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of TNN mRNA | CTD | PMID:38568856 | Tnn | Rat | calcitriol | decreases expression | ISO | TNN (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of TNN mRNA | CTD | PMID:16002434 | Tnn | Rat | carbon nanotube | decreases expression | ISO | Tnn (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Tnn | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of TNN mRNA | CTD | PMID:26033743 | Tnn | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of TNN mRNA | CTD | PMID:26033743 | Tnn | Rat | DDT | decreases methylation | EXP | | 6480464 | DDT results in decreased methylation of TNN gene | CTD | PMID:31682807 | Tnn | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of TNN mRNA | CTD | PMID:21266533 | Tnn | Rat | dibutyl phthalate | increases expression | ISO | Tnn (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of TNN mRNA | CTD | PMID:21266533 | Tnn | Rat | dioxygen | multiple interactions | ISO | Tnn (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TNN mRNA | CTD | PMID:30529165 | Tnn | Rat | diquat | decreases expression | ISO | Tnn (Mus musculus) | 6480464 | Diquat results in decreased expression of TNN mRNA | CTD | PMID:36851058 | Tnn | Rat | dorsomorphin | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Tnn | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of TNN mRNA | CTD | PMID:29391264 | Tnn | Rat | entinostat | increases expression | ISO | TNN (Homo sapiens) | 6480464 | entinostat results in increased expression of TNN mRNA | CTD | PMID:26272509 | Tnn | Rat | entinostat | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA | CTD | PMID:27188386 | Tnn | Rat | ethyl methanesulfonate | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of TNN mRNA | CTD | PMID:23649840 | Tnn | Rat | ethylparaben | increases expression | ISO | TNN (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in increased expression of TNN mRNA | CTD | PMID:37690743 | Tnn | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of TNN mRNA | CTD | PMID:34044035 | Tnn | Rat | formaldehyde | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of TNN mRNA | CTD | PMID:23649840 | Tnn | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of TNN mRNA | CTD | PMID:27387713 | Tnn | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of TNN mRNA | CTD | PMID:33387578 | Tnn | Rat | isotretinoin | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Isotretinoin results in increased expression of TNN mRNA | CTD | PMID:20436886 | Tnn | Rat | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of TNN mRNA | CTD | PMID:28801915 | Tnn | Rat | manganese(II) chloride | increases methylation | EXP | | 6480464 | manganese chloride results in increased methylation of TNN gene | CTD | PMID:28801915 | Tnn | Rat | methapyrilene | increases methylation | ISO | TNN (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of TNN exon | CTD | PMID:30157460 | Tnn | Rat | methyl methanesulfonate | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of TNN mRNA | CTD | PMID:23649840 | Tnn | Rat | monocrotaline | increases expression | EXP | | 6480464 | Monocrotaline results in increased expression of TNN protein | CTD | PMID:24947524 | Tnn | Rat | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of TNN mRNA | CTD | PMID:28801915 | Tnn | Rat | nickel atom | decreases expression | ISO | TNN (Homo sapiens) | 6480464 | Nickel results in decreased expression of TNN mRNA | CTD | PMID:24768652 and PMID:25583101 | Tnn | Rat | ozone | multiple interactions | ISO | Tnn (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TNN mRNA | CTD | PMID:34911549 | Tnn | Rat | panobinostat | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA | CTD | PMID:27188386 | Tnn | Rat | panobinostat | increases expression | ISO | TNN (Homo sapiens) | 6480464 | panobinostat results in increased expression of TNN mRNA | CTD | PMID:26272509 | Tnn | Rat | pentane-2,3-dione | increases expression | EXP | | 6480464 | 2 and 3-pentanedione results in increased expression of TNN mRNA | CTD | PMID:25710175 | Tnn | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of TNN mRNA | CTD | PMID:27979718 | Tnn | Rat | SB 431542 | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Tnn | Rat | sodium arsenite | increases expression | ISO | TNN (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TNN mRNA | CTD | PMID:38568856 | Tnn | Rat | sodium fluoride | decreases expression | EXP | | 6480464 | Sodium Fluoride results in decreased expression of TNN mRNA | CTD | PMID:27257137 | Tnn | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNN mRNA] | CTD | PMID:31150632 | Tnn | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TNN mRNA | CTD | PMID:31150632 | Tnn | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of TNN mRNA | CTD | PMID:34492290 | Tnn | Rat | thiram | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Thiram results in increased expression of TNN mRNA | CTD | PMID:38568856 | Tnn | Rat | titanium dioxide | decreases expression | ISO | Tnn (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of TNN mRNA | CTD | PMID:19464567 | Tnn | Rat | titanium dioxide | increases expression | ISO | Tnn (Mus musculus) | 6480464 | titanium dioxide results in increased expression of TNN mRNA | CTD | PMID:35295148 | Tnn | Rat | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of TNN mRNA | CTD | PMID:30012374 | Tnn | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of TNN mRNA | CTD | PMID:33387578 | Tnn | Rat | trichostatin A | increases expression | ISO | TNN (Homo sapiens) | 6480464 | trichostatin A results in increased expression of TNN mRNA | CTD | PMID:24935251 | Tnn | Rat | trimellitic anhydride | increases expression | ISO | Tnn (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of TNN mRNA | CTD | PMID:19042947 | Tnn | Rat | valproic acid | increases expression | ISO | TNN (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TNN mRNA | CTD | PMID:24383497 and PMID:24935251 | Tnn | Rat | vorinostat | increases expression | ISO | TNN (Homo sapiens) | 6480464 | vorinostat results in increased expression of TNN mRNA | CTD | PMID:26272509 | Tnn | Rat | vorinostat | multiple interactions | ISO | TNN (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA | CTD | PMID:27188386 | |