Enables ciliary neurotrophic factor receptor activity and cytokine binding activity. Predicted to be involved in ciliary neurotrophic factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including brainstem development; negative regulation of motor neuron apoptotic process; and suckling behavior. Predicted to be located in apical plasma membrane. Predicted to be part of CNTFR-CLCF1 complex and ciliary neurotrophic factor receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human CNTFR (ciliary neurotrophic factor receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CNTFR mRNA, [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of CNTFR mRNA
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]
The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway.