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Gene: Cntfr (ciliary neurotrophic factor receptor) Rattus norvegicus

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Symbol:

Cntfr

Name:

ciliary neurotrophic factor receptor

RGD ID:

1303100

Description:

Enables ciliary neurotrophic factor receptor activity and cytokine binding activity. Predicted to be involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Predicted to act upstream of or within several processes, including brainstem development; negative regulation of motor neuron apoptotic process; and suckling behavior. Predicted to be located in apical plasma membrane. Predicted to be part of CNTFR-CLCF1 complex and ciliary neurotrophic factor receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human CNTFR (ciliary neurotrophic factor receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ciliary neurotrophic factor receptor alpha; ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR alpha; CNTFR-alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	61,619,326 - 61,657,359 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	61,619,326 - 61,645,795 (-)	Ensembl				GRCr8
mRatBN7.2	5	56,823,448 - 56,861,049 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,823,965 - 56,841,392 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	58,803,485 - 58,832,001 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	60,622,311 - 60,650,828 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	60,608,710 - 60,637,223 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	58,041,114 - 58,078,687 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	58,041,146 - 58,078,545 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	62,566,649 - 62,594,369 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	5	55,418,121 - 55,446,426 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

anauxetic dysplasia (ISO)

autosomal recessive distal hereditary motor neuronopathy 2 (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

capsaicin (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cytarabine (ISO)

dextran sulfate (ISO)

dimethylarsinic acid (EXP)

ethanol (ISO)

ethylparaben (ISO)

fenvalerate (EXP)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

GW 4064 (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

N-methyl-4-phenylpyridinium (ISO)

naproxen (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sumatriptan (EXP)

sunitinib (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

valproic acid (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brainstem development (ISO)

ciliary neurotrophic factor-mediated signaling pathway (IBA,IEA,ISO)

cytokine-mediated signaling pathway (IEA)

interleukin-11-mediated signaling pathway (IEA)

motor neuron apoptotic process (ISO)

negative regulation of motor neuron apoptotic process (ISO)

negative regulation of neuron apoptotic process (IEA,ISO)

positive regulation of cell population proliferation (IBA,ISO)

sex differentiation (ISO)

skeletal muscle organ development (ISO)

suckling behavior (ISO)

Cellular Component

apical plasma membrane (IEA,ISO)

ciliary neurotrophic factor receptor complex (IBA,IEA,ISO)

CNTFR-CLCF1 complex (IBA,IEA,ISO)

external side of plasma membrane (IBA)

membrane (IEA)

plasma membrane (IEA)

side of membrane (IEA)

Molecular Function

ciliary neurotrophic factor receptor activity (IEA,IMP,ISO)

cytokine binding (IEA,IPI,ISO)

cytokine receptor activity (IEA)

interleukin-11 binding (IBA)

interleukin-11 receptor activity (IBA)

protein binding (ISO)

signaling receptor binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cytokine mediated signaling pathway (IEA)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus in response to kainic acid-induced excitotoxicity.	Choi JS, etal., Mol Cells 2004 Apr 30;17(2):292-6.
2.	The receptor for ciliary neurotrophic factor.	Davis S, etal., Science. 1991 Jul 5;253(5015):59-63.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.	Ip NY, etal., Neuron 1993 Jan;10(1):89-102.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway.	Ozog MA, etal., Mol Biol Cell 2004 Nov;15(11):4761-74. Epub 2004 Sep 1.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7585948	PMID:8385113	PMID:8460125	PMID:10526311	PMID:11285233	PMID:11312299	PMID:12643274	PMID:12707266	PMID:15051883	PMID:15272019	PMID:15755520	PMID:18086669
PMID:18588528	PMID:19666135	PMID:21912637	PMID:22037350	PMID:22146310	PMID:23325260	PMID:25799580	PMID:30861131	PMID:31185137

Genomics

Comparative Map Data

Cntfr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	61,619,326 - 61,657,359 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	61,619,326 - 61,645,795 (-)	Ensembl				GRCr8
mRatBN7.2	5	56,823,448 - 56,861,049 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,823,965 - 56,841,392 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	58,803,485 - 58,832,001 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	60,622,311 - 60,650,828 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	60,608,710 - 60,637,223 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	58,041,114 - 58,078,687 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	58,041,146 - 58,078,545 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	62,566,649 - 62,594,369 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	5	55,418,121 - 55,446,426 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

CNTFR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	34,551,433 - 34,590,852 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	34,551,432 - 34,590,140 (-)	Ensembl			hg38	GRCh38
GRCh37	9	34,551,431 - 34,590,157 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	34,541,431 - 34,579,722 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	34,541,430 - 34,579,722	NCBI
Celera	9	34,482,940 - 34,521,225 (-)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	34,505,791 - 34,566,338 (-)	NCBI		HuRef
CHM1_1	9	34,551,220 - 34,589,921 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	34,569,984 - 34,609,005 (-)	NCBI		T2T-CHM13v2.0

Cntfr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	41,657,498 - 41,697,091 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	41,657,498 - 41,697,089 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	41,657,498 - 41,697,091 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	41,657,498 - 41,697,089 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	41,604,529 - 41,644,123 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	41,846,167 - 41,885,712 (-)	NCBI		MGSCv36	mm8
Celera	4	41,319,986 - 41,355,439 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	21.81	NCBI

Cntfr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	1,540,973 - 1,579,947 (+)	Ensembl
ChiLan1.0	NW_004955472	1,540,973 - 1,577,734 (+)	NCBI	ChiLan1.0	ChiLan1.0

CNTFR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	90,013,433 - 90,052,344 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	90,019,374 - 90,058,284 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	34,387,929 - 34,426,907 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	35,197,474 - 35,236,234 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	35,197,474 - 35,214,977 (-)	Ensembl			panPan2	panpan1.1

CNTFR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	51,226,951 - 51,266,431 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	51,227,509 - 51,245,188 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	49,856,718 - 49,885,981 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	52,168,591 - 52,207,166 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	52,156,483 - 52,206,853 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	50,831,810 - 50,861,067 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	50,699,974 - 50,729,298 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	51,464,730 - 51,493,994 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cntfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	166,088,587 - 166,127,184 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	2,636,166 - 2,674,192 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	2,636,166 - 2,674,488 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CNTFR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	32,211,777 - 32,251,503 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	32,211,809 - 32,251,412 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	36,352,329 - 36,392,542 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CNTFR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	46,017,992 - 46,068,187 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	46,030,203 - 46,069,944 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	43,135,677 - 43,185,259 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cntfr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	38,943,803 - 38,961,547 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	38,943,842 - 38,983,473 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Cntfr
204 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	71
Count of miRNA genes:	59
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000075777
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Markers in Region

UniSTS:496823

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	56,829,132 - 56,829,498 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	58,046,798 - 58,047,163	NCBI	Rnor6.0
Rnor_5.0	5	62,571,816 - 62,572,181	UniSTS	Rnor5.0
Celera	5	55,423,261 - 55,423,626	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
11	11	67	154	90	89	59	57	59	6	308	156	9	133	74	92	30	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S54212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000075777 ⟹ ENSRNOP00000066185

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	61,620,066 - 61,633,938 (-)	Ensembl
mRatBN7.2 Ensembl	5	56,824,188 - 56,838,061 (-)	Ensembl
Rnor_6.0 Ensembl	5	58,041,146 - 58,078,545 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120096 ⟹ ENSRNOP00000077340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	61,619,326 - 61,645,795 (-)	Ensembl
mRatBN7.2 Ensembl	5	56,823,965 - 56,841,392 (-)	Ensembl

RefSeq Acc Id:

NM_001003929 ⟹ NP_001003929

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	61,619,326 - 61,656,918 (-)	NCBI
mRatBN7.2	5	56,823,448 - 56,861,049 (-)	NCBI
Rnor_6.0	5	58,041,631 - 58,070,125 (-)	NCBI
Rnor_5.0	5	62,566,649 - 62,594,369 (-)	NCBI
Celera	5	55,418,121 - 55,446,426 (-)	RGD

Sequence:

show sequence

CAACACATCATCCCAGGAAGACTTTGGTCTGCAGAGGAGGATAATATTGATGTGCTTGGAGAGC
ATCTGGTGGTAACGAGATGGCTGCTTCTGTCCCTTGGGCCTGCTGTGCTGTGCTTGCCGCTGCC
GCTGCCGCTGTCTACACCCAGAAACACAGTCCACAGGAGGCACCCCATGTTCAGTATGAGCGTC
TGGGCACAGATGTGACGCTGCCATGTGGGACAGCAAGTTGGGACGCAGCTGTGACCTGGAGGGT
AAATGGAACAGATCTGGCCCCTGACCTGCTCAATGGCTCTCAGCTGATACTACGAAGCTTAGAA
CTGGGCCACAGTGGCCTGTATGCCTGTTTCCACCGTGACTCCTGGCACCTGCGCCACCAAGTCC
TTCTGCATGTGGGTTTGCCGCCTCGGGAACCCGTGCTCAGCTGCCGTTCCAACACTTACCCCAA
GGGCTTCTACTGCAGCTGGCACCTGTCCGCCCCCACCTACATCCCCAATACCTTCAATGTGACT
GTACTGCATGGCTCCAAAATGATGGTCTGTGAGAAGGACCCAGCCCTCAAGAACCGCTGTCACA
TTCGGTACATGCACCTGTTCTCAACCATCAAGTACAAGGTCTCCATAAGTGTCAGCAACGCCTT
GGGTCACAACACCACGGCTATCACCTTCGACGAATTCACCATTGTGAAGCCCGATCCTCCAGAA
AATGTGGTGGCCCGGCCAGTGCCCAGCAACCCCCGTCGACTGGAGGTGACATGGCAGACCCCCT
CAACTTGGCCTGATCCCGAATCCTTTCCACTCAAGTTTTTTCTGCGCTACCGGCCTCTCATCCT
GGATCAATGGCAGCATGTGGAGCTCTCGAATGGCACAGCCCACACCATCACGGATGCCTATGCT
GGGAAGGAGTACATCATCCAGGTGGCCGCCAAGGACAATGAGATTGGGACATGGAGTGACTGGA
GTGTGGCTGCTCACGCCACACCCTGGACTGAGGAACCACGGCATCTCACCACTGAAGCCCAGGC
CCCCGAGACCACGACCAGCACCACCAGCTCCTTGGCACCCCCACCCACCACGAAGATCTGTGAC
CCCGGGGAGCTCAGCAGCGGCGGAGGACCCTCCATACCCTTCTTGACCAGTGTCCCTGTCACTC
TGGTCCTGGCTGCCGCTGCTGCCACAGCCAACAATCTCCTGATCTGAGCCCTGCATCCCATGAG
GACACGCCAGACGCCTACAGAGGAGCAGGAGGCCGGAGCTGAGCCTGCAGACCCCGGTTTCTAT
TTTGCACACGGGCAGGAGGACCTTTTGCATTCTCTTCAGACACAATTTGTAG

hide sequence

RefSeq Acc Id:

XM_017593358 ⟹ XP_017448847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	61,619,326 - 61,656,933 (-)	NCBI
mRatBN7.2	5	56,823,448 - 56,860,825 (-)	NCBI
Rnor_6.0	5	58,041,114 - 58,078,687 (-)	NCBI

Sequence:

show sequence

AGAGGAGCCGGTGCAGAGCGGGCGGCGGCGGCGGCAGTGGAGGCGGCGGCTCCAGCCGGCGCGG
CGCGGGGTTCGGCAGTGGGATCCGGCCGCAGTGCTCACTCCGCGCTCCTGCCTCCCTCACCGCC
TGCAGCGGCCGAAGGGCGCGGCGCGGAGCCCGAGTGGCCCGAGGGCGCGGTGAGTGTTCCGCGT
CGGTCTGCGCGAGGCTTGACCCTCGAACGCTCAGGCGGACAGATCCGCGGCCCTCGTGCGTGCG
GAACCCGGTCCCAACACATCATCCCAGGAAGACTTTGGTCTGCAGAGGAGGATAATATTGATGT
GCTTGGAGAGCATCTGGTGGTAACGAGATGGCTGCTTCTGTCCCTTGGGCCTGCTGTGCTGTGC
TTGCCGCTGCCGCTGCCGCTGTCTACACCCAGAAACACAGTCCACAGGAGGCACCCCATGTTCA
GTATGAGCGTCTGGGCACAGATGTGACGCTGCCATGTGGGACAGCAAGTTGGGACGCAGCTGTG
ACCTGGAGGGTAAATGGAACAGATCTGGCCCCTGACCTGCTCAATGGCTCTCAGCTGATACTAC
GAAGCTTAGAACTGGGCCACAGTGGCCTGTATGCCTGTTTCCACCGTGACTCCTGGCACCTGCG
CCACCAAGTCCTTCTGCATGTGGGTTTGCCGCCTCGGGAACCCGTGCTCAGCTGCCGTTCCAAC
ACTTACCCCAAGGGCTTCTACTGCAGCTGGCACCTGTCCGCCCCCACCTACATCCCCAATACCT
TCAATGTGACTGTACTGCATGGCTCCAAAATGATGGTCTGTGAGAAGGACCCAGCCCTCAAGAA
CCGCTGTCACATTCGGTACATGCACCTGTTCTCAACCATCAAGTACAAGGTCTCCATAAGTGTC
AGCAACGCCTTGGGTCACAACACCACGGCTATCACCTTCGACGAATTCACCATTGTGAAGCCCG
ATCCTCCAGAAAATGTGGTGGCCCGGCCAGTGCCCAGCAACCCCCGTCGACTGGAGGTGACATG
GCAGACGCCCTCAACTTGGCCTGATCCCGAATCCTTTCCACTCAAGTTTTTTCTGCGCTACCGG
CCTCTCATCCTGGACCAATGGCAGCATGTGGAGCTCTCGGATGGCACAGCCCACACCATCACGG
ATGCCTATGCTGGAAAGGAGTACATCATCCAGGTGGCCGCCAAGGACAATGAGATTGGGACATG
GAGTGACTGGAGTGTGGCTGCTCACGCCACACCCTGGACTGAGGAACCACGGCATCTCACCACT
GAAGCCCAGGCCCCCGAGACCACGACCAGCACCACCAGCTCCTTGGCACCCCCACCCACCACGA
AGATCTGTGACCCCGGGGAGCTCAGCAGCGGCGGAGGACCCTCCATACCCTTCTTGACCAGTGT
CCCTGTCACTCTGGTCCTGGCTGCCGCTGCTGCCACAGCCAACAATCTCCTGATCTGAGCCCTG
CATCCCATGAGGACACGCCAGACGCCTACAGAGGAGCAGGAGGCCGGAGCTGAGCCTGCAGACC
CCGGTTTCTATTTTGCACACGGGCAGGAGGACCTTTTGCATTCTCTTCAGACACAATTTGTAGA
GACCCCGGCAGGCCCGGGCCTGCCGTCCGTCCCCCTAGCCTCATCACACCAAGCCGGCTCTCCT
TTCCACCCAGAGAGGAGGGCCATGCAGCTAACCCACCCACCAAAGACCCCTCTCATCTTACCCC
TCGGGCTGGACCCTCCAACGCCAGCGACTCCCAGGAGCCCTTGGGGGAACCTGAGGGGAGCCCC
CACCCCATATCTACAGTTTCCCCCTCCTGCCCCAGCCTCCTGTCTGTCCCAGGGTCTCTGTTGC
ACCATCAGATTATAAGCTCCTGACACTGGGGGGGCCCAGCCATCCCCTTCCCCCCGGTGCCCAC
ACTTTTCAGTCCCTCCACCTCTGCCCCTGTTTTGTACGACCCTCCATTGGCCCTTTCCTACTCC
CAGTATTTAATGTCCTGTCAGTCCCTTCTAGTCTGACTCAATGGTAACTTGCTGTATTTGAATT
TTTTATAGATGTATATACATGGGAGGGAGGGGTAGGGAGTTCTCATTAAACGTCACCATTTCAT
GAGA

hide sequence

RefSeq Acc Id:

XM_039109845 ⟹ XP_038965773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	61,619,326 - 61,645,533 (-)	NCBI
mRatBN7.2	5	56,823,448 - 56,849,656 (-)	NCBI

RefSeq Acc Id:

XM_063287617 ⟹ XP_063143687

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	61,619,326 - 61,656,662 (-)	NCBI

RefSeq Acc Id:

XM_063287618 ⟹ XP_063143688

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	61,619,326 - 61,657,359 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003929	(Get FASTA)	NCBI Sequence Viewer
	XP_017448847	(Get FASTA)	NCBI Sequence Viewer
	XP_038965773	(Get FASTA)	NCBI Sequence Viewer
	XP_063143687	(Get FASTA)	NCBI Sequence Viewer
	XP_063143688	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB25290	(Get FASTA)	NCBI Sequence Viewer
	EDL98683	(Get FASTA)	NCBI Sequence Viewer
	EDL98684	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066185
	ENSRNOP00000077340
GenBank Protein	Q08406	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001003929 ⟸ NM_001003929
- Peptide Label:	precursor
- UniProtKB:	Q08406 (UniProtKB/Swiss-Prot), A0A8I5Y668 (UniProtKB/TrEMBL), A6IIW4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDL APDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCS WHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTT AITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQH VELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTT STTSSLAPPPTTKICDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI hide sequence

RefSeq Acc Id:	XP_017448847 ⟸ XM_017593358
- Peptide Label:	isoform X2
- UniProtKB:	Q08406 (UniProtKB/Swiss-Prot), A0A8I5Y668 (UniProtKB/TrEMBL), A6IIW4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDL APDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCS WHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTT AITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQH VELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTT STTSSLAPPPTTKICDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI hide sequence

Ensembl Acc Id:

ENSRNOP00000066185 ⟸ ENSRNOT00000075777

RefSeq Acc Id:	XP_038965773 ⟸ XM_039109845
- Peptide Label:	isoform X1
- UniProtKB:	Q08406 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000077340 ⟸ ENSRNOT00000120096

RefSeq Acc Id:	XP_063143688 ⟸ XM_063287618
- Peptide Label:	isoform X2
- UniProtKB:	Q08406 (UniProtKB/Swiss-Prot), A0A8I5Y668 (UniProtKB/TrEMBL), A6IIW4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143687 ⟸ XM_063287617
- Peptide Label:	isoform X2
- UniProtKB:	Q08406 (UniProtKB/Swiss-Prot), A0A8I5Y668 (UniProtKB/TrEMBL), A6IIW4 (UniProtKB/TrEMBL)

Protein Domains

Fibronectin type-III Ig-like Ig-like C2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q08406-F1-model_v2	AlphaFold	Q08406	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303100	AgrOrtholog
BioCyc Gene	G2FUF-41547	BioCyc
Ensembl Genes	ENSRNOG00000047307	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000075777	ENTREZGENE
	ENSRNOT00000120096	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
InterPro	FN3_dom	UniProtKB/Swiss-Prot
	FN3_sf	UniProtKB/Swiss-Prot
	Hematopoietin_rcpt_L_F3_CS	UniProtKB/Swiss-Prot
	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	Type-I_Cytokine_Rcpt	UniProtKB/Swiss-Prot
KEGG Report	rno:313173	UniProtKB/Swiss-Prot
NCBI Gene	313173	ENTREZGENE
PANTHER	CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA	UniProtKB/Swiss-Prot
	CYTOKINE RECEPTOR	UniProtKB/Swiss-Prot
Pfam	fn3	UniProtKB/Swiss-Prot
PhenoGen	Cntfr	PhenoGen
PROSITE	FN3	UniProtKB/Swiss-Prot
	HEMATOPO_REC_L_F3	UniProtKB/Swiss-Prot
	IG_LIKE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000047307	RatGTEx
SMART	FN3	UniProtKB/Swiss-Prot
	IGc2	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
	SSF49265	UniProtKB/Swiss-Prot
UniProt	A0A8I5Y668	ENTREZGENE, UniProtKB/TrEMBL
	A6IIW3_RAT	UniProtKB/TrEMBL
	A6IIW4	ENTREZGENE, UniProtKB/TrEMBL
	CNTFR_RAT	UniProtKB/Swiss-Prot
	M0R9L2_RAT	UniProtKB/TrEMBL
	Q08406	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Cntfr	ciliary neurotrophic factor receptor			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Cntfr	ciliary neurotrophic factor receptor			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)