diethyl maleate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diethyl maleate	go back to main search page
Accession:	CHEBI:68508	browse the term
Definition:	A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Synonyms:	exact_synonym:	diethyl (2Z)-but-2-enedioate
	related_synonym:	2-butenedioic acid (2Z)-, dimethyl ester; Formula=C8H12O4; InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5-; InChIKey=IEPRKVQEAMIZSS-WAYWQWQTSA-N; SMILES=CCOC(=O)\\C=C/C(=O)OCC; maleic acid, diethyl ester
	xref:	CAS:141-05-9
	xref_mesh:	MESH:C014476
	xref:	PMID:1471155; PMID:1609410; PMID:3341033; Reaxys:907616

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Genes (402)

diethyl maleate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

diethyl maleate results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

diethyl maleate results in increased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

acetyl-CoA carboxylase alpha

decreases expression

diethyl maleate results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA oxidase 1

multiple interactions

diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

aminoacylase 3

decreases expression

diethyl maleate results in decreased expression of ACY3 mRNA

NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175

G

adrenomedullin

increases expression

diethyl maleate results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A3 receptor

decreases expression

diethyl maleate results in decreased expression of ADORA3 mRNA

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

apoptosis enhancing nuclease

increases expression

diethyl maleate results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

alpha-fetoprotein

increases expression

diethyl maleate results in increased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

adenosylhomocysteinase-like 1

increases expression

diethyl maleate results in increased expression of AHCYL1 mRNA

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

aldo-keto reductase family 1 member A1

increases expression

diethyl maleate results in increased expression of AKR1A1 protein

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1 member B10

increases expression

diethyl maleate results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

increases expression

diethyl maleate results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldehyde dehydrogenase 1 family, member A1

affects reduction

diethyl maleate affects the reduction of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

diethyl maleate results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 2 family member

decreases reduction
decreases expression
increases expression

diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein

PMID:19843705 PMID:21161181

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldolase, fructose-bisphosphate A

affects expression

diethyl maleate affects the expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

decreases expression

diethyl maleate results in decreased expression of ALDOB protein

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

adhesion molecule with Ig like domain 2

decreases expression

diethyl maleate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiopoietin-like 2

decreases expression

diethyl maleate results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin-like 4

increases expression

diethyl maleate results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat domain 46

decreases expression

diethyl maleate results in decreased expression of ANKRD46 mRNA

NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132

G

anillin, actin binding protein

increases expression

diethyl maleate results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

annexin A1

affects expression

diethyl maleate affects the expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A3

decreases expression

diethyl maleate results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

adaptor related protein complex 3 subunit mu 2

decreases expression

diethyl maleate results in decreased expression of AP3M2 mRNA

NCBI chr16:69,217,526...69,237,372
Ensembl chr16:69,217,633...69,235,431

G

apoptotic peptidase activating factor 1

increases expression

diethyl maleate results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor like protein 1

decreases expression

diethyl maleate results in decreased expression of APLP1 mRNA

NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155

G

apolipoprotein L9a

decreases expression

diethyl maleate results in decreased expression of APOL9A mRNA

NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649

G

Rho GTPase activating protein 9

increases expression

diethyl maleate results in increased expression of ARHGAP9 mRNA

NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524

G

arrestin domain containing 2

decreases expression

diethyl maleate results in decreased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

arrestin domain containing 4

decreases expression

diethyl maleate results in decreased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

anti-silencing function 1B histone chaperone

increases expression

diethyl maleate results in increased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

ASXL transcriptional regulator 1

decreases expression

diethyl maleate results in decreased expression of ASXL1 mRNA

NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538

G

ATM serine/threonine kinase

increases expression

diethyl maleate results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATP synthase F1 subunit beta

increases expression

diethyl maleate results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

aurora kinase A

increases expression
decreases expression

diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA

PMID:21161181 PMID:25270620

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

Bcl-2 binding component 3

increases expression

diethyl maleate results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA

PMID:22564015 PMID:33545341

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

decreases expression

diethyl maleate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

BCL3, transcription coactivator

decreases expression

diethyl maleate results in decreased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6B, transcription repressor

decreases expression

diethyl maleate results in decreased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

basic helix-loop-helix family, member e41

decreases expression

diethyl maleate results in decreased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

betaine-homocysteine S-methyltransferase

decreases expression

diethyl maleate results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

baculoviral IAP repeat-containing 3

multiple interactions

diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

biliverdin reductase B

increases expression

diethyl maleate results in increased expression of BLVRB mRNA

PMID:25270620 PMID:34626751

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

Bcl2 modifying factor

decreases expression

diethyl maleate results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BRCA1 interacting helicase 1

increases expression

diethyl maleate results in increased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

BTB domain containing 2

decreases expression

diethyl maleate results in decreased expression of BTBD2 mRNA

NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344

G

BTG anti-proliferation factor 2

increases expression
multiple interactions
decreases expression

diethyl maleate results in increased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
diethyl maleate results in decreased expression of BTG2 mRNA

PMID:22003191 PMID:25270620 PMID:34626751

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C6

decreases expression

diethyl maleate results in decreased expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

caspase 2

increases expression

diethyl maleate results in increased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases expression
increases cleavage

diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein

PMID:11875189 PMID:21105742

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression

diethyl maleate results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

diethyl maleate results in decreased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

increases expression

diethyl maleate results in increased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

carbonyl reductase 3

increases expression
multiple interactions

diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]

PMID:20806931 PMID:25270620

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

chromobox 4

increases expression

diethyl maleate results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 50

decreases expression

diethyl maleate results in decreased expression of CCDC50 mRNA

NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150

G

cyclin A1

decreases expression

diethyl maleate results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

increases expression

diethyl maleate results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression
increases expression

diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA

PMID:11875189 PMID:21161181 PMID:25270620

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

increases expression

diethyl maleate results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin K

decreases expression

diethyl maleate results in decreased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

Cd80 molecule

multiple interactions
increases expression

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

multiple interactions
increases expression

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]

PMID:24136171 PMID:31958493

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 25A

increases expression

diethyl maleate results in increased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle associated 2

increases expression

diethyl maleate results in increased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 3

increases expression

diethyl maleate results in increased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 8

increases expression

diethyl maleate results in increased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 11

decreases expression

diethyl maleate results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]

PMID:11875189 PMID:27982581

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CDP-diacylglycerol synthase 2

increases expression

diethyl maleate results in increased expression of CDS2 mRNA

NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541

G

carboxylesterase 1D

decreases expression
increases reduction

diethyl maleate results in decreased expression of CES1D protein
diethyl maleate results in increased reduction of CES1D protein

PMID:19843705 PMID:21161181

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

CASP8 and FADD-like apoptosis regulator

decreases expression

diethyl maleate results in decreased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

cholinergic receptor nicotinic alpha 4 subunit

increases expression

diethyl maleate results in increased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cell death-inducing DFFA-like effector c

decreases expression

diethyl maleate results in decreased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

diethyl maleate results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

decreases expression

diethyl maleate results in decreased expression of CITED4 mRNA

NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135

G

creatine kinase B

decreases reduction

diethyl maleate results in decreased reduction of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CDC28 protein kinase regulatory subunit 2

increases expression

diethyl maleate results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

CDC-like kinase 1

increases expression

diethyl maleate results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

cytidine/uridine monophosphate kinase 2

decreases expression

diethyl maleate results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

contactin 1

increases expression

diethyl maleate results in increased expression of CNTN1 mRNA

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

collagen type I alpha 1 chain

decreases expression

diethyl maleate results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression

diethyl maleate results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 3

increases expression

diethyl maleate results in increased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

G

catechol-O-methyltransferase

decreases expression

diethyl maleate results in decreased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

decreases expression

diethyl maleate results in decreased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cleavage and polyadenylation specific factor 4-like

increases expression

diethyl maleate results in increased expression of CPSF4L mRNA

NCBI chr10:98,741,816...98,756,069
Ensembl chr10:98,743,649...98,751,590

G

crystallin, mu

decreases expression

diethyl maleate results in decreased expression of CRYM mRNA

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

cysteine and glycine-rich protein 1

decreases expression

diethyl maleate results in decreased expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

cysteine and glycine rich protein 3

decreases reduction

diethyl maleate results in decreased reduction of CSRP3 protein

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

C-X-C motif chemokine ligand 10

decreases expression

diethyl maleate results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

diethyl maleate results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

decreases expression

diethyl maleate results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

cytochrome b5 type A

increases expression

diethyl maleate results in increased expression of CYB5A mRNA

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

diethyl maleate results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

D-box binding PAR bZIP transcription factor

decreases expression

diethyl maleate results in decreased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DNA-damage inducible transcript 3

increases expression

diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein

PMID:33545341 PMID:35724838

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

diethyl maleate results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA-damage-inducible transcript 4-like

increases expression

diethyl maleate results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DEXD/H-box helicase 60

decreases expression

diethyl maleate results in decreased expression of DDX60 mRNA

NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526

G

DEXH-box helicase 58

decreases expression

diethyl maleate results in decreased expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

diethyl maleate results in increased expression of DNAJB1 mRNA

PMID:33545341 PMID:34480604

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

diethyl maleate results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

dynamin binding protein

decreases expression

diethyl maleate results in decreased expression of DNMBP mRNA

NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604

G

dihydropyrimidinase-like 2

decreases reduction

diethyl maleate results in decreased reduction of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

deltex E3 ubiquitin ligase 3L

decreases expression

diethyl maleate results in decreased expression of DTX3L mRNA

NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538

G

dihydrouridine synthase 3-like

decreases expression

diethyl maleate results in decreased expression of DUS3L mRNA

NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655

G

dual specificity phosphatase 6

increases expression

diethyl maleate results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

eukaryotic elongation factor-2 kinase

decreases expression

diethyl maleate results in decreased expression of EEF2K mRNA

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

egl-9 family hypoxia-inducible factor 3

increases expression

diethyl maleate results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

diethyl maleate results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

diethyl maleate results in increased expression of ENTPD5 mRNA

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

ES cell expressed Ras

decreases expression

diethyl maleate results in decreased expression of ERAS mRNA

NCBI chr X:14,573,987...14,578,455
Ensembl chr X:14,573,987...14,578,374

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

increases expression

diethyl maleate results in increased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

exonuclease 1

increases expression

diethyl maleate results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

fatty acid binding protein 1

increases expression

diethyl maleate results in increased expression of FABP1 protein

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 7

decreases expression

diethyl maleate results in decreased expression of FABP7 mRNA

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

fumarylacetoacetate hydrolase

affects expression

diethyl maleate affects the expression of FAH mRNA

NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505

G

family with sequence similarity 83, member D

increases expression

diethyl maleate results in increased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

fatty acid synthase

decreases expression

diethyl maleate results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillin 1

decreases expression

diethyl maleate results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fructose-bisphosphatase 1

decreases expression

diethyl maleate results in decreased expression of FBP1 protein

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

fibroblast growth factor 17

decreases expression

diethyl maleate results in decreased expression of FGF17 mRNA

NCBI chr15:45,711,498...45,717,622
Ensembl chr15:45,711,998...45,717,063

G

fibrinogen gamma chain

decreases expression

diethyl maleate results in decreased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

diethyl maleate results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

fibronectin type III domain containing 3B

decreases expression

diethyl maleate results in decreased expression of FNDC3B mRNA

NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

diethyl maleate results in increased expression of FOS mRNA

PMID:10915739 PMID:33545341

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

increases expression

diethyl maleate results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follistatin like 3

increases expression

diethyl maleate results in increased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

diethyl maleate results in decreased expression of G6PC1 mRNA

PMID:25270620 PMID:30261343

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases activity
increases expression

diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA

PMID:3099627 PMID:30261343 PMID:33545341

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GRB2-associated binding protein 1

decreases expression

diethyl maleate results in decreased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

growth arrest and DNA-damage-inducible, alpha

increases expression

diethyl maleate results in increased expression of GADD45A mRNA

PMID:33545341 PMID:34480604

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

increases expression

diethyl maleate results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

glyceraldehyde-3-phosphate dehydrogenase

increases reduction

diethyl maleate results in increased reduction of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glucosylceramidase beta 2

decreases expression

diethyl maleate results in decreased expression of GBA2 mRNA

NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072

G

guanylate binding protein 2

decreases expression

diethyl maleate results in decreased expression of GBP2 mRNA

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

G

glutamate-cysteine ligase, catalytic subunit

increases activity
increases expression

diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein

PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More...

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein

PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 More...

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

diethyl maleate results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

diethyl maleate results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 9

increases expression

diethyl maleate results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

increases expression

diethyl maleate results in increased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

G

glutamate-ammonia ligase

decreases expression

diethyl maleate results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutamic-oxaloacetic transaminase 2

decreases expression

diethyl maleate results in decreased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

decreases expression

diethyl maleate results in decreased expression of GPIHBP1 mRNA

NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702

G

glutathione peroxidase 2

affects expression

diethyl maleate affects the expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

diethyl maleate results in decreased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

gelsolin

decreases reduction

diethyl maleate results in decreased reduction of GSN protein

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

increases expression

diethyl maleate results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

diethyl maleate results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

affects expression

diethyl maleate affects the expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

increases expression

diethyl maleate results in increased expression of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 5

increases expression

diethyl maleate results in increased expression of GSTA5 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase kappa 1

multiple interactions

[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

decreases expression

diethyl maleate results in decreased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase omega 1

increases expression

diethyl maleate results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

increases expression

diethyl maleate results in increased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases expression

diethyl maleate results in increased expression of GSTT1 protein

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

G-2 and S-phase expressed 1

increases expression

diethyl maleate results in increased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

H2A.Z variant histone 2

increases expression

diethyl maleate results in increased expression of H2AZ2 mRNA

NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

increases expression

diethyl maleate results in increased expression of H6PD mRNA

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hepcidin antimicrobial peptide

increases expression

diethyl maleate results in increased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

DNA helicase B

decreases expression

diethyl maleate results in decreased expression of HELB mRNA

NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585

G

hes family bHLH transcription factor 6

decreases expression

diethyl maleate results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

Holliday junction recognition protein

increases expression

diethyl maleate results in increased expression of HJURP mRNA

NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728

G

heme oxygenase 1

increases expression

diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein

PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein H1

decreases reduction

diethyl maleate results in decreased reduction of HNRNPH1 protein

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

hydroxysteroid (17-beta) dehydrogenase 10

increases expression

diethyl maleate results in increased expression of HSD17B10 mRNA

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

hydroxysteroid (17-beta) dehydrogenase 2

decreases expression

diethyl maleate results in decreased expression of HSD17B2 mRNA

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

heat shock protein family A (Hsp70) member 1B

increases expression

diethyl maleate results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

increases expression

diethyl maleate results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 5

decreases reduction

diethyl maleate results in decreased reduction of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

diethyl maleate results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

increases reduction

diethyl maleate results in increased reduction of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

HIV-1 Tat interactive protein 2

increases expression

diethyl maleate results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

hyccin PI4KA lipid kinase complex subunit 2

decreases expression

diethyl maleate results in decreased expression of HYCC2 mRNA

NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

diethyl maleate results in decreased expression of ICAM1 mRNA
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]

PMID:25270620 PMID:35724838

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 3

decreases expression

diethyl maleate results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

inhibitor of DNA binding 4

decreases expression

diethyl maleate results in decreased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

diethyl maleate results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon-related developmental regulator 1

increases expression

diethyl maleate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

decreases expression

diethyl maleate results in decreased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

increases expression

diethyl maleate results in increased expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

increases secretion

diethyl maleate results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

increases expression

diethyl maleate results in increased expression of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

affects expression

diethyl maleate affects the expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 4

multiple interactions

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

inhibin subunit beta B

decreases expression

diethyl maleate results in decreased expression of INHBB mRNA

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

indolethylamine N-methyltransferase

decreases expression

diethyl maleate results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin 2

multiple interactions

diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

integrator complex subunit 7

decreases expression

diethyl maleate results in decreased expression of INTS7 mRNA

NCBI chr13:103,155,123...103,207,953
Ensembl chr13:103,155,090...103,208,592

G

interferon regulatory factor 7

decreases expression

diethyl maleate results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 9

decreases expression

diethyl maleate results in decreased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

immunity-related GTPase M

decreases expression

diethyl maleate results in decreased expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

integrin subunit alpha L

decreases expression

diethyl maleate results in decreased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

diethyl maleate results in decreased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

inter-alpha-trypsin inhibitor heavy chain 4

decreases expression

diethyl maleate results in decreased expression of ITIH4 mRNA

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

junctional adhesion molecule 3

decreases expression

diethyl maleate results in decreased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation
increases expression

pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN mRNA
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]

PMID:10915739 PMID:12774022 PMID:30261343

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily E regulatory subunit 3

decreases expression

diethyl maleate results in decreased expression of KCNE3 mRNA

NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020

G

Kelch-like ECH-associated protein 1

increases expression

diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein

PMID:27358234 PMID:33545341 PMID:34480604

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KH RNA binding domain containing, signal transduction associated 3

increases expression

diethyl maleate results in increased expression of KHDRBS3 mRNA

NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460

G

kinesin family member C1

increases expression

diethyl maleate results in increased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

G

KLF transcription factor 10

decreases expression

diethyl maleate results in decreased expression of KLF10 mRNA

PMID:21161181 PMID:25270620

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

keratin 75

increases reduction

diethyl maleate results in increased reduction of KRT75 protein

NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345

G

laminin subunit alpha 1

decreases expression

diethyl maleate results in decreased expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

LanC like glutathione S-transferase 2

decreases expression

diethyl maleate results in decreased expression of LANCL2 mRNA

NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800

G

low density lipoprotein receptor

decreases expression

diethyl maleate results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin receptor

decreases expression

diethyl maleate results in decreased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3 binding protein

decreases expression

diethyl maleate results in decreased expression of LGALS3BP mRNA

NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256

G

lamin B1

increases expression

diethyl maleate results in increased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LIM domain 7

decreases expression

diethyl maleate results in decreased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

leucine-rich repeats and immunoglobulin-like domains 3

decreases expression

diethyl maleate results in decreased expression of LRIG3 mRNA

NCBI chr 7:61,816,313...61,866,275
Ensembl chr 7:61,816,342...61,866,481

G

leucine rich repeat neuronal 4

increases expression

diethyl maleate results in increased expression of LRRN4 mRNA

NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831

G

leucine-rich repeats and transmembrane domains 2

decreases expression

diethyl maleate results in decreased expression of LRTM2 mRNA

NCBI chr 4:152,485,863...152,508,248
Ensembl chr 4:152,485,866...152,500,377

G

leukotriene C4 synthase

decreases expression

diethyl maleate results in decreased expression of LTC4S mRNA

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

lumican

decreases expression

diethyl maleate results in decreased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

Ly6-C antigen

decreases expression

diethyl maleate results in decreased expression of LY6C mRNA

NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329

G

MAF bZIP transcription factor F

increases expression

diethyl maleate results in increased expression of MAFF mRNA

PMID:20491607 PMID:33545341

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor G

increases expression

diethyl maleate results in increased expression of MAFG mRNA

PMID:33545341 PMID:34480604

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

monoamine oxidase A

increases expression

diethyl maleate results in increased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen-activated protein kinase 1 interacting protein 1-like

increases expression

diethyl maleate results in increased expression of MAPK1IP1L mRNA

NCBI chr15:20,545,043...20,571,466
Ensembl chr15:20,545,059...20,569,674

G

mitogen-activated protein kinase 8

increases expression
multiple interactions

diethyl maleate results in increased expression of MAPK8 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MARVEL domain containing 1

decreases expression

diethyl maleate results in decreased expression of MARVELD1 mRNA

NCBI chr 1:240,954,050...240,958,101
Ensembl chr 1:240,954,452...240,958,384

G

membrane bound O-acyltransferase domain containing 7

increases expression

diethyl maleate results in increased expression of MBOAT7 mRNA

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

G

minichromosome maintenance 10 replication initiation factor

increases expression

diethyl maleate results in increased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 4

increases expression

diethyl maleate results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

malic enzyme 1

increases expression

diethyl maleate results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

microfibril associated protein 4

decreases expression

diethyl maleate results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

O-6-methylguanine-DNA methyltransferase

decreases activity

diethyl maleate results in decreased activity of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

increases expression

diethyl maleate results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

decreases expression

diethyl maleate results in decreased expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

matrix metallopeptidase 1

increases expression

diethyl maleate results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 12

increases expression

diethyl maleate results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 2

decreases expression

diethyl maleate results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

increases expression

diethyl maleate results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myelin protein zero-like 1

decreases expression

diethyl maleate results in decreased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

moesin

increases reduction

diethyl maleate results in increased reduction of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

metallothionein 1

increases expression

diethyl maleate results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

increases expression

diethyl maleate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MX dynamin like GTPase 1

decreases expression

diethyl maleate results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MX dynamin like GTPase 2

decreases expression

diethyl maleate results in decreased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYB proto-oncogene like 2

increases expression

diethyl maleate results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYCN proto-oncogene, bHLH transcription factor

decreases expression

diethyl maleate results in decreased expression of MYCN mRNA

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

N-acetyltransferase 8

decreases expression

diethyl maleate results in decreased expression of NAT8 mRNA

NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763

G

non-SMC condensin I complex, subunit H

increases expression

diethyl maleate results in increased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

N-myc downstream regulated 1

increases expression

diethyl maleate results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions
decreases response to substance
increases expression
increases activity

diethyl maleate affects the localization of NFE2L2 protein
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
NFE2L2 results in decreased susceptibility to diethyl maleate
diethyl maleate results in increased expression of NFE2L2 protein
[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
diethyl maleate results in increased activity of NFE2L2 protein

PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]

PMID:12774022 PMID:35724838

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NHERF family PDZ scaffold protein 1

decreases expression

diethyl maleate results in decreased expression of NHERF1 mRNA

NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598

G

nitric oxide synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]

PMID:7532384 PMID:9918918 PMID:12774022

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

increases expression

diethyl maleate results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NAD(P)H quinone dehydrogenase 1

increases expression

diethyl maleate results in increased expression of NQO1 mRNA

PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

diethyl maleate results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

decreases expression

diethyl maleate results in decreased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

neuronal regeneration related protein

decreases expression

diethyl maleate results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

NMDA receptor synaptonuclear signaling and neuronal migration factor

decreases expression

diethyl maleate results in decreased expression of NSMF mRNA

NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614

G

neurotrophin 3

decreases expression

diethyl maleate results in decreased expression of NTF3 mRNA

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

nucleoporin 153

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein

NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876

G

nucleoporin 88

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein

NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257

G

out at first homolog

decreases expression

diethyl maleate results in decreased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

2 ' -5 ' oligoadenylate synthetase 1I

decreases expression

diethyl maleate results in decreased expression of OAS1I mRNA

NCBI chr12:35,624,566...35,636,608
Ensembl chr12:35,624,592...35,636,604

G

8-oxoguanine DNA glycosylase

multiple interactions

[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

origin recognition complex, subunit 1

increases expression

diethyl maleate results in increased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

oxidative stress induced growth inhibitor 1

increases expression

diethyl maleate results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

purinergic receptor P2X 7

decreases expression

diethyl maleate results in decreased expression of P2RX7 mRNA

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

poly (ADP-ribose) polymerase 1

increases cleavage

diethyl maleate results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phenazine biosynthesis-like protein domain containing 1

decreases expression

diethyl maleate results in decreased expression of PBLD protein

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614

G

proliferating cell nuclear antigen

decreases expression

diethyl maleate results in decreased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

PDZ and LIM domain 2

decreases expression

diethyl maleate results in decreased expression of PDLIM2 mRNA

NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242

G

p53 and DNA damage regulated 1

increases expression

diethyl maleate results in increased expression of PDRG1 mRNA

NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858
Ensembl chr 3:141,476,501...141,483,858

G

period circadian regulator 2

decreases expression

diethyl maleate results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

period circadian regulator 3

decreases expression

diethyl maleate results in decreased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

phosphogluconate dehydrogenase

increases activity

diethyl maleate results in increased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

progesterone receptor membrane component 1

increases expression

diethyl maleate results in increased expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

pirin

increases expression

diethyl maleate results in increased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

pyruvate kinase L/R

decreases expression

diethyl maleate results in decreased expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

plasminogen activator, tissue type

increases expression
decreases expression

diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA

PMID:21161181 PMID:25270620

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

pleckstrin

decreases expression

diethyl maleate results in decreased expression of PLEK mRNA

NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131

G

pleckstrin homology and RUN domain containing M1

increases expression

diethyl maleate results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412

G

perilipin 2

increases expression

diethyl maleate results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

polo-like kinase 1

increases expression

diethyl maleate results in increased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 3

increases expression

diethyl maleate results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

POU class 5 homeobox 1

increases expression

diethyl maleate results in increased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases activity

diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 beta

decreases expression

diethyl maleate results in decreased expression of PPARGC1B mRNA

NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

diethyl maleate results in decreased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

diethyl maleate results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

PR/SET domain 14

decreases expression

diethyl maleate results in decreased expression of PRDM14 mRNA

NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712

G

peroxiredoxin 1

increases expression

diethyl maleate results in increased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

protein kinase AMP-activated non-catalytic subunit beta 1

decreases expression

diethyl maleate results in decreased expression of PRKAB1 mRNA

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

protein kinase AMP-activated non-catalytic subunit gamma 2

increases expression

diethyl maleate results in increased expression of PRKAG2 mRNA

NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142

G

protein kinase C, beta

affects expression

diethyl maleate affects the expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

multiple interactions

Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, epsilon

multiple interactions

Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

serine protease 8

decreases expression

diethyl maleate results in decreased expression of PRSS8 mRNA

NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815

G

prostaglandin reductase 1

increases expression

diethyl maleate results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

protein tyrosine phosphatase, non-receptor type 14

increases expression

diethyl maleate results in increased expression of PTPN14 mRNA

NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088

G

pseudouridine synthase 1

decreases expression

diethyl maleate results in decreased expression of PUS1 mRNA

NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196

G

paxillin

increases expression

diethyl maleate results in increased expression of PXN mRNA

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

RAB27A, member RAS oncogene family

decreases expression

diethyl maleate results in decreased expression of RAB27A mRNA

NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]

PMID:20116392 PMID:35724838

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

rhodopsin

increases expression

diethyl maleate results in increased expression of RHO mRNA

NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773

G

ring finger protein 114

decreases expression

diethyl maleate results in decreased expression of RNF114 mRNA

NCBI chr 3:156,222,487...156,234,263
Ensembl chr 3:156,222,498...156,234,256

G

ring finger protein 14

increases expression

diethyl maleate results in increased expression of RNF14 mRNA

NCBI chr18:30,131,627...30,155,686
Ensembl chr18:30,131,691...30,155,685

G

ribonucleotide reductase regulatory subunit M2

increases expression

diethyl maleate results in increased expression of RRM2 mRNA

PMID:21161181 PMID:33545341

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

decreases expression

diethyl maleate results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class Ib, locus S3

decreases expression

diethyl maleate results in decreased expression of RT1-S3 mRNA

NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411

G

S100 calcium binding protein A9

decreases expression

diethyl maleate results in decreased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

SAM and SH3 domain containing 3

decreases expression

diethyl maleate results in decreased expression of SASH3 mRNA

NCBI chr X:127,326,815...127,341,521
Ensembl chr X:127,326,859...127,341,519

G

scavenger receptor class B, member 1

decreases expression

diethyl maleate results in decreased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

stearoyl-CoA desaturase

decreases expression

diethyl maleate results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serine dehydratase

decreases expression

diethyl maleate results in decreased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203

G

selenoprotein P

decreases expression

diethyl maleate results in decreased expression of SELENOP mRNA

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

serpin family D member 1

decreases expression

diethyl maleate results in decreased expression of SERPIND1 mRNA

NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519

G

SERTA domain containing 1

increases expression

diethyl maleate results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

seizure related 6 homolog

decreases expression

diethyl maleate results in decreased expression of SEZ6 mRNA

NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671

G

sideroflexin 1

decreases expression

diethyl maleate results in decreased expression of SFXN1 mRNA

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

SH3-domain binding protein 5

increases expression
affects expression

diethyl maleate results in increased expression of SH3BP5 mRNA
diethyl maleate affects the expression of SH3BP5 mRNA

PMID:33545341 PMID:34480604

NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975

G

SIX homeobox 4

increases expression

diethyl maleate results in increased expression of SIX4 mRNA

NCBI chr 6:91,802,328...91,816,002
Ensembl chr 6:91,802,329...91,815,992

G

solute carrier family 16, member 6

decreases expression

diethyl maleate results in decreased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

increases expression

diethyl maleate results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 2 member 2

decreases expression

diethyl maleate results in decreased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 5

decreases expression

diethyl maleate results in decreased expression of SLC2A5 mRNA

NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 39 member 14

decreases expression

diethyl maleate results in decreased expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 3 member 2

increases expression

diethyl maleate results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 40 member 1

multiple interactions

diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 44, member 4

decreases expression

diethyl maleate results in decreased expression of SLC44A4 mRNA

NCBI chr20:3,903,099...3,919,215
Ensembl chr20:3,903,099...3,919,215

G

solute carrier family 7 member 11

multiple interactions
increases expression

NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]

PMID:12235164 PMID:33545341

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier organic anion transporter family, member 2a1

decreases expression

diethyl maleate results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

schlafen family member 3

decreases expression

diethyl maleate results in decreased expression of SLFN3 mRNA

NCBI chr10:68,020,482...68,060,248

G

structural maintenance of chromosomes 4

increases expression

diethyl maleate results in increased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

sphingomyelin phosphodiesterase 1

increases expression
increases activity
multiple interactions

diethyl maleate results in increased expression of SMPD1 mRNA
diethyl maleate results in increased activity of SMPD1 protein
Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

smoothelin

increases expression

diethyl maleate results in increased expression of SMTN mRNA

NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886

G

suppressor of cytokine signaling 3

decreases expression

diethyl maleate results in decreased expression of SOCS3 mRNA

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 2

multiple interactions

diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sortilin related receptor 1

decreases expression

diethyl maleate results in decreased expression of SORL1 mRNA

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

SRY-box transcription factor 9

increases expression

diethyl maleate results in increased expression of SOX9 mRNA

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

Sp5 transcription factor

decreases expression

diethyl maleate results in decreased expression of SP5 mRNA

NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733

G

SPC25 component of NDC80 kinetochore complex

increases expression

diethyl maleate results in increased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

spectrin, alpha, erythrocytic 1

increases expression

diethyl maleate results in increased expression of SPTA1 mRNA

NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371

G

spectrin, alpha, non-erythrocytic 1

increases cleavage

diethyl maleate results in increased cleavage of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

spectrin, beta, non-erythrocytic 4

increases expression

diethyl maleate results in increased expression of SPTBN4 mRNA

NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228

G

serine palmitoyltransferase, long chain base subunit 1

increases expression

diethyl maleate results in increased expression of SPTLC1 mRNA

NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295

G

sequestosome 1

increases expression

diethyl maleate results in increased expression of SQSTM1 mRNA

PMID:25270620 PMID:33545341 PMID:34480604

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

decreases expression

diethyl maleate results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sulfiredoxin 1

multiple interactions
increases expression
decreases expression

[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in decreased expression of SRXN1 mRNA

PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 More...

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

signal transducer and activator of transcription 1

decreases expression

diethyl maleate results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

STEAP4 metalloreductase

decreases expression

diethyl maleate results in decreased expression of STEAP4 mRNA

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

G

sulfatase 2

decreases expression

diethyl maleate results in decreased expression of SULF2 mRNA

NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415

G

sulfotransferase family 1A member 1

decreases expression

diethyl maleate results in decreased expression of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

transgelin

decreases expression

diethyl maleate results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TatD DNase domain containing 2

increases expression

diethyl maleate results in increased expression of TATDN2 mRNA

NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897

G

tubulin folding cofactor E-like

increases expression

diethyl maleate results in increased expression of TBCEL mRNA

NCBI chr 8:42,795,648...42,854,552
Ensembl chr 8:42,796,730...42,854,552

G

terminal nucleotidyltransferase 4A

increases expression

diethyl maleate results in increased expression of TENT4A mRNA

NCBI chr 1:33,765,949...33,799,405
Ensembl chr 1:33,765,672...33,799,433

G

terminal nucleotidyltransferase 5A

decreases expression

diethyl maleate results in decreased expression of TENT5A mRNA

NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045

G

testis expressed metallothionein like protein

affects localization

diethyl maleate affects the localization of TESMIN protein

NCBI chr 1:200,629,688...200,648,434
Ensembl chr 1:200,630,144...200,648,433

G

transferrin

decreases expression

diethyl maleate results in decreased expression of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor EB

decreases expression

diethyl maleate results in decreased expression of TFEB mRNA

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

transglutaminase 2

increases expression

diethyl maleate results in increased expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thrombospondin 1

increases expression

diethyl maleate results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone responsive

decreases expression

diethyl maleate results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

transmembrane 4 L six family member 1

increases expression

diethyl maleate results in increased expression of TM4SF1 mRNA

NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146

G

transmembrane protein 209

increases expression

diethyl maleate results in increased expression of TMEM209 mRNA

NCBI chr 4:59,102,943...59,128,636
Ensembl chr 4:59,101,550...59,128,630

G

tumor necrosis factor

multiple interactions

[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]

PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 14

decreases expression

diethyl maleate results in decreased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

tumor protein p53

multiple interactions

TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]

PMID:22003191 PMID:27982581

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 2

decreases expression

diethyl maleate results in decreased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

TNF receptor-associated protein 1

multiple interactions
decreases response to substance

diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate

NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981

G

tRNA aspartic acid methyltransferase 1

decreases expression

diethyl maleate results in decreased expression of TRDMT1 mRNA

NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439

G

tribbles pseudokinase 1

increases expression

diethyl maleate results in increased expression of TRIB1 mRNA

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tribbles pseudokinase 3

increases expression

diethyl maleate results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif containing 6

decreases expression

diethyl maleate results in decreased expression of TRIM6 mRNA

NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914

G

thyroid hormone receptor interactor 13

increases expression

diethyl maleate results in increased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

TSC22 domain family, member 1

decreases expression

diethyl maleate results in decreased expression of TSC22D1 mRNA

NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958

G

tetraspanin 8

decreases expression

diethyl maleate results in decreased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

thiosulfate sulfurtransferase like domain containing 1

decreases expression

diethyl maleate results in decreased expression of TSTD1 mRNA

NCBI chr13:83,853,421...83,854,875
Ensembl chr13:83,822,035...83,854,885

G

thioredoxin 1

decreases activity

diethyl maleate results in decreased activity of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

increases expression

diethyl maleate results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

increases expression

diethyl maleate results in increased expression of TXNRD1 mRNA

PMID:15521073 PMID:33545341 PMID:34480604

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin D

decreases expression

diethyl maleate results in decreased expression of UBD mRNA

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

ubiquitin-like with PHD and ring finger domains 1

increases expression

diethyl maleate results in increased expression of UHRF1 mRNA

NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631

G

ubiquitin specific peptidase 18

decreases expression

diethyl maleate results in decreased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 2

decreases expression

diethyl maleate results in decreased expression of USP2 mRNA

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

vascular endothelial growth factor A

increases expression

diethyl maleate results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

WD repeat domain 31

decreases expression

diethyl maleate results in decreased expression of WDR31 mRNA

NCBI chr 5:75,897,074...75,917,461
Ensembl chr 5:75,898,353...75,917,417

G

WD repeat domain 6

decreases expression

diethyl maleate results in decreased expression of WDR6 mRNA

NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499

G

yippee-like 5

increases expression

diethyl maleate results in increased expression of YPEL5 mRNA

NCBI chr 6:22,656,284...22,671,741
Ensembl chr 6:22,656,285...22,671,691

G

zinc finger AN1-type containing 2A

increases expression

diethyl maleate results in increased expression of ZFAND2A mRNA

PMID:33545341 PMID:34480604

NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677

G

zinc finger protein 36

increases expression

diethyl maleate results in increased expression of ZFP36 protein

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 367

increases expression

diethyl maleate results in increased expression of ZNF367 mRNA

NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287

G

zinc finger protein 37

decreases expression

diethyl maleate results in decreased expression of ZFP37 mRNA

NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942

G

zinc ribbon domain containing 2

decreases expression

diethyl maleate results in decreased expression of ZNRD2 mRNA

NCBI chr 1:203,017,682...203,019,465
Ensembl chr 1:203,017,682...203,019,465

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
role	19784
biological role	19782
glutathione depleting agent	402
diethyl maleate	402
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
heteroorganic entity	19460
organochalcogen compound	19224
organooxygen compound	19141
carbonyl compound	18869
dicarboxylic acids and O-substituted derivatives	11070
dicarboxylic acid	11064
C4-dicarboxylic acid	1322
butenedioic acid	620
maleic acid	586
maleate ester	402
diethyl maleate	402

paths to the root