CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | C4-dicarboxylic acid |
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Accession: | CHEBI:66873
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browse the term
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Definition: | Any dicarboxylic acid that contains four carbon atoms. |
Synonyms: | related_synonym: | C4-dicarboxylic acids |
| cyclic_relationship: | is_conjugate_acid_of CHEBI:61336 |
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Folh1 |
folate hydrolase 1 |
affects binding multiple interactions |
ISO |
isospaglumic acid binds to FOLH1 protein [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] |
CTD |
PMID:24508213 |
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NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:30551460 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
artesunate affects the localization of AIFM1 protein |
CTD |
PMID:24704559 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ar |
androgen receptor |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atg12 |
autophagy related 12 |
increases expression |
ISO |
Artesunate results in increased expression of ATG12 mRNA |
CTD |
PMID:30551460 |
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NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg3 |
autophagy related 3 |
increases expression |
ISO |
Artesunate results in increased expression of ATG3 mRNA |
CTD |
PMID:30551460 |
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NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
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Atg5 |
autophagy related 5 |
increases expression |
ISO |
Artesunate results in increased expression of ATG5 mRNA |
CTD |
PMID:30551460 |
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NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Artesunate results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein] [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr13:22,689,783...22,853,920
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Bst1 |
bone marrow stromal cell antigen 1 |
increases response to substance |
ISO |
BST1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions |
ISO |
artesunate results in increased activity of CASP3 protein Artesunate results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein] |
CTD |
PMID:19513562 PMID:24704559 PMID:33002460 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
affects expression |
ISO |
artesunate affects the expression of CASP9 protein |
CTD |
PMID:24704559 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
increases expression decreases response to substance |
ISO |
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate |
CTD |
PMID:19513562 PMID:20144594 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cct2 |
chaperonin containing TCP1 subunit 2 |
decreases response to substance |
ISO |
CCT2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] |
CTD |
PMID:31664825 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:31664825 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
increases response to substance |
ISO |
CLIP4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
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Coq8a |
coenzyme Q8A |
decreases response to substance |
ISO |
COQ8A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] |
CTD |
PMID:29031619 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Dbh |
dopamine beta-hydroxylase |
increases response to substance |
ISO |
DBH mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Des |
desmin |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein |
CTD |
PMID:30551460 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fas |
Fas cell surface death receptor |
increases expression |
ISO |
artesunate results in increased expression of FAS protein |
CTD |
PMID:19513562 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Flna |
filamin A |
increases response to substance |
ISO |
FLNA mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein |
CTD |
PMID:30551460 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fth1 |
ferritin heavy chain 1 |
decreases expression multiple interactions |
ISO |
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA] |
CTD |
PMID:30551460 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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Fzd7 |
frizzled class receptor 7 |
increases response to substance |
ISO |
FZD7 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects response to substance decreases response to substance |
ISO |
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm |
glutamate cysteine ligase, modifier subunit |
decreases response to substance |
ISO |
GCLM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gpx4 |
glutathione peroxidase 4 |
decreases activity multiple interactions |
ISO |
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] |
CTD |
PMID:30551460 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Gstm4 |
glutathione S-transferase mu 4 |
affects response to substance |
ISO |
GSTM4 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
artesunate results in decreased expression of GSTP1 protein |
CTD |
PMID:19513562 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Gstt2 |
glutathione S-transferase, theta 2 |
affects response to substance |
ISO |
GSTT2 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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Gstz1 |
glutathione S-transferase zeta 1 |
affects response to substance |
ISO |
GSTZ1 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] |
CTD |
PMID:31664825 |
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NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6 |
interleukin 6 |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb1 |
integrin subunit beta 1 |
increases response to substance |
ISO |
ITGB1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases lipidation |
ISO |
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:33002460 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mgst3 |
microsomal glutathione S-transferase 3 |
affects response to substance |
ISO |
MGST3 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP ISO |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA] |
CTD |
PMID:29031619 PMID:30551460 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo |
myeloperoxidase |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:27474069 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
decreases response to substance |
ISO |
MTHFD2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:33002460 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] |
CTD |
PMID:30031708 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Naca |
nascent polypeptide associated complex subunit alpha |
decreases response to substance |
ISO |
NACA mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
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Nckap1 |
NCK-associated protein 1 |
increases response to substance |
ISO |
NCKAP1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
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Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein |
CTD |
PMID:30551460 |
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NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
artesunate affects the localization of NFE2L2 protein |
CTD |
PMID:26340163 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] |
CTD |
PMID:30031708 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
Artesunate results in increased cleavage of PARP1 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] |
CTD |
PMID:24704559 PMID:33002460 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] |
CTD |
PMID:29031619 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pgr |
progesterone receptor |
multiple interactions |
ISO |
artesunate binds to and results in increased activity of PGR protein |
CTD |
PMID:25752796 |
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NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein |
CTD |
PMID:30551460 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rpa2 |
replication protein A2 |
increases phosphorylation |
ISO |
Artesunate results in increased phosphorylation of RPA2 protein |
CTD |
PMID:31664825 |
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NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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Rpl41 |
ribosomal protein L41 |
decreases response to substance |
ISO |
RPL41 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:977,885...978,965
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Rpl6 |
ribosomal protein L6 |
decreases response to substance |
ISO |
RPL6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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Rpl7 |
ribosomal protein L7 |
decreases response to substance |
ISO |
RPL7 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 5:3,217,184...3,220,192
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G |
Rps12 |
ribosomal protein S12 |
decreases response to substance |
ISO |
RPS12 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
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G |
Rps15a |
ribosomal protein S15a |
decreases response to substance |
ISO |
RPS15A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
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G |
Rps6 |
ribosomal protein S6 |
decreases response to substance |
ISO |
RPS6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Slc25a19 |
solute carrier family 25 member 19 |
decreases response to substance |
ISO |
SLC25A19 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
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G |
Sp1 |
Sp1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of SP1 protein |
CTD |
PMID:19513562 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein |
CTD |
PMID:30551460 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases response to substance |
ISO |
SRSF2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] |
CTD |
PMID:30551460 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] |
CTD |
PMID:30031708 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TP53 protein Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:33259807 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects response to substance multiple interactions |
ISO |
TPT1 protein affects the susceptibility to artesunate Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:15878303 PMID:33259807 |
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NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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G |
Tufm |
Tu translation elongation factor, mitochondrial |
decreases response to substance |
ISO |
TUFM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Artesunate results in increased phosphorylation of ULK1 protein acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein] |
CTD |
PMID:33002460 |
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NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] |
CTD |
PMID:29031619 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Yy1 |
YY1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of YY1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
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G |
Zbtb4 |
zinc finger and BTB domain containing 4 |
increases response to substance |
ISO |
ZBTB4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcd1 |
ATP binding cassette subfamily D member 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
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G |
Abcd2 |
ATP binding cassette subfamily D member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
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G |
Acaa1b |
acetyl-Coenzyme A acyltransferase 1B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA |
CTD |
PMID:23783067 |
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NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO EXP |
Aspartame metabolite results in decreased activity of ACHE protein |
CTD |
PMID:16129618 PMID:17580119 PMID:17673349 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Aco1 |
aconitase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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G |
Acot1 |
acyl-CoA thioesterase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Agt |
angiotensinogen |
decreases expression |
ISO |
Aspartame results in decreased expression of AGT mRNA |
CTD |
PMID:31655124 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
ISO |
Aspartame results in decreased expression of AGTR1 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of AKT1 protein |
CTD |
PMID:33992720 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alox15 |
arachidonate 15-lipoxygenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Apoe |
apolipoprotein E |
decreases expression |
ISO |
Aspartame results in decreased expression of APOE mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein Aspartame results in increased expression of BAX mRNA [Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA |
CTD |
PMID:23783067 PMID:25009784 PMID:32951320 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein Aspartame results in decreased expression of BCL2 mRNA |
CTD |
PMID:25009784 PMID:32951320 |
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NCBI chr13:22,689,783...22,853,920
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G |
Cabp2 |
calcium binding protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469
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G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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G |
Cacna1i |
calcium voltage-gated channel subunit alpha1 I |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
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G |
Cacna2d4 |
calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:152,408,657...152,524,614
Ensembl chr 4:152,408,657...152,521,268
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G |
Cacnb2 |
calcium voltage-gated channel auxiliary subunit beta 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
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G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:92,686,100...92,745,601
Ensembl chr10:92,683,761...92,746,126
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G |
Cacng8 |
calcium voltage-gated channel auxiliary subunit gamma 8 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089
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G |
Calhm2 |
calcium homeostasis modulator family member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218
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G |
Calr3 |
calreticulin 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
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G |
Cant1 |
calcium activated nucleotidase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form Aspartame results in increased expression of CASP3 mRNA |
CTD |
PMID:25009784 PMID:32951320 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein Aspartame results in decreased activity of CAT protein |
CTD |
PMID:25009784 PMID:32951320 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] |
CTD |
PMID:23783067 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cdh1 |
cadherin 1 |
decreases expression |
ISO |
Aspartame results in decreased expression of CDH1 protein |
CTD |
PMID:33992720 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
affects localization multiple interactions |
ISO |
Aspartame affects the localization of CDKN1A protein TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein] |
CTD |
PMID:33992720 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions decreases expression |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA Aspartame results in decreased expression of CDKN1B protein |
CTD |
PMID:23783067 PMID:33992720 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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|
G |
Cherp |
calcium homeostasis endoplasmic reticulum protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA |
CTD |
PMID:23783067 |
|
NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507
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G |
Cmc1 |
C-x(9)-C motif containing 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:117,798,945...117,900,462
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G |
Cox11 |
cytochrome c oxidase copper chaperone COX11 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
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G |
Cox7a1 |
cytochrome c oxidase subunit 7A1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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|
G |
Cpt1c |
carnitine palmitoyltransferase 1c |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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|
G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity |
EXP |
Aspartame results in increased activity of CYP1A1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity |
EXP |
Aspartame results in increased activity of CYP1A2 protein |
CTD |
PMID:16937917 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
Aspartame results in increased expression of and results in increased activity of CYP2B1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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|
G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases activity |
EXP |
Aspartame results in increased activity of CYP2B2 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
Aspartame results in increased expression of and results in increased activity of CYP2E1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity |
EXP |
Aspartame results in increased activity of CYP3A62 protein |
CTD |
PMID:16937917 |
|
NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833
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|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA |
CTD |
PMID:23783067 |
|
NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
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|
G |
Dnajc27 |
DnaJ heat shock protein family (Hsp40) member C27 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:27,068,686...27,098,449
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|
G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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|
G |
Edn2 |
endothelin 2 |
decreases expression |
ISO |
Aspartame results in decreased expression of EDN2 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
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G |
Ednra |
endothelin receptor type A |
decreases expression |
ISO |
Aspartame results in decreased expression of EDNRA mRNA |
CTD |
PMID:31655124 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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|
G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA |
CTD |
PMID:23783067 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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|
G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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|
G |
F2 |
coagulation factor II |
decreases activity |
ISO |
Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein |
CTD |
PMID:15572260 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
ISO |
Aspartame results in increased expression of FGF1 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
ISO |
Aspartame results in decreased expression of FSHB protein |
CTD |
PMID:32951320 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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|
G |
Gfm2 |
GTP dependent ribosome recycling factor mitochondrial 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197
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G |
Gip |
gastric inhibitory polypeptide |
multiple interactions |
ISO |
Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] |
CTD |
PMID:23783067 |
|
NCBI chr10:80,968,410...80,976,506
Ensembl chr10:80,968,352...80,976,503
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G |
Gli1 |
GLI family zinc finger 1 |
affects localization multiple interactions |
ISO |
Aspartame affects the localization of GLI1 protein TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein] |
CTD |
PMID:33992720 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
decreases expression |
ISO |
Aspartame results in decreased expression of GLI2 protein |
CTD |
PMID:33992720 |
|
NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of GSK3B protein |
CTD |
PMID:33992720 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
[Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein |
CTD |
PMID:25009784 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac5 |
histone deacetylase 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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|
G |
Hgf |
hepatocyte growth factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hras |
HRas proto-oncogene, GTPase |
increases expression |
ISO |
Aspartame results in increased expression of HRAS |
CTD |
PMID:17354619 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hspg2 |
heparan sulfate proteoglycan 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
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|
G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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|
G |
Il11 |
interleukin 11 |
decreases expression |
ISO |
Aspartame results in decreased expression of IL11 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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|
G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
Aspartame results in increased expression of IL1B mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il3 |
interleukin 3 |
decreases expression |
ISO |
Aspartame results in decreased expression of IL3 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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|
G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
Aspartame results in increased secretion of IL6 protein |
CTD |
PMID:20837131 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Immt |
inner membrane mitochondrial protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
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|
G |
Ins2 |
insulin 2 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of INS protein [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein] |
CTD |
PMID:1805284 PMID:23783067 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Kdr |
kinase insert domain receptor |
increases secretion |
ISO |
Aspartame results in increased secretion of KDR protein |
CTD |
PMID:20837131 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Lep |
leptin |
decreases expression multiple interactions |
EXP ISO |
Aspartame results in decreased expression of LEP protein [Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein] |
CTD |
PMID:11890951 PMID:23783067 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Aspartame results in decreased expression of LHB protein |
CTD |
PMID:32951320 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lipg |
lipase G, endothelial type |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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G |
Lrp1 |
LDL receptor related protein 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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G |
Lrp2 |
LDL receptor related protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
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G |
Lrp4 |
LDL receptor related protein 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20837131 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:20837131 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mcu |
mitochondrial calcium uniporter |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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|
G |
Med23 |
mediator complex subunit 23 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
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G |
Mef2d |
myocyte enhancer factor 2D |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
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G |
Micos10 |
mitochondrial contact site and cristae organizing system subunit 10 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485
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G |
Micu1 |
mitochondrial calcium uptake 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964
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G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492
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|
G |
Mrpl3 |
mitochondrial ribosomal protein L3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544
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G |
Mrps12 |
mitochondrial ribosomal protein S12 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:84,025,896...84,028,896
Ensembl chr 1:84,025,899...84,028,780
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|
G |
Mrps24 |
mitochondrial ribosomal protein S24 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871
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|
G |
Mrps27 |
mitochondrial ribosomal protein S27 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577
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|
G |
Mrps7 |
mitochondrial ribosomal protein S7 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129
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G |
Mtfp1 |
mitochondrial fission process 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Aspartame results in increased expression of MYC Aspartame results in increased expression of MYC protein |
CTD |
PMID:17354619 PMID:33992720 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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|
G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
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|
G |
Ndufa12 |
NADH:ubiquinone oxidoreductase subunit A12 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
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|
G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
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G |
Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
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G |
Ndufb2 |
NADH:ubiquinone oxidoreductase subunit B2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851 Ensembl chr 4:46,536,062...46,536,851
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G |
Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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G |
Ndufs1 |
NADH:ubiquinone oxidoreductase core subunit S1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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G |
Ndufs6 |
NADH:ubiquinone oxidoreductase subunit S6 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:27,201,713...27,202,126
Ensembl chr 2:27,201,713...27,202,258
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G |
Ndufv1 |
NADH:ubiquinone oxidoreductase core subunit V1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
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G |
Nf1 |
neurofibromin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
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G |
Notch1 |
notch receptor 1 |
multiple interactions affects localization |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA Aspartame affects the localization of NOTCH1 protein modified form TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form] |
CTD |
PMID:23783067 PMID:33992720 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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G |
Nppb |
natriuretic peptide B |
decreases expression |
ISO |
Aspartame results in decreased expression of NPPB mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Aspartame results in decreased expression of NPY protein |
CTD |
PMID:11890951 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Onecut1 |
one cut homeobox 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
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G |
Pdha2 |
pyruvate dehydrogenase E1 subunit alpha 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:229,872,300...229,873,848
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G |
Pdhb |
pyruvate dehydrogenase E1 subunit beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
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G |
Pex1 |
peroxisomal biogenesis factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:30,519,955...30,558,921
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G |
Pex11a |
peroxisomal biogenesis factor 11 alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
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G |
Pex13 |
peroxisomal biogenesis factor 13 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262
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G |
Pex5 |
peroxisomal biogenesis factor 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431
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G |
Pex7 |
peroxisomal biogenesis factor 7 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748
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G |
Pfkfb2 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
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G |
Pfkfb4 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
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G |
Pld2 |
phospholipase D2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Plg |
plasminogen |
decreases expression |
ISO |
Aspartame results in decreased expression of PLG mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
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G |
Plxnd1 |
plexin D1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:149,002,784...149,043,097
Ensembl chr 4:149,002,784...149,043,244
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G |
Polg |
DNA polymerase gamma, catalytic subunit |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
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G |
Pomc |
proopiomelanocortin |
increases expression |
ISO |
Aspartame results in increased expression of POMC protein alternative form |
CTD |
PMID:1805284 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pou5f1 |
POU class 5 homeobox 1 |
affects localization |
ISO |
Aspartame affects the localization of POU5F1 protein |
CTD |
PMID:33992720 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prdx5 |
peroxiredoxin 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
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G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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G |
S100a13 |
S100 calcium binding protein A13 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:175,999,439...176,005,933
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G |
S100a8 |
S100 calcium binding protein A8 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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G |
Sirt2 |
sirtuin 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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G |
Slc15a1 |
solute carrier family 15 member 1 |
decreases activity |
ISO |
Aspartame results in decreased activity of SLC15A1 protein |
CTD |
PMID:15846457 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
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G |
Slc4a2 |
solute carrier family 4 member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
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G |
Slc8a1 |
solute carrier family 8 member A1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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G |
Sox2 |
SRY-box transcription factor 2 |
affects localization |
ISO |
Aspartame affects the localization of SOX2 protein |
CTD |
PMID:33992720 |
|
NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Surf1 |
SURF1, cytochrome c oxidase assembly factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315
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G |
Tas1r1 |
taste 1 receptor member 1 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of TAS1R1 protein Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form] |
CTD |
PMID:33992720 |
|
NCBI chr 5:162,533,838...162,546,408
Ensembl chr 5:162,533,841...162,545,562
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G |
Tas1r2 |
taste 1 receptor member 2 |
multiple interactions affects binding |
ISO |
Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]] Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein |
CTD |
PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720 |
|
NCBI chr 5:151,909,648...151,925,345
Ensembl chr 5:151,830,701...151,925,345
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G |
Tas1r3 |
taste 1 receptor member 3 |
affects binding decreases expression multiple interactions |
ISO |
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein] Aspartame results in decreased expression of TAS1R3 protein Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]] |
CTD |
PMID:17168764 PMID:17935609 PMID:33992720 |
|
NCBI chr 5:166,469,589...166,472,742
Ensembl chr 5:166,469,589...166,472,742
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G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Thbs1 |
thrombospondin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] |
CTD |
PMID:23783067 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA [Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA |
CTD |
PMID:17354619 PMID:23783067 PMID:32951320 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases activity |
ISO |
Aspartame results in increased activity of TRPV1 protein |
CTD |
PMID:17567713 PMID:18804451 |
|
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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|
G |
Tufm |
Tu translation elongation factor, mitochondrial |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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|
G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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|
G |
Uqcr11 |
ubiquinol-cytochrome c reductase, complex III subunit XI |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA |
CTD |
PMID:23783067 |
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NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
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G |
Vegfa |
vascular endothelial growth factor A |
increases secretion |
ISO |
Aspartame results in increased secretion of VEGFA protein |
CTD |
PMID:20837131 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
increases expression |
ISO |
Aspartame results in increased expression of VIM protein |
CTD |
PMID:33992720 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA |
CTD |
PMID:23783067 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Bach1 |
BTB domain and CNC homolog 1 |
affects localization |
ISO |
citraconic acid affects the localization of BACH1 protein |
CTD |
PMID:27277809 |
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NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
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G |
Foxm1 |
forkhead box M1 |
increases expression |
ISO |
citraconic acid results in increased expression of FOXM1 protein |
CTD |
PMID:28289076 |
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NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
citraconic acid results in increased expression of FTH1 protein |
CTD |
PMID:28289076 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions increases expression |
ISO |
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein] |
CTD |
PMID:28289076 |
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NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
EXP ISO |
citraconic acid results in increased expression of GCLC protein citraconic acid results in increased expression of GCLC mRNA |
CTD |
PMID:27277809 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
EXP ISO |
citraconic acid results in increased expression of GCLM protein citraconic acid results in increased expression of GCLM mRNA |
CTD |
PMID:27277809 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO EXP |
citraconic acid results in increased expression of GSR mRNA citraconic acid results in increased expression of GSR protein |
CTD |
PMID:27277809 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hcar2 |
hydroxycarboxylic acid receptor 2 |
multiple interactions |
ISO |
citraconic acid binds to and results in increased activity of HCAR2 protein |
CTD |
PMID:18722346 |
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NCBI chr12:32,726,334...32,727,416
Ensembl chr12:32,726,184...32,728,504
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP ISO |
citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein |
CTD |
PMID:27277809 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Mt-cyb |
mitochondrially encoded cytochrome b |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA] |
CTD |
PMID:27277809 |
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NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
increases expression multiple interactions |
ISO |
citraconic acid results in increased expression of ND1 mRNA NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA] |
CTD |
PMID:27277809 |
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NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G |
Mt-nd5 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 |
increases expression multiple interactions |
ISO |
citraconic acid results in increased expression of ND5 mRNA NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA] |
CTD |
PMID:27277809 |
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NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
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G |
Mt-nd6 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA] |
CTD |
PMID:27277809 |
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NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
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G |
Mterf1 |
mitochondrial transcription termination factor 1 |
increases expression |
ISO |
citraconic acid results in increased expression of MTERF1A mRNA |
CTD |
PMID:27277809 |
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NCBI chr 4:30,226,345...30,233,402
Ensembl chr 4:30,226,343...30,233,584
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects localization |
ISO |
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA] citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein] citraconic acid affects the localization of NFE2L2 protein |
CTD |
PMID:27277809 PMID:28289076 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein |
CTD |
PMID:27277809 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Polrmt |
RNA polymerase mitochondrial |
increases expression multiple interactions |
ISO |
citraconic acid results in increased expression of POLRMT mRNA NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA] |
CTD |
PMID:27277809 |
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NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO EXP |
D-Aspartic Acid results in increased phosphorylation of AKT1 protein |
CTD |
PMID:26189884 PMID:31398714 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Ar |
androgen receptor |
affects expression increases expression |
EXP |
D-Aspartic Acid affects the expression of AR mRNA D-Aspartic Acid results in increased expression of AR protein |
CTD |
PMID:24439162 PMID:26044185 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Aurkb |
aurora kinase B |
increases expression |
ISO |
D-Aspartic Acid results in increased expression of AURKB protein |
CTD |
PMID:26189884 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein] |
CTD |
PMID:30822420 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cln8 |
CLN8, transmembrane ER and ERGIC protein |
multiple interactions affects export |
ISO |
CLN8 protein affects the reaction [[Ionomycin co-treated with Calcium] results in increased transport of D-Aspartic Acid]; CLN8 protein affects the reaction [[Potassium Chloride co-treated with Calcium] results in increased transport of D-Aspartic Acid] CLN8 protein affects the export of D-Aspartic Acid |
CTD |
PMID:22302580 |
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NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of CYP11A1 mRNA |
CTD |
PMID:24713504 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression decreases expression |
ISO EXP |
D-Aspartic Acid results in increased expression of CYP19A1 mRNA; D-Aspartic Acid results in increased expression of CYP19A1 protein D-Aspartic Acid results in decreased expression of CYP19A1 protein |
CTD |
PMID:24439162 PMID:26044185 PMID:26189884 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Ddo |
D-aspartate oxidase |
affects abundance increases metabolic processing increases degradation |
ISO EXP |
DDO protein affects the abundance of D-Aspartic Acid DDO protein results in increased metabolism of D-Aspartic Acid DDO protein results in increased degradation of D-Aspartic Acid |
CTD |
PMID:16516413 PMID:16525061 PMID:16725213 PMID:18842900 PMID:26961959 PMID:32185508 PMID:32376478 More...
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NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095
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G |
Esr1 |
estrogen receptor 1 |
increases expression decreases expression |
EXP |
D-Aspartic Acid results in increased expression of ESR1 mRNA D-Aspartic Acid results in decreased expression of ESR1 protein |
CTD |
PMID:24439162 PMID:26044185 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
increases expression |
ISO |
D-Aspartic Acid results in increased expression of ESR2 protein |
CTD |
PMID:26189884 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of GRIN1 mRNA |
CTD |
PMID:24439162 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of GRIN2A mRNA |
CTD |
PMID:24439162 |
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NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
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G |
Itpr3 |
inositol 1,4,5-trisphosphate receptor, type 3 |
affects metabolic processing |
ISO |
ITPR3 mutant form affects the metabolism of D-Aspartic Acid |
CTD |
PMID:32853769 |
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NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
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G |
Lhb |
luteinizing hormone subunit beta |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of LHB protein |
CTD |
PMID:24713504 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
EXP ISO |
D-Aspartic Acid results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:24439162 PMID:26189884 PMID:31398714 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO EXP |
D-Aspartic Acid results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:24439162 PMID:26189884 PMID:31398714 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions increases cleavage |
EXP |
D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein] |
CTD |
PMID:30822420 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
D-Aspartic Acid results in increased expression of PCNA protein |
CTD |
PMID:26189884 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Prep |
prolyl endopeptidase |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of PREP protein |
CTD |
PMID:31398714 |
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NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
SOD1 protein affects the reaction [Glycine results in increased secretion of D-Aspartic Acid] |
CTD |
PMID:12684256 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of SRD5A1 mRNA |
CTD |
PMID:26044185 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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G |
Srd5a2 |
steroid 5 alpha-reductase 2 |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of SRD5A2 mRNA |
CTD |
PMID:26044185 |
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NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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G |
Srr |
serine racemase |
increases abundance multiple interactions |
EXP ISO |
SRR protein results in increased abundance of D-Aspartic Acid [SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid; Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Adenosine Triphosphate promotes the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]] |
CTD |
PMID:27387750 |
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NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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G |
Star |
steroidogenic acute regulatory protein |
increases expression |
EXP |
D-Aspartic Acid results in increased expression of STAR mRNA; D-Aspartic Acid results in increased expression of STAR protein |
CTD |
PMID:24713504 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
diethyl fumarate results in increased cleavage of CASP3 protein |
CTD |
PMID:21105742 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
diethyl fumarate results in increased cleavage of PARP1 protein |
CTD |
PMID:21105742 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
increases cleavage |
ISO |
diethyl fumarate results in increased cleavage of SPTAN1 protein |
CTD |
PMID:21105742 |
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NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
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G |
Acta2 |
actin alpha 2, smooth muscle |
affects expression |
ISO |
diethyl malate affects the expression of ACTA2 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Actc1 |
actin, alpha, cardiac muscle 1 |
affects expression |
ISO |
diethyl malate affects the expression of ACTC1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
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G |
Actn3 |
actinin alpha 3 |
affects expression |
ISO |
diethyl malate affects the expression of ACTN3 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
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G |
Adcy1 |
adenylate cyclase 1 |
affects expression |
ISO |
diethyl malate affects the expression of ADCY1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
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G |
Adh1 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
affects expression |
ISO |
diethyl malate affects the expression of ADH1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Agt |
angiotensinogen |
affects expression |
ISO |
diethyl malate affects the expression of AGT mRNA |
CTD |
PMID:24814887 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
C3 |
complement C3 |
affects expression |
ISO |
diethyl malate affects the expression of C3 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
Cacnb2 |
calcium voltage-gated channel auxiliary subunit beta 2 |
affects expression |
ISO |
diethyl malate affects the expression of CACNB2 mRNA |
CTD |
PMID:24814887 |
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NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
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G |
Cacnb4 |
calcium voltage-gated channel auxiliary subunit beta 4 |
affects expression |
ISO |
diethyl malate affects the expression of CACNB4 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions affects expression |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] |
CTD |
PMID:24814887 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
affects expression |
ISO |
diethyl malate affects the expression of CCL20 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl6 |
C-C motif chemokine ligand 6 |
affects expression |
ISO |
diethyl malate affects the expression of CCL6 mRNA |
CTD |
PMID:24814887 |
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NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
affects expression |
ISO |
diethyl malate affects the expression of CCL7 mRNA |
CTD |
PMID:24814887 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Col11a1 |
collagen type XI alpha 1 chain |
affects expression |
ISO |
diethyl malate affects the expression of COL11A1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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G |
Col2a1 |
collagen type II alpha 1 chain |
affects expression |
ISO |
diethyl malate affects the expression of COL2A1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
affects expression |
ISO |
diethyl malate affects the expression of COL3A1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col6a1 |
collagen type VI alpha 1 chain |
affects expression |
ISO |
diethyl malate affects the expression of COL6A1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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G |
Comp |
cartilage oligomeric matrix protein |
affects expression |
ISO |
diethyl malate affects the expression of COMP mRNA |
CTD |
PMID:24814887 |
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NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
affects expression multiple interactions |
ISO |
diethyl malate affects the expression of CXCL12 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA] |
CTD |
PMID:24814887 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
affects expression |
ISO |
diethyl malate affects the expression of CXCL1 mRNA |
CTD |
PMID:24814887 |
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NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
affects expression |
ISO |
diethyl malate affects the expression of CXCL5 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
|
|
G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
affects expression |
ISO |
diethyl malate affects the expression of CYP2J9 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
|
|
G |
Dapk2 |
death-associated protein kinase 2 |
affects expression |
ISO |
diethyl malate affects the expression of DAPK2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
|
|
G |
Ddx58 |
DEXD/H-box helicase 58 |
affects expression |
ISO |
diethyl malate affects the expression of DDX58 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
|
|
G |
Dhrs3 |
dehydrogenase/reductase 3 |
affects expression |
ISO |
diethyl malate affects the expression of DHRS3 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
|
|
G |
Dhx58 |
DEXH-box helicase 58 |
affects expression |
ISO |
diethyl malate affects the expression of DHX58 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
|
|
G |
Edar |
ectodysplasin-A receptor |
affects expression |
ISO |
diethyl malate affects the expression of EDAR mRNA |
CTD |
PMID:24814887 |
|
NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
|
|
G |
Ednra |
endothelin receptor type A |
affects expression |
ISO |
diethyl malate affects the expression of EDNRA mRNA |
CTD |
PMID:24814887 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
|
|
G |
Epas1 |
endothelial PAS domain protein 1 |
affects expression |
ISO |
diethyl malate affects the expression of EPAS1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
|
|
G |
Epha7 |
Eph receptor A7 |
affects expression |
ISO |
diethyl malate affects the expression of EPHA7 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
|
|
G |
Ephb2 |
Eph receptor B2 |
affects expression |
ISO |
diethyl malate affects the expression of EPHB2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
|
|
G |
Ephb6 |
Eph receptor B6 |
affects expression |
ISO |
diethyl malate affects the expression of EPHB6 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
|
|
G |
Fgf10 |
fibroblast growth factor 10 |
affects expression |
ISO |
diethyl malate affects the expression of FGF10 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
|
|
G |
Fgf18 |
fibroblast growth factor 18 |
multiple interactions affects expression |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
|
|
G |
Fgfr2 |
fibroblast growth factor receptor 2 |
affects expression |
ISO |
diethyl malate affects the expression of FGFR2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
|
|
G |
Fst |
follistatin |
affects expression |
ISO |
diethyl malate affects the expression of FST mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
|
|
G |
Fzd2 |
frizzled class receptor 2 |
affects expression |
ISO |
diethyl malate affects the expression of FZD2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
|
|
G |
Fzd7 |
frizzled class receptor 7 |
affects expression |
ISO |
diethyl malate affects the expression of FZD7 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects expression |
ISO |
diethyl malate affects the expression of GCLC mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions affects expression |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Ggt6 |
gamma-glutamyl transferase 6 |
affects expression |
ISO |
diethyl malate affects the expression of GGT6 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr10:57,052,025...57,054,502
Ensembl chr10:57,051,825...57,067,260
|
|
G |
Gli2 |
GLI family zinc finger 2 |
affects expression |
ISO |
diethyl malate affects the expression of GLI2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
|
|
G |
Gnao1 |
G protein subunit alpha o1 |
affects expression |
ISO |
diethyl malate affects the expression of GNAO1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr19:11,034,874...11,192,502
Ensembl chr19:11,035,956...11,192,493
|
|
G |
Gng7 |
G protein subunit gamma 7 |
affects expression |
ISO |
diethyl malate affects the expression of GNG7 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
|
|
G |
Gsr |
glutathione-disulfide reductase |
affects expression |
ISO |
diethyl malate affects the expression of GSR mRNA |
CTD |
PMID:24814887 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gss |
glutathione synthetase |
multiple interactions affects expression |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
affects expression multiple interactions |
ISO |
diethyl malate affects the expression of GSTA3 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
affects expression multiple interactions |
ISO |
diethyl malate affects the expression of GSTA1 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
|
|
G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
affects expression |
ISO |
diethyl malate affects the expression of GUCY1A1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
|
|
G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
affects expression |
ISO |
diethyl malate affects the expression of GUCY1B1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
|
|
G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
affects expression |
ISO |
diethyl malate affects the expression of HCK mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
|
|
G |
Hgf |
hepatocyte growth factor |
affects expression |
ISO |
diethyl malate affects the expression of HGF mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G |
Igf1 |
insulin-like growth factor 1 |
affects expression |
ISO |
diethyl malate affects the expression of IGF1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Il15 |
interleukin 15 |
affects expression |
ISO |
diethyl malate affects the expression of IL15 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
|
|
G |
Il18 |
interleukin 18 |
affects expression |
ISO |
diethyl malate affects the expression of IL18 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
|
|
G |
Irag1 |
inositol 1,4,5-triphosphate receptor associated 1 |
affects expression |
ISO |
diethyl malate affects the expression of IRAG1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
|
|
G |
Irf7 |
interferon regulatory factor 7 |
affects expression |
ISO |
diethyl malate affects the expression of IRF7 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
|
|
G |
Isg15 |
ISG15 ubiquitin-like modifier |
affects expression |
ISO |
diethyl malate affects the expression of ISG15 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
|
|
G |
Itga11 |
integrin subunit alpha 11 |
affects expression |
ISO |
diethyl malate affects the expression of ITGA11 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:63,145,950...63,254,717
Ensembl chr 8:63,146,001...63,254,407
|
|
G |
Itga3 |
integrin subunit alpha 3 |
affects expression |
ISO |
diethyl malate affects the expression of ITGA3 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
|
|
G |
Kcnmb4 |
potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
affects expression |
ISO |
diethyl malate affects the expression of KCNMB4 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
|
|
G |
Lama1 |
laminin subunit alpha 1 |
affects expression |
ISO |
diethyl malate affects the expression of LAMA1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
|
|
G |
Lama4 |
laminin subunit alpha 4 |
affects expression |
ISO |
diethyl malate affects the expression of LAMA4 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
|
|
G |
LOC100909797 |
RT1 class I histocompatibility antigen, AA alpha chain-like |
affects expression |
ISO |
diethyl malate affects the expression of H2-M3 mRNA |
CTD |
PMID:24814887 |
|
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
affects phosphorylation multiple interactions |
ISO |
diethyl malate affects the phosphorylation of MAPK1 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein] |
CTD |
PMID:24814887 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
affects phosphorylation multiple interactions |
ISO |
diethyl malate affects the phosphorylation of MAPK3 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein] |
CTD |
PMID:24814887 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Myl9 |
myosin light chain 9 |
affects expression |
ISO |
diethyl malate affects the expression of MYL9 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
|
|
G |
Odc1 |
ornithine decarboxylase 1 |
affects expression |
ISO |
diethyl malate affects the expression of ODC1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
affects expression multiple interactions |
ISO |
diethyl malate affects the expression of PDGFB mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Pdgfd |
platelet derived growth factor D |
affects expression |
ISO |
diethyl malate affects the expression of PDGFD mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
|
|
G |
Pf4 |
platelet factor 4 |
affects expression |
ISO |
diethyl malate affects the expression of PF4 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
|
|
G |
Pik3ip1 |
phosphoinositide-3-kinase interacting protein 1 |
affects expression |
ISO |
diethyl malate affects the expression of PIK3IP1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608
|
|
G |
Plxnc1 |
plexin C1 |
affects expression |
ISO |
diethyl malate affects the expression of PLXNC1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779
|
|
G |
Prkg1 |
protein kinase cGMP-dependent 1 |
affects expression |
ISO |
diethyl malate affects the expression of PRKG1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080
|
|
G |
Ptgis |
prostaglandin I2 synthase |
affects expression |
ISO |
diethyl malate affects the expression of PTGIS mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
|
|
G |
Ramp2 |
receptor activity modifying protein 2 |
affects expression |
ISO |
diethyl malate affects the expression of RAMP2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
|
|
G |
Rgs3 |
regulator of G-protein signaling 3 |
affects expression |
ISO |
diethyl malate affects the expression of RGS3 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
|
|
G |
Runx1t1 |
RUNX1 partner transcriptional co-repressor 1 |
affects expression |
ISO |
diethyl malate affects the expression of RUNX1T1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
|
|
G |
Sema3b |
semaphorin 3B |
affects expression |
ISO |
diethyl malate affects the expression of SEMA3B mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
|
|
G |
Sema4g |
semaphorin 4G |
affects expression |
ISO |
diethyl malate affects the expression of SEMA4G mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341
|
|
G |
Sema5a |
semaphorin 5A |
affects expression |
ISO |
diethyl malate affects the expression of SEMA5A mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
affects expression |
ISO |
diethyl malate affects the expression of STAT1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Tgfb2 |
transforming growth factor, beta 2 |
affects expression multiple interactions |
ISO |
diethyl malate affects the expression of TGFB2 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
|
|
G |
Thbs1 |
thrombospondin 1 |
affects expression |
ISO |
diethyl malate affects the expression of THBS1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
|
|
G |
Thbs2 |
thrombospondin 2 |
affects expression |
ISO |
diethyl malate affects the expression of THBS2 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
|
|
G |
Tnc |
tenascin C |
affects expression |
ISO |
diethyl malate affects the expression of TNC mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
|
|
G |
Tnfrsf11b |
TNF receptor superfamily member 11B |
affects expression |
ISO |
diethyl malate affects the expression of TNFRSF11B mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
|
|
G |
Tnnt1 |
troponin T1, slow skeletal type |
affects expression |
ISO |
diethyl malate affects the expression of TNNT1 mRNA |
CTD |
PMID:24814887 |
|
NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
|
|
G |
Tslp |
thymic stromal lymphopoietin |
affects expression |
ISO |
diethyl malate affects the expression of TSLP mRNA |
CTD |
PMID:24814887 |
|
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
|
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of ABCC2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Abhd4 |
abhydrolase domain containing 4, N-acyl phospholipase B |
increases expression |
ISO |
diethyl maleate results in increased expression of ABHD4 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
|
|
G |
Acaca |
acetyl-CoA carboxylase alpha |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ACACA mRNA |
CTD |
PMID:25270620 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
|
|
G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] |
CTD |
PMID:17134953 |
|
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
|
|
G |
Acy3 |
aminoacylase 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ACY3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175
|
|
G |
Adm |
adrenomedullin |
increases expression |
ISO |
diethyl maleate results in increased expression of ADM mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Adora3 |
adenosine A3 receptor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ADORA3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
diethyl maleate results in increased expression of AEN mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Afp |
alpha-fetoprotein |
increases expression |
ISO |
diethyl maleate results in increased expression of AFP mRNA |
CTD |
PMID:25270620 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahcyl1 |
adenosylhomocysteinase-like 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of AHCYL1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
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G |
Akr1a1 |
aldo-keto reductase family 1 member A1 |
increases expression |
EXP |
diethyl maleate results in increased expression of AKR1A1 protein |
CTD |
PMID:21161181 |
|
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
diethyl maleate results in increased expression of AKR1B10 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases expression |
ISO |
diethyl maleate results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects reduction |
ISO |
diethyl maleate affects the reduction of ALDH1A1 protein |
CTD |
PMID:19843705 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ALDH1B1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases reduction increases expression decreases expression |
ISO EXP |
diethyl maleate results in decreased reduction of ALDH2 protein diethyl maleate results in increased expression of ALDH2 protein diethyl maleate results in decreased expression of ALDH2 protein |
CTD |
PMID:19843705 PMID:21161181 |
|
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
affects expression |
ISO |
diethyl maleate affects the expression of ALDOA mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Aldob |
aldolase, fructose-bisphosphate B |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ALDOB protein |
CTD |
PMID:21161181 |
|
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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G |
Amigo2 |
adhesion molecule with Ig like domain 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of AMIGO2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ANGPTL2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl4 |
angiopoietin-like 4 |
increases expression |
ISO |
diethyl maleate results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Ankrd46 |
ankyrin repeat domain 46 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ANKRD46 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132
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G |
Anln |
anillin, actin binding protein |
increases expression |
EXP |
diethyl maleate results in increased expression of ANLN mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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G |
Anxa1 |
annexin A1 |
affects expression |
ISO |
diethyl maleate affects the expression of ANXA1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa3 |
annexin A3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ANXA3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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G |
Ap3m2 |
adaptor related protein complex 3 subunit mu 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of AP3M2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr16:69,217,526...69,237,372
Ensembl chr16:69,217,633...69,235,431
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of APAF1 mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Aplp1 |
amyloid beta precursor like protein 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of APLP1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
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G |
Apol9a |
apolipoprotein L 9a |
decreases expression |
EXP |
diethyl maleate results in decreased expression of APOL9A mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649
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G |
Arhgap9 |
Rho GTPase activating protein 9 |
increases expression |
ISO |
diethyl maleate results in increased expression of ARHGAP9 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524
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G |
Arrdc2 |
arrestin domain containing 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ARRDC2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
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G |
Arrdc4 |
arrestin domain containing 4 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ARRDC4 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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G |
Asf1b |
anti-silencing function 1B histone chaperone |
increases expression |
EXP |
diethyl maleate results in increased expression of ASF1B mRNA |
CTD |
PMID:21161181 |
|
NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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G |
Asxl1 |
ASXL transcriptional regulator 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ASXL1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
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G |
Atm |
ATM serine/threonine kinase |
increases expression |
ISO |
diethyl maleate results in increased expression of ATM mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp5f1b |
ATP synthase F1 subunit beta |
increases expression |
EXP |
diethyl maleate results in increased expression of ATP5F1B protein |
CTD |
PMID:21161181 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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G |
Aurka |
aurora kinase A |
increases expression decreases expression |
EXP ISO |
diethyl maleate results in increased expression of AURKA mRNA diethyl maleate results in decreased expression of AURKA mRNA |
CTD |
PMID:21161181 PMID:25270620 |
|
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of BBC3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA diethyl maleate results in increased expression of BCL2 mRNA |
CTD |
PMID:22564015 PMID:33545341 |
|
NCBI chr13:22,689,783...22,853,920
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G |
Bcl2a1 |
BCL2-related protein A1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl3 |
BCL3, transcription coactivator |
decreases expression |
ISO |
diethyl maleate results in decreased expression of BCL3 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcl6b |
BCL6B, transcription repressor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BCL6B mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
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G |
Bhlhe41 |
basic helix-loop-helix family, member e41 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BHLHE41 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468
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G |
Bhmt |
betaine-homocysteine S-methyltransferase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BHMT mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] |
CTD |
PMID:12774022 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Blvrb |
biliverdin reductase B |
increases expression |
ISO |
diethyl maleate results in increased expression of BLVRB mRNA |
CTD |
PMID:25270620 PMID:34626751 |
|
NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BMF mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Brip1 |
BRCA1 interacting helicase 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of BRIP1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
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G |
Btbd2 |
BTB domain containing 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of BTBD2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression decreases expression multiple interactions |
ISO |
diethyl maleate results in increased expression of BTG2 mRNA diethyl maleate results in decreased expression of BTG2 mRNA NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA] |
CTD |
PMID:22003191 PMID:25270620 PMID:34626751 |
|
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
C6 |
complement C6 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of C6 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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G |
Casp2 |
caspase 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of CASP2 mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage |
ISO |
diethyl maleate results in increased expression of CASP3 mRNA diethyl maleate results in increased cleavage of CASP3 protein |
CTD |
PMID:11875189 PMID:21105742 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
diethyl maleate results in increased expression of CASP9 mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CAT protein |
CTD |
PMID:21161181 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of CBR1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,857,991...32,895,275
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G |
Cbr3 |
carbonyl reductase 3 |
increases expression multiple interactions |
ISO |
diethyl maleate results in increased expression of CBR3 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA] |
CTD |
PMID:20806931 PMID:25270620 |
|
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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G |
Cbx4 |
chromobox 4 |
increases expression |
ISO |
diethyl maleate results in increased expression of CBX4 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
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G |
Ccdc50 |
coiled-coil domain containing 50 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of CCDC50 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of CCNA1 mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccna2 |
cyclin A2 |
increases expression |
EXP |
diethyl maleate results in increased expression of CCNA2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
decreases expression increases expression |
ISO EXP |
diethyl maleate results in decreased expression of CCND1 mRNA diethyl maleate results in increased expression of CCND1 mRNA |
CTD |
PMID:11875189 PMID:21161181 PMID:25270620 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne2 |
cyclin E2 |
increases expression |
EXP |
diethyl maleate results in increased expression of CCNE2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Ccnk |
cyclin K |
decreases expression |
ISO |
diethyl maleate results in decreased expression of CCNK mRNA |
CTD |
PMID:11875189 |
|
NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
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G |
Cd80 |
Cd80 molecule |
multiple interactions increases expression |
ISO |
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein diethyl maleate results in increased expression of CD80 protein |
CTD |
PMID:31958493 |
|
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
|
|
G |
Cd86 |
CD86 molecule |
multiple interactions increases expression |
ISO |
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] |
CTD |
PMID:24136171 PMID:31958493 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
|
|
G |
Cdc25a |
cell division cycle 25A |
increases expression |
EXP |
diethyl maleate results in increased expression of CDC25A mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdca2 |
cell division cycle associated 2 |
increases expression |
EXP |
diethyl maleate results in increased expression of CDCA2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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G |
Cdca3 |
cell division cycle associated 3 |
increases expression |
EXP |
diethyl maleate results in increased expression of CDCA3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
|
|
G |
Cdca8 |
cell division cycle associated 8 |
increases expression |
EXP |
diethyl maleate results in increased expression of CDCA8 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
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|
G |
Cdh11 |
cadherin 11 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CDH11 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein] |
CTD |
PMID:11875189 PMID:27982581 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cds2 |
CDP-diacylglycerol synthase 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of CDS2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541
|
|
G |
Ces1d |
carboxylesterase 1D |
decreases expression increases reduction |
EXP ISO |
diethyl maleate results in decreased expression of CES1D protein diethyl maleate results in increased reduction of CES1D protein |
CTD |
PMID:19843705 PMID:21161181 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CFLAR mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
increases expression |
ISO |
diethyl maleate results in increased expression of CHRNA4 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
|
|
G |
Cidec |
cell death-inducing DFFA-like effector c |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CIDEC mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CITED2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
|
|
G |
Cited4 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CITED4 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
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G |
Ckb |
creatine kinase B |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of CKB protein |
CTD |
PMID:19843705 |
|
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of CKS2 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr17:13,570,611...13,575,770
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G |
Clk1 |
CDC-like kinase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of CLK1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CMPK2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
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G |
Cntn1 |
contactin 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of CNTN1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
diethyl maleate results in decreased expression of COL1A1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
ISO |
diethyl maleate results in decreased expression of COL3A1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Commd3 |
COMM domain containing 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of COMMD3 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
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G |
Comt |
catechol-O-methyltransferase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of COMT mRNA |
CTD |
PMID:21161181 |
|
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Cp |
ceruloplasmin |
decreases expression |
ISO |
diethyl maleate results in decreased expression of CP mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpsf4l |
cleavage and polyadenylation specific factor 4-like |
increases expression |
ISO |
diethyl maleate results in increased expression of CPSF4L mRNA |
CTD |
PMID:33545341 |
|
NCBI chr10:98,741,816...98,756,069
Ensembl chr10:98,743,649...98,751,590
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G |
Crym |
crystallin, mu |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CRYM mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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G |
Csrp1 |
cysteine and glycine-rich protein 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CSRP1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
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G |
Csrp3 |
cysteine and glycine rich protein 3 |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of CSRP3 protein |
CTD |
PMID:19843705 |
|
NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CXCL10 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CXCL12 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CXCL9 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cyb5a |
cytochrome b5 type A |
increases expression |
ISO |
diethyl maleate results in increased expression of CYB5A mRNA |
CTD |
PMID:25270620 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of DBP mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of DDIT3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
diethyl maleate results in increased expression of DDIT4 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
increases expression |
ISO |
diethyl maleate results in increased expression of DDIT4L mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Ddx60 |
DEXD/H-box helicase 60 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of DDX60 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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G |
Dhx58 |
DEXH-box helicase 58 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of DHX58 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
diethyl maleate results in increased expression of DNAJB1 mRNA |
CTD |
PMID:33545341 PMID:34480604 |
|
NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
diethyl maleate results in increased expression of DNAJB4 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Dnmbp |
dynamin binding protein |
decreases expression |
EXP |
diethyl maleate results in decreased expression of DNMBP mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:242,736,189...242,829,498
Ensembl chr 1:242,736,189...242,802,604
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G |
Dpysl2 |
dihydropyrimidinase-like 2 |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of DPYSL2 protein |
CTD |
PMID:19843705 |
|
NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
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G |
Dtx3l |
deltex E3 ubiquitin ligase 3L |
decreases expression |
EXP |
diethyl maleate results in decreased expression of DTX3L mRNA |
CTD |
PMID:21161181 |
|
NCBI chr11:64,814,926...64,824,538
Ensembl chr11:64,814,926...64,824,538
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G |
Dus3l |
dihydrouridine synthase 3-like |
decreases expression |
ISO |
diethyl maleate results in decreased expression of DUS3L mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
ISO |
diethyl maleate results in increased expression of DUSP6 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Eef2k |
eukaryotic elongation factor-2 kinase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of EEF2K mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:175,393,119...175,454,452
Ensembl chr 1:175,393,154...175,455,164
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of EGLN3 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of EIF2AK2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
increases expression |
ISO |
diethyl maleate results in increased expression of ENTPD5 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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G |
Eras |
ES cell expressed Ras |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ERAS mRNA |
CTD |
PMID:25270620 |
|
NCBI chr X:14,573,987...14,578,455
Ensembl chr X:14,573,987...14,578,374
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G |
Ercc6l |
ERCC excision repair 6 like, spindle assembly checkpoint helicase |
increases expression |
EXP |
diethyl maleate results in increased expression of ERCC6L mRNA |
CTD |
PMID:21161181 |
|
NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756
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G |
Exo1 |
exonuclease 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of EXO1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of FABP1 protein |
CTD |
PMID:21161181 |
|
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp7 |
fatty acid binding protein 7 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FABP7 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
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G |
Fah |
fumarylacetoacetate hydrolase |
affects expression |
ISO |
diethyl maleate affects the expression of FAH mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
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G |
Fam126b |
family with sequence similarity 126, member B |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FAM126B mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007
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G |
Fam83d |
family with sequence similarity 83, member D |
increases expression |
ISO |
diethyl maleate results in increased expression of FAM83D mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
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G |
Fasn |
fatty acid synthase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FASN mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbn1 |
fibrillin 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FBN1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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G |
Fbp1 |
fructose-bisphosphatase 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FBP1 protein |
CTD |
PMID:21161181 |
|
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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G |
Fgf17 |
fibroblast growth factor 17 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of FGF17 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr15:45,711,901...45,717,063
Ensembl chr15:45,711,998...45,717,063
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G |
Fgg |
fibrinogen gamma chain |
decreases expression |
ISO |
diethyl maleate results in decreased expression of FGG mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of FGR mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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G |
Fndc3b |
fibronectin type III domain containing 3B |
decreases expression |
ISO |
diethyl maleate results in decreased expression of FNDC3B mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
diethyl maleate results in increased expression of FOS mRNA |
CTD |
PMID:10915739 PMID:33545341 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] |
CTD |
PMID:30261343 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxo3 |
forkhead box O3 |
increases expression |
ISO |
diethyl maleate results in increased expression of FOXO3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fstl3 |
follistatin like 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of FSTL3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of G6PC mRNA diethyl maleate results in decreased expression of G6PC1 mRNA |
CTD |
PMID:25270620 PMID:30261343 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity increases expression |
EXP ISO |
diethyl maleate results in increased activity of G6PD protein diethyl maleate results in increased expression of G6PD mRNA |
CTD |
PMID:3099627 PMID:30261343 PMID:33545341 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gab1 |
GRB2-associated binding protein 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of GAB1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
diethyl maleate results in increased expression of GADD45A mRNA |
CTD |
PMID:33545341 PMID:34480604 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
diethyl maleate results in increased expression of GADD45G mRNA |
CTD |
PMID:33545341 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases reduction |
ISO |
diethyl maleate results in increased reduction of GAPDH protein |
CTD |
PMID:19843705 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gba2 |
glucosylceramidase beta 2 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of GBA2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072
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G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of GBP2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases activity increases expression |
ISO EXP |
diethyl maleate results in increased activity of GCLC protein diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein |
CTD |
PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34021431 PMID:34480604 More...
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
EXP ISO |
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein |
CTD |
PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34480604 More...
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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|
G |
Gcnt3 |
glucosaminyl (N-acetyl) transferase 3, mucin type |
increases expression |
ISO |
diethyl maleate results in increased expression of GCNT3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
diethyl maleate results in increased expression of GDF15 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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|
G |
Gdf9 |
growth differentiation factor 9 |
increases expression |
ISO |
diethyl maleate results in increased expression of GDF9 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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|
G |
Gfod1 |
glucose-fructose oxidoreductase domain containing 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of GFOD1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938
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G |
Glul |
glutamate-ammonia ligase |
decreases expression |
ISO |
diethyl maleate results in decreased expression of GLUL mRNA |
CTD |
PMID:25270620 |
|
NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
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|
G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of GOT2 protein |
CTD |
PMID:21161181 |
|
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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|
G |
Gpihbp1 |
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of GPIHBP1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
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|
G |
Gpx2 |
glutathione peroxidase 2 |
affects expression |
ISO |
diethyl maleate affects the expression of GPX2 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
|
|
G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of GRIA3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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|
G |
Gsn |
gelsolin |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of GSN protein |
CTD |
PMID:19843705 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
|
|
G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO |
diethyl maleate results in increased expression of GSR mRNA |
CTD |
PMID:25270620 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Gss |
glutathione synthetase |
increases expression |
EXP |
diethyl maleate results in increased expression of GSS mRNA |
CTD |
PMID:10978506 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
affects expression |
ISO |
diethyl maleate affects the expression of GSTA1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of GSTA2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
diethyl maleate results in increased expression of GSTA3 protein |
CTD |
PMID:9794803 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
diethyl maleate results in increased expression of GSTA5 protein |
CTD |
PMID:9794803 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gsta6 |
glutathione S-transferase alpha 6 |
increases expression |
ISO |
diethyl maleate results in increased expression of GSTA2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
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|
G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA |
CTD |
PMID:22564015 |
|
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of GSTM1 protein |
CTD |
PMID:21161181 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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|
G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of GSTO1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of GSTP1 protein |
CTD |
PMID:9794803 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of GSTT1 protein |
CTD |
PMID:9794803 |
|
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of GTSE1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
|
|
G |
H2az2 |
H2A.Z variant histone 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of H2AZ2 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr14:81,293,299...81,312,209
Ensembl chr14:81,293,299...81,312,144
|
|
G |
H6pd |
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
increases expression |
ISO |
diethyl maleate results in increased expression of H6PD mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
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|
G |
Hamp |
hepcidin antimicrobial peptide |
increases expression |
ISO |
diethyl maleate results in increased expression of HAMP mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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|
G |
Helb |
DNA helicase B |
decreases expression |
ISO |
diethyl maleate results in decreased expression of HELB mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585
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|
G |
Hes6 |
hes family bHLH transcription factor 6 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of HES6 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 9:92,001,838...92,003,580
Ensembl chr 9:92,001,841...92,003,559
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G |
Hjurp |
Holliday junction recognition protein |
increases expression |
EXP |
diethyl maleate results in increased expression of HJURP mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of HMOX1 mRNA |
CTD |
PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of HNRNPH1 protein |
CTD |
PMID:19843705 |
|
NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
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|
G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
increases expression |
ISO |
diethyl maleate results in increased expression of HSD17B10 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr X:21,089,152...21,091,597
Ensembl chr X:21,089,122...21,109,488
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of HSD17B2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
ISO |
diethyl maleate results in increased expression of HSPA1B mRNA |
CTD |
PMID:33545341 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
increases expression |
ISO |
diethyl maleate results in increased expression of HSPA1L mRNA |
CTD |
PMID:33545341 |
|
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases reduction |
ISO |
diethyl maleate results in decreased reduction of HSPA5 protein |
CTD |
PMID:19843705 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases reduction |
ISO |
diethyl maleate results in increased reduction of HSPA8 protein |
CTD |
PMID:19843705 |
|
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Htatip2 |
HIV-1 Tat interactive protein 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of HTATIP2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ICAM1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id3 |
inhibitor of DNA binding 3, HLH protein |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ID3 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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|
G |
Id4 |
inhibitor of DNA binding 4, HLH protein |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ID4 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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|
G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of IFIT3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of IFRD1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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G |
Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
decreases expression |
ISO |
diethyl maleate results in decreased expression of IKBKE mRNA |
CTD |
PMID:25270620 |
|
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
increases expression |
ISO |
diethyl maleate results in increased expression of IKBKG mRNA |
CTD |
PMID:25270620 |
|
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il10 |
interleukin 10 |
increases secretion |
ISO |
diethyl maleate results in increased secretion of IL10 protein |
CTD |
PMID:31958493 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il18 |
interleukin 18 |
increases expression |
ISO |
diethyl maleate results in increased expression of IL18 protein |
CTD |
PMID:23063874 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1r1 |
interleukin 1 receptor type 1 |
affects expression |
ISO |
diethyl maleate affects the expression of IL1R1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein |
CTD |
PMID:31958493 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Inhbb |
inhibin subunit beta B |
decreases expression |
ISO |
diethyl maleate results in decreased expression of INHBB mRNA |
CTD |
PMID:25270620 |
|
NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
|
|
G |
Inmt |
indolethylamine N-methyltransferase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of INMT mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
|
|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] |
CTD |
PMID:30261343 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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|
G |
Ints7 |
integrator complex subunit 7 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of INTS7 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr13:103,155,123...103,207,953
Ensembl chr13:103,155,090...103,208,592
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G |
Irf7 |
interferon regulatory factor 7 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of IRF7 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
|
|
G |
Irf9 |
interferon regulatory factor 9 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of IRF9 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
|
|
G |
Irgm |
immunity-related GTPase M |
decreases expression |
EXP |
diethyl maleate results in decreased expression of IRGM mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
|
|
G |
Itgal |
integrin subunit alpha L |
decreases expression |
EXP |
diethyl maleate results in decreased expression of ITGAL mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
|
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G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ITIH3 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
|
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G |
Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of ITIH4 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
|
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G |
Jam3 |
junctional adhesion molecule 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of JAM3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
|
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression increases phosphorylation |
ISO |
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein] diethyl maleate results in increased expression of JUN protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form] diethyl maleate results in increased expression of JUN mRNA |
CTD |
PMID:10915739 PMID:12774022 PMID:30261343 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Kcne3 |
potassium voltage-gated channel subfamily E regulatory subunit 3 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of KCNE3 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein |
CTD |
PMID:27358234 PMID:33545341 PMID:34480604 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Khdrbs3 |
KH RNA binding domain containing, signal transduction associated 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of KHDRBS3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460
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|
G |
Kifc1 |
kinesin family member C1 |
increases expression |
EXP |
diethyl maleate results in increased expression of KIFC1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
|
|
G |
Klf10 |
Kruppel-like factor 10 |
decreases expression |
EXP ISO |
diethyl maleate results in decreased expression of KLF10 mRNA |
CTD |
PMID:21161181 PMID:25270620 |
|
NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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|
G |
Krt75 |
keratin 75 |
increases reduction |
ISO |
diethyl maleate results in increased reduction of KRT75 protein |
CTD |
PMID:19843705 |
|
NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
|
|
G |
Lama1 |
laminin subunit alpha 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of LAMA1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
|
|
G |
Lancl2 |
LanC like 2 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of LANCL2 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800
|
|
G |
Ldlr |
low density lipoprotein receptor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LDLR mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
|
|
G |
Lepr |
leptin receptor |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LEPR mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
|
|
G |
Lgals3bp |
galectin 3 binding protein |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LGALS3BP mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
|
|
G |
Lmnb1 |
lamin B1 |
increases expression |
EXP |
diethyl maleate results in increased expression of LMNB1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
|
|
G |
Lmo7 |
LIM domain 7 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LMO7 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
|
|
G |
LOC686035 |
similar to heat shock 70kDa protein 6 (HSP70B) |
increases expression |
ISO |
diethyl maleate results in increased expression of HSPA6 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr13:83,271,340...83,275,267
|
|
G |
Lrig3 |
leucine-rich repeats and immunoglobulin-like domains 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LRIG3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:61,816,313...61,866,275
Ensembl chr 7:61,816,342...61,866,481
|
|
G |
Lrrn4 |
leucine rich repeat neuronal 4 |
increases expression |
EXP |
diethyl maleate results in increased expression of LRRN4 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831
|
|
G |
Lrtm2 |
leucine-rich repeats and transmembrane domains 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LRTM2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 4:152,485,863...152,508,248
Ensembl chr 4:152,485,866...152,500,377
|
|
G |
Ltc4s |
leukotriene C4 synthase |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LTC4S mRNA |
CTD |
PMID:21161181 |
|
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
|
|
G |
Lum |
lumican |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LUM mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
|
|
G |
Ly6c |
Ly6-C antigen |
decreases expression |
EXP |
diethyl maleate results in decreased expression of LY6C mRNA |
CTD |
PMID:21161181 |
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NCBI chr 7:106,959,508...106,963,360
Ensembl chr 7:106,959,511...106,963,329
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
diethyl maleate results in increased expression of MAFF mRNA |
CTD |
PMID:20491607 PMID:33545341 |
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NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
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G |
Mafg |
MAF bZIP transcription factor G |
increases expression |
ISO |
diethyl maleate results in increased expression of MAFG mRNA |
CTD |
PMID:33545341 PMID:34480604 |
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NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
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G |
Maoa |
monoamine oxidase A |
increases expression |
ISO |
diethyl maleate results in increased expression of MAOA mRNA |
CTD |
PMID:25270620 |
|
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Mapk1ip1l |
mitogen-activated protein kinase 1 interacting protein 1-like |
increases expression |
ISO |
diethyl maleate results in increased expression of MAPK1IP1L mRNA |
CTD |
PMID:33545341 |
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NCBI chr15:20,545,028...20,567,010
Ensembl chr15:20,545,059...20,569,674
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases expression multiple interactions |
ISO |
diethyl maleate results in increased expression of MAPK8 protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form] |
CTD |
PMID:30261343 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases expression |
ISO |
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form] |
CTD |
PMID:30261343 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Marveld1 |
MARVEL domain containing 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MARVELD1 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 1:240,954,452...240,958,384 NCBI chr 1:240,953,889...240,958,096
Ensembl chr 1:240,954,452...240,958,384
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G |
Mboat7 |
membrane bound O-acyltransferase domain containing 7 |
increases expression |
ISO |
diethyl maleate results in increased expression of MBOAT7 mRNA |
CTD |
PMID:33545341 |
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NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538
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G |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
increases expression |
EXP |
diethyl maleate results in increased expression of MCM10 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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G |
Mcm4 |
minichromosome maintenance complex component 4 |
increases expression |
EXP |
diethyl maleate results in increased expression of MCM4 mRNA |
CTD |
PMID:21161181 |
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NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
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G |
Me1 |
malic enzyme 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of ME1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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G |
Mfap4 |
microfibril associated protein 4 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MFAP4 mRNA |
CTD |
PMID:21161181 |
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NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases activity |
ISO |
diethyl maleate results in decreased activity of MGMT protein |
CTD |
PMID:16950796 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
EXP |
diethyl maleate results in increased expression of MKI67 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mknk2 |
MAPK interacting serine/threonine kinase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MKNK2 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
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G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of MMP1 mRNA |
CTD |
PMID:33545341 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp12 |
matrix metallopeptidase 12 |
increases expression |
ISO |
diethyl maleate results in increased expression of MMP12 mRNA |
CTD |
PMID:10216232 |
|
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MMP2 mRNA |
CTD |
PMID:21161181 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of MMP3 mRNA |
CTD |
PMID:33545341 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mpzl1 |
myelin protein zero-like 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of MPZL1 mRNA |
CTD |
PMID:34480604 |
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NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
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G |
Msn |
moesin |
increases reduction |
ISO |
diethyl maleate results in increased reduction of MSN protein |
CTD |
PMID:19843705 |
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NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628
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G |
Mt1 |
metallothionein 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of MT1A mRNA |
CTD |
PMID:20491607 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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G |
Mt2A |
metallothionein 2A |
increases expression |
ISO |
diethyl maleate results in increased expression of MT2A mRNA |
CTD |
PMID:20491607 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mx1 |
MX dynamin like GTPase 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MX1 mRNA |
CTD |
PMID:21161181 |
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NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Mx2 |
MX dynamin like GTPase 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of MX2 mRNA |
CTD |
PMID:21161181 |
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NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
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G |
Mybl2 |
MYB proto-oncogene like 2 |
increases expression |
EXP |
diethyl maleate results in increased expression of MYBL2 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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G |
Mycn |
MYCN proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
diethyl maleate results in decreased expression of MYCN mRNA |
CTD |
PMID:25270620 |
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NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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G |
Nat8 |
N-acetyltransferase 8 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of NAT8 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763
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G |
Ncaph |
non-SMC condensin I complex, subunit H |
increases expression |
EXP |
diethyl maleate results in increased expression of NCAPH mRNA |
CTD |
PMID:21161181 |
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NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
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G |
Ndrg1 |
N-myc downstream regulated 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of NDRG1 mRNA |
CTD |
PMID:33545341 |
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NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization increases activity increases expression multiple interactions decreases response to substance |
ISO EXP |
diethyl maleate affects the localization of NFE2L2 protein diethyl maleate results in increased activity of NFE2L2 protein diethyl maleate results in increased expression of NFE2L2 protein diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein] NFE2L2 results in decreased susceptibility to diethyl maleate NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] |
CTD |
PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:27358234 PMID:27982581 PMID:30114225 PMID:34021431 More...
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] |
CTD |
PMID:12774022 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate] |
CTD |
PMID:7532384 PMID:9918918 PMID:12774022 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Notch1 |
notch receptor 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of NOTCH1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of NQO1 mRNA |
CTD |
PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of NR0B2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of NR1D1 mRNA |
CTD |
PMID:21161181 |
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NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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G |
Nrep |
neuronal regeneration related protein |
decreases expression |
EXP |
diethyl maleate results in decreased expression of NREP mRNA |
CTD |
PMID:21161181 |
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NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
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G |
Nsmf |
NMDA receptor synaptonuclear signaling and neuronal migration factor |
decreases expression |
ISO |
diethyl maleate results in decreased expression of NSMF mRNA |
CTD |
PMID:25270620 |
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NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
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G |
Ntf3 |
neurotrophin 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of NTF3 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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G |
Nup153 |
nucleoporin 153 |
multiple interactions affects localization |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein |
CTD |
PMID:20041180 |
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NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
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G |
Nup88 |
nucleoporin 88 |
multiple interactions affects localization |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein |
CTD |
PMID:20041180 |
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NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257
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G |
Oaf |
out at first homolog |
decreases expression |
EXP |
diethyl maleate results in decreased expression of OAF mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
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G |
Oas1i |
2 ' -5 ' oligoadenylate synthetase 1I |
decreases expression |
EXP |
diethyl maleate results in decreased expression of OAS1I mRNA |
CTD |
PMID:21161181 |
|
NCBI chr12:35,624,566...35,636,608
Ensembl chr12:35,624,592...35,636,604
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA |
CTD |
PMID:22564015 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Orc1 |
origin recognition complex, subunit 1 |
increases expression |
EXP |
diethyl maleate results in increased expression of ORC1 mRNA |
CTD |
PMID:21161181 |
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NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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G |
Osgin1 |
oxidative stress induced growth inhibitor 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of OSGIN1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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G |
P2rx7 |
purinergic receptor P2X 7 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of P2RX7 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
diethyl maleate results in increased cleavage of PARP1 protein |
CTD |
PMID:21105742 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pbld1 |
phenazine biosynthesis-like protein domain containing 1 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PBLD protein |
CTD |
PMID:21161181 |
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NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
diethyl maleate results in decreased expression of PCNA mRNA |
CTD |
PMID:11875189 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdlim2 |
PDZ and LIM domain 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PDLIM2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242
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G |
Pdrg1 |
p53 and DNA damage regulated 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of PDRG1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
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G |
Per2 |
period circadian regulator 2 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PER2 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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G |
Per3 |
period circadian regulator 3 |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PER3 mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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G |
Pgd |
phosphogluconate dehydrogenase |
increases activity |
EXP |
diethyl maleate results in increased activity of PGD protein |
CTD |
PMID:3099627 |
|
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Pgrmc1 |
progesterone receptor membrane component 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of PGRMC1 mRNA |
CTD |
PMID:25270620 |
|
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
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G |
Pir |
pirin |
increases expression |
ISO |
diethyl maleate results in increased expression of PIR mRNA |
CTD |
PMID:25270620 |
|
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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G |
Pklr |
pyruvate kinase L/R |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PKLR mRNA |
CTD |
PMID:21161181 |
|
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Plat |
plasminogen activator, tissue type |
increases expression decreases expression |
EXP ISO |
diethyl maleate results in increased expression of PLAT mRNA diethyl maleate results in decreased expression of PLAT mRNA |
CTD |
PMID:21161181 PMID:25270620 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plek |
pleckstrin |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PLEK mRNA |
CTD |
PMID:21161181 |
|
NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131
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G |
Plekhm1 |
pleckstrin homology and RUN domain containing M1 |
increases expression |
ISO |
diethyl maleate results in increased expression of PLEKHM1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
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G |
Plin2 |
perilipin 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of PLIN2 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Plk1 |
polo-like kinase 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of PLK1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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G |
Plk3 |
polo-like kinase 3 |
increases expression |
ISO |
diethyl maleate results in increased expression of PLK3 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
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G |
Pou5f1 |
POU class 5 homeobox 1 |
increases expression |
ISO |
diethyl maleate results in increased expression of POU5F1 mRNA |
CTD |
PMID:33545341 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions decreases activity |
EXP |
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] |
CTD |
PMID:17134953 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1b |
PPARG coactivator 1 beta |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PPARGC1B mRNA |
CTD |
PMID:21161181 |
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NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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G |
Ppp1r3b |
protein phosphatase 1, regulatory subunit 3B |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PPP1R3B mRNA |
CTD |
PMID:21161181 |
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NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
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G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
decreases expression |
EXP |
diethyl maleate results in decreased expression of PPP1R3C mRNA |
CTD |
PMID:21161181 |
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NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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G |
Prdm14 |
PR/SET domain 14 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of PRDM14 mRNA |
CTD |
PMID:25270620 |
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NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712
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G |
Prdx1 |
peroxiredoxin 1 |
increases expression |
EXP ISO |
diethyl maleate results in increased expression of PRDX1 mRNA |
CTD |
PMID:9506838 |
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NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
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G |
Prkab1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
decreases expression |
ISO |
diethyl maleate results in decreased expression of PRKAB1 mRNA |
CTD |
PMID:25270620 |
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NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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G |
Prkag2 |
protein kinase AMP-activated non-catalytic subunit gamma 2 |
increases expression |
ISO |
diethyl maleate results in increased expression of PRKAG2 mRNA |
CTD |
PMID:33545341 |
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NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
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G |
Prkcb |
protein kinase C, beta |
affects expression |
ISO |
diethyl maleate affects the expression of PRKCB protein |
CTD |
PMID:31958493 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein |
CTD |
PMID:11118818 |
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NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
EXP |
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein |
CTD |
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