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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:maleic acid
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Accession:CHEBI:18300 term browser browse the term
Definition:A butenedioic acid in which the double bond has cis- (Z)-configuration.
Synonyms:related_synonym: (2Z)-but-2-enedioic acid;   (Z)-2-butenedioic acid;   (Z)-butenedioic acid;   Formula=C4H4O4;   H2male;   InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-;   InChIKey=VZCYOOQTPOCHFL-UPHRSURJSA-N;   SMILES=OC(=O)\\C=C/C(O)=O;   cis-1,2-ethylenedicarboxylic acid;   cis-Butenedioic acid;   cis-but-2-enedioic acid;   toxilic acid
 alt_id: CHEBI:25119;   CHEBI:43836;   CHEBI:6653
 xref: Beilstein:1903639;   Beilstein:605762;   CAS:110-16-7;   DrugBank:DB04299;   Gmelin:49854;   HMDB:HMDB0000176;   KEGG:C01384;   KNApSAcK:C00007417
 xref_mesh: MESH:C030272
 xref: MetaCyc:MALEATE;   PDBeChem:MAE;   PMID:10952545;   PMID:11386868;   PMID:22770225;   PMID:9591280;   Reaxys:605762;   Wikipedia:Maleic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132951;   is_conjugate_acid_of CHEBI:37156


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maleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 increases expression ISO maleic acid results in increased expression of ABCA7 mRNA CTD PMID:28392987 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases expression ISO maleic acid results in increased expression of AGAP1 mRNA CTD PMID:28392987 NCBI chr 9:90,039,760...90,475,196
Ensembl chr 9:90,039,605...90,470,958
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression ISO maleic acid results in decreased expression of AKT2 mRNA CTD PMID:28392987 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G B4galnt4 beta-1,4-N-acetyl-galactosaminyl transferase 4 decreases expression ISO maleic acid results in decreased expression of B4GALNT4 mRNA CTD PMID:28392987 NCBI chr 1:196,171,394...196,182,294
Ensembl chr 1:196,171,394...196,182,294
JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 increases expression ISO maleic acid results in increased expression of CCBE1 mRNA CTD PMID:28392987 NCBI chr18:59,579,851...59,823,977 JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cldn25 claudin 25 increases expression ISO maleic acid results in increased expression of CLDN25 mRNA CTD PMID:28392987 NCBI chr 8:49,391,975...49,392,664
Ensembl chr 8:49,391,975...49,392,664
JBrowse link
G Cracr2b calcium release activated channel regulator 2B increases expression ISO maleic acid results in increased expression of CRACR2B mRNA CTD PMID:28392987 NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771
JBrowse link
G Exoc3l2 exocyst complex component 3-like 2 increases expression ISO maleic acid results in increased expression of EXOC3L2 mRNA CTD PMID:28392987 NCBI chr 1:79,113,784...79,145,359
Ensembl chr 1:79,112,506...79,145,465
JBrowse link
G Fbxo40 F-box protein 40 increases expression ISO maleic acid results in increased expression of FBXO40 mRNA CTD PMID:28392987 NCBI chr11:63,794,452...63,812,697
Ensembl chr11:63,794,624...63,812,697
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia increases expression ISO maleic acid results in increased expression of FCGR1A mRNA CTD PMID:28392987 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression ISO maleic acid results in increased expression of FMO1 mRNA CTD PMID:28392987 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases expression ISO maleic acid results in increased expression of GGT5 mRNA CTD PMID:28392987 NCBI chr20:13,043,255...13,071,523 JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression ISO maleic acid results in increased expression of GNRHR mRNA CTD PMID:28392987 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression ISO maleic acid results in increased expression of GRIA1 mRNA CTD PMID:28392987 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
EXP maleic acid results in increased expression of HAVCR1 protein
Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]
CTD PMID:25119790 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hist1h2bl histone cluster 1 H2B family member l decreases expression ISO maleic acid results in decreased expression of H2BC8 mRNA CTD PMID:28392987 NCBI chr17:42,708,646...42,709,435 JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP maleic acid affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO maleic acid results in increased expression of IGF1 mRNA CTD PMID:28392987 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 decreases expression ISO maleic acid results in decreased expression of KCNC1 mRNA CTD PMID:28392987 NCBI chr 1:96,902,953...96,944,744
Ensembl chr 1:96,902,953...96,944,744
JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases secretion
EXP Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein] CTD PMID:25119790 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G LOC102550306 uncharacterized LOC102550306 increases expression ISO maleic acid results in increased expression of C20ORF173 mRNA CTD PMID:28392987 NCBI chr 3:144,514,060...144,524,979 JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO maleic acid results in increased expression of NFAT5 mRNA CTD PMID:28392987 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects expression
EXP Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein] CTD PMID:25119790 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Olr1620 olfactory receptor 1620 increases expression ISO maleic acid results in increased expression of OR11G2 mRNA CTD PMID:28392987 NCBI chr15:23,770,417...23,771,391
Ensembl chr15:23,770,417...23,771,391
JBrowse link
G Olr947 olfactory receptor 947 increases expression ISO maleic acid results in increased expression of OR6C65 mRNA CTD PMID:28392987 NCBI chr 7:3,511,569...3,512,507 JBrowse link
G Pcdhac1 protocadherin alpha subfamily C, 1 increases expression ISO maleic acid results in increased expression of PCDHAC1 mRNA CTD PMID:28392987
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases expression ISO maleic acid results in decreased expression of PDPK1 mRNA CTD PMID:28392987 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pkd1l1 polycystin 1 like 1, transient receptor potential channel interacting increases expression ISO maleic acid results in increased expression of PKD1L1 mRNA CTD PMID:28392987 NCBI chr14:83,552,964...83,670,062
Ensembl chr14:83,545,469...83,638,498
JBrowse link
G Rsph6a radial spoke head 6 homolog A increases expression ISO maleic acid results in increased expression of RSPH6A mRNA CTD PMID:28392987 NCBI chr 1:78,700,727...78,720,444
Ensembl chr 1:78,700,814...78,720,431
JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression ISO maleic acid results in increased expression of S100A3 mRNA CTD PMID:28392987 NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702
JBrowse link
G Skap1 src kinase associated phosphoprotein 1 increases expression ISO maleic acid results in increased expression of SKAP1 mRNA CTD PMID:28392987 NCBI chr10:81,425,472...81,732,651
Ensembl chr10:81,425,525...81,732,650
JBrowse link
G Slc25a48 solute carrier family 25, member 48 increases expression ISO maleic acid results in increased expression of SLC25A48 mRNA CTD PMID:28392987 NCBI chr17:8,119,964...8,161,293
Ensembl chr17:8,121,175...8,160,748
JBrowse link
G Sox17 SRY-box transcription factor 17 increases expression ISO maleic acid results in increased expression of SOX17 mRNA CTD PMID:28392987 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Spata1 spermatogenesis associated 1 increases expression ISO maleic acid results in increased expression of SPATA1 mRNA CTD PMID:28392987 NCBI chr 2:235,349,126...235,394,578
Ensembl chr 2:235,349,127...235,394,502
JBrowse link
G Spem1 spermatid maturation 1 increases expression ISO maleic acid results in increased expression of SPEM1 mRNA CTD PMID:28392987 NCBI chr10:54,541,454...54,542,755
Ensembl chr10:54,541,471...54,546,131
JBrowse link
G Tcaf2 TRPM8 channel-associated factor 2 increases expression ISO maleic acid results in increased expression of TCAF2 mRNA CTD PMID:28392987
G Tnf tumor necrosis factor increases expression ISO maleic acid results in increased expression of TNF mRNA CTD PMID:28392987 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Zfp800 zinc finger protein 800 decreases expression ISO maleic acid results in decreased expression of ZNF800 mRNA CTD PMID:28392987 NCBI chr 4:56,798,326...56,849,766
Ensembl chr 4:56,826,997...56,849,791
JBrowse link
G Zgrf1 zinc finger, GRF-type containing 1 decreases expression ISO maleic acid results in decreased expression of ZGRF1 mRNA CTD PMID:28392987 NCBI chr 2:216,012,911...216,075,608
Ensembl chr 2:216,013,005...216,074,750
JBrowse link
citraconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach1 BTB domain and CNC homolog 1 affects localization ISO citraconic acid affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO citraconic acid results in increased expression of FOXM1 protein CTD PMID:28289076 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO citraconic acid results in increased expression of FTH1 protein CTD PMID:28289076 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein] CTD PMID:28289076 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP
ISO
citraconic acid results in increased expression of GCLC protein
citraconic acid results in increased expression of GCLC mRNA
CTD PMID:27277809 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP
ISO
citraconic acid results in increased expression of GCLM protein
citraconic acid results in increased expression of GCLM mRNA
CTD PMID:27277809 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO
EXP
citraconic acid results in increased expression of GSR mRNA
citraconic acid results in increased expression of GSR protein
CTD PMID:27277809 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO citraconic acid binds to and results in increased activity of HCAR2 protein CTD PMID:18722346 NCBI chr12:32,726,334...32,727,416
Ensembl chr12:32,726,184...32,728,504
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein CTD PMID:27277809 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 increases expression
multiple interactions
ISO citraconic acid results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]
CTD PMID:27277809 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 increases expression
multiple interactions
ISO citraconic acid results in increased expression of ND5 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]
CTD PMID:27277809 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA] CTD PMID:27277809 Ensembl chr MT:13,543...14,061 JBrowse link
G Mterf1 mitochondrial transcription termination factor 1 increases expression ISO citraconic acid results in increased expression of MTERF1A mRNA CTD PMID:27277809 NCBI chr 4:30,226,345...30,233,402
Ensembl chr 4:30,226,343...30,233,584
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
citraconic acid affects the localization of NFE2L2 protein
CTD PMID:27277809 PMID:28289076 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein CTD PMID:27277809 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Polrmt RNA polymerase mitochondrial increases expression
multiple interactions
ISO citraconic acid results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
CTD PMID:27277809 NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acy3 aminoacylase 3 decreases expression EXP diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175
JBrowse link
G Adm adrenomedullin increases expression ISO diethyl maleate results in increased expression of ADM mRNA CTD PMID:33545341 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora3 adenosine A3 receptor decreases expression EXP diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181
G Aen apoptosis enhancing nuclease increases expression ISO diethyl maleate results in increased expression of AEN mRNA CTD PMID:33545341 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
JBrowse link
G Afp alpha-fetoprotein increases expression ISO diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 increases expression ISO diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression EXP diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO diethyl maleate results in increased expression of AKR1B10 mRNA CTD PMID:33545341 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects reduction ISO diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases reduction
increases expression
decreases expression
ISO
EXP
diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705 PMID:21161181 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression EXP diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression EXP diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression EXP diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO diethyl maleate results in increased expression of ANGPTL4 mRNA CTD PMID:33545341 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression EXP diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132
JBrowse link
G Anln anillin, actin binding protein increases expression EXP diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
JBrowse link
G Anxa3 annexin A3 decreases expression EXP diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Ap3m2 adaptor related protein complex 3 subunit mu 2 decreases expression EXP diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr16:69,217,526...69,237,372
Ensembl chr16:69,217,633...69,235,431
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression ISO diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression EXP diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 increases expression ISO diethyl maleate results in increased expression of ARHGAP9 mRNA CTD PMID:33545341 NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524
JBrowse link
G Arrdc2 arrestin domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression ISO diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression EXP diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression ISO diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Aurka aurora kinase A increases expression
decreases expression
EXP
ISO
diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO diethyl maleate results in increased expression of BBC3 mRNA CTD PMID:33545341 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA
CTD PMID:22564015 PMID:33545341 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl6b BCL6B, transcription repressor decreases expression EXP diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 decreases expression EXP diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Blvrb biliverdin reductase B increases expression ISO diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Brip1 BRCA1 interacting helicase 1 increases expression EXP diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Btbd2 BTB domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
ISO diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191 PMID:25270620 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G C6 complement C6 decreases expression EXP diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
G Casp2 caspase 2 increases expression ISO diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189 PMID:21105742 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression ISO diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression EXP diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931 PMID:25270620 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Cbx4 chromobox 4 increases expression ISO diethyl maleate results in increased expression of CBX4 mRNA CTD PMID:33545341 NCBI chr10:104,337,140...104,343,210 JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression ISO diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr11:73,332,798...73,395,333
Ensembl chr11:73,334,248...73,395,150
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 increases expression EXP diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189 PMID:21161181 PMID:25270620 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne2 cyclin E2 increases expression EXP diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnk cyclin K decreases expression ISO diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171 PMID:31958493 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc25a cell division cycle 25A increases expression EXP diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression EXP diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression EXP diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh11 cadherin 11 decreases expression EXP diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189 PMID:27982581 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 increases expression ISO diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541
JBrowse link
G Ces1d carboxylesterase 1D decreases expression
increases reduction
EXP
ISO
diethyl maleate results in decreased expression of CES1D protein
diethyl maleate results in increased reduction of CES1D protein
CTD PMID:19843705 PMID:21161181 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression EXP diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit increases expression ISO diethyl maleate results in increased expression of CHRNA4 mRNA CTD PMID:33545341 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression EXP diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression EXP diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
JBrowse link
G Ckb creatine kinase B decreases reduction ISO diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO diethyl maleate results in increased expression of CKS2 mRNA CTD PMID:33545341 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO diethyl maleate results in increased expression of CLK1 mRNA CTD PMID:33545341 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression EXP diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
JBrowse link
G Cntn1 contactin 1 increases expression ISO diethyl maleate results in increased expression of CNTN1 mRNA CTD PMID:33545341 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
JBrowse link
G Comt catechol-O-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cp ceruloplasmin decreases expression ISO diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpsf4l cleavage and polyadenylation specific factor 4-like increases expression ISO diethyl maleate results in increased expression of CPSF4L mRNA CTD PMID:33545341 NCBI chr10:98,741,816...98,756,069 JBrowse link
G Crym crystallin, mu decreases expression EXP diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 decreases reduction ISO diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyb5a cytochrome b5 type A increases expression ISO diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO diethyl maleate results in increased expression of DDIT3 mRNA CTD PMID:33545341 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO diethyl maleate results in increased expression of DDIT4 mRNA CTD PMID:33545341 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Dhx58 DEXH-box helicase 58 decreases expression EXP diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO diethyl maleate results in increased expression of DNAJB1 mRNA CTD PMID:33545341 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO diethyl maleate results in increased expression of DNAJB4 mRNA CTD PMID:33545341 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Dnmbp dynamin binding protein decreases expression EXP diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr 1:242,736,189...242,829,498
Ensembl chr 1:242,736,189...242,802,604
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases reduction ISO diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L decreases expression EXP diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr11:64,814,926...64,824,538
Ensembl chr11:64,814,926...64,824,538
JBrowse link
G Dus3l dihydrouridine synthase 3-like decreases expression ISO diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO diethyl maleate results in increased expression of DUSP6 mRNA CTD PMID:33545341 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression EXP diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr 1:175,393,119...175,454,452
Ensembl chr 1:175,393,154...175,455,164
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression EXP diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression ISO diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
JBrowse link
G Eras ES cell expressed Ras decreases expression ISO diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:14,573,987...14,578,455
Ensembl chr  X:14,573,987...14,578,374
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression EXP diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:67,245,414...67,261,222
Ensembl chr  X:67,245,414...67,280,756
JBrowse link
G Exo1 exonuclease 1 increases expression EXP diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression EXP diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
JBrowse link
G Fam126b family with sequence similarity 126, member B decreases expression EXP diethyl maleate results in decreased expression of FAM126B mRNA CTD PMID:21161181 NCBI chr 9:60,056,883...60,129,176
Ensembl chr 9:60,056,890...60,093,007
JBrowse link
G Fam83d family with sequence similarity 83, member D increases expression ISO diethyl maleate results in increased expression of FAM83D mRNA CTD PMID:33545341 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fasn fatty acid synthase decreases expression EXP diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbn1 fibrillin 1 decreases expression EXP diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression EXP diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fgf17 fibroblast growth factor 17 decreases expression ISO diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr15:45,711,901...45,717,063
Ensembl chr15:45,711,998...45,717,063
JBrowse link
G Fgg fibrinogen gamma chain decreases expression ISO diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression ISO diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 PMID:33545341 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO diethyl maleate results in increased expression of FOXO3 mRNA CTD PMID:33545341 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fstl3 follistatin like 3 increases expression ISO diethyl maleate results in increased expression of FSTL3 mRNA CTD PMID:33545341 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO diethyl maleate results in decreased expression of G6PC mRNA CTD PMID:25270620 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
increases expression
EXP
ISO
diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA
CTD PMID:3099627 PMID:33545341 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gab1 GRB2-associated binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO diethyl maleate results in increased expression of GADD45A mRNA CTD PMID:33545341 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO diethyl maleate results in increased expression of GADD45G mRNA CTD PMID:33545341 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases reduction ISO diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gba2 glucosylceramidase beta 2 decreases expression ISO diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression EXP diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO
EXP
diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More... NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP
ISO
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO diethyl maleate results in increased expression of GCNT3 mRNA CTD PMID:33545341 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO diethyl maleate results in increased expression of GDF15 mRNA CTD PMID:33545341 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO diethyl maleate results in increased expression of GDF9 mRNA CTD PMID:33545341 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 increases expression ISO diethyl maleate results in increased expression of GFOD1 mRNA CTD PMID:33545341 NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938
JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression EXP diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Gsn gelsolin decreases reduction ISO diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase increases expression EXP diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP diethyl maleate results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression EXP diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
JBrowse link
G H2az2 H2A.Z variant histone 2 increases expression ISO diethyl maleate results in increased expression of H2AZ2 mRNA CTD PMID:33545341 NCBI chr14:81,293,299...81,312,209
Ensembl chr14:81,293,299...81,312,144
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) increases expression ISO diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO diethyl maleate results in increased expression of HAMP mRNA CTD PMID:33545341 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Helb DNA helicase B decreases expression ISO diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression EXP diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 9:92,001,838...92,003,580
Ensembl chr 9:92,001,841...92,003,559
JBrowse link
G Hjurp Holliday junction recognition protein increases expression EXP diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO diethyl maleate results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction ISO diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression ISO diethyl maleate results in increased expression of HSD17B10 mRNA CTD PMID:33545341 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO diethyl maleate results in increased expression of HSPA1B mRNA CTD PMID:33545341 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO diethyl maleate results in increased expression of HSPA1L mRNA CTD PMID:33545341 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases reduction ISO diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases reduction ISO diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO diethyl maleate results in decreased expression of ICAM1 mRNA CTD PMID:25270620 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression EXP diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO diethyl maleate results in increased expression of IFRD1 mRNA CTD PMID:33545341 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il10 interleukin 10 increases secretion ISO diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 increases expression ISO diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Inhbb inhibin subunit beta B decreases expression ISO diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Ints7 integrator complex subunit 7 decreases expression ISO diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr13:103,155,123...103,207,953
Ensembl chr13:103,155,090...103,208,592
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression EXP diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
JBrowse link
G Irgm immunity-related GTPase M decreases expression EXP diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Itgal integrin subunit alpha L decreases expression EXP diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression ISO diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 decreases expression ISO diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression EXP diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739 PMID:12774022 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 decreases expression ISO diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 PMID:33545341 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Khdrbs3 KH RNA binding domain containing, signal transduction associated 3 increases expression ISO diethyl maleate results in increased expression of KHDRBS3 mRNA CTD PMID:33545341 NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460
JBrowse link
G Kifc1 kinesin family member C1 increases expression EXP diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression EXP
ISO
diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181 PMID:25270620 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Krt75 keratin 75 increases reduction ISO diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
JBrowse link
G Lama1 laminin subunit alpha 1 decreases expression ISO diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
JBrowse link
G Lancl2 LanC like 2 decreases expression ISO diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression EXP diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lepr leptin receptor decreases expression EXP diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression EXP diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
JBrowse link
G Lmnb1 lamin B1 increases expression EXP diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Lmo7 LIM domain 7 decreases expression EXP diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G LOC100363405 hypothetical LOC100363405 decreases expression EXP diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 5:74,930,335...74,960,075
Ensembl chr 5:74,863,483...74,960,101
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO diethyl maleate results in increased expression of HSPA6 mRNA CTD PMID:33545341 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 decreases expression EXP diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr 7:61,816,313...61,866,275
Ensembl chr 7:61,816,342...61,866,481
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases expression EXP diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831
JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 decreases expression EXP diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr 4:152,485,863...152,508,248
Ensembl chr 4:152,485,866...152,500,377
JBrowse link
G Ltc4s leukotriene C4 synthase decreases expression EXP diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Lum lumican decreases expression EXP diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
JBrowse link
G Ly6c Ly6-C antigen decreases expression EXP diethyl maleate results in decreased expression of LY6C mRNA CTD PMID:21161181 NCBI chr 7:106,959,508...106,963,360
Ensembl chr 7:106,959,511...106,963,329
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 PMID:33545341 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO diethyl maleate results in increased expression of MAFG mRNA CTD PMID:33545341 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Maoa monoamine oxidase A increases expression ISO diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mapk1ip1l mitogen-activated protein kinase 1 interacting protein 1-like increases expression ISO diethyl maleate results in increased expression of MAPK1IP1L mRNA CTD PMID:33545341 NCBI chr15:20,545,028...20,567,010
Ensembl chr15:20,545,059...20,569,674
JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr 1:240,954,452...240,958,384
Ensembl chr 1:240,954,452...240,958,384
JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 increases expression ISO diethyl maleate results in increased expression of MBOAT7 mRNA CTD PMID:33545341 NCBI chr 1:65,525,206...65,539,538 JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression EXP diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Me1 malic enzyme 1 increases expression ISO diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mfap4 microfibril associated protein 4 decreases expression EXP diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 decreases expression EXP diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO diethyl maleate results in increased expression of MMP1 mRNA CTD PMID:33545341 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO diethyl maleate results in increased expression of MMP3 mRNA CTD PMID:33545341 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Msn moesin increases reduction ISO diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mt1 metallothionein 1 increases expression ISO diethyl maleate results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A increases expression ISO diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression EXP diethyl maleate results in decreased expression of MX1 mRNA; diethyl maleate results in decreased expression of MX2 mRNA CTD PMID:21161181 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases expression ISO diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Nat8 N-acetyltransferase 8 decreases expression EXP diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO diethyl maleate results in increased expression of NDRG1 mRNA CTD PMID:33545341 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
ISO
EXP
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:27358234 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] CTD PMID:12774022 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate] CTD PMID:7532384 PMID:9918918 PMID:12774022 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 increases expression ISO diethyl maleate results in increased expression of NOTCH1 mRNA CTD PMID:33545341 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression ISO diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
JBrowse link
G Ntf3 neurotrophin 3 decreases expression EXP diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Nup153 nucleoporin 153 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
JBrowse link
G Nup88 nucleoporin 88 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257
JBrowse link
G Oaf out at first homolog decreases expression EXP diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Oas1i 2 ' -5 ' oligoadenylate synthetase 1I decreases expression EXP diethyl maleate results in decreased expression of OAS1I mRNA CTD PMID:21161181 NCBI chr12:35,624,566...35,636,608
Ensembl chr12:35,624,592...35,636,604
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO diethyl maleate results in increased expression of OSGIN1 mRNA CTD PMID:33545341 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases expression EXP diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression EXP diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 increases expression ISO diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858
Ensembl chr 3:141,476,501...141,483,858
JBrowse link
G Per2 period circadian regulator 2 decreases expression EXP diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Per3 period circadian regulator 3 decreases expression EXP diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity EXP diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression ISO diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Pir pirin increases expression ISO diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Plat plasminogen activator, tissue type increases expression
decreases expression
EXP
ISO
diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plek pleckstrin decreases expression EXP diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO diethyl maleate results in increased expression of PLEKHM1 mRNA CTD PMID:33545341 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
JBrowse link
G Plin2 perilipin 2 increases expression ISO diethyl maleate results in increased expression of PLIN2 mRNA CTD PMID:33545341 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plk1 polo-like kinase 1 increases expression ISO diethyl maleate results in increased expression of PLK1 mRNA CTD PMID:33545341 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO diethyl maleate results in increased expression of PLK3 mRNA CTD PMID:33545341 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO diethyl maleate results in increased expression of POU5F1 mRNA CTD PMID:33545341 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
EXP diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression EXP diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression EXP diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression EXP diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
JBrowse link
G Prdm14 PR/SET domain 14 decreases expression ISO diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression ISO diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression ISO diethyl maleate results in increased expression of PRKAG2 mRNA CTD PMID:33545341 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Prkcb protein kinase C, beta affects expression ISO diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prss8 serine protease 8 decreases expression EXP diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression ISO diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196
JBrowse link
G Pxn paxillin increases expression ISO diethyl maleate results in increased expression of PXN mRNA CTD PMID:33545341 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases expression EXP diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] CTD PMID:20116392 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rho rhodopsin increases expression ISO diethyl maleate results in increased expression of RHO mRNA CTD PMID:33545341 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773
JBrowse link
G Rnf114 ring finger protein 114 decreases expression ISO diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr 3:156,222,487...156,234,263
Ensembl chr 3:156,222,498...156,234,256
JBrowse link
G Rnf14 ring finger protein 14 increases expression ISO diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr18:30,131,627...30,155,686
Ensembl chr18:30,131,691...30,155,685
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression EXP
ISO
diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 PMID:33545341 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP diethyl maleate results in decreased expression of RT1-S3 mRNA CTD PMID:21161181 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression EXP diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sash3 SAM and SH3 domain containing 3 decreases expression EXP diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sds serine dehydratase decreases expression EXP diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO diethyl maleate results in increased expression of SERTAD1 mRNA CTD PMID:33545341 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
JBrowse link
G Sez6 seizure related 6 homolog decreases expression EXP diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression ISO diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression ISO diethyl maleate results in increased expression of SH3BP5 mRNA CTD PMID:33545341 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Six4 SIX homeobox 4 increases expression ISO diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr 6:91,802,328...91,816,062
Ensembl chr 6:91,802,329...91,815,992
JBrowse link
G Slc16a6 solute carrier family 16, member 6 decreases expression ISO diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr10:94,424,377...94,447,984
Ensembl chr10:94,426,244...94,448,779
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression EXP diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
JBrowse link
G Slc39a14 solute carrier family 39 member 14 decreases expression ISO diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO diethyl maleate results in increased expression of SLC3A2 mRNA CTD PMID:33545341 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc44a4 solute carrier family 44, member 4 decreases expression EXP diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr20:3,903,099...3,919,215
Ensembl chr20:3,903,099...3,919,215
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 PMID:33545341 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 decreases expression EXP diethyl maleate results in decreased expression of SLC9A3R1 mRNA CTD PMID:21161181 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression EXP diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Slfn3 schlafen family member 3 decreases expression EXP diethyl maleate results in decreased expression of SLFN3 mRNA CTD PMID:21161181 NCBI chr10:68,020,482...68,060,248 JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Smtn smoothelin increases expression EXP diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression EXP diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 increases expression ISO diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 increases expression ISO diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO diethyl maleate results in increased expression of SPTLC1 mRNA CTD PMID:33545341 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 PMID:33545341 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
decreases expression
increases expression
ISO [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in decreased expression of SRXN1 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression EXP diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Steap4 STEAP4 metalloreductase decreases expression ISO diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Sulf2 sulfatase 2 decreases expression EXP diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP diethyl maleate results in decreased expression of SULT1A1 protein CTD PMID:21161181 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tagln transgelin decreases expression EXP diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tatdn2 TatD DNase domain containing 2 increases expression ISO diethyl maleate results in increased expression of TATDN2 mRNA CTD PMID:33545341 NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897
JBrowse link
G Tbcel tubulin folding cofactor E-like increases expression ISO diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr 8:42,795,648...42,854,552
Ensembl chr 8:42,796,730...42,854,552
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases expression ISO diethyl maleate results in increased expression of TENT4A mRNA CTD PMID:33545341 NCBI chr 1:33,766,121...33,799,433
Ensembl chr 1:33,765,672...33,799,433
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A decreases expression EXP diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045
JBrowse link
G Tesmin testis expressed metallothionein like protein affects localization ISO diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr 1:200,629,688...200,648,434
Ensembl chr 1:200,630,144...200,648,433
JBrowse link
G Tf transferrin decreases expression EXP diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfeb transcription factor EB decreases expression ISO diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tgm2 transglutaminase 2 increases expression EXP diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tm4sf1 transmembrane 4 L six family member 1 increases expression EXP diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146
JBrowse link
G Tmem209 transmembrane protein 209 increases expression ISO diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 4:59,101,656...59,128,687
Ensembl chr 4:59,101,550...59,128,630
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 decreases expression EXP diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27982581 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpm2 tropomyosin 2 decreases expression EXP diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases response to substance
ISO diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression ISO diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO diethyl maleate results in increased expression of TRIB1 mRNA CTD PMID:33545341 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO diethyl maleate results in increased expression of TRIB3 mRNA CTD PMID:33545341 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim6 tripartite motif containing 6 decreases expression EXP diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression EXP diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tspan8 tetraspanin 8 decreases expression EXP diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356
JBrowse link
G Tstd1 thiosulfate sulfurtransferase like domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr13:83,853,421...83,854,875 JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnip thioredoxin interacting protein increases expression EXP diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 PMID:33545341 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ubd ubiquitin D decreases expression EXP diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression EXP diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression EXP diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO diethyl maleate results in increased expression of VEGFA mRNA CTD PMID:33545341 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression ISO diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 5:75,897,074...75,917,461
Ensembl chr 5:75,898,353...75,917,417
JBrowse link
G Wdr6 WD repeat domain 6 decreases expression EXP diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499
JBrowse link
G Ypel5 yippee-like 5 increases expression ISO diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr 6:22,656,284...22,671,741
Ensembl chr 6:22,656,285...22,671,691
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO diethyl maleate results in increased expression of ZFAND2A mRNA CTD PMID:33545341 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr 1:203,017,682...203,019,465
Ensembl chr 1:203,017,682...203,019,465
JBrowse link
dimethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dimethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO dimethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
maleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 multiple interactions ISO maleimide analog binds to and results in increased activity of TP53 protein mutant form CTD PMID:15998635 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
maleimides term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Maleimides analog results in decreased activity of PTGS2 protein CTD PMID:8648609 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions
ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Alb albumin decreases transport EXP Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions EXP Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chat choline O-acetyltransferase decreases activity ISO Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:85,098,792...85,099,984
Ensembl chr13:85,097,899...85,100,093
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Hoxb13 homeo box B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr10:81,160,498...81,162,777
Ensembl chr10:81,160,498...81,162,777
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Pah phenylalanine hydroxylase multiple interactions ISO Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Senp1 SUMO specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170
JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases activity
multiple interactions
ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr10:100,771,941...100,784,503 JBrowse link
G Tf transferrin decreases uptake ISO Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding EXP Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
N-Ethylmaleimide-S-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
affects transport
ISO Benzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Indomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Probenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] CTD PMID:11880368 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
Ro 31-8220 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]
Ro 31-8220 results in decreased expression of ABCA1 mRNA
CTD PMID:15037193 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein] CTD PMID:22001173 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Ro 31-8220 results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:17561261 PMID:18054255 PMID:22001173 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] CTD PMID:22001173 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] CTD PMID:21393419 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]
CTD PMID:15522277 PMID:16280361 PMID:22138297 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 PMID:16877402 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Ro 31-8220 results in decreased expression of FOS mRNA
CTD PMID:11353138 PMID:11568973 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Ro 31-8220 results in decreased activity of GSK3B protein CTD PMID:10998351 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18048804 PMID:18357586 PMID:26275128 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] CTD PMID:18360087 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10712238 PMID:11854442 PMID:18054255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA] CTD PMID:16818790 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Ro 31-8220 results in decreased expression of JUN mRNA
Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:11353138 PMID:11568973 PMID:12169099 PMID:19002563 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] CTD PMID:11756236 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK9 protein] CTD PMID:11756236 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
Ro 31-8220 results in decreased expression of MT1 mRNA
CTD PMID:11551972 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein] CTD PMID:32416088 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nts neurotensin increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of NTS protein
Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]
CTD PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein] CTD PMID:32416088 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkci protein kinase C, iota decreases activity ISO Ro 31-8220 results in decreased activity of PRKCI protein CTD PMID:14511371 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD PMID:11854442 PMID:19576865 PMID:32416088 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form] CTD PMID:18986333 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnf187 ring finger protein 187 multiple interactions
decreases stability
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] CTD PMID:25851810 NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity EXP Ro 31-8220 results in decreased activity of RPS6KA5 protein CTD PMID:15522277 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA] CTD PMID:15037193 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sftpb surfactant protein B multiple interactions EXP Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein] CTD PMID:11704537 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sftpc surfactant protein C multiple interactions EXP Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein] CTD PMID:11704537 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Ro 31-8220 inhibits the reaction [decitabine results in increased expression of TNFSF10 protein] CTD PMID:17283156 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Ro 31-8220 results in decreased expression of VEGFA mRNA CTD PMID:12590138 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
SB 415286 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein] CTD PMID:33548343 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 PMID:15942663 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP
ISO
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
CTD PMID:15753396 PMID:25381574 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
CTD PMID:23292070 PMID:29723552 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein CTD PMID:19159680 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dbn1 drebrin 1 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]] CTD PMID:33548343 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]] CTD PMID:33548343 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases activity
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein
CTD PMID:15753396 PMID:19159680 PMID:31563592 PMID:33548343 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gys1 glycogen synthase 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein] CTD PMID:23292070 NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] CTD PMID:24560772 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA
bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]
CTD PMID:25381574 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:23292070 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Syp synaptophysin multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] CTD PMID:24560772 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA] CTD PMID:25381574 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
sotrastaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcb protein kinase C, beta decreases activity
multiple interactions
ISO sotrastaurin results in decreased activity of PRKCB protein
sotrastaurin inhibits the reaction [docetaxel results in increased phosphorylation of PRKCB protein]
CTD PMID:25634538 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
ISO tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008 PMID:16621434 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Brca1 BRCA1, DNA repair associated affects binding ISO tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases metabolic processing
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of tetramethrin CTD PMID:19249324 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Folh1 folate hydrolase 1 decreases expression ISO tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G S100g S100 calcium binding protein G decreases expression
multiple interactions
EXP tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO tetramethrin results in increased expression of TMPRSS2 mRNA CTD PMID:12711008 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
U-73122 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agt angiotensinogen multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [AGT protein affects the localization of Calcium]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 PMID:21613610 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:15177934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] CTD PMID:19927300 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cck cholecystokinin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 protein]
CTD PMID:17680988 PMID:33421459 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [imidacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] CTD PMID:29701941 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of DLG4 protein] CTD PMID:33421459 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G F2 coagulation factor II multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA] CTD PMID:19225867 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gcg glucagon multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 9:75,862,151...75,863,140
Ensembl chr 9:75,860,677...75,863,168
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:33421459 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]]
CTD PMID:19281832 PMID:22214447 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein] CTD PMID:24631921 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases activity ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein results in increased susceptibility to Capsaicin] CTD PMID:16696851 PMID:17324588 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lep leptin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] CTD PMID:21245013 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]] CTD PMID:22214447 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:15240149 PMID:16714034 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nts neurotensin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PLCB1 mRNA]
CTD PMID:16714034 PMID:33421459 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
JBrowse link
G Plcd1 phospholipase C, delta 1 decreases activity
multiple interactions
ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]
CTD PMID:16618758 PMID:16714034 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein] CTD PMID:16714034 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA protein]
CTD PMID:16581232 PMID:19281832 PMID:33421459 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]] CTD PMID:22214447 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Selp selectin P multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]; resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]] CTD PMID:18291361 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein] CTD PMID:19281832 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of STK11 protein] CTD PMID:33676887 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Syp synaptophysin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of SYP protein] CTD PMID:33421459 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]] CTD PMID:16696851 PMID:18809416 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]] CTD PMID:22214447 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] CTD PMID:15046718 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity
multiple interactions
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of TRPC6 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein]
CTD PMID:11179201 PMID:17603544 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8] CTD PMID:15046718 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 PMID:18809416 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vim vimentin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              algal metabolite 13939
                maleic acid 563
                  (Z)-3-carboxyprop-2-enoyl group 0
                  2-(omega-methylthio)alkylmaleic acid + 0
                  2-isopropylmaleic acid 0
                  N-formylmaleamic acid 0
                  citraconic acid 17
                  dimethylmaleic acid 0
                  maleamic acid 0
                  maleate ester + 384
                  maleimide + 77
                  maleimides + 156
                  maleoyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      dicarboxylic acids and O-substituted derivatives 10366
                                        dicarboxylic acid 10358
                                          C4-dicarboxylic acid 871
                                            butenedioic acid 587
                                              maleic acid 563
                                                (Z)-3-carboxyprop-2-enoyl group 0
                                                2-(omega-methylthio)alkylmaleic acid + 0
                                                2-isopropylmaleic acid 0
                                                N-formylmaleamic acid 0
                                                citraconic acid 17
                                                dimethylmaleic acid 0
                                                maleamic acid 0
                                                maleate ester + 384
                                                maleimide + 77
                                                maleimides + 156
                                                maleoyl group 0
paths to the root