CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: maleate ester
Accession: CHEBI:35486
browse the term
Definition: Compounds of the general formula ROOC-CH=CH-COOR' where R and R' are organyl groups
Synonyms: related_synonym: maleate esters
G
Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
diethyl maleate results in increased expression of ABCC2 mRNA
CTD
PMID:25270620
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
G
Abhd4
abhydrolase domain containing 4, N-acyl phospholipase B
increases expression
ISO
diethyl maleate results in increased expression of ABHD4 mRNA
CTD
PMID:25270620
NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
G
Acaca
acetyl-CoA carboxylase alpha
decreases expression
ISO
diethyl maleate results in decreased expression of ACACA mRNA
CTD
PMID:25270620
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
G
Acox1
acyl-CoA oxidase 1
multiple interactions
EXP
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]
CTD
PMID:17134953
NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
G
Acy3
aminoacylase 3
decreases expression
EXP
diethyl maleate results in decreased expression of ACY3 mRNA
CTD
PMID:21161181
NCBI chr 1:219,233,712...219,237,103
Ensembl chr 1:219,233,750...219,237,098
G
Adora3
adenosine A3 receptor
decreases expression
EXP
diethyl maleate results in decreased expression of ADORA3 mRNA
CTD
PMID:21161181
NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
G
Afp
alpha-fetoprotein
increases expression
ISO
diethyl maleate results in increased expression of AFP mRNA
CTD
PMID:25270620
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
G
Ahcyl1
adenosylhomocysteinase-like 1
increases expression
ISO
diethyl maleate results in increased expression of AHCYL1 mRNA
CTD
PMID:25270620
NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
G
Akr1a1
aldo-keto reductase family 1 member A1
increases expression
EXP
diethyl maleate results in increased expression of AKR1A1 protein
CTD
PMID:21161181
NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
G
Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
diethyl maleate results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
affects reduction
ISO
diethyl maleate affects the reduction of ALDH1A1 protein
CTD
PMID:19843705
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
G
Aldh1b1
aldehyde dehydrogenase 1 family, member B1
decreases expression
EXP
diethyl maleate results in decreased expression of ALDH1B1 mRNA
CTD
PMID:21161181
NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
G
Aldh2
aldehyde dehydrogenase 2 family member
decreases reduction increases expression decreases expression
ISO EXP
diethyl maleate results in decreased reduction of ALDH2 protein diethyl maleate results in increased expression of ALDH2 protein diethyl maleate results in decreased expression of ALDH2 protein
CTD
PMID:19843705 PMID:21161181
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
G
Aldob
aldolase, fructose-bisphosphate B
decreases expression
EXP
diethyl maleate results in decreased expression of ALDOB protein
CTD
PMID:21161181
NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
G
Amigo2
adhesion molecule with Ig like domain 2
decreases expression
EXP
diethyl maleate results in decreased expression of AMIGO2 mRNA
CTD
PMID:21161181
NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
G
Angptl2
angiopoietin-like 2
decreases expression
EXP
diethyl maleate results in decreased expression of ANGPTL2 mRNA
CTD
PMID:21161181
NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
G
Ankrd46
ankyrin repeat domain 46
decreases expression
EXP
diethyl maleate results in decreased expression of ANKRD46 mRNA
CTD
PMID:21161181
NCBI chr 7:75,279,443...75,300,442
Ensembl chr 7:75,279,446...75,288,365
G
Anln
anillin, actin binding protein
increases expression
EXP
diethyl maleate results in increased expression of ANLN mRNA
CTD
PMID:21161181
NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
G
Anxa3
annexin A3
decreases expression
EXP
diethyl maleate results in decreased expression of ANXA3 mRNA
CTD
PMID:21161181
NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
G
Ap3m2
adaptor related protein complex 3 subunit mu 2
decreases expression
EXP
diethyl maleate results in decreased expression of AP3M2 mRNA
CTD
PMID:21161181
NCBI chr16:74,075,842...74,091,230
Ensembl chr16:74,076,812...74,091,139
G
Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
diethyl maleate results in increased expression of APAF1 mRNA
CTD
PMID:11875189
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
G
Aplp1
amyloid beta precursor like protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of APLP1 mRNA
CTD
PMID:25270620
NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
G
Apol9a
apolipoprotein L 9a
decreases expression
EXP
diethyl maleate results in decreased expression of APOL9A mRNA
CTD
PMID:21161181
NCBI chr 7:118,927,013...118,933,778
Ensembl chr 7:118,927,008...118,933,812
G
Arrdc2
arrestin domain containing 2
decreases expression
EXP
diethyl maleate results in decreased expression of ARRDC2 mRNA
CTD
PMID:21161181
NCBI chr16:20,352,480...20,356,612
Ensembl chr16:20,352,480...20,356,612
G
Arrdc4
arrestin domain containing 4
decreases expression
ISO
diethyl maleate results in decreased expression of ARRDC4 mRNA
CTD
PMID:25270620
NCBI chr 1:129,766,097...129,780,076
Ensembl chr 1:129,766,100...129,780,356
G
Asf1b
anti-silencing function 1B histone chaperone
increases expression
EXP
diethyl maleate results in increased expression of ASF1B mRNA
CTD
PMID:21161181
NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491
G
Asxl1
ASXL transcriptional regulator 1
decreases expression
ISO
diethyl maleate results in decreased expression of ASXL1 mRNA
CTD
PMID:25270620
NCBI chr 3:148,832,231...148,902,356
Ensembl chr 3:148,837,814...148,900,452
G
Atm
ATM serine/threonine kinase
increases expression
ISO
diethyl maleate results in increased expression of ATM mRNA
CTD
PMID:11875189
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
G
Atp5f1b
ATP synthase F1 subunit beta
increases expression
EXP
diethyl maleate results in increased expression of ATP5F1B protein
CTD
PMID:21161181
NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
G
Aurka
aurora kinase A
increases expression decreases expression
EXP ISO
diethyl maleate results in increased expression of AURKA mRNA diethyl maleate results in decreased expression of AURKA mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
CTD
PMID:22564015
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Bcl2a1
BCL2-related protein A1
decreases expression
EXP
diethyl maleate results in decreased expression of BCL2A1 mRNA
CTD
PMID:21161181
NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
G
Bcl3
BCL3, transcription coactivator
decreases expression
ISO
diethyl maleate results in decreased expression of BCL3 mRNA
CTD
PMID:25270620
NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
G
Bcl6b
BCL6B, transcription repressor
decreases expression
EXP
diethyl maleate results in decreased expression of BCL6B mRNA
CTD
PMID:21161181
NCBI chr10:56,834,363...56,840,058
Ensembl chr10:56,834,364...56,839,437
G
Bhlhe41
basic helix-loop-helix family, member e41
decreases expression
EXP
diethyl maleate results in decreased expression of BHLHE41 mRNA
CTD
PMID:21161181
NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
G
Bhmt
betaine-homocysteine S-methyltransferase
decreases expression
EXP
diethyl maleate results in decreased expression of BHMT mRNA
CTD
PMID:21161181
NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
G
Birc3
baculoviral IAP repeat-containing 3
multiple interactions
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
CTD
PMID:12774022
NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
G
Blvrb
biliverdin reductase B
increases expression
ISO
diethyl maleate results in increased expression of BLVRB mRNA
CTD
PMID:25270620
NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
G
Bmf
Bcl2 modifying factor
decreases expression
EXP
diethyl maleate results in decreased expression of BMF mRNA
CTD
PMID:21161181
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
G
Brip1
BRCA1 interacting protein C-terminal helicase 1
increases expression
EXP
diethyl maleate results in increased expression of BRIP1 mRNA
CTD
PMID:21161181
NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
G
Btbd2
BTB domain containing 2
decreases expression
EXP
diethyl maleate results in decreased expression of BTBD2 mRNA
CTD
PMID:21161181
NCBI chr 7:11,929,859...11,943,559
Ensembl chr 7:11,930,135...11,942,799
G
Btg2
BTG anti-proliferation factor 2
increases expression decreases expression multiple interactions
ISO
diethyl maleate results in increased expression of BTG2 mRNA diethyl maleate results in decreased expression of BTG2 mRNA NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD
PMID:22003191 PMID:25270620
NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
G
C6
complement C6
decreases expression
EXP
diethyl maleate results in decreased expression of C6 mRNA
CTD
PMID:21161181
NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
G
Casp2
caspase 2
increases expression
ISO
diethyl maleate results in increased expression of CASP2 mRNA
CTD
PMID:11875189
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
G
Casp3
caspase 3
increases expression increases cleavage
ISO
diethyl maleate results in increased expression of CASP3 mRNA diethyl maleate results in increased cleavage of CASP3 protein
CTD
PMID:11875189 PMID:21105742
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp9
caspase 9
increases expression
ISO
diethyl maleate results in increased expression of CASP9 mRNA
CTD
PMID:11875189
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Cat
catalase
decreases expression
EXP
diethyl maleate results in decreased expression of CAT protein
CTD
PMID:21161181
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
G
Cbr1
carbonyl reductase 1
increases expression
ISO
diethyl maleate results in increased expression of CBR1 mRNA
CTD
PMID:25270620
NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
G
Cbr3
carbonyl reductase 3
increases expression multiple interactions
ISO
diethyl maleate results in increased expression of CBR3 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD
PMID:20806931 PMID:25270620
NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
G
Ccdc50
coiled-coil domain containing 50
decreases expression
ISO
diethyl maleate results in decreased expression of CCDC50 mRNA
CTD
PMID:25270620
NCBI chr11:76,742,179...76,804,695
Ensembl chr11:76,747,865...76,804,510
G
Ccna1
cyclin A1
decreases expression
ISO
diethyl maleate results in decreased expression of CCNA1 mRNA
CTD
PMID:11875189
NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
G
Ccna2
cyclin A2
increases expression
EXP
diethyl maleate results in increased expression of CCNA2 mRNA
CTD
PMID:21161181
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
G
Ccnd1
cyclin D1
decreases expression increases expression
ISO EXP
diethyl maleate results in decreased expression of CCND1 mRNA diethyl maleate results in increased expression of CCND1 mRNA
CTD
PMID:11875189 PMID:21161181 PMID:25270620
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
G
Ccne2
cyclin E2
increases expression
EXP
diethyl maleate results in increased expression of CCNE2 mRNA
CTD
PMID:21161181
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
G
Ccnk
cyclin K
decreases expression
ISO
diethyl maleate results in decreased expression of CCNK mRNA
CTD
PMID:11875189
NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
G
Cd80
Cd80 molecule
multiple interactions increases expression
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein diethyl maleate results in increased expression of CD80 protein
CTD
PMID:31958493
NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
G
Cd86
CD86 molecule
multiple interactions increases expression
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]
CTD
PMID:24136171 PMID:31958493
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
G
Cdc25a
cell division cycle 25A
increases expression
EXP
diethyl maleate results in increased expression of CDC25A mRNA
CTD
PMID:21161181
NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
G
Cdca2
cell division cycle associated 2
increases expression
EXP
diethyl maleate results in increased expression of CDCA2 mRNA
CTD
PMID:21161181
NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
G
Cdca3
cell division cycle associated 3
increases expression
EXP
diethyl maleate results in increased expression of CDCA3 mRNA
CTD
PMID:21161181
NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
G
Cdca8
cell division cycle associated 8
increases expression
EXP
diethyl maleate results in increased expression of CDCA8 mRNA
CTD
PMID:21161181
NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
G
Cdh11
cadherin 11
decreases expression
EXP
diethyl maleate results in decreased expression of CDH11 mRNA
CTD
PMID:21161181
NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD
PMID:11875189 PMID:27982581
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cds2
CDP-diacylglycerol synthase 2
increases expression
ISO
diethyl maleate results in increased expression of CDS2 mRNA
CTD
PMID:25270620
NCBI chr 3:124,896,657...124,935,221
Ensembl chr 3:124,896,618...124,935,226
G
Ces1d
carboxylesterase 1D
decreases expression increases reduction
EXP ISO
diethyl maleate results in decreased expression of CES1D protein diethyl maleate results in increased reduction of CES1D protein
CTD
PMID:19843705 PMID:21161181
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
G
Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
EXP
diethyl maleate results in decreased expression of CFLAR mRNA
CTD
PMID:21161181
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
G
Cidec
cell death-inducing DFFA-like effector c
decreases expression
EXP
diethyl maleate results in decreased expression of CIDEC mRNA
CTD
PMID:21161181
NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
EXP
diethyl maleate results in decreased expression of CITED2 mRNA
CTD
PMID:21161181
NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
G
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
decreases expression
EXP
diethyl maleate results in decreased expression of CITED4 mRNA
CTD
PMID:21161181
NCBI chr 5:139,597,731...139,598,622
Ensembl chr 5:139,597,731...139,598,622
G
Ckb
creatine kinase B
decreases reduction
ISO
diethyl maleate results in decreased reduction of CKB protein
CTD
PMID:19843705
NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
G
Cmpk2
cytidine/uridine monophosphate kinase 2
decreases expression
EXP
diethyl maleate results in decreased expression of CMPK2 mRNA
CTD
PMID:21161181
NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
G
Col1a1
collagen type I alpha 1 chain
decreases expression
EXP
diethyl maleate results in decreased expression of COL1A1 mRNA
CTD
PMID:21161181
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
G
Col3a1
collagen type III alpha 1 chain
decreases expression
ISO
diethyl maleate results in decreased expression of COL3A1 mRNA
CTD
PMID:25270620
NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
G
Commd3
COMM domain containing 3
increases expression
ISO
diethyl maleate results in increased expression of COMMD3 mRNA
CTD
PMID:25270620
NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
G
Comt
catechol-O-methyltransferase
decreases expression
EXP
diethyl maleate results in decreased expression of COMT mRNA
CTD
PMID:21161181
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
G
Cp
ceruloplasmin
decreases expression
ISO
diethyl maleate results in decreased expression of CP mRNA
CTD
PMID:25270620
NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
G
Crym
crystallin, mu
decreases expression
EXP
diethyl maleate results in decreased expression of CRYM mRNA
CTD
PMID:21161181
NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
G
Csrp1
cysteine and glycine-rich protein 1
decreases expression
EXP
diethyl maleate results in decreased expression of CSRP1 mRNA
CTD
PMID:21161181
NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
G
Csrp3
cysteine and glycine rich protein 3
decreases reduction
ISO
diethyl maleate results in decreased reduction of CSRP3 protein
CTD
PMID:19843705
NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
G
Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
EXP
diethyl maleate results in decreased expression of CXCL10 mRNA
CTD
PMID:21161181
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
G
Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
EXP
diethyl maleate results in decreased expression of CXCL12 mRNA
CTD
PMID:21161181
NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
G
Cxcl9
C-X-C motif chemokine ligand 9
decreases expression
EXP
diethyl maleate results in decreased expression of CXCL9 mRNA
CTD
PMID:21161181
NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
G
Cyb5a
cytochrome b5 type A
increases expression
ISO
diethyl maleate results in increased expression of CYB5A mRNA
CTD
PMID:25270620
NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
G
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
decreases expression
EXP
diethyl maleate results in decreased expression of CYP26B1 mRNA
CTD
PMID:21161181
NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
G
Dbp
D-box binding PAR bZIP transcription factor
decreases expression
EXP
diethyl maleate results in decreased expression of DBP mRNA
CTD
PMID:21161181
NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
G
Ddit4l
DNA-damage-inducible transcript 4-like
increases expression
ISO
diethyl maleate results in increased expression of DDIT4L mRNA
CTD
PMID:25270620
NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
G
Dhx58
DEXH-box helicase 58
decreases expression
EXP
diethyl maleate results in decreased expression of DHX58 mRNA
CTD
PMID:21161181
NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
G
Dnmbp
dynamin binding protein
decreases expression
EXP
diethyl maleate results in decreased expression of DNMBP mRNA
CTD
PMID:21161181
NCBI chr 1:263,625,503...263,718,784
Ensembl chr 1:263,625,501...263,718,745
G
Dpysl2
dihydropyrimidinase-like 2
decreases reduction
ISO
diethyl maleate results in decreased reduction of DPYSL2 protein
CTD
PMID:19843705
NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
G
Dtx3l
deltex E3 ubiquitin ligase 3L
decreases expression
EXP
diethyl maleate results in decreased expression of DTX3L mRNA
CTD
PMID:21161181
NCBI chr11:67,758,093...67,767,623 NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
G
Dus3l
dihydrouridine synthase 3-like
decreases expression
ISO
diethyl maleate results in decreased expression of DUS3L mRNA
CTD
PMID:25270620
NCBI chr 9:10,289,440...10,294,213
Ensembl chr 9:10,289,446...10,293,980
G
Eef2k
eukaryotic elongation factor-2 kinase
decreases expression
EXP
diethyl maleate results in decreased expression of EEF2K mRNA
CTD
PMID:21161181
NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
G
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
decreases expression
EXP
diethyl maleate results in decreased expression of EIF2AK2 mRNA
CTD
PMID:21161181
NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
G
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
increases expression
ISO
diethyl maleate results in increased expression of ENTPD5 mRNA
CTD
PMID:25270620
NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579
G
Eras
ES cell expressed Ras
decreases expression
ISO
diethyl maleate results in decreased expression of ERAS mRNA
CTD
PMID:25270620
NCBI chr X:15,318,215...15,322,601
Ensembl chr X:15,419,028...15,423,414 Ensembl chr X:15,419,028...15,423,414
G
Ercc6l
ERCC excision repair 6 like, spindle assembly checkpoint helicase
increases expression
EXP
diethyl maleate results in increased expression of ERCC6L mRNA
CTD
PMID:21161181
NCBI chr X:72,018,373...72,034,140
Ensembl chr X:72,018,373...72,034,099
G
Exo1
exonuclease 1
increases expression
EXP
diethyl maleate results in increased expression of EXO1 mRNA
CTD
PMID:21161181
NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
G
Fabp1
fatty acid binding protein 1
increases expression
EXP
diethyl maleate results in increased expression of FABP1 protein
CTD
PMID:21161181
NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
G
Fabp7
fatty acid binding protein 7
decreases expression
EXP
diethyl maleate results in decreased expression of FABP7 mRNA
CTD
PMID:21161181
NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
G
Fam126b
family with sequence similarity 126, member B
decreases expression
EXP
diethyl maleate results in decreased expression of FAM126B mRNA
CTD
PMID:21161181
NCBI chr 9:65,406,136...65,478,399
Ensembl chr 9:65,406,138...65,442,257
G
Fasn
fatty acid synthase
decreases expression
EXP
diethyl maleate results in decreased expression of FASN mRNA
CTD
PMID:21161181
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
G
Fbn1
fibrillin 1
decreases expression
EXP
diethyl maleate results in decreased expression of FBN1 mRNA
CTD
PMID:21161181
NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
G
Fbp1
fructose-bisphosphatase 1
decreases expression
EXP
diethyl maleate results in decreased expression of FBP1 protein
CTD
PMID:21161181
NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
G
Fgf17
fibroblast growth factor 17
decreases expression
ISO
diethyl maleate results in decreased expression of FGF17 mRNA
CTD
PMID:25270620
NCBI chr15:52,326,758...52,337,360
Ensembl chr15:52,326,778...52,332,097
G
Fgg
fibrinogen gamma chain
decreases expression
ISO
diethyl maleate results in decreased expression of FGG mRNA
CTD
PMID:25270620
NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
G
Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
EXP
diethyl maleate results in decreased expression of FGR mRNA
CTD
PMID:21161181
NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
G
Fndc3b
fibronectin type III domain containing 3B
decreases expression
ISO
diethyl maleate results in decreased expression of FNDC3B mRNA
CTD
PMID:25270620
NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
diethyl maleate results in increased expression of FOS mRNA
CTD
PMID:10915739
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
diethyl maleate results in decreased expression of G6PC mRNA
CTD
PMID:25270620
NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
G
G6pd
glucose-6-phosphate dehydrogenase
increases activity
EXP
diethyl maleate results in increased activity of G6PD protein
CTD
PMID:3099627
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
G
Gab1
GRB2-associated binding protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of GAB1 mRNA
CTD
PMID:25270620
NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
increases reduction
ISO
diethyl maleate results in increased reduction of GAPDH protein
CTD
PMID:19843705
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
G
Gba2
glucosylceramidase beta 2
decreases expression
ISO
diethyl maleate results in decreased expression of GBA2 mRNA
CTD
PMID:25270620
NCBI chr 5:59,068,081...59,079,719
Ensembl chr 5:59,068,081...59,079,719
G
Gbp2
guanylate binding protein 2
decreases expression
EXP
diethyl maleate results in decreased expression of GBP2 mRNA
CTD
PMID:21161181
NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases activity increases expression
ISO EXP
diethyl maleate results in increased activity of GCLC protein diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD
PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
EXP ISO
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein
CTD
PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
G
Glul
glutamate-ammonia ligase
decreases expression
ISO
diethyl maleate results in decreased expression of GLUL mRNA
CTD
PMID:25270620
NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
G
Got2
glutamic-oxaloacetic transaminase 2
decreases expression
EXP
diethyl maleate results in decreased expression of GOT2 protein
CTD
PMID:21161181
NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
G
Gpihbp1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of GPIHBP1 mRNA
CTD
PMID:25270620
NCBI chr 7:116,632,496...116,635,543
Ensembl chr 7:116,632,506...116,634,293
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
decreases expression
EXP
diethyl maleate results in decreased expression of GRIA3 mRNA
CTD
PMID:21161181
NCBI chr X:127,561,843...127,829,763
Ensembl chr X:127,562,660...127,829,753
G
Gsn
gelsolin
decreases reduction
ISO
diethyl maleate results in decreased reduction of GSN protein
CTD
PMID:19843705
NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
G
Gsr
glutathione-disulfide reductase
increases expression
ISO
diethyl maleate results in increased expression of GSR mRNA
CTD
PMID:25270620
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
G
Gss
glutathione synthetase
increases expression
EXP
diethyl maleate results in increased expression of GSS mRNA
CTD
PMID:10978506
NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
G
Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
diethyl maleate results in increased expression of GSTA3 protein
CTD
PMID:9794803
NCBI chr 8:85,640,081...85,645,621
G
Gsta3
glutathione S-transferase alpha 3
increases expression
ISO
diethyl maleate results in increased expression of GSTA2 mRNA
CTD
PMID:25270620
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
G
Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
diethyl maleate results in increased expression of GSTA5 protein
CTD
PMID:9794803
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
G
Gstk1
glutathione S-transferase kappa 1
multiple interactions
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA
CTD
PMID:22564015
NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
G
Gstm1
glutathione S-transferase mu 1
decreases expression
EXP
diethyl maleate results in decreased expression of GSTM1 protein
CTD
PMID:21161181
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
G
Gsto1
glutathione S-transferase omega 1
increases expression
ISO
diethyl maleate results in increased expression of GSTO1 mRNA
CTD
PMID:25270620
NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
diethyl maleate results in increased expression of GSTP1 protein
CTD
PMID:9794803
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
G
Gstt1
glutathione S-transferase theta 1
increases expression
EXP
diethyl maleate results in increased expression of GSTT1 protein
CTD
PMID:9794803
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
G
Gtse1
G-2 and S-phase expressed 1
increases expression
EXP
diethyl maleate results in increased expression of GTSE1 mRNA
CTD
PMID:21161181
NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
increases expression
ISO
diethyl maleate results in increased expression of H6PD mRNA
CTD
PMID:25270620
NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
G
Helb
DNA helicase B
decreases expression
ISO
diethyl maleate results in decreased expression of HELB mRNA
CTD
PMID:25270620
NCBI chr 7:64,860,641...64,888,146
Ensembl chr 7:64,860,666...64,887,448
G
Hes6
hes family bHLH transcription factor 6
decreases expression
EXP
diethyl maleate results in decreased expression of HES6 mRNA
CTD
PMID:21161181
NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
G
Hjurp
Holliday junction recognition protein
increases expression
EXP
diethyl maleate results in increased expression of HJURP mRNA
CTD
PMID:21161181
NCBI chr 9:95,347,739...95,362,228
Ensembl chr 9:95,349,086...95,362,014
G
Hmox1
heme oxygenase 1
increases expression
ISO
diethyl maleate results in increased expression of HMOX1 mRNA
CTD
PMID:20491607 PMID:25270620
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
decreases reduction
ISO
diethyl maleate results in decreased reduction of HNRNPH1 protein
CTD
PMID:19843705
NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression
EXP
diethyl maleate results in decreased expression of HSD17B2 mRNA
CTD
PMID:21161181
NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
G
Hspa5
heat shock protein family A (Hsp70) member 5
decreases reduction
ISO
diethyl maleate results in decreased reduction of HSPA5 protein
CTD
PMID:19843705
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Hspa8
heat shock protein family A (Hsp70) member 8
increases reduction
ISO
diethyl maleate results in increased reduction of HSPA8 protein
CTD
PMID:19843705
NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
G
Htatip2
HIV-1 Tat interactive protein 2
increases expression
ISO
diethyl maleate results in increased expression of HTATIP2 mRNA
CTD
PMID:25270620
NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
G
Icam1
intercellular adhesion molecule 1
decreases expression
ISO
diethyl maleate results in decreased expression of ICAM1 mRNA
CTD
PMID:25270620
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Id3
inhibitor of DNA binding 3, HLH protein
decreases expression
ISO
diethyl maleate results in decreased expression of ID3 mRNA
CTD
PMID:25270620
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
G
Id4
inhibitor of DNA binding 4, HLH protein
decreases expression
ISO
diethyl maleate results in decreased expression of ID4 mRNA
CTD
PMID:25270620
NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
G
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
decreases expression
EXP
diethyl maleate results in decreased expression of IFIT3 mRNA
CTD
PMID:21161181
NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
G
Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
decreases expression
ISO
diethyl maleate results in decreased expression of IKBKE mRNA
CTD
PMID:25270620
NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
increases expression
ISO
diethyl maleate results in increased expression of IKBKG mRNA
CTD
PMID:25270620
NCBI chr X:156,254,187...156,280,046
Ensembl chr X:156,257,173...156,270,748
G
Il10
interleukin 10
increases secretion
ISO
diethyl maleate results in increased secretion of IL10 protein
CTD
PMID:31958493
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il18
interleukin 18
increases expression
ISO
diethyl maleate results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il4
interleukin 4
multiple interactions
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD
PMID:31958493
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Inhbb
inhibin subunit beta B
decreases expression
ISO
diethyl maleate results in decreased expression of INHBB mRNA
CTD
PMID:25270620
NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
G
Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
diethyl maleate results in decreased expression of INMT mRNA
CTD
PMID:21161181
NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
G
Ints7
integrator complex subunit 7
decreases expression
ISO
diethyl maleate results in decreased expression of INTS7 mRNA
CTD
PMID:25270620
NCBI chr13:110,257,571...110,310,413
Ensembl chr13:110,257,571...110,310,413
G
Irf7
interferon regulatory factor 7
decreases expression
EXP
diethyl maleate results in decreased expression of IRF7 mRNA
CTD
PMID:21161181
NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
G
Irf9
interferon regulatory factor 9
decreases expression
EXP
diethyl maleate results in decreased expression of IRF9 mRNA
CTD
PMID:21161181
NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
G
Irgm
immunity-related GTPase M
decreases expression
EXP
diethyl maleate results in decreased expression of IRGM mRNA
CTD
PMID:21161181
NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
G
Itgal
integrin subunit alpha L
decreases expression
EXP
diethyl maleate results in decreased expression of ITGAL mRNA
CTD
PMID:21161181
NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
G
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
ISO
diethyl maleate results in decreased expression of ITIH3 mRNA
CTD
PMID:25270620
NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
G
Itih4
inter-alpha-trypsin inhibitor heavy chain 4
decreases expression
ISO
diethyl maleate results in decreased expression of ITIH4 mRNA
CTD
PMID:25270620
NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
G
Jam3
junctional adhesion molecule 3
decreases expression
EXP
diethyl maleate results in decreased expression of JAM3 mRNA
CTD
PMID:21161181
NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression increases phosphorylation
ISO
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein] diethyl maleate results in increased expression of JUN mRNA
CTD
PMID:10915739 PMID:12774022
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Kcne3
potassium voltage-gated channel subfamily E regulatory subunit 3
decreases expression
ISO
diethyl maleate results in decreased expression of KCNE3 mRNA
CTD
PMID:25270620
NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
G
Keap1
Kelch-like ECH-associated protein 1
increases expression
ISO
diethyl maleate results in increased expression of KEAP1 protein
CTD
PMID:27358234
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
G
Kifc1
kinesin family member C1
increases expression
EXP
diethyl maleate results in increased expression of KIFC1 mRNA
CTD
PMID:21161181
NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
G
Klf10
Kruppel-like factor 10
decreases expression
EXP ISO
diethyl maleate results in decreased expression of KLF10 mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
G
Krt75
keratin 75
increases reduction
ISO
diethyl maleate results in increased reduction of KRT75 protein
CTD
PMID:19843705
NCBI chr 7:143,219,012...143,228,237
Ensembl chr 7:143,219,012...143,228,060
G
Lama1
laminin subunit alpha 1
decreases expression
ISO
diethyl maleate results in decreased expression of LAMA1 mRNA
CTD
PMID:25270620
NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
G
Lancl2
LanC like 2
decreases expression
ISO
diethyl maleate results in decreased expression of LANCL2 mRNA
CTD
PMID:25270620
NCBI chr 4:88,524,212...88,565,113
Ensembl chr 4:88,525,695...88,565,292
G
Ldlr
low density lipoprotein receptor
decreases expression
EXP
diethyl maleate results in decreased expression of LDLR mRNA
CTD
PMID:21161181
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
G
Lepr
leptin receptor
decreases expression
EXP
diethyl maleate results in decreased expression of LEPR mRNA
CTD
PMID:21161181
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
G
Lgals3bp
galectin 3 binding protein
decreases expression
EXP
diethyl maleate results in decreased expression of LGALS3BP mRNA
CTD
PMID:21161181
NCBI chr10:107,415,334...107,424,672
Ensembl chr10:107,415,326...107,424,710
G
Lmnb1
lamin B1
increases expression
EXP
diethyl maleate results in increased expression of LMNB1 mRNA
CTD
PMID:21161181
NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
G
Lmo7
LIM domain 7
decreases expression
EXP
diethyl maleate results in decreased expression of LMO7 mRNA
CTD
PMID:21161181
NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
G
LOC100363405
hypothetical LOC100363405
decreases expression
EXP
diethyl maleate results in decreased expression of ZFP37 mRNA
CTD
PMID:21161181
NCBI chr 5:77,265,335...77,294,739
Ensembl chr 5:77,266,842...77,294,765
G
Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
decreases expression
EXP
diethyl maleate results in decreased expression of LRIG3 mRNA
CTD
PMID:21161181
NCBI chr 7:69,213,098...69,263,251
Ensembl chr 7:69,213,147...69,263,142
G
Lrrn4
leucine rich repeat neuronal 4
increases expression
EXP
diethyl maleate results in increased expression of LRRN4 mRNA
CTD
PMID:21161181
NCBI chr 3:125,521,879...125,547,685
Ensembl chr 3:125,523,781...125,533,600
G
Lrtm2
leucine-rich repeats and transmembrane domains 2
decreases expression
EXP
diethyl maleate results in decreased expression of LRTM2 mRNA
CTD
PMID:21161181
NCBI chr 4:151,375,568...151,397,485
Ensembl chr 4:151,375,572...151,390,263
G
Ltc4s
leukotriene C4 synthase
decreases expression
EXP
diethyl maleate results in decreased expression of LTC4S mRNA
CTD
PMID:21161181
NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
G
Lum
lumican
decreases expression
EXP
diethyl maleate results in decreased expression of LUM mRNA
CTD
PMID:21161181
NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
G
Ly6c
Ly6-C antigen
decreases expression
EXP
diethyl maleate results in decreased expression of LY6C mRNA
CTD
PMID:21161181
G
Maff
MAF bZIP transcription factor F
increases expression
ISO
diethyl maleate results in increased expression of MAFF mRNA
CTD
PMID:20491607
NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
G
Maoa
monoamine oxidase A
increases expression
ISO
diethyl maleate results in increased expression of MAOA mRNA
CTD
PMID:25270620
NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
G
Marveld1
MARVEL domain containing 1
decreases expression
EXP
diethyl maleate results in decreased expression of MARVELD1 mRNA
CTD
PMID:21161181
NCBI chr 1:261,389,804...261,393,736
Ensembl chr 1:261,389,804...261,393,736
G
Mcm10
minichromosome maintenance 10 replication initiation factor
increases expression
EXP
diethyl maleate results in increased expression of MCM10 mRNA
CTD
PMID:21161181
NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
G
Mcm4
minichromosome maintenance complex component 4
increases expression
EXP
diethyl maleate results in increased expression of MCM4 mRNA
CTD
PMID:21161181
NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
G
Me1
malic enzyme 1
increases expression
ISO
diethyl maleate results in increased expression of ME1 mRNA
CTD
PMID:25270620
NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
G
Mfap4
microfibril associated protein 4
decreases expression
EXP
diethyl maleate results in decreased expression of MFAP4 mRNA
CTD
PMID:21161181
NCBI chr10:47,765,463...47,768,484
Ensembl chr10:47,765,432...47,768,483
G
Mgmt
O-6-methylguanine-DNA methyltransferase
decreases activity
ISO
diethyl maleate results in decreased activity of MGMT protein
CTD
PMID:16950796
NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
G
Mki67
marker of proliferation Ki-67
increases expression
EXP
diethyl maleate results in increased expression of MKI67 mRNA
CTD
PMID:21161181
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
G
Mknk2
MAPK interacting serine/threonine kinase 2
decreases expression
EXP
diethyl maleate results in decreased expression of MKNK2 mRNA
CTD
PMID:21161181
NCBI chr 7:11,908,107...11,919,161
Ensembl chr 7:11,908,107...11,919,156
G
Mmp12
matrix metallopeptidase 12
increases expression
ISO
diethyl maleate results in increased expression of MMP12 mRNA
CTD
PMID:10216232
NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
G
Mmp2
matrix metallopeptidase 2
decreases expression
EXP
diethyl maleate results in decreased expression of MMP2 mRNA
CTD
PMID:21161181
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
G
Msn
moesin
increases reduction
ISO
diethyl maleate results in increased reduction of MSN protein
CTD
PMID:19843705
NCBI chr X:65,226,834...65,294,192
Ensembl chr X:65,226,748...65,295,810
G
Mt1
metallothionein 1
increases expression
ISO
diethyl maleate results in increased expression of MT1A mRNA
CTD
PMID:20491607
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
G
Mt2A
metallothionein 2A
increases expression
ISO
diethyl maleate results in increased expression of MT2A mRNA
CTD
PMID:20491607
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
G
Mx1
myxovirus (influenza virus) resistance 1
decreases expression
EXP
diethyl maleate results in decreased expression of MX2 mRNA
CTD
PMID:21161181
NCBI chr11:37,891,150...37,916,775
Ensembl chr11:37,891,156...37,914,983
G
Mx2
MX dynamin like GTPase 2
decreases expression
EXP
diethyl maleate results in decreased expression of MX1 mRNA
CTD
PMID:21161181
NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
G
Mybl2
MYB proto-oncogene like 2
increases expression
EXP
diethyl maleate results in increased expression of MYBL2 mRNA
CTD
PMID:21161181
NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
G
Mycn
MYCN proto-oncogene, bHLH transcription factor
decreases expression
ISO
diethyl maleate results in decreased expression of MYCN mRNA
CTD
PMID:25270620
NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
G
Nat8
N-acetyltransferase 8
decreases expression
EXP
diethyl maleate results in decreased expression of NAT8 mRNA
CTD
PMID:21161181
NCBI chr 4:117,525,963...117,527,443
G
Ncaph
non-SMC condensin I complex, subunit H
increases expression
EXP
diethyl maleate results in increased expression of NCAPH mRNA
CTD
PMID:21161181
NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
G
Nfe2l2
nuclear factor, erythroid 2-like 2
affects localization increases activity increases expression multiple interactions decreases response to substance
ISO EXP
diethyl maleate affects the localization of NFE2L2 protein diethyl maleate results in increased activity of NFE2L2 protein diethyl maleate results in increased expression of NFE2L2 protein diethyl maleate binds to and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein] NFE2L2 results in decreased susceptibility to diethyl maleate NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD
PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:27358234 PMID:27982581 PMID:30114225
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
CTD
PMID:12774022
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP ISO
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD
PMID:7532384 PMID:9918918 PMID:12774022
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
diethyl maleate results in increased expression of NQO1 mRNA
CTD
PMID:20491607 PMID:25270620
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
EXP
diethyl maleate results in decreased expression of NR0B2 mRNA
CTD
PMID:21161181
NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
decreases expression
EXP
diethyl maleate results in decreased expression of NR1D1 mRNA
CTD
PMID:21161181
NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
G
Nrep
neuronal regeneration related protein
decreases expression
EXP
diethyl maleate results in decreased expression of NREP mRNA
CTD
PMID:21161181
NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
G
Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
decreases expression
ISO
diethyl maleate results in decreased expression of NSMF mRNA
CTD
PMID:25270620
NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995
G
Ntf3
neurotrophin 3
decreases expression
EXP
diethyl maleate results in decreased expression of NTF3 mRNA
CTD
PMID:21161181
NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
G
Nup153
nucleoporin 153
multiple interactions affects localization
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein
CTD
PMID:20041180
NCBI chr17:18,358,712...18,411,368
Ensembl chr17:18,358,712...18,411,368
G
Nup88
nucleoporin 88
multiple interactions affects localization
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein
CTD
PMID:20041180
NCBI chr10:57,581,828...57,606,171
Ensembl chr10:57,581,828...57,606,171
G
Oaf
out at first homolog
decreases expression
EXP
diethyl maleate results in decreased expression of OAF mRNA
CTD
PMID:21161181
NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
G
Oas1i
2 ' -5 ' oligoadenylate synthetase 1I
decreases expression
EXP
diethyl maleate results in decreased expression of OAS1I mRNA
CTD
PMID:21161181
NCBI chr12:41,155,489...41,167,501
Ensembl chr12:41,155,497...41,167,505
G
Ogg1
8-oxoguanine DNA glycosylase
multiple interactions
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA
CTD
PMID:22564015
NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
G
Orc1
origin recognition complex, subunit 1
increases expression
EXP
diethyl maleate results in increased expression of ORC1 mRNA
CTD
PMID:21161181
NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
G
P2rx7
purinergic receptor P2X 7
decreases expression
EXP
diethyl maleate results in decreased expression of P2RX7 mRNA
CTD
PMID:21161181
NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
diethyl maleate results in increased cleavage of PARP1 protein
CTD
PMID:21105742
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pbld1
phenazine biosynthesis-like protein domain containing 1
decreases expression
EXP
diethyl maleate results in decreased expression of PBLD protein
CTD
PMID:21161181
NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
G
Pcna
proliferating cell nuclear antigen
decreases expression
ISO
diethyl maleate results in decreased expression of PCNA mRNA
CTD
PMID:11875189
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
G
Pdlim2
PDZ and LIM domain 2
decreases expression
EXP
diethyl maleate results in decreased expression of PDLIM2 mRNA
CTD
PMID:21161181
NCBI chr15:51,843,562...51,856,785
Ensembl chr15:51,843,564...51,855,325
G
Pdrg1
p53 and DNA damage regulated 1
increases expression
ISO
diethyl maleate results in increased expression of PDRG1 mRNA
CTD
PMID:25270620
NCBI chr 3:148,487,056...148,493,225
Ensembl chr 3:148,487,059...148,493,225
G
Per2
period circadian regulator 2
decreases expression
EXP
diethyl maleate results in decreased expression of PER2 mRNA
CTD
PMID:21161181
NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
G
Per3
period circadian regulator 3
decreases expression
EXP
diethyl maleate results in decreased expression of PER3 mRNA
CTD
PMID:21161181
NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
G
Pgd
phosphogluconate dehydrogenase
increases activity
EXP
diethyl maleate results in increased activity of PGD protein
CTD
PMID:3099627
NCBI chr 5:165,966,128...165,982,327
G
Pgrmc1
progesterone receptor membrane component 1
increases expression
ISO
diethyl maleate results in increased expression of PGRMC1 mRNA
CTD
PMID:25270620
NCBI chr X:123,205,869...123,213,880
Ensembl chr X:123,205,869...123,213,882
G
Pir
pirin
increases expression
ISO
diethyl maleate results in increased expression of PIR mRNA
CTD
PMID:25270620
NCBI chr X:31,852,322...31,968,152
Ensembl chr X:31,852,323...31,968,152
G
Pklr
pyruvate kinase L/R
decreases expression
EXP
diethyl maleate results in decreased expression of PKLR mRNA
CTD
PMID:21161181
NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
G
Plat
plasminogen activator, tissue type
increases expression decreases expression
EXP ISO
diethyl maleate results in increased expression of PLAT mRNA diethyl maleate results in decreased expression of PLAT mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Plek
pleckstrin
decreases expression
EXP
diethyl maleate results in decreased expression of PLEK mRNA
CTD
PMID:21161181
NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions decreases activity
EXP
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein]
CTD
PMID:17134953
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
G
Ppargc1b
PPARG coactivator 1 beta
decreases expression
EXP
diethyl maleate results in decreased expression of PPARGC1B mRNA
CTD
PMID:21161181
NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
G
Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
EXP
diethyl maleate results in decreased expression of PPP1R3B mRNA
CTD
PMID:21161181
NCBI chr16:60,415,192...60,427,498
Ensembl chr16:60,415,229...60,427,474
G
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
decreases expression
EXP
diethyl maleate results in decreased expression of PPP1R3C mRNA
CTD
PMID:21161181
NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
G
Prdm14
PR/SET domain 14
decreases expression
ISO
diethyl maleate results in decreased expression of PRDM14 mRNA
CTD
PMID:25270620
NCBI chr 5:5,710,076...5,730,560
Ensembl chr 5:5,710,392...5,730,560
G
Prdx1
peroxiredoxin 1
increases expression
EXP ISO
diethyl maleate results in increased expression of PRDX1 mRNA
CTD
PMID:9506838
NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
G
Prkab1
protein kinase AMP-activated non-catalytic subunit beta 1
decreases expression
ISO
diethyl maleate results in decreased expression of PRKAB1 mRNA
CTD
PMID:25270620
NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
G
Prkcb
protein kinase C, beta
affects expression
ISO
diethyl maleate affects the expression of PRKCB protein
CTD
PMID:31958493
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
G
Prkcd
protein kinase C, delta
multiple interactions
EXP
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein
CTD
PMID:11118818
NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
G
Prkce
protein kinase C, epsilon
multiple interactions
EXP
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein
CTD
PMID:11118818
NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
G
Prss8
serine protease 8
decreases expression
EXP
diethyl maleate results in decreased expression of PRSS8 mRNA
CTD
PMID:21161181
NCBI chr 1:199,372,519...199,377,035
Ensembl chr 1:199,372,519...199,377,035
G
Ptgr1
prostaglandin reductase 1
increases expression
ISO
diethyl maleate results in increased expression of PTGR1 mRNA
CTD
PMID:25270620
NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
G
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
increases expression
ISO
diethyl maleate results in increased expression of PTPN14 mRNA
CTD
PMID:25270620
NCBI chr13:108,689,916...108,841,593
Ensembl chr13:108,696,336...108,841,511
G
Pus1
pseudouridine synthase 1
decreases expression
ISO
diethyl maleate results in decreased expression of PUS1 mRNA
CTD
PMID:25270620
NCBI chr12:51,936,721...51,945,930
Ensembl chr12:51,937,175...51,945,928
G
Rab27a
RAB27A, member RAS oncogene family
decreases expression
EXP
diethyl maleate results in decreased expression of RAB27A mRNA
CTD
PMID:21161181
NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]
CTD
PMID:20116392
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Rnf114
ring finger protein 114
decreases expression
ISO
diethyl maleate results in decreased expression of RNF114 mRNA
CTD
PMID:25270620
NCBI chr 3:164,248,736...164,260,499
Ensembl chr 3:164,248,731...164,260,497
G
Rnf14
ring finger protein 14
increases expression
ISO
diethyl maleate results in increased expression of RNF14 mRNA
CTD
PMID:25270620
NCBI chr18:31,443,424...31,468,641
Ensembl chr18:31,444,472...31,468,640
G
Rrm2
ribonucleotide reductase regulatory subunit M2
increases expression
EXP
diethyl maleate results in increased expression of RRM2 mRNA
CTD
PMID:21161181
NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
G
Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
EXP
diethyl maleate results in decreased expression of RSAD2 mRNA
CTD
PMID:21161181
NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
G
RT1-S3
RT1 class Ib, locus S3
decreases expression
EXP
diethyl maleate results in decreased expression of RT1-S3 mRNA
CTD
PMID:21161181
NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
G
S100a9
S100 calcium binding protein A9
decreases expression
EXP
diethyl maleate results in decreased expression of S100A9 mRNA
CTD
PMID:21161181
NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
G
Sash3
SAM and SH3 domain containing 3
decreases expression
EXP
diethyl maleate results in decreased expression of SASH3 mRNA
CTD
PMID:21161181
NCBI chr X:134,979,637...134,994,351
Ensembl chr X:134,979,646...134,994,349
G
Scd
stearoyl-CoA desaturase
decreases expression
EXP
diethyl maleate results in decreased expression of SCD1 mRNA
CTD
PMID:21161181
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
G
Sds
serine dehydratase
decreases expression
EXP
diethyl maleate results in decreased expression of SDS mRNA
CTD
PMID:21161181
NCBI chr12:41,620,429...41,627,741
Ensembl chr12:41,620,393...41,627,741
G
Serpind1
serpin family D member 1
decreases expression
ISO
diethyl maleate results in decreased expression of SERPIND1 mRNA
CTD
PMID:25270620
NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
G
Sez6
seizure related 6 homolog
decreases expression
EXP
diethyl maleate results in decreased expression of SEZ6 mRNA
CTD
PMID:21161181
NCBI chr10:64,865,802...64,915,461
Ensembl chr10:64,865,805...64,915,148
G
Sfxn1
sideroflexin 1
decreases expression
ISO
diethyl maleate results in decreased expression of SFXN1 mRNA
CTD
PMID:25270620
NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
G
Six4
SIX homeobox 4
increases expression
ISO
diethyl maleate results in increased expression of SIX4 mRNA
CTD
PMID:25270620
NCBI chr 6:95,984,868...95,999,709
Ensembl chr 6:95,984,868...95,998,529
G
Slc16a6
solute carrier family 16, member 6
decreases expression
ISO
diethyl maleate results in decreased expression of SLC16A6 mRNA
CTD
PMID:25270620
NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
G
Slc1a4
solute carrier family 1 member 4
increases expression
ISO
diethyl maleate results in increased expression of SLC1A4 mRNA
CTD
PMID:25270620
NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
G
Slc2a2
solute carrier family 2 member 2
decreases expression
EXP
diethyl maleate results in decreased expression of SLC2A2 mRNA
CTD
PMID:21161181
NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
G
Slc2a5
solute carrier family 2 member 5
decreases expression
EXP
diethyl maleate results in decreased expression of SLC2A5 mRNA
CTD
PMID:21161181
NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
G
Slc39a14
solute carrier family 39 member 14
decreases expression
ISO
diethyl maleate results in decreased expression of SLC39A14 mRNA
CTD
PMID:25270620
NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
G
Slc40a1
solute carrier family 40 member 1
multiple interactions
ISO
diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]
CTD
PMID:21303654
NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
G
Slc44a4
solute carrier family 44, member 4
decreases expression
EXP
diethyl maleate results in decreased expression of SLC44A4 mRNA
CTD
PMID:21161181
NCBI chr20:4,593,389...4,609,641
Ensembl chr20:4,593,389...4,609,631
G
Slc7a11
solute carrier family 7 member 11
multiple interactions increases expression
ISO
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]
CTD
PMID:12235164
NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
G
Slc9a3r1
SLC9A3 regulator 1
decreases expression
EXP
diethyl maleate results in decreased expression of SLC9A3R1 mRNA
CTD
PMID:21161181
NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
G
Slco2a1
solute carrier organic anion transporter family, member 2a1
decreases expression
EXP
diethyl maleate results in decreased expression of SLCO2A1 mRNA
CTD
PMID:21161181
NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
G
Slfn3
schlafen family member 3
decreases expression
EXP
diethyl maleate results in decreased expression of SLFN3 mRNA
CTD
PMID:21161181
NCBI chr10:70,438,012...70,477,259
G
Smc4
structural maintenance of chromosomes 4
increases expression
EXP
diethyl maleate results in increased expression of SMC4 mRNA
CTD
PMID:21161181
NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
G
Smtn
smoothelin
increases expression
EXP
diethyl maleate results in increased expression of SMTN mRNA
CTD
PMID:21161181
NCBI chr14:83,755,141...83,776,871
Ensembl chr14:83,755,142...83,776,863
G
Socs3
suppressor of cytokine signaling 3
decreases expression
ISO
diethyl maleate results in decreased expression of SOCS3 mRNA
CTD
PMID:25270620
NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
G
Sod2
superoxide dismutase 2
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Sorl1
sortilin related receptor 1
decreases expression
EXP
diethyl maleate results in decreased expression of SORL1 mRNA
CTD
PMID:21161181
NCBI chr 8:46,228,077...46,287,171
G
Sox9
SRY-box transcription factor 9
increases expression
EXP
diethyl maleate results in increased expression of SOX9 mRNA
CTD
PMID:21161181
NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
G
Sp5
Sp5 transcription factor
decreases expression
ISO
diethyl maleate results in decreased expression of SP5 mRNA
CTD
PMID:25270620
NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
G
Spc25
SPC25 component of NDC80 kinetochore complex
increases expression
EXP
diethyl maleate results in increased expression of SPC25 mRNA
CTD
PMID:21161181
NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
G
Spta1
spectrin, alpha, erythrocytic 1
increases expression
ISO
diethyl maleate results in increased expression of SPTA1 mRNA
CTD
PMID:25270620
NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
G
Sptan1
spectrin, alpha, non-erythrocytic 1
increases cleavage
ISO
diethyl maleate results in increased cleavage of SPTAN1 protein
CTD
PMID:21105742
NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
G
Sptbn4
spectrin, beta, non-erythrocytic 4
increases expression
ISO
diethyl maleate results in increased expression of SPTBN4 mRNA
CTD
PMID:25270620
NCBI chr 1:84,168,494...84,254,679
Ensembl chr 1:84,168,495...84,254,645
G
Sqstm1
sequestosome 1
increases expression
ISO
diethyl maleate results in increased expression of SQSTM1 mRNA
CTD
PMID:25270620
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
G
Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
diethyl maleate results in decreased expression of SREBF1 mRNA
CTD
PMID:21161181
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
G
Srxn1
sulfiredoxin 1
multiple interactions increases expression
ISO
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein] diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD
PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
G
Stat1
signal transducer and activator of transcription 1
decreases expression
EXP
diethyl maleate results in decreased expression of STAT1 mRNA
CTD
PMID:21161181
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
G
Steap4
STEAP4 metalloreductase
decreases expression
ISO
diethyl maleate results in decreased expression of STEAP4 mRNA
CTD
PMID:25270620
NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
G
Sulf2
sulfatase 2
decreases expression
EXP
diethyl maleate results in decreased expression of SULF2 mRNA
CTD
PMID:21161181
NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
G
Sult1a1
sulfotransferase family 1A member 1
decreases expression
EXP
diethyl maleate results in decreased expression of SULT1A1 protein
CTD
PMID:21161181
NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
G
Tagln
transgelin
decreases expression
EXP
diethyl maleate results in decreased expression of TAGLN mRNA
CTD
PMID:21161181
NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
G
Tbcel
tubulin folding cofactor E-like
increases expression
ISO
diethyl maleate results in increased expression of TBCEL mRNA
CTD
PMID:25270620
NCBI chr 8:46,691,488...46,750,816
Ensembl chr 8:46,694,561...46,750,898
G
Tent5a
terminal nucleotidyltransferase 5A
decreases expression
EXP
diethyl maleate results in decreased expression of TENT5A mRNA
CTD
PMID:21161181
NCBI chr 8:92,935,474...92,942,267
Ensembl chr 8:92,937,739...92,942,076
G
Tesmin
testis expressed metallothionein like protein
affects localization
ISO
diethyl maleate affects the localization of TESMIN protein
CTD
PMID:12606435
NCBI chr 1:218,632,764...218,651,054
Ensembl chr 1:218,632,764...218,651,053
G
Tf
transferrin
decreases expression
EXP
diethyl maleate results in decreased expression of TF protein
CTD
PMID:21161181
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
G
Tfeb
transcription factor EB
decreases expression
ISO
diethyl maleate results in decreased expression of TFEB mRNA
CTD
PMID:25270620
NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
G
Tgm2
transglutaminase 2
increases expression
EXP
diethyl maleate results in increased expression of TGM2 mRNA
CTD
PMID:21161181
NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
G
Thbs1
thrombospondin 1
increases expression
EXP
diethyl maleate results in increased expression of THBS1 mRNA
CTD
PMID:21161181
NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
G
Thrsp
thyroid hormone responsive
decreases expression
EXP
diethyl maleate results in decreased expression of THRSP mRNA
CTD
PMID:21161181
NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
G
Tm4sf1
transmembrane 4 L six family member 1
increases expression
EXP
diethyl maleate results in increased expression of TM4SF1 mRNA
CTD
PMID:21161181
NCBI chr 2:147,382,866...147,392,062
Ensembl chr 2:147,382,866...147,392,062
G
Tmem209
transmembrane protein 209
increases expression
ISO
diethyl maleate results in increased expression of TMEM209 mRNA
CTD
PMID:25270620
NCBI chr 4:57,796,337...57,823,283
Ensembl chr 4:57,796,338...57,823,295
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate] diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD
PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Tnfrsf14
TNF receptor superfamily member 14
decreases expression
EXP
diethyl maleate results in decreased expression of TNFRSF14 mRNA
CTD
PMID:21161181
NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
G
Tp53
tumor protein p53
multiple interactions
ISO
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA] TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:22003191 PMID:27982581
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Tpm2
tropomyosin 2
decreases expression
EXP
diethyl maleate results in decreased expression of TPM2 mRNA
CTD
PMID:21161181
NCBI chr 5:59,016,616...59,025,971
Ensembl chr 5:59,016,622...59,025,631
G
Trap1
TNF receptor-associated protein 1
multiple interactions decreases response to substance
ISO
diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein] TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD
PMID:17853063
NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
G
Trdmt1
tRNA aspartic acid methyltransferase 1
decreases expression
ISO
diethyl maleate results in decreased expression of TRDMT1 mRNA
CTD
PMID:25270620
NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195
G
Trim6
tripartite motif containing 6
decreases expression
EXP
diethyl maleate results in decreased expression of TRIM6 mRNA
CTD
PMID:21161181
NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
G
Trip13
thyroid hormone receptor interactor 13
increases expression
EXP
diethyl maleate results in increased expression of TRIP13 mRNA
CTD
PMID:21161181
NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
G
Tsc22d1
TSC22 domain family, member 1
decreases expression
EXP
diethyl maleate results in decreased expression of TSC22D1 mRNA
CTD
PMID:21161181
NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
G
Tspan8
tetraspanin 8
decreases expression
EXP
diethyl maleate results in decreased expression of TSPAN8 mRNA
CTD
PMID:21161181
NCBI chr 7:58,814,805...58,847,564
Ensembl chr 7:58,814,805...58,847,563
G
Tstd1
thiosulfate sulfurtransferase like domain containing 1
decreases expression
ISO
diethyl maleate results in decreased expression of TSTD1 mRNA
CTD
PMID:25270620
NCBI chr13:89,805,652...89,807,355
Ensembl chr13:89,805,962...89,807,243
G
Txn1
thioredoxin 1
decreases activity
ISO
diethyl maleate results in decreased activity of TXN protein
CTD
PMID:15388247
NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
G
Txnip
thioredoxin interacting protein
increases expression
EXP
diethyl maleate results in increased expression of TXNIP mRNA
CTD
PMID:21161181
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
diethyl maleate results in increased expression of TXNRD1 mRNA
CTD
PMID:15521073
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
G
Ubd
ubiquitin D
decreases expression
EXP
diethyl maleate results in decreased expression of UBD mRNA
CTD
PMID:21161181
NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
G
Uhrf1
ubiquitin-like with PHD and ring finger domains 1
increases expression
EXP
diethyl maleate results in increased expression of UHRF1 mRNA
CTD
PMID:21161181
NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
G
Usp18
ubiquitin specific peptidase 18
decreases expression
EXP
diethyl maleate results in decreased expression of USP18 mRNA
CTD
PMID:21161181
NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
G
Usp2
ubiquitin specific peptidase 2
decreases expression
EXP
diethyl maleate results in decreased expression of USP2 mRNA
CTD
PMID:21161181
NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
G
Wdr31
WD repeat domain 31
decreases expression
ISO
diethyl maleate results in decreased expression of WDR31 mRNA
CTD
PMID:25270620
NCBI chr 5:78,305,526...78,324,318
Ensembl chr 5:78,305,526...78,324,278
G
Wdr6
WD repeat domain 6
decreases expression
EXP
diethyl maleate results in decreased expression of WDR6 mRNA
CTD
PMID:21161181
NCBI chr 8:117,358,345...117,364,761
Ensembl chr 8:117,358,787...117,366,096
G
Ypel5
yippee-like 5
increases expression
ISO
diethyl maleate results in increased expression of YPEL5 mRNA
CTD
PMID:25270620
NCBI chr 6:24,069,351...24,084,758
Ensembl chr 6:24,064,738...24,084,757
G
Zfp36
zinc finger protein 36
increases expression
ISO
diethyl maleate results in increased expression of ZFP36 protein
CTD
PMID:21969073
NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
G
Zfp367
zinc finger protein 367
increases expression
EXP
diethyl maleate results in increased expression of ZNF367 mRNA
CTD
PMID:21161181
NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
G
Znrd2
zinc ribbon domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of ZNRD2 mRNA
CTD
PMID:25270620
NCBI chr 1:221,087,803...221,089,586
Ensembl chr 1:221,087,803...221,089,586
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
dimethyl maleate results in increased cleavage of PARP1 protein
CTD
PMID:21105742
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Sptan1
spectrin, alpha, non-erythrocytic 1
increases cleavage
ISO
dimethyl maleate results in increased cleavage of SPTAN1 protein
CTD
PMID:21105742
NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all