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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylephrine
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Accession:CHEBI:8093 term browser browse the term
Definition:A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Synonyms:exact_synonym: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
 related_synonym: (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;   Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-;   Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, (-)-;   Formula=C9H13NO2;   InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1;   InChIKey=SONNWYBIRXJNDC-VIFPVBQESA-N;   R(-)-Phenylephrine;   SMILES=CNC[C@H](O)c1cccc(O)c1;   fenilefrina;   l-(3-Hydroxyphenyl)-N-methylethanolamine;   phenylephrinum
 xref: CAS:59-42-7;   DrugBank:DB00388;   Drug_Central:2146;   HMDB:HMDB0002182;   KEGG:C07441;   KEGG:D08365;   LINCS:LSM-15380
 xref_mesh: MESH:D010656
 xref: PMID:10100801;   PMID:11064374;   PMID:11528305;   PMID:12172708;   PMID:15492464;   PMID:15522277;   PMID:15686119;   PMID:19372348;   PMID:19427353;   PMID:24588024;   PMID:25719378;   PMID:25902390;   PMID:26143019;   PMID:26428281;   PMID:26513673;   PMID:26597497;   PMID:26709790;   PMID:26873547;   PMID:26928367;   PMID:26991619;   PMID:26992790;   PMID:27020488;   PMID:27117950;   PMID:27164015;   PMID:27249899;   PMID:27288620;   PMID:28166217;   PMID:7516005;   PMID:7879981;   PMID:8763311;   PMID:8853328;   Patent:US1932347;   Patent:US1954389;   Reaxys:3198815;   Wikipedia:Phenylephrine
 cyclic_relationship: is_conjugate_base_of CHEBI:132294


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phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP-binding cassette, sub-family C member 9 decreases expression ISO Phenylephrine results in decreased expression of ABCC9 mRNA CTD PMID:18158353 NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041 		JBrowse link
G Abhd2 abhydrolase domain containing 2 increases expression ISO Phenylephrine results in increased expression of ABHD2 mRNA CTD PMID:18158353 NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256 		JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions
affects response to substance
increases phosphorylation		 ISO ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
ABL1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased phosphorylation of ABL1 protein		 CTD PMID:17615370 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression ISO Phenylephrine results in decreased expression of ABTB3 mRNA CTD PMID:18158353 NCBI chr10:85,220,835...85,496,156
Ensembl chr10:85,222,678...85,496,156 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions
decreases expression		 ISO AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA] CTD PMID:19699196 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 increases expression ISO Phenylephrine results in increased expression of ACAT2 mRNA CTD PMID:18158353 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634 		JBrowse link
G Ace angiotensin I converting enzyme affects response to substance ISO ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Phenylephrine results in increased expression of ACOT2 mRNA CTD PMID:18158353 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647 		JBrowse link
G Acta1 actin alpha 1, skeletal muscle multiple interactions
increases expression		 EXP
ISO		 [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]		 CTD PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More... NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
increases expression		 ISO MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA] CTD PMID:16556869 PMID:18158353 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Actr3 ARP3 actin-related protein 3 increases expression ISO Phenylephrine results in increased expression of ACTR3 mRNA CTD PMID:18158353 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 multiple interactions ISO ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein] CTD PMID:16760267 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance EXP ADCY5 protein results in increased susceptibility to Phenylephrine CTD PMID:12869393 NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression ISO Phenylephrine results in decreased expression of ADHFE1 mRNA CTD PMID:18158353 NCBI chr 1:9,618,173...9,648,195
Ensembl chr 1:9,618,173...9,650,898 		JBrowse link
G Adm adrenomedullin multiple interactions
decreases response to substance
decreases expression
decreases secretion
increases expression		 ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
ADM protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of ADM mRNA
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein		 CTD PMID:11470465 PMID:15370692 PMID:17250927 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
increases expression		 ISO 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein		 CTD PMID:19966059 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
increases expression		 ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein		 CTD PMID:19966059 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
increases expression		 ISO 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein		 CTD PMID:19966059 NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242 		JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 increases expression ISO Phenylephrine results in increased expression of ADPRHL1 mRNA CTD PMID:18158353 NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a multiple interactions
affects response to substance
affects binding
increases response to substance
affects activity
increases activity		 ISO 5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
ADRA1A protein affects the susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine affects the activity of ADRA1A protein
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein		 CTD PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More... NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Adra1b adrenergic receptor, alpha 1b affects response to substance
increases response to substance
multiple interactions
decreases expression
increases activity		 ISO
EXP		 ADRA1B protein affects the susceptibility to Phenylephrine
ADRA1B protein results in increased susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
Phenylephrine results in increased activity of ADRA1B protein
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]		 CTD PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More... NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037 		JBrowse link
G Adra1d adrenergic receptor, alpha 1d affects response to substance
increases response to substance
multiple interactions
affects binding
increases activity		 ISO
EXP		 ADRA1D protein affects the susceptibility to Phenylephrine
ADRA1D affects the susceptibility to Phenylephrine
ADRA1D protein results in increased susceptibility to Phenylephrine
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
Phenylephrine binds to ADRA1D protein		 CTD PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More... NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a multiple interactions ISO Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:10742289 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Adra2b adrenergic receptor, alpha 2b affects response to substance
multiple interactions		 EXP ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]		 CTD PMID:16815979 NCBI chr 2:127,205,099...127,209,141
Ensembl chr 2:127,205,128...127,209,141 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine] CTD PMID:16474418 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions
increases response to substance		 ISO amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine] CTD PMID:16022967 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Agt angiotensinogen affects response to substance
multiple interactions
increases expression
increases response to substance		 ISO AGT protein affects the susceptibility to Phenylephrine
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]		 CTD PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
affects response to substance		 ISO
EXP		 [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine		 CTD PMID:11714657 PMID:19151255 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases expression ISO Phenylephrine results in increased expression of AIFM1 protein CTD PMID:31605733 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Ak4 adenylate kinase 4 increases expression ISO Phenylephrine results in increased expression of AK4 mRNA CTD PMID:18158353 NCBI chr 4:101,273,675...101,324,968
Ensembl chr 4:101,276,474...101,324,192 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
affects phosphorylation
increases phosphorylation		 EXP
ISO		 Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]		 CTD PMID:10679475 PMID:18084315 PMID:28759639 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression ISO Phenylephrine results in increased expression of ALDH18A1 mRNA CTD PMID:18158353 NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907 		JBrowse link
G Angpt1 angiopoietin 1 multiple interactions
increases expression		 EXP ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein		 CTD PMID:18502941 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO Phenylephrine results in decreased expression of ANGPTL4 mRNA CTD PMID:18158353 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804 		JBrowse link
G Apoe apolipoprotein E affects response to substance EXP APOE protein affects the susceptibility to Phenylephrine CTD PMID:17899169 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Areg amphiregulin increases expression ISO Phenylephrine results in increased expression of AREG mRNA CTD PMID:18158353 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression ISO Phenylephrine results in decreased expression of ARHGEF12 mRNA CTD PMID:18158353 NCBI chr 9:42,875,138...43,017,069
Ensembl chr 9:42,875,138...43,018,534 		JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression ISO Phenylephrine results in decreased expression of ARRDC3 mRNA CTD PMID:18158353 NCBI chr13:81,031,508...81,044,161
Ensembl chr13:81,031,503...81,044,161 		JBrowse link
G Asb18 ankyrin repeat and SOCS box-containing 18 decreases expression ISO Phenylephrine results in decreased expression of ASB18 mRNA CTD PMID:18158353 NCBI chr 1:89,880,313...89,942,388
Ensembl chr 1:89,877,942...89,942,388 		JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 increases expression ISO Phenylephrine results in increased expression of ASB4 mRNA CTD PMID:18158353 NCBI chr 6:5,383,386...5,433,022
Ensembl chr 6:5,383,386...5,433,022 		JBrowse link
G Asns asparagine synthetase increases expression ISO Phenylephrine results in increased expression of ASNS mRNA CTD PMID:18158353 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Phenylephrine results in increased expression of ATF5 mRNA CTD PMID:18158353 NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide increases expression ISO Phenylephrine results in increased expression of ATP1B1 mRNA CTD PMID:11204457 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 multiple interactions
decreases activity
increases expression
affects response to substance
decreases expression		 EXP
ISO		 [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased activity of ATP2A2 protein
Phenylephrine results in increased expression of ATP2A2 mRNA
ATP2A2 protein affects the susceptibility to Phenylephrine
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein		 CTD PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More... NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Phenylephrine CTD PMID:12933703 NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779 		JBrowse link
G Atp9a ATPase, class II, type 9A increases expression ISO Phenylephrine results in increased expression of ATP9A mRNA CTD PMID:18158353 NCBI chr 2:168,476,358...168,584,290
Ensembl chr 2:168,476,358...168,584,329 		JBrowse link
G Atxn1 ataxin 1 multiple interactions ISO Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]] CTD PMID:32278511 NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484 		JBrowse link
G Auts2 autism susceptibility candidate 2 decreases expression ISO Phenylephrine results in decreased expression of AUTS2 mRNA CTD PMID:18158353 NCBI chr 5:131,466,171...132,572,059
Ensembl chr 5:131,466,171...132,572,183 		JBrowse link
G Avp arginine vasopressin multiple interactions
increases secretion		 ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:2271928 PMID:11102496 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Avpi1 arginine vasopressin-induced 1 increases expression ISO Phenylephrine results in increased expression of AVPI1 mRNA CTD PMID:18158353 NCBI chr19:42,111,714...42,117,432
Ensembl chr19:42,111,712...42,117,498 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Phenylephrine results in increased expression of BAD protein CTD PMID:31605733 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Phenylephrine results in increased expression of BAMBI mRNA CTD PMID:18158353 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
increases expression		 ISO Phenylephrine results in decreased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]
Phenylephrine results in increased expression of BAX protein		 CTD PMID:19910689 PMID:31605733 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 multiple interactions
increases phosphorylation		 ISO ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441 		JBrowse link
G Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide decreases expression ISO Phenylephrine results in decreased expression of BCKDHA mRNA CTD PMID:18158353 NCBI chr 7:25,329,371...25,358,178
Ensembl chr 7:25,329,371...25,358,406 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
decreases expression		 ISO BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein
Phenylephrine results in decreased expression of BCL2 protein		 CTD PMID:11042672 PMID:19910689 PMID:31605733 PMID:35979984 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression		 ISO Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein		 CTD PMID:11042672 PMID:31605733 PMID:35979984 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase, type 1 increases expression ISO Phenylephrine results in increased expression of BDH1 mRNA CTD PMID:18158353 NCBI chr16:31,241,115...31,277,719
Ensembl chr16:31,241,098...31,277,719 		JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 decreases expression ISO Phenylephrine results in decreased expression of BDH2 mRNA CTD PMID:18158353 NCBI chr 3:134,986,982...135,010,187
Ensembl chr 3:134,986,982...135,010,187 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 affects response to substance
increases expression		 EXP
ISO		 BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA		 CTD PMID:10614985 PMID:18158353 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G Bdnf brain derived neurotrophic factor increases expression ISO Phenylephrine results in increased expression of BDNF mRNA CTD PMID:18158353 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes RGD PMID:26873969 RGD:11526363 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes RGD PMID:26873969 RGD:11526363 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression
increases expression 		ISO Phenylephrine results in decreased expression of BMP7 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes		 CTD
RGD		 PMID:18158353 PMID:26873969 RGD:11526363 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like increases expression ISO Phenylephrine results in increased expression of BNIP3L mRNA CTD PMID:16291751 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326 		JBrowse link
G Boll boule homolog, RNA binding protein decreases expression ISO Phenylephrine results in decreased expression of BOLL mRNA CTD PMID:18158353 NCBI chr 1:55,282,725...55,402,948
Ensembl chr 1:55,287,817...55,402,628 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
increases expression		 ISO Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein		 CTD PMID:23939492 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression ISO Phenylephrine results in increased expression of BTG3 mRNA CTD PMID:18158353 NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080 		JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions ISO CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein] CTD PMID:10655507 PMID:17060317 NCBI chr10:75,481,944...75,600,194
Ensembl chr10:75,481,946...75,600,175 		JBrowse link
G Cadps Ca2+-dependent secretion activator decreases expression ISO Phenylephrine results in decreased expression of CADPS mRNA CTD PMID:18158353 NCBI chr14:9,646,424...10,097,203
Ensembl chr14:9,646,684...10,097,200 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects response to substance EXP
ISO		 CALCA protein affects the susceptibility to Phenylephrine CTD PMID:11728430 PMID:18055875 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Calcrl calcitonin receptor-like multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA CTD PMID:17250927 NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression ISO Phenylephrine results in decreased expression of CAMK2A mRNA CTD PMID:18158353 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta multiple interactions ISO CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylephrine results in decreased activity of CA1 protein CTD PMID:28800181 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity		 ISO Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein		 CTD PMID:17124262 PMID:28800181 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Car4 carbonic anhydrase 4 increases expression ISO Phenylephrine results in increased expression of CA4 protein CTD PMID:17124262 NCBI chr11:84,848,580...84,856,880
Ensembl chr11:84,848,612...84,856,870 		JBrowse link
G Casp2 caspase 2 affects activity ISO Phenylephrine affects the activity of CASP2 protein CTD PMID:31605733 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein		 CTD PMID:11042672 PMID:31605733 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 affects activity ISO Phenylephrine affects the activity of CASP8 protein CTD PMID:31605733 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity ISO Phenylephrine results in increased activity of CASP9 protein CTD PMID:31605733 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] CTD PMID:11071898 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cat catalase multiple interactions
decreases expression		 ISO CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein		 CTD PMID:16513848 PMID:18171680 PMID:20886221 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions EXP Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine] CTD PMID:18178722 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Cav3 caveolin 3 multiple interactions
affects localization
decreases response to substance		 ISO CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Phenylephrine affects the localization of CAV3 protein
CAV3 protein results in decreased susceptibility to Phenylephrine		 CTD PMID:12847114 PMID:19299911 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein
4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]		 CTD PMID:15721863 PMID:15728586 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl27a C-C motif chemokine ligand 27A increases expression ISO Phenylephrine results in increased expression of CCL27 mRNA CTD PMID:18158353 NCBI chr 4:41,769,467...41,774,251
Ensembl chr 4:41,769,467...41,774,247 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein		 CTD PMID:15117851 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein CTD PMID:15276029 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein] CTD PMID:12163013 PMID:15603588 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Phenylephrine results in increased expression of CCND2 protein CTD PMID:12163013 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein] CTD PMID:12163013 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr15:98,436,570...98,468,340
Ensembl chr15:98,436,570...98,468,804 		JBrowse link
G Cd200 CD200 molecule decreases expression ISO Phenylephrine results in decreased expression of CD200 mRNA CTD PMID:18158353 NCBI chr16:45,202,474...45,229,419
Ensembl chr16:45,202,498...45,229,416 		JBrowse link
G Cdh2 cadherin 2 increases expression ISO Phenylephrine results in increased expression of CDH2 protein CTD PMID:17526999 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Phenylephrine results in increased expression of CDK2 protein CTD PMID:15603588 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 increases expression ISO Phenylephrine results in increased expression of CDK4 protein CTD PMID:15603588 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
increases stability		 ISO Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA		 CTD PMID:10766810 PMID:15603588 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Phenylephrine results in increased expression of CDKN1B CTD PMID:15603588 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Phenylephrine results in decreased expression of CEBPA mRNA CTD PMID:19443575 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO [Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein] CTD PMID:17596272 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression ISO Phenylephrine results in increased expression of CHCHD6 mRNA CTD PMID:18158353 NCBI chr 6:89,360,128...89,572,634
Ensembl chr 6:89,360,128...89,572,634 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Phenylephrine results in increased expression of CLIC4 mRNA CTD PMID:18158353 NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125 		JBrowse link
G Clu clusterin increases expression ISO Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein CTD PMID:19443575 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cnn1 calponin 1 increases expression ISO Phenylephrine results in increased expression of CNN1 mRNA CTD PMID:18158353 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926 		JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 decreases expression ISO Phenylephrine results in decreased expression of COL18A1 mRNA CTD PMID:18158353 NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO Phenylephrine results in decreased expression of COLEC12 mRNA CTD PMID:18158353 NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644 		JBrowse link
G Corin corin, serine peptidase increases expression ISO Phenylephrine results in increased expression of CORIN mRNA CTD PMID:15191894 NCBI chr 5:72,457,291...72,661,884
Ensembl chr 5:72,457,368...72,661,816 		JBrowse link
G Cox11 cytochrome c oxidase assembly protein 11, copper chaperone multiple interactions
decreases expression		 ISO Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein] CTD PMID:23818984 PMID:25107896 NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757 		JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone multiple interactions
decreases expression		 ISO Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein] CTD PMID:23818984 PMID:25107896 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 decreases expression
multiple interactions		 ISO Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]		 CTD PMID:23818984 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle multiple interactions
increases expression
decreases expression		 ISO 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in increased expression of CPT1B mRNA
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein		 CTD PMID:11879187 PMID:15721863 PMID:19699196 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:14741741 PMID:15522277 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein multiple interactions
increases response to substance		 ISO [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine		 CTD PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Phenylephrine results in increased expression of CREM mRNA CTD PMID:12791704 PMID:18158353 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog multiple interactions ISO ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734 		JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide decreases expression ISO Phenylephrine results in decreased expression of CSNK2A1 mRNA CTD PMID:18158353 NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772 		JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression ISO Phenylephrine results in increased expression of CSPG4 mRNA CTD PMID:18158353 NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO Phenylephrine results in increased expression of CSRP2 mRNA CTD PMID:18158353 NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483 		JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 increases localization ISO Phenylephrine results in increased localization of CSRP3 protein CTD PMID:19376126 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781 		JBrowse link
G Cth cystathionine gamma lyase increases activity ISO Phenylephrine results in increased activity of CTH protein CTD PMID:18184479 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter] CTD PMID:19799869 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsc cathepsin C decreases expression ISO Phenylephrine results in decreased expression of CTSC mRNA CTD PMID:18158353 NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Phenylephrine results in decreased expression of CXCL1 mRNA CTD PMID:18158353 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Phenylephrine results in decreased expression of CXCL10 mRNA CTD PMID:18158353 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 decreases expression ISO Phenylephrine results in decreased expression of CXCL11 mRNA CTD PMID:18158353 NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344 		JBrowse link
G Cxxc4 CXXC finger 4 decreases expression ISO Phenylephrine results in decreased expression of CXXC4 mRNA CTD PMID:18158353 NCBI chr 3:133,938,927...133,967,924
Ensembl chr 3:133,942,245...133,967,922 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO Phenylephrine results in increased expression of CYP11B2 mRNA CTD PMID:19966502 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]] CTD PMID:16510159 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression ISO Phenylephrine results in increased expression of CYP26B1 mRNA CTD PMID:18158353 NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890 		JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B multiple interactions
affects response to substance
increases response to substance		 ISO 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine] CTD PMID:11124159 PMID:12388396 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Phenylephrine results in increased expression of CYP51 mRNA CTD PMID:18158353 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO Phenylephrine results in decreased expression of DAPK1 mRNA CTD PMID:18158353 NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005 		JBrowse link
G Dgke diacylglycerol kinase, epsilon multiple interactions EXP DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein] CTD PMID:18487437 NCBI chr11:88,926,005...88,951,644
Ensembl chr11:88,926,005...88,957,676 		JBrowse link
G Dgkz diacylglycerol kinase zeta multiple interactions EXP DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16380548 NCBI chr 2:91,763,167...91,806,788
Ensembl chr 2:91,763,169...91,806,209 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Phenylephrine results in increased expression of DHCR7 mRNA CTD PMID:18158353 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II increases activity
increases expression		 ISO Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA		 CTD PMID:15345674 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression ISO Phenylephrine results in decreased expression of DNAH12 mRNA CTD PMID:18158353 NCBI chr14:26,412,709...26,614,250
Ensembl chr14:26,414,429...26,613,660 		JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression ISO Phenylephrine results in increased expression of DNAJB5 mRNA CTD PMID:18158353 NCBI chr 4:42,949,866...42,959,425
Ensembl chr 4:42,949,814...42,959,425 		JBrowse link
G Dnm1l dynamin 1-like increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]		 CTD PMID:20886221 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Dpt dermatopontin decreases expression ISO Phenylephrine results in decreased expression of DPT mRNA CTD PMID:18158353 NCBI chr 1:164,624,232...164,651,843
Ensembl chr 1:164,624,213...164,651,835 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Phenylephrine results in increased expression of DUSP1 mRNA CTD PMID:18158353 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15757502 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351 		JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO Phenylephrine results in increased expression of E2F3 protein CTD PMID:12682052 NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046 		JBrowse link
G E2f4 E2F transcription factor 4 increases expression ISO Phenylephrine results in increased expression of E2F4 protein CTD PMID:12682052 NCBI chr 8:106,024,295...106,032,002
Ensembl chr 8:106,024,295...106,032,002 		JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Phenylephrine results in increased expression of E2F5 protein CTD PMID:12682052 NCBI chr 3:14,638,370...14,671,369
Ensembl chr 3:14,643,701...14,671,369 		JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression ISO Phenylephrine results in increased expression of ECE1 mRNA CTD PMID:15007106 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540 		JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression ISO Phenylephrine results in increased expression of ECM1 mRNA CTD PMID:18158353 NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881 		JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
affects response to substance
increases expression		 ISO MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
MBF1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of MBF1		 CTD PMID:12729799 NCBI chr 2:25,447,838...25,452,096
Ensembl chr 2:25,447,859...25,452,094 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
increases response to substance		 ISO EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein		 CTD PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More... NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093 		JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Phenylephrine results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein CTD PMID:16760267 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 EXP
ISO		 Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Phenylephrine results in increased phosphorylation of EGFR protein		 CTD PMID:14676212 PMID:16760267 PMID:18360054 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO Phenylephrine results in increased expression of EGLN3 mRNA CTD PMID:18158353 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 EXP
ISO		 EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA		 CTD PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation		 ISO CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein] CTD PMID:15757502 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation		 ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions
increases expression
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein		 CTD PMID:10900171 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression ISO Phenylephrine results in increased expression of ELOVL5 mRNA CTD PMID:18158353 NCBI chr 9:77,824,647...77,891,801
Ensembl chr 9:77,824,646...77,891,801 		JBrowse link
G Eno2 enolase 2, gamma neuronal increases expression ISO Phenylephrine results in increased expression of ENO2 mRNA CTD PMID:18158353 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Eno3 enolase 3, beta muscle increases expression ISO Phenylephrine results in increased expression of ENO3 mRNA CTD PMID:18158353 NCBI chr11:70,543,973...70,553,339
Ensembl chr11:70,548,028...70,553,339 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
increases response to substance
increases expression		 ISO EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
EP300 protein results in increased susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein		 CTD PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More... NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Phenylephrine results in decreased expression of EPAS1 mRNA CTD PMID:18158353 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4b increases expression ISO Phenylephrine results in increased expression of EPB41L4B mRNA CTD PMID:18158353 NCBI chr 4:56,991,977...57,143,753
Ensembl chr 4:56,991,972...57,143,437 		JBrowse link
G Epha4 Eph receptor A4 decreases expression ISO Phenylephrine results in decreased expression of EPHA4 mRNA CTD PMID:18158353 NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic decreases expression ISO Phenylephrine results in decreased expression of EPHX2 mRNA CTD PMID:18158353 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions EXP ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] CTD PMID:17158209 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 multiple interactions ISO EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:17327491 NCBI chr 2:165,436,892...165,613,645
Ensembl chr 2:165,436,952...165,613,647 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression ISO Phenylephrine results in decreased expression of FABP4 mRNA CTD PMID:18158353 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fads3 fatty acid desaturase 3 increases expression ISO Phenylephrine results in increased expression of FADS3 mRNA CTD PMID:18158353 NCBI chr19:10,018,189...10,037,477
Ensembl chr19:10,018,933...10,037,474 		JBrowse link
G Fam110b family with sequence similarity 110, member B decreases expression ISO Phenylephrine results in decreased expression of FAM110B mRNA CTD PMID:18158353 NCBI chr 4:5,644,009...5,801,101
Ensembl chr 4:5,644,090...6,108,223 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions EXP FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Fdx1 ferredoxin 1 increases expression ISO Phenylephrine results in increased expression of FDX1 mRNA CTD PMID:18158353 NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856 		JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression ISO Phenylephrine results in increased expression of FGF12 mRNA CTD PMID:18158353 NCBI chr16:27,976,535...28,571,995
Ensembl chr16:27,978,850...28,571,820 		JBrowse link
G Fgf18 fibroblast growth factor 18 increases expression ISO Phenylephrine results in increased expression of FGF18 mRNA CTD PMID:18158353 NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter] CTD PMID:10779383 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression ISO Phenylephrine results in increased expression of FHL1 mRNA CTD PMID:18158353 NCBI chr  X:55,776,569...55,838,704
Ensembl chr  X:55,777,147...55,838,706 		JBrowse link
G Fhl2 four and a half LIM domains 2 decreases response to substance ISO FHL2 gene mutant form results in decreased susceptibility to Phenylephrine CTD PMID:25358972 NCBI chr 1:43,162,233...43,237,501
Ensembl chr 1:43,162,234...43,236,144 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions
increases expression		 ISO CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein] CTD PMID:20886221 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions
increases expression		 ISO FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein		 CTD PMID:19542178 PMID:24903162 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Phenylephrine results in increased expression of FN1 protein CTD PMID:11821714 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
affects response to substance
affects expression		 EXP
ISO		 [Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine affects the expression of FOS protein		 CTD PMID:7844257 PMID:7900855 PMID:7905536 PMID:8750937 PMID:8809800 More... NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B increases activity
increases expression		 ISO Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB		 CTD PMID:7905536 PMID:15949472 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein CTD PMID:16020479 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Fstl3 follistatin-like 3 affects expression ISO Phenylephrine affects the expression of FSTL3 mRNA CTD PMID:18158353 NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464 		JBrowse link
G Fxyd5 FXYD domain-containing ion transport regulator 5 increases expression ISO Phenylephrine results in increased expression of FXYD5 mRNA CTD PMID:18158353 NCBI chr 7:30,732,153...30,741,565
Ensembl chr 7:30,732,147...30,741,906 		JBrowse link
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 decreases expression ISO Phenylephrine results in decreased expression of GALNT13 mRNA CTD PMID:18158353 NCBI chr 2:54,326,217...55,008,321
Ensembl chr 2:54,326,329...55,008,321 		JBrowse link
G Gamt guanidinoacetate methyltransferase decreases expression ISO Phenylephrine results in decreased expression of GAMT mRNA CTD PMID:18158353 NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
affects response to substance
increases acetylation
increases expression
increases activity		 ISO
EXP		 EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA
GATA4 protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
Phenylephrine results in increased acetylation of GATA4 protein
Phenylephrine results in increased expression of GATA4 protein		 CTD PMID:10710348 PMID:10788492 PMID:11739382 PMID:12724418 PMID:15220332 More... NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141 		JBrowse link
G Gdf15 growth differentiation factor 15 affects expression ISO Phenylephrine affects the expression of GDF15 mRNA CTD PMID:19505289 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein] CTD PMID:12628311 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
affects response to substance
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
GJA1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein		 CTD PMID:16352648 PMID:18445782 PMID:18593691 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression ISO Phenylephrine results in decreased expression of GJA5 mRNA CTD PMID:18158353 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gla galactosidase, alpha affects response to substance EXP GLA protein affects the susceptibility to Phenylephrine CTD PMID:18565198 NCBI chr  X:133,488,912...133,501,707
Ensembl chr  X:133,488,898...133,501,874 		JBrowse link
G Glrx3 glutaredoxin 3 affects response to substance
multiple interactions
increases expression		 ISO GLRX3 protein affects the susceptibility to Phenylephrine
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]
Phenylephrine results in increased expression of GLRX3 mRNA		 CTD PMID:16809552 NCBI chr 7:137,039,302...137,071,360
Ensembl chr 7:137,039,343...137,070,323 		JBrowse link
G Gmfg glia maturation factor, gamma increases expression ISO Phenylephrine results in increased expression of GMFG mRNA CTD PMID:18158353 NCBI chr 7:28,136,894...28,147,655
Ensembl chr 7:28,136,872...28,147,658 		JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide multiple interactions ISO RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] CTD PMID:14676212 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827 		JBrowse link
G Gnas GNAS complex locus affects response to substance ISO GNAS protein affects the susceptibility to Phenylephrine CTD PMID:10696522 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions
decreases secretion
increases secretion		 ISO alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888 		JBrowse link
G Gpm6a glycoprotein m6a decreases expression ISO Phenylephrine results in decreased expression of GPM6A mRNA CTD PMID:18158353 NCBI chr 8:55,232,469...55,513,913
Ensembl chr 8:55,407,878...55,513,906 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
increases expression		 EXP
ISO		 [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]		 CTD PMID:11499749 PMID:28759639 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 ISO GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein] CTD PMID:15795328 PMID:28759639 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Phenylephrine results in decreased expression of GSTK1 mRNA CTD PMID:18158353 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Phenylephrine results in decreased expression of GSTM3 mRNA CTD PMID:18158353 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gys2 glycogen synthase 2 decreases activity ISO Phenylephrine results in decreased activity of GYS2 protein CTD PMID:747652 NCBI chr 6:142,368,339...142,418,856
Ensembl chr 6:142,368,339...142,418,835 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Phenylephrine results in decreased expression of HAMP mRNA CTD PMID:18158353 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Phenylephrine results in increased expression of DTR mRNA CTD PMID:18158353 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein CTD PMID:19124542 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Hdgfl2 HDGF like 2 decreases expression ISO Phenylephrine results in decreased expression of HDGFL2 mRNA CTD PMID:18158353 NCBI chr17:56,386,661...56,407,605
Ensembl chr17:56,386,634...56,407,607 		JBrowse link
G Herc3 hect domain and RLD 3 increases expression ISO Phenylephrine results in increased expression of HERC3 mRNA CTD PMID:18158353 NCBI chr 6:58,808,440...58,897,383
Ensembl chr 6:58,808,450...58,897,383 		JBrowse link
G Hexim1 hexamethylene bis-acetamide inducible 1 multiple interactions ISO Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr11:103,007,151...103,010,551
Ensembl chr11:103,007,057...103,010,551 		JBrowse link
G Hey2 hairy/enhancer-of-split related with YRPW motif 2 multiple interactions
decreases response to substance
decreases expression		 EXP HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
HEY2 protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of HEY2 mRNA		 CTD PMID:16603706 PMID:20001863 NCBI chr10:30,708,355...30,718,779
Ensembl chr10:30,708,355...30,718,797 		JBrowse link
G Higd1a HIG1 domain family, member 1A increases expression ISO Phenylephrine results in increased expression of HIGD1A mRNA CTD PMID:18158353 NCBI chr 9:121,677,623...121,686,862
Ensembl chr 9:121,677,629...121,687,428 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Phenylephrine results in increased expression of HMGCS1 mRNA CTD PMID:18158353 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Homer1 homer scaffolding protein 1 increases expression ISO Phenylephrine results in increased expression of HOMER1 mRNA alternative form CTD PMID:16786172 NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637 		JBrowse link
G Hspb3 heat shock protein 3 increases expression ISO Phenylephrine results in increased expression of HSPB3 mRNA CTD PMID:18158353 NCBI chr13:113,799,432...113,800,212
Ensembl chr13:113,799,432...113,800,212 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression
increases expression 		ISO Phenylephrine results in increased expression of ID1 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes		 CTD
RGD		 PMID:18158353 PMID:26873969 RGD:11526363 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330 		JBrowse link
G Id4 inhibitor of DNA binding 4 increases expression ISO Phenylephrine results in increased expression of ID4 mRNA CTD PMID:18158353 NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase increases expression ISO Phenylephrine results in increased expression of IDI1 mRNA CTD PMID:18158353 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487 		JBrowse link
G Ier3 immediate early response 3 decreases response to substance
affects localization		 EXP IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein		 CTD PMID:11934837 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Igf1 insulin-like growth factor 1 affects response to substance ISO IGF1 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 affects response to substance ISO IGFBP4 protein affects the susceptibility to Phenylephrine CTD PMID:11159833 NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO Phenylephrine results in decreased expression of IGFBP5 mRNA CTD PMID:18158353 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases activity
multiple interactions		 ISO Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]		 CTD PMID:11381115 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects response to substance
decreases response to substance		 ISO Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine		 CTD PMID:11506125 PMID:13679239 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
multiple interactions		 ISO Phenylephrine results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA		 CTD PMID:11406463 PMID:12423672 PMID:22748497 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ilk integrin linked kinase multiple interactions
affects localization		 EXP
ISO		 Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine affects the localization of ILK protein		 CTD PMID:16170337 PMID:18502941 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Inha inhibin alpha increases expression ISO Phenylephrine results in increased expression of INHA mRNA CTD PMID:18158353 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Phenylephrine results in decreased expression of IRF7 mRNA CTD PMID:18158353 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Phenylephrine results in decreased expression of ISG15 mRNA CTD PMID:18158353 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253 		JBrowse link
G Itga9 integrin alpha 9 increases expression ISO Phenylephrine results in increased expression of ITGA9 mRNA CTD PMID:18158353 NCBI chr 9:118,435,777...118,730,071
Ensembl chr 9:118,435,758...118,730,071 		JBrowse link
G Itgb3bp integrin beta 3 binding protein (beta3-endonexin) increases expression ISO Phenylephrine results in increased expression of ITGB3BP mRNA CTD PMID:18158353 NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010 		JBrowse link
G Itgb8 integrin beta 8 increases expression ISO Phenylephrine results in increased expression of ITGB8 mRNA CTD PMID:18158353 NCBI chr12:119,121,757...119,202,891
Ensembl chr12:119,121,757...119,202,537 		JBrowse link
G Itpr2 inositol 1,4,5-triphosphate receptor 2 increases activity
multiple interactions		 EXP Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA		 CTD PMID:15201137 NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721 		JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
affects response to substance
increases activity
increases phosphorylation		 EXP
ISO		 [Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased expression of JUN mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
JUN protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein		 CTD PMID:7905536 PMID:10710348 PMID:11799083 PMID:12169099 PMID:12574153 More... NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene increases expression
increases activity		 ISO Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein		 CTD PMID:7905536 PMID:15949472 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Jund jun D proto-oncogene multiple interactions
decreases expression		 EXP JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA		 CTD PMID:16690042 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 multiple interactions
decreases response to substance
decreases expression		 ISO CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
KCND2 protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein		 CTD PMID:12403671 PMID:16385079 PMID:17060317 NCBI chr 6:21,212,101...21,729,804
Ensembl chr 6:21,215,502...21,729,804 		JBrowse link
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 multiple interactions
decreases expression		 ISO [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein		 CTD PMID:11249870 PMID:11709419 PMID:16385079 PMID:17060317 NCBI chr 3:105,359,206...105,581,318
Ensembl chr 3:105,359,646...105,581,318 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnip2 Kv channel-interacting protein 2 multiple interactions
decreases expression		 ISO MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein		 CTD PMID:16385079 PMID:17060317 PMID:18158353 NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500 		JBrowse link
G Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 increases expression ISO Phenylephrine results in increased expression of KDELR3 mRNA CTD PMID:18158353 NCBI chr15:79,400,609...79,411,940
Ensembl chr15:79,400,612...79,411,940 		JBrowse link
G Kdr kinase insert domain protein receptor decreases expression
increases expression
multiple interactions		 ISO Phenylephrine results in decreased expression of KDR mRNA
Phenylephrine results in increased expression of KDR protein
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]		 CTD PMID:18158353 PMID:24903162 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Kif5b kinesin family member 5B decreases expression ISO Phenylephrine results in decreased expression of KIF5B mRNA CTD PMID:18158353 NCBI chr18:6,201,005...6,241,524
Ensembl chr18:6,201,002...6,242,174 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) multiple interactions
decreases expression		 ISO Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein		 CTD PMID:19729022 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Klhl24 kelch-like 24 decreases expression ISO Phenylephrine results in decreased expression of KLHL24 mRNA CTD PMID:18158353 NCBI chr16:19,916,286...19,947,976
Ensembl chr16:19,916,292...19,947,971 		JBrowse link
G Kmt2e lysine (K)-specific methyltransferase 2E decreases expression ISO Phenylephrine results in decreased expression of KMT2E mRNA CTD PMID:18158353 NCBI chr 5:23,638,034...23,709,233
Ensembl chr 5:23,639,439...23,709,233 		JBrowse link
G Lamc1 laminin, gamma 1 increases expression ISO Phenylephrine results in increased expression of LAMC1 mRNA CTD PMID:18158353 NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532 		JBrowse link
G Lamc2 laminin, gamma 2 increases expression ISO Phenylephrine results in increased expression of LAMC2 mRNA CTD PMID:18158353 NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Phenylephrine results in increased expression of LDLR mRNA CTD PMID:18158353 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein decreases expression ISO Phenylephrine results in decreased expression of LGALS3BP mRNA CTD PMID:18158353 NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918 		JBrowse link
G Lims1 LIM and senescent cell antigen-like domains 1 affects localization ISO Phenylephrine affects the localization of LIMS1 protein CTD PMID:16170337 NCBI chr10:58,159,164...58,260,513
Ensembl chr10:58,159,288...58,260,513 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO Phenylephrine results in increased expression of LMCD1 mRNA CTD PMID:18158353 NCBI chr 6:112,250,747...112,307,384
Ensembl chr 6:112,250,719...112,307,386 		JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Phenylephrine CTD PMID:11786490 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression ISO Phenylephrine results in decreased expression of LRRC27 mRNA CTD PMID:18158353 NCBI chr 7:138,791,548...138,822,895
Ensembl chr 7:138,792,904...138,822,895 		JBrowse link
G Lyl1 lymphoblastomic leukemia 1 increases expression ISO Phenylephrine results in increased expression of LYL1 mRNA CTD PMID:18158353 NCBI chr 8:85,428,051...85,432,876
Ensembl chr 8:85,428,078...85,431,569 		JBrowse link
G Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) increases expression ISO Phenylephrine results in increased expression of MAFK mRNA CTD PMID:18158353 NCBI chr 5:139,777,291...139,788,409
Ensembl chr 5:139,777,268...139,788,408 		JBrowse link
G Man1a mannosidase 1, alpha decreases expression ISO Phenylephrine results in decreased expression of MAN1A mRNA CTD PMID:18158353 NCBI chr10:53,780,881...53,952,712
Ensembl chr10:53,780,881...53,952,705 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine CTD PMID:11834493 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:10888249 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions ISO MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:10727428 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases activity		 ISO CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 increases phosphorylation
multiple interactions		 ISO phenylephrin increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes
Phenylephrine increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes
Phenylephrine promotes the reaction [Map3k7 protein binds to Ripk2 protein]
Phenylephrine promotes the reaction [Map3k7 protein binds to Tab1 protein in neonatal cardiomyocytes]		 RGD PMID:32971071 PMID:35490166 PMID:34733837 PMID:35352799 RGD:155791643, RGD:155791668, RGD:155791674, RGD:155804287 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases activity
affects phosphorylation
increases expression
increases phosphorylation		 ISO
EXP		 [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Phenylephrine results in increased activity of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine affects the phosphorylation of MAPK1 protein
Phenylephrine results in increased expression of MAPK1 protein modified form		 CTD PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 multiple interactions EXP MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine] CTD PMID:16949803 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases phosphorylation ISO Phenylephrine results in increased phosphorylation of MAPK14 protein CTD PMID:15757502 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases activity
affects phosphorylation
increases expression
increases phosphorylation		 ISO
EXP		 [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Phenylephrine results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine affects the phosphorylation of MAPK3 protein
Phenylephrine results in increased expression of MAPK3 protein modified form		 CTD PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein] CTD PMID:12574153 NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein		 CTD PMID:10727428 PMID:16385079 PMID:16517124 PMID:16809552 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 affects response to substance
multiple interactions		 ISO MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]		 CTD PMID:11513749 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
affects response to substance
increases phosphorylation		 EXP
ISO		 MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein		 CTD PMID:10727428 PMID:16949803 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Masp1 MBL associated serine protease 1 decreases expression ISO Phenylephrine results in decreased expression of MASP1 mRNA CTD PMID:18158353 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565 		JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases activity
increases expression		 EXP
ISO		 Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]		 CTD PMID:10737771 PMID:19124542 NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199 		JBrowse link
G Mfap4 microfibrillar-associated protein 4 decreases expression ISO Phenylephrine results in decreased expression of MFAP4 mRNA CTD PMID:18158353 NCBI chr11:61,376,257...61,379,536
Ensembl chr11:61,376,257...61,379,726 		JBrowse link
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 decreases expression ISO Phenylephrine results in decreased expression of MFHAS1 mRNA CTD PMID:18158353 NCBI chr 8:36,054,922...36,146,603
Ensembl chr 8:36,054,952...36,146,603 		JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions		 ISO Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]		 CTD PMID:17499311 PMID:20886221 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Phenylephrine results in decreased expression of MGLL mRNA CTD PMID:18158353 NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342 		JBrowse link
G Mir21a microRNA 21a increases expression ISO Phenylephrine results in increased expression of MIR21 mRNA CTD PMID:17525252 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mlkl mixed lineage kinase domain-like increases expression ISO Phenylephrine results in increased expression of MLKL protein CTD PMID:31605733 NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809 		JBrowse link
G Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 increases expression ISO Phenylephrine results in increased expression of MLLT11 mRNA CTD PMID:18158353 NCBI chr 3:95,125,852...95,139,486
Ensembl chr 3:95,126,446...95,139,482 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]		 CTD PMID:16251426 PMID:16980344 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Phenylephrine results in increased expression of MMP9 mRNA CTD PMID:16574429 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mov10l1 Mov10 like RISC complex RNA helicase 1 multiple interactions EXP
ISO		 MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]		 CTD PMID:11854500 PMID:12754203 NCBI chr15:88,867,094...88,939,355
Ensembl chr15:88,867,112...88,939,355 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 increases expression ISO Phenylephrine results in increased expression of MSMO1 mRNA CTD PMID:18158353 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G Msn moesin increases expression ISO Phenylephrine results in increased expression of MSN mRNA CTD PMID:18158353 NCBI chr  X:95,139,651...95,212,159
Ensembl chr  X:95,139,648...95,212,158 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO Phenylephrine results in increased expression of MTHFD1L mRNA CTD PMID:18158353 NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein] CTD PMID:12935885 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Mustn1 musculoskeletal, embryonic nuclear protein 1 increases expression ISO Phenylephrine results in increased expression of MUSTN1 mRNA CTD PMID:18158353 NCBI chr14:30,601,214...30,603,567
Ensembl chr14:30,601,157...30,603,567 		JBrowse link
G Mybl1 myeloblastosis oncogene-like 1 increases expression ISO Phenylephrine results in increased expression of MYBL1 mRNA CTD PMID:18158353 NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434 		JBrowse link
G Mybpc3 myosin binding protein C, cardiac multiple interactions EXP
ISO		 MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]		 CTD PMID:22076249 NCBI chr 2:90,948,459...90,966,862
Ensembl chr 2:90,948,489...90,966,861 		JBrowse link
G Myh14 myosin, heavy polypeptide 14 decreases expression ISO Phenylephrine results in decreased expression of MYH14 mRNA CTD PMID:18158353 NCBI chr 7:44,255,227...44,320,296
Ensembl chr 7:44,255,227...44,320,267 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha multiple interactions
decreases expression		 ISO Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024 PMID:15578571 PMID:15795322 PMID:17592507 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions
increases expression		 ISO
EXP		 CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein		 CTD PMID:10642269 PMID:10710348 PMID:11249870 PMID:11513749 PMID:11577024 More... NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Myl1 myosin, light polypeptide 1 increases expression ISO Phenylephrine results in increased expression of MYL1 mRNA CTD PMID:18158353 NCBI chr 1:66,963,454...66,987,091
Ensembl chr 1:66,963,454...66,984,563 		JBrowse link
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow increases phosphorylation
multiple interactions
increases expression		 ISO Phenylephrine results in increased phosphorylation of MYL2 protein
ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]		 CTD PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106 PMID:18202317 NCBI chr 5:122,230,787...122,251,536
Ensembl chr 5:122,239,014...122,251,535 		JBrowse link
G Myl7 myosin, light polypeptide 7, regulatory multiple interactions
increases phosphorylation		 ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein] CTD PMID:15621049 NCBI chr11:5,846,637...5,848,782
Ensembl chr11:5,846,637...5,848,782 		JBrowse link
G Myl9 myosin, light polypeptide 9, regulatory increases phosphorylation ISO Phenylephrine results in increased phosphorylation of MYL9 protein CTD PMID:18835913 NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578 		JBrowse link
G Mylk3 myosin light chain kinase 3 increases phosphorylation EXP Phenylephrine results in increased phosphorylation of MYLK3 protein CTD PMID:18202317 NCBI chr 8:86,050,933...86,112,969
Ensembl chr 8:86,050,932...86,112,974 		JBrowse link
G Myocd myocardin multiple interactions
increases expression		 ISO MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein		 CTD PMID:14676212 PMID:16556869 NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815 		JBrowse link
G Myoz2 myozenin 2 multiple interactions
decreases response to substance		 EXP MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine		 CTD PMID:18025526 NCBI chr 3:122,799,855...122,828,649
Ensembl chr 3:122,799,855...122,828,664 		JBrowse link
G Nab1 Ngfi-A binding protein 1 multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA CTD PMID:10710348 NCBI chr 1:52,494,146...52,539,553
Ensembl chr 1:52,496,453...52,539,838 		JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA] CTD PMID:10710348 NCBI chr10:127,496,787...127,502,572
Ensembl chr10:127,496,787...127,504,437 		JBrowse link
G Ncald neurocalcin delta increases expression ISO Phenylephrine results in increased expression of NCALD mRNA CTD PMID:18158353 NCBI chr15:37,366,419...37,792,816
Ensembl chr15:37,366,419...37,792,814 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases phosphorylation
increases expression		 ISO
EXP		 Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA		 CTD PMID:14656924 PMID:15936005 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions
affects localization		 ISO Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein; sanggenone C inhibits the reaction [Phenylephrine affects the localization of NFATC1 protein] CTD PMID:12403671 PMID:19349967 PMID:28849031 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 increases localization
multiple interactions		 EXP Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]		 CTD PMID:15939815 NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169 		JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 multiple interactions
increases localization
affects localization		 ISO Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]		 CTD PMID:11044444 PMID:16055480 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400 		JBrowse link
G Nfil3 nuclear factor, interleukin 3, regulated multiple interactions EXP U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA] CTD PMID:12729908 NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
decreases expression
increases degradation		 ISO 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11381115 PMID:15629441 PMID:16421291 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nid2 nidogen 2 increases expression ISO Phenylephrine results in increased expression of NID2 mRNA CTD PMID:18158353 NCBI chr14:19,801,325...19,861,855
Ensembl chr14:19,801,333...19,861,855 		JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA CTD PMID:10710348 NCBI chr17:27,057,638...27,063,962
Ensembl chr17:27,057,638...27,063,983 		JBrowse link
G Nodal nodal growth differentiation factor affects expression ISO Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein CTD PMID:11029149 NCBI chr10:61,253,751...61,261,117
Ensembl chr10:61,253,751...61,261,117 		JBrowse link
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) decreases phosphorylation ISO Phenylephrine results in decreased phosphorylation of NOL3 protein CTD PMID:18171680 NCBI chr 8:106,002,777...106,008,571
Ensembl chr 8:106,002,772...106,008,571 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
affects response to substance
decreases response to substance
increases activity		 EXP
ISO		 NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
NOS2 protein affects the susceptibility to Phenylephrine
NOS2 protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased activity of NOS2 protein
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]		 CTD PMID:11498454 PMID:15753950 PMID:15902277 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell affects response to substance
decreases response to substance
increases expression
multiple interactions		 EXP
ISO		 NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]		 CTD PMID:10954898 PMID:11504159 PMID:15381055 PMID:15753950 PMID:17403420 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppa natriuretic peptide type A increases secretion
multiple interactions
increases expression
decreases response to substance
increases expression 		ISO
EXP		 Phenylephrine results in increased secretion of NPPA protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
NPPA protein results in decreased susceptibility to Phenylephrine
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes		 CTD
RGD		 PMID:2847676 PMID:8188982 PMID:10642269 PMID:10655507 PMID:10679475 More... RGD:11526363 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions
increases expression
increases secretion
increases expression 		EXP
ISO		 ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in increased secretion of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes		 CTD
RGD		 PMID:10642269 PMID:11754973 PMID:11799083 PMID:11804996 PMID:11854500 More... RGD:11526363 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nppc natriuretic peptide type C affects response to substance
multiple interactions		 ISO NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]		 CTD PMID:17026587 NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293 		JBrowse link
G Npr1 natriuretic peptide receptor 1 multiple interactions EXP [NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein] CTD PMID:15939815 NCBI chr 3:90,357,898...90,373,235
Ensembl chr 3:90,357,898...90,373,173 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688 PMID:11499749 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 multiple interactions EXP NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]] CTD PMID:10660688 NCBI chr 8:67,132,617...67,140,746
Ensembl chr 8:67,132,617...67,140,780 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance EXP NR1I2 protein affects the susceptibility to Phenylephrine CTD PMID:17159084 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Phenylephrine results in increased expression of NR3C1 mRNA CTD PMID:16533503 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases expression		 ISO Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA		 CTD PMID:16533503 PMID:19966502 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO Phenylephrine results in increased expression of NR4A3 mRNA CTD PMID:18158353 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Phenylephrine results in decreased expression of NREP mRNA CTD PMID:18158353 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082 		JBrowse link
G Nrg1 neuregulin 1 decreases expression ISO Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein CTD PMID:16698793 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nts neurotensin decreases response to substance ISO NTS protein results in decreased susceptibility to Phenylephrine CTD PMID:2326505 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Nup62 nucleoporin 62 multiple interactions
decreases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 7:44,465,512...44,481,260
Ensembl chr 7:44,465,512...44,480,236 		JBrowse link
G Ogn osteoglycin decreases expression ISO Phenylephrine results in decreased expression of OGN mRNA CTD PMID:18158353 NCBI chr13:49,761,491...49,777,977
Ensembl chr13:49,761,522...49,777,977 		JBrowse link
G Oxt oxytocin multiple interactions
increases secretion		 ISO Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein] CTD PMID:11102496 PMID:15149956 NCBI chr 2:130,416,432...130,418,974
Ensembl chr 2:130,418,093...130,418,974 		JBrowse link
G P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 increases expression ISO Phenylephrine results in increased expression of P2RX5 mRNA CTD PMID:18158353 NCBI chr11:73,029,164...73,063,509
Ensembl chr11:73,051,247...73,063,511 		JBrowse link
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide increases expression ISO Phenylephrine results in increased expression of P4HA1 mRNA CTD PMID:18158353 NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126 		JBrowse link
G Pacc1 proton activated chloride channel 1 decreases expression ISO Phenylephrine results in decreased expression of PACC1 mRNA CTD PMID:18158353 NCBI chr 1:191,058,099...191,083,481
Ensembl chr 1:191,058,109...191,083,111 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 multiple interactions ISO Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]; Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]; Phenylephrine inhibits the reaction [Iodine-131 results in decreased expression of PAFAH1B1 protein] CTD PMID:32278511 NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein] CTD PMID:11042672 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Parva parvin, alpha affects localization ISO Phenylephrine affects the localization of PARVA protein CTD PMID:16170337 NCBI chr 7:112,027,102...112,190,899
Ensembl chr 7:112,026,712...112,190,899 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of PCNA protein
Phenylephrine promotes the reaction [Iodine-131 results in increased expression of PCNA protein]		 CTD PMID:15603588 PMID:32278511 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression ISO Phenylephrine results in decreased expression of PCP4 mRNA CTD PMID:18158353 NCBI chr16:96,268,806...96,326,993
Ensembl chr16:96,268,806...96,326,993 		JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 increases expression ISO Phenylephrine results in increased expression of PCSK6 mRNA CTD PMID:18158353 NCBI chr 7:65,511,884...65,700,134
Ensembl chr 7:65,511,482...65,700,134 		JBrowse link
G Pde1a phosphodiesterase 1A, calmodulin-dependent multiple interactions ISO PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein] CTD PMID:19797176 NCBI chr 2:79,664,797...80,026,862
Ensembl chr 2:79,664,797...79,959,802 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific increases expression ISO Phenylephrine results in increased expression of PDE4B mRNA CTD PMID:18158353 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific multiple interactions ISO PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:18790048 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 decreases expression ISO Phenylephrine results in decreased expression of PDK2 mRNA CTD PMID:18158353 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 multiple interactions
decreases expression		 ISO 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15721863 PMID:15728586 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 increases expression ISO Phenylephrine results in increased expression of PDLIM3 mRNA CTD PMID:18158353 NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585 		JBrowse link
G Pea15a proliferation and apoptosis adaptor protein 15A increases expression ISO Phenylephrine results in increased expression of PEA15 mRNA CTD PMID:18158353 NCBI chr 1:172,024,295...172,034,298
Ensembl chr 1:172,024,295...172,034,371 		JBrowse link
G Per1 period circadian clock 1 multiple interactions EXP U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA] CTD PMID:12729908 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Per2 period circadian clock 2 multiple interactions EXP U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA] CTD PMID:12729908 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha decreases expression ISO Phenylephrine results in decreased expression of PEX11A mRNA CTD PMID:18158353 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Pfkl phosphofructokinase, liver, B-type increases expression ISO Phenylephrine results in increased expression of PFKL mRNA CTD PMID:18158353 NCBI chr10:77,822,781...77,845,641
Ensembl chr10:77,822,781...77,845,917 		JBrowse link
G Phgdh 3-phosphoglycerate dehydrogenase increases expression ISO Phenylephrine results in increased expression of PHGDH mRNA CTD PMID:18158353 NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306 		JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 increases expression ISO Phenylephrine results in increased expression of PHLDA1 mRNA CTD PMID:18158353 NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting affects response to substance EXP PKD1 protein affects the susceptibility to Phenylephrine CTD PMID:18679710 NCBI chr17:24,767,657...24,815,457
Ensembl chr17:24,768,808...24,815,482 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell multiple interactions
decreases activity		 ISO Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein] CTD PMID:747652 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Pkp4 plakophilin 4 decreases expression ISO Phenylephrine results in decreased expression of PKP4 mRNA CTD PMID:18158353 NCBI chr 2:58,991,123...59,185,549
Ensembl chr 2:58,991,194...59,185,552 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) decreases expression ISO Phenylephrine results in decreased expression of PLA2G2A mRNA CTD PMID:18158353 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Pla2g6 phospholipase A2, group VI affects response to substance ISO PLA2G6 protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590 		JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 increases expression ISO Phenylephrine results in increased expression of PLAAT1 mRNA CTD PMID:18158353 NCBI chr16:29,027,883...29,049,283
Ensembl chr16:29,028,447...29,049,283 		JBrowse link
G Plcb1 phospholipase C, beta 1 increases expression ISO Phenylephrine results in increased expression of PLCB1 mRNA CTD PMID:16714034 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178 		JBrowse link
G Plcb3 phospholipase C, beta 3 increases expression ISO Phenylephrine results in increased expression of PLCB3 mRNA CTD PMID:16714034 NCBI chr19:6,931,081...6,951,738
Ensembl chr19:6,929,693...6,953,838 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression ISO Phenylephrine results in increased expression of PLCD1 mRNA CTD PMID:16714034 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Phenylephrine results in increased expression of PLCG1 mRNA CTD PMID:16714034 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions
increases secretion
increases response to substance		 ISO Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine		 CTD PMID:2822310 PMID:3015460 PMID:10898105 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression		 ISO [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein		 CTD PMID:18701451 PMID:19699196 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions ISO [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:15721863 PMID:18701451 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions
increases phosphorylation		 ISO geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:24449418 PMID:25449040 NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A multiple interactions
increases phosphorylation		 ISO geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:24449418 NCBI chr 7:28,988,732...28,992,817
Ensembl chr 7:28,988,733...28,993,226 		JBrowse link
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform increases expression
multiple interactions
increases activity		 EXP
ISO		 Phenylephrine results in increased expression of PPP3CB mRNA
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein		 CTD PMID:10655507 PMID:16024800 NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases localization
increases activity
increases expression		 EXP
ISO		 DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased activity of PRKCA protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein		 CTD PMID:12435817 PMID:16809552 PMID:18487437 PMID:21565836 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases expression		 ISO Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein] CTD PMID:17121852 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkcd protein kinase C, delta increases expression
affects localization		 ISO Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein		 CTD PMID:12720544 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
affects localization
increases localization
increases expression		 EXP
ISO		 DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein
Phenylephrine results in increased expression of PRKCE protein		 CTD PMID:12003851 PMID:12700091 PMID:12720544 PMID:16809552 PMID:18487437 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Prkcz protein kinase C, zeta affects localization
multiple interactions
decreases activity
increases phosphorylation		 ISO Phenylephrine affects the localization of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]
Phenylephrine results in decreased activity of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein		 CTD PMID:14736339 PMID:16809552 PMID:27094369 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Prkd1 protein kinase D1 affects localization
increases activity
multiple interactions
increases phosphorylation		 EXP
ISO		 Phenylephrine affects the localization of PRKD1 protein
Phenylephrine results in increased activity of PRKD1 protein
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein
Phenylephrine increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes		 CTD
RGD		 PMID:19124542 PMID:16648482 RGD:243065275 NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions
decreases activity
increases activity
increases expression		 ISO [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein		 CTD PMID:11799084 PMID:16378109 PMID:19542178 PMID:19797176 PMID:26168186 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
G Procr protein C receptor, endothelial increases expression ISO Phenylephrine results in increased expression of PROCR mRNA CTD PMID:18158353 NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391 		JBrowse link
G Psph phosphoserine phosphatase increases expression ISO Phenylephrine results in increased expression of PSPH mRNA CTD PMID:18158353 NCBI chr 5:129,842,622...129,864,318
Ensembl chr 5:129,842,622...129,864,513 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase increases expression ISO Phenylephrine results in increased expression of PTGIS mRNA CTD PMID:18158353 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
affects response to substance		 EXP FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein] CTD PMID:17244722 PMID:18701451 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pthlh parathyroid hormone-like peptide increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]		 CTD PMID:19910689 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F decreases expression ISO Phenylephrine results in decreased expression of PTPRF mRNA CTD PMID:18158353 NCBI chr 4:118,065,410...118,148,602
Ensembl chr 4:118,065,410...118,148,602 		JBrowse link
G Ptprk protein tyrosine phosphatase receptor type K decreases expression ISO Phenylephrine results in decreased expression of PTPRK mRNA CTD PMID:18158353 NCBI chr10:27,950,406...28,473,393
Ensembl chr10:27,950,816...28,473,393 		JBrowse link
G Pvr poliovirus receptor increases expression ISO Phenylephrine results in increased expression of PVR mRNA CTD PMID:18158353 NCBI chr 7:19,637,503...19,655,068
Ensembl chr 7:19,637,503...19,655,085 		JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO Phenylephrine results in decreased expression of PYCARD mRNA CTD PMID:18158353 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Pygl liver glycogen phosphorylase multiple interactions
increases expression		 ISO [Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA		 CTD PMID:747652 PMID:18158353 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family decreases expression ISO Phenylephrine results in decreased expression of RAB3B mRNA CTD PMID:18158353 NCBI chr 4:108,736,267...108,800,521
Ensembl chr 4:108,736,260...108,800,521 		JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO Phenylephrine results in increased activity of RAC1 protein CTD PMID:11158304 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions
increases phosphorylation		 ISO Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein] CTD PMID:15258898 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rai14 retinoic acid induced 14 increases expression ISO Phenylephrine results in increased expression of RAI14 mRNA CTD PMID:18158353 NCBI chr15:10,569,057...10,719,353
Ensembl chr15:10,569,055...10,714,710 		JBrowse link
G Ramp1 receptor (calcitonin) activity modifying protein 1 affects expression ISO Phenylephrine affects the expression of RAMP1 mRNA CTD PMID:17250927 NCBI chr 1:91,107,544...91,152,918
Ensembl chr 1:91,107,544...91,152,918 		JBrowse link
G Ramp2 receptor (calcitonin) activity modifying protein 2 multiple interactions
decreases expression
increases expression		 ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA		 CTD PMID:12899678 PMID:17250927 NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372 		JBrowse link
G Ramp3 receptor (calcitonin) activity modifying protein 3 increases expression ISO Phenylephrine results in increased expression of RAMP3 mRNA CTD PMID:18158353 NCBI chr11:6,608,507...6,627,478
Ensembl chr11:6,608,521...6,627,475 		JBrowse link
G Ranbp1 RAN binding protein 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein] CTD PMID:25341891 NCBI chr16:18,057,843...18,066,558
Ensembl chr16:18,057,648...18,066,596 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 increases expression ISO Phenylephrine results in increased expression of RAPGEF4 mRNA CTD PMID:18158353 NCBI chr 2:71,811,559...72,087,818
Ensembl chr 2:71,811,584...72,087,818 		JBrowse link
G Rapsn receptor-associated protein of the synapse decreases expression ISO Phenylephrine results in decreased expression of RAPSN mRNA CTD PMID:18158353 NCBI chr 2:90,864,594...90,876,074
Ensembl chr 2:90,865,965...90,876,074 		JBrowse link
G Rasd2 RASD family, member 2 decreases expression ISO Phenylephrine results in decreased expression of RASD2 mRNA CTD PMID:18158353 NCBI chr 8:75,940,572...75,950,741
Ensembl chr 8:75,940,572...75,950,741 		JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 decreases response to substance EXP
ISO		 RASSF1 protein results in decreased susceptibility to Phenylephrine CTD PMID:19652091 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
affects phosphorylation		 ISO Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein		 CTD PMID:15603588 PMID:18084315 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 multiple interactions
affects response to substance		 ISO Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine		 CTD PMID:17121852 NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573 		JBrowse link
G Rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 ISO Phenylephrine increases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells RGD PMID:28993448 RGD:329848961 NCBI chr15:76,963,190...77,193,058
Ensembl chr15:76,963,190...77,191,204 		JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression
multiple interactions		 EXP
ISO		 Phenylephrine results in increased expression of RCAN1 protein
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
Phenylephrine results in increased expression of RCAN1 mRNA		 CTD PMID:18025526 PMID:25358972 NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
affects localization
increases activity		 ISO [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein		 CTD PMID:11381115 PMID:18701451 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ren1 renin 1 structural decreases activity
affects response to substance		 ISO
EXP		 Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine		 CTD PMID:2847676 PMID:17679040 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit decreases expression ISO Phenylephrine results in decreased expression of REV3L mRNA CTD PMID:18158353 NCBI chr10:39,607,557...39,751,207
Ensembl chr10:39,608,114...39,751,207 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
affects response to substance
increases expression		 ISO
EXP		 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine		 CTD PMID:15452191 PMID:16517124 PMID:17644703 PMID:18158353 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 4:62,478,079...62,621,256
Ensembl chr 4:62,478,084...62,622,238 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases activity		 ISO geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:10843871 PMID:15081308 PMID:21708234 PMID:24449418 PMID:25449040 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 increases expression ISO Phenylephrine results in increased expression of RIPK1 protein CTD PMID:31605733 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO Phenylephrine results in increased expression of RIPK3 protein CTD PMID:31605733 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO Phenylephrine results in increased expression of RND1 mRNA CTD PMID:18158353 NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342 		JBrowse link
G Rnf39 ring finger protein 39 increases expression ISO Phenylephrine results in increased expression of RNF39 mRNA CTD PMID:18158353 NCBI chr17:37,253,943...37,258,878
Ensembl chr17:37,253,810...37,258,878 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO Phenylephrine results in increased expression of ROCK2 mRNA CTD PMID:18158353 NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein] CTD PMID:15522277 PMID:19002563 NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
increases phosphorylation		 ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 PMID:15795328 More... NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase, polypeptide 2 multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr19:4,206,791...4,213,382
Ensembl chr19:4,203,990...4,213,353 		JBrowse link
G Rrad Ras-related associated with diabetes decreases expression ISO Phenylephrine results in decreased expression of RRAD protein CTD PMID:18056528 NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959 		JBrowse link
G Runx1t1 RUNX1 translocation partner 1 decreases expression ISO Phenylephrine results in decreased expression of RUNX1T1 mRNA CTD PMID:18158353 NCBI chr 4:13,742,628...13,895,056
Ensembl chr 4:13,743,436...13,893,649 		JBrowse link
G S100a6 S100 calcium binding protein A6 (calcyclin) multiple interactions ISO S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA] CTD PMID:15652358 NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488 		JBrowse link
G S100b S100 protein, beta polypeptide, neural increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]		 CTD PMID:15652358 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Phenylephrine results in increased expression of SC5D mRNA CTD PMID:18158353 NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Phenylephrine results in increased expression of SCD2 mRNA CTD PMID:18158353 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Phenylephrine results in decreased expression of SELENBP1 mRNA CTD PMID:18158353 NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069 		JBrowse link
G Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D decreases expression ISO Phenylephrine results in decreased expression of SEMA6D mRNA CTD PMID:18158353 NCBI chr 2:123,931,089...124,509,711
Ensembl chr 2:123,931,889...124,509,690 		JBrowse link
G Septin5 septin 5 increases expression ISO Phenylephrine results in increased expression of SEPTIN5 mRNA CTD PMID:18158353 NCBI chr16:18,440,561...18,448,688
Ensembl chr16:18,439,252...18,448,704 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression EXP
ISO		 Phenylephrine results in increased expression of SERPINE1 mRNA CTD PMID:15808835 PMID:15850565 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases phosphorylation
multiple interactions		 ISO Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]		 CTD PMID:15795328 PMID:16533503 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Sik1 salt inducible kinase 1 increases expression ISO Phenylephrine results in increased expression of SIK1 mRNA CTD PMID:18158353 NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778 		JBrowse link
G Sirt6 sirtuin 6 multiple interactions ISO [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA] CTD PMID:27094368 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium] CTD PMID:14630635 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Slc16a10 solute carrier family 16 (monocarboxylic acid transporters), member 10 decreases expression ISO Phenylephrine results in decreased expression of SLC16A10 mRNA CTD PMID:18158353 NCBI chr10:39,909,528...40,018,262
Ensembl chr10:39,909,528...40,018,254 		JBrowse link
G Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 increases expression ISO Phenylephrine results in increased expression of SLC16A3 mRNA CTD PMID:18158353 NCBI chr11:120,839,310...120,849,826
Ensembl chr11:120,839,306...120,851,694 		JBrowse link
G Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 decreases expression ISO Phenylephrine results in decreased expression of SLC16A7 mRNA CTD PMID:18158353 NCBI chr10:125,055,139...125,225,455
Ensembl chr10:125,055,139...125,225,334 		JBrowse link
G Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 increases expression ISO Phenylephrine results in increased expression of SLC1A3 mRNA CTD PMID:18158353 NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions ISO [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591 		JBrowse link
G Slc26a6 solute carrier family 26, member 6 decreases activity
increases expression		 ISO Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein		 CTD PMID:17124262 NCBI chr 9:108,731,239...108,742,117
Ensembl chr 9:108,730,482...108,742,117 		JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 increases expression ISO Phenylephrine results in increased expression of SLC29A1 mRNA CTD PMID:19966059 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression ISO Phenylephrine results in increased expression of SLC2A1 mRNA CTD PMID:15808844 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc4a1ap solute carrier family 4 (anion exchanger), member 1, adaptor protein decreases expression ISO Phenylephrine results in decreased expression of SLC4A1AP mRNA CTD PMID:18158353 NCBI chr 5:31,684,125...31,711,386
Ensembl chr 5:31,684,339...31,714,276 		JBrowse link
G Slc4a3 solute carrier family 4 (anion exchanger), member 3 increases activity ISO Phenylephrine results in increased activity of SLC4A3 protein CTD PMID:17124262 NCBI chr 1:75,522,688...75,536,075
Ensembl chr 1:75,522,910...75,538,816 		JBrowse link
G Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 increases expression ISO Phenylephrine results in increased expression of SLC7A1 mRNA CTD PMID:18158353 NCBI chr 5:148,264,220...148,336,714
Ensembl chr 5:148,264,220...148,336,714 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in decreased expression of SLC8A1 protein
Phenylephrine results in increased expression of SLC8A1 mRNA		 CTD PMID:11179087 PMID:15621046 PMID:19244478 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 multiple interactions
increases activity
increases expression		 ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein		 CTD PMID:15452191 PMID:16236312 PMID:16513848 PMID:16517124 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein CTD PMID:19443575 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smoc2 SPARC related modular calcium binding 2 decreases expression ISO Phenylephrine results in decreased expression of SMOC2 mRNA CTD PMID:18158353 NCBI chr17:14,499,768...14,625,052
Ensembl chr17:14,499,768...14,625,052 		JBrowse link
G Smr2l submaxillary gland androgen regulated protein 2 like multiple interactions ISO SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine] CTD PMID:17026587 NCBI chr 5:88,416,786...88,430,694
Ensembl chr 5:88,416,778...88,430,694 		JBrowse link
G Sord sorbitol dehydrogenase decreases expression ISO Phenylephrine results in decreased expression of SORD mRNA CTD PMID:18158353 NCBI chr 2:122,065,320...122,095,818
Ensembl chr 2:122,065,230...122,095,821 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 multiple interactions ISO Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]] CTD PMID:32278511 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Sox6 SRY (sex determining region Y)-box 6 decreases expression ISO Phenylephrine results in decreased expression of SOX6 mRNA CTD PMID:18158353 NCBI chr 7:115,070,107...115,639,186
Ensembl chr 7:115,070,107...115,638,031 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Phenylephrine results in increased expression of SPP1 protein CTD PMID:10406839 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 increases expression ISO Phenylephrine results in increased expression of SPRY1 mRNA CTD PMID:18158353 NCBI chr 3:37,694,096...37,698,748
Ensembl chr 3:37,694,096...37,698,747 		JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 decreases expression ISO Phenylephrine results in decreased expression of SPTA1 mRNA CTD PMID:18158353 NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Phenylephrine results in increased expression of SQLE mRNA CTD PMID:18158353 NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Phenylephrine results in decreased expression of SQSTM1 mRNA CTD PMID:18158353 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 increases expression ISO Phenylephrine results in increased expression of ST3GAL2 mRNA CTD PMID:18158353 NCBI chr 8:111,646,520...111,699,132
Ensembl chr 8:111,646,554...111,699,112 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases expression ISO Phenylephrine results in increased expression of ST3GAL4 mRNA CTD PMID:18158353 NCBI chr 9:34,957,872...35,028,160
Ensembl chr 9:34,957,872...35,030,564 		JBrowse link
G St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 increases expression ISO Phenylephrine results in increased expression of ST8SIA5 mRNA CTD PMID:18158353 NCBI chr18:77,273,529...77,343,146
Ensembl chr18:77,273,535...77,346,467 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Phenylephrine results in decreased expression of STAT1 mRNA CTD PMID:18158353 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
multiple interactions
increases expression		 ISO Phenylephrine affects the localization of STAT3 protein
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]
Phenylephrine results in increased expression of STAT3		 CTD PMID:19299911 PMID:27094369 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO Phenylephrine affects the expression of STC1 mRNA CTD PMID:18158353 NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253 		JBrowse link
G Stmn1 stathmin 1 decreases expression ISO Phenylephrine results in decreased expression of STMN1 mRNA CTD PMID:18158353 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Stx11 syntaxin 11 affects expression ISO Phenylephrine affects the expression of STX11 mRNA CTD PMID:18158353 NCBI chr10:12,813,961...12,840,242
Ensembl chr10:12,813,953...12,840,042 		JBrowse link
G Tac1 tachykinin 1 multiple interactions
affects response to substance
increases secretion		 ISO alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine		 CTD PMID:11270094 PMID:17240043 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tacr1 tachykinin receptor 1 increases response to substance ISO TACR1 protein results in increased susceptibility to Phenylephrine CTD PMID:16982039 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Taf1 TATA-box binding protein associated factor 1 increases expression ISO Phenylephrine results in increased expression of TAF1 mRNA CTD PMID:15808844 NCBI chr  X:100,576,335...100,644,635
Ensembl chr  X:100,576,279...100,644,640 		JBrowse link
G Tcte1 t-complex-associated testis expressed 1 decreases expression ISO Phenylephrine results in decreased expression of TCTE1 mRNA CTD PMID:18158353 NCBI chr17:45,834,360...45,853,605
Ensembl chr17:45,834,360...45,853,606 		JBrowse link
G Tfdp1 transcription factor Dp 1 increases expression ISO Phenylephrine results in increased expression of TFDP1 protein CTD PMID:12682052 NCBI chr 8:13,388,273...13,428,448
Ensembl chr 8:13,388,751...13,428,448 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein		 CTD PMID:10406839 PMID:11821714 PMID:19443575 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]		 CTD PMID:19540241 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Phenylephrine results in increased expression of TGFB2 mRNA CTD PMID:19443575 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Phenylephrine results in increased expression of TGFB3 mRNA CTD PMID:18158353 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I increases expression ISO Phenylephrine results in increased expression of TGFBR1 mRNA CTD PMID:19443575 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II increases expression ISO Phenylephrine results in increased expression of TGFBR2 mRNA CTD PMID:19443575 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide multiple interactions
increases expression
decreases activity		 ISO ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA		 CTD PMID:10801782 PMID:18158353 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Thra thyroid hormone receptor alpha increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of THRA protein
THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]		 CTD PMID:11577024 PMID:17389455 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression
multiple interactions
increases expression		 ISO Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]
Phenylephrine results in increased expression of THRB protein		 CTD PMID:11577024 PMID:17389455 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
increases expression		 ISO BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein		 CTD PMID:18158353 PMID:19910689 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tmem140 transmembrane protein 140 decreases expression ISO Phenylephrine results in decreased expression of TMEM140 mRNA CTD PMID:18158353 NCBI chr 6:34,840,081...34,851,881
Ensembl chr 6:34,840,081...34,851,881 		JBrowse link
G Tmem176b transmembrane protein 176B decreases expression ISO Phenylephrine results in decreased expression of TMEM176B mRNA CTD PMID:18158353 NCBI chr 6:48,810,745...48,818,363
Ensembl chr 6:48,810,752...48,818,430 		JBrowse link
G Tmem43 transmembrane protein 43 increases expression ISO Phenylephrine results in increased expression of TMEM43 mRNA CTD PMID:18158353 NCBI chr 6:91,450,689...91,465,445
Ensembl chr 6:91,450,685...91,465,445 		JBrowse link
G Tmsb15b2 thymosin beta 15b2 increases expression ISO Phenylephrine results in increased expression of TMSB15B2 mRNA CTD PMID:18158353 NCBI chr  X:135,855,737...135,858,728
Ensembl chr  X:135,856,014...135,858,774 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
increases expression
decreases response to substance		 ISO Phenylephrine results in decreased secretion of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine		 CTD PMID:12423672 PMID:13679239 PMID:16020479 PMID:17872965 PMID:18701451 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 increases expression EXP Phenylephrine results in increased expression of TNFAIP3 protein CTD PMID:12900338 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a increases expression ISO Phenylephrine results in increased expression of TNFRSF12A mRNA CTD PMID:18158353 NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 increases expression
multiple interactions		 EXP Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]		 CTD PMID:17306214 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tox thymocyte selection-associated high mobility group box decreases expression ISO Phenylephrine results in decreased expression of TOX mRNA CTD PMID:18158353 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
G Tpm2 tropomyosin 2, beta increases expression ISO Phenylephrine results in increased expression of TPM2 mRNA CTD PMID:18158353 NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765 		JBrowse link
G Trdn triadin decreases expression ISO Phenylephrine results in decreased expression of TRDN mRNA CTD PMID:18158353 NCBI chr10:32,959,479...33,352,705
Ensembl chr10:32,956,550...33,352,705 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Phenylephrine results in increased expression of TRIB3 mRNA CTD PMID:18158353 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Phenylephrine results in decreased expression of TRIM2 mRNA CTD PMID:18158353 NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184 		JBrowse link
G Trim25 tripartite motif-containing 25 decreases expression ISO Phenylephrine results in decreased expression of TRIM25 mRNA CTD PMID:18158353 NCBI chr11:88,890,194...88,911,119
Ensembl chr11:88,890,202...88,911,119 		JBrowse link
G Trim34a tripartite motif-containing 34A decreases expression ISO Phenylephrine results in decreased expression of TRIM34 mRNA CTD PMID:18158353 NCBI chr 7:103,893,657...103,911,446
Ensembl chr 7:103,893,664...103,911,441 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression ISO Phenylephrine results in increased expression of TRPC1 protein CTD PMID:17174323 NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions
increases expression		 ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein		 CTD PMID:15672411 PMID:19244478 NCBI chr 3:36,674,626...36,744,276
Ensembl chr 3:36,674,631...36,744,316 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium] CTD PMID:15672411 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions ISO 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein CTD PMID:19363131 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine] CTD PMID:17082722 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
increases phosphorylation		 ISO SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein] CTD PMID:15757502 PMID:15795328 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression ISO Phenylephrine results in increased expression of TUBB6 mRNA CTD PMID:18158353 NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression		 ISO VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein] CTD PMID:25107896 NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242 		JBrowse link
G Tyr tyrosinase multiple interactions
increases activity		 ISO Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720 		JBrowse link
G Ubn1 ubinuclein 1 decreases expression ISO Phenylephrine results in decreased expression of UBN1 mRNA CTD PMID:18158353 NCBI chr16:4,867,921...4,904,153
Ensembl chr16:4,867,921...4,904,153 		JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 increases expression ISO Phenylephrine results in increased expression of UCHL1 mRNA CTD PMID:18158353 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577 		JBrowse link
G Ucn urocortin affects response to substance ISO UCN protein affects the susceptibility to Phenylephrine CTD PMID:17885217 NCBI chr 5:31,295,333...31,296,239
Ensembl chr 5:31,295,407...31,296,173 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Phenylephrine results in decreased expression of VCAM1 mRNA CTD PMID:18158353 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vcan versican increases expression ISO Phenylephrine results in increased expression of VCAN mRNA CTD PMID:18158353 NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein] CTD PMID:25107896 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin increases expression
multiple interactions		 ISO Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]		 CTD PMID:26168186 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Vip vasoactive intestinal polypeptide affects response to substance EXP VIP protein affects the susceptibility to Phenylephrine CTD PMID:11728430 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
G Wasl WASP like actin nucleation promoting factor multiple interactions ISO ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]] CTD PMID:17615370 NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008 		JBrowse link
G Wfdc1 WAP four-disulfide core domain 1 increases expression ISO Phenylephrine results in increased expression of WFDC1 mRNA CTD PMID:18158353 NCBI chr 8:120,393,104...120,414,759
Ensembl chr 8:120,393,104...120,414,961 		JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression ISO Phenylephrine results in increased expression of WIF1 mRNA CTD PMID:18158353 NCBI chr10:120,869,909...120,936,547
Ensembl chr10:120,869,865...120,936,555 		JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression ISO Phenylephrine results in increased expression of XPR1 mRNA CTD PMID:18158353 NCBI chr 1:155,151,403...155,293,190
Ensembl chr 1:155,151,447...155,293,161 		JBrowse link
G Zdhhc2 zinc finger, DHHC domain containing 2 increases expression ISO Phenylephrine results in increased expression of ZDHHC2 mRNA CTD PMID:18158353 NCBI chr 8:40,876,526...40,946,178
Ensembl chr 8:40,876,856...40,963,309 		JBrowse link
G Zfp46 zinc finger protein 46 decreases expression ISO Phenylephrine results in decreased expression of ZFP46 mRNA CTD PMID:18158353 NCBI chr 4:136,011,479...136,021,163
Ensembl chr 4:136,011,994...136,021,253 		JBrowse link
G Zfp503 zinc finger protein 503 decreases expression ISO Phenylephrine results in decreased expression of ZFP503 mRNA CTD PMID:18158353 NCBI chr14:22,034,030...22,039,669
Ensembl chr14:22,034,027...22,039,669 		JBrowse link
G Zfp997 zinc finger protein 997 decreases expression ISO Phenylephrine results in decreased expression of CXCL5 mRNA CTD PMID:18158353 NCBI chr13:66,258,188...66,271,523
Ensembl chr13:66,261,294...66,271,953 		JBrowse link
G Zfpm2 zinc finger protein, multitype 2 decreases response to substance
multiple interactions		 EXP
ISO		 ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]		 CTD PMID:15220332 NCBI chr15:40,518,438...40,967,988
Ensembl chr15:40,518,431...40,967,988 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      application 21752
        pharmaceutical 21167
          drug 21167
            protective agent 18631
              phenylephrine 522
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        amino alcohol 1076
                                          ethanolamines 826
                                            phenylethanolamines 600
                                              phenylephrine 522
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