Fbn1 (fibrillin 1) - Rat Genome Database

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Gene: Fbn1 (fibrillin 1) Mus musculus
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Symbol: Fbn1
Name: fibrillin 1
RGD ID: 731578
MGI Page MGI
Description: Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of osteoclast development; sequestering of BMP in extracellular matrix; and sequestering of TGFbeta in extracellular matrix. Located in collagen-containing extracellular matrix and microfibril. Is expressed in several structures, including cardiovascular system; connective tissue; genitourinary system; musculoskeletal system; and respiratory system. Used to study Marfan syndrome; Weill-Marchesani syndrome; heart disease; pulmonary emphysema; and systemic scleroderma. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; Weill-Marchesani syndrome; aortic disease (multiple); autosomal dominant isolated ectopia lentis 1; and bone disease (multiple). Orthologous to human FBN1 (fibrillin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI536462; B430209H23; Fib-; Fib-1; fibrillin-1; tight skin; Tsk
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,142,514 - 125,348,417 (-)NCBIGRCm39mm39
GRCm39 Ensembl2125,142,514 - 125,349,913 (-)Ensembl
GRCm382125,300,594 - 125,506,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,300,594 - 125,507,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv372125,126,330 - 125,332,174 (-)NCBIGRCm37mm9NCBIm37
MGSCv362124,992,037 - 125,197,826 (-)NCBImm8
Celera2126,545,438 - 126,751,399 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model