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Gene: Hbegf (heparin-binding EGF-like growth factor) Mus musculus
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Description: Exhibits epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in several processes, including positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Localizes to the extracellular space and integral component of plasma membrane. Human ortholog(s) of this gene implicated in perinatal necrotizing enterocolitis. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW047313; diphtheria toxin receptor; Dtr; Dts; Hegfl; heparin binding epidermal growth factor-like growth factor; MGC107656; proheparin-binding EGF-like growth factor
Homo sapiens (human) : HBEGF (heparin binding EGF like growth factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hbegf (heparin-binding EGF-like growth factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hbegf (heparin binding EGF like growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HBEGF (heparin binding EGF like growth factor)
Canis lupus familiaris (dog) : HBEGF (heparin binding EGF like growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hbegf (heparin binding EGF like growth factor)
Sus scrofa (pig) : HBEGF (heparin binding EGF like growth factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381836,504,927 - 36,515,805 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371836,664,581 - 36,675,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361836,630,906 - 36,641,748 (-)NCBImm8
Celera1836,954,561 - 36,965,476 (-)NCBICelera
Cytogenetic Map18 B2NCBI
cM Map1819.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hbegf
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552258
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.