Nol3 (nucleolar protein 3 (apoptosis repressor with CARD domain)) - Rat Genome Database
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Gene: Nol3 (nucleolar protein 3 (apoptosis repressor with CARD domain)) Mus musculus
Analyze
Symbol: Nol3
Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
RGD ID: 1552509
MGI Page MGI
Description: Exhibits death effector domain binding activity and death receptor binding activity. Involved in several processes, including negative regulation of cell death; regulation of muscle adaptation; and regulation of signal transduction. Localizes to mitochondrion and sarcoplasm. Is expressed in adrenal gland; brain; lung; metanephros; and musculature. Orthologous to human NOL3 (nucleolar protein 3); INTERACTS WITH 1,2-dimethylhydrazine; 1H-pyrazole; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; apoptosis repressor with CARD; ARC; B430311C09Rik; MYC; No; NOP; Nop30; nucleolar protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,002,777 - 106,008,571 (+)NCBIGRCm39mm39
GRCm388105,276,145 - 105,281,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,800,347 - 107,805,839 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,165,576 - 108,171,068 (+)NCBImm8
Celera8109,499,596 - 109,505,088 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
Brevetoxin B  (ISO)
butanal  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
furosemide  (ISO)
glyphosate  (ISO)
GW 4064  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
Mitotane  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
razoxane  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
Soman  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IMP)
cardiac muscle cell apoptotic process  (IMP)
cellular response to hypoxia  (ISO)
inhibition of cysteine-type endopeptidase activity  (ISO)
inhibition of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
intrinsic apoptotic signaling pathway  (IMP)
mRNA processing  (IEA)
mRNA splice site selection  (ISO)
myoblast differentiation  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of death-inducing signaling complex assembly  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of mitochondrial calcium ion concentration  (ISO)
negative regulation of mitochondrial membrane permeability involved in apoptotic process  (IMP)
negative regulation of muscle atrophy  (IMP)
negative regulation of necrotic cell death  (IMP)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of protein targeting to mitochondrion  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of striated muscle cell apoptotic process  (IMP)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IMP)
protein complex oligomerization  (ISO)
regulation of apoptotic process  (IEA)
regulation of gene expression  (IMP)
regulation of NIK/NF-kappaB signaling  (IMP)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to hypoxia  (IMP)
response to injury involved in regulation of muscle adaptation  (IMP)
response to ischemia  (IMP)
smooth muscle cell proliferation  (ISO)

Cellular Component

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11812828   PMID:12477932   PMID:14645204   PMID:15383280   PMID:15537664   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16249178  
PMID:16505176   PMID:18171680   PMID:18782777   PMID:19138695   PMID:20436479   PMID:22037876   PMID:22082675   PMID:22933109   PMID:24312627   PMID:24440909   PMID:24531537   PMID:25596718  
PMID:26709830   PMID:27106802   PMID:27556499   PMID:28232469   PMID:28765602   PMID:30415165   PMID:31356897   PMID:32325033  


Genomics

Comparative Map Data
Nol3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,002,777 - 106,008,571 (+)NCBIGRCm39mm39
GRCm388105,276,145 - 105,281,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,800,347 - 107,805,839 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,165,576 - 108,171,068 (+)NCBImm8
Celera8109,499,596 - 109,505,088 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
NOL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1667,170,154 - 67,175,735 (+)EnsemblGRCh38hg38GRCh38
GRCh381667,170,538 - 67,175,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,204,400 - 67,209,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,765,371 - 65,767,127 (+)NCBINCBI36hg18NCBI36
Build 341665,765,370 - 65,767,125NCBI
Celera1651,712,649 - 51,717,887 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,077,589 - 53,082,828 (+)NCBIHuRef
CHM1_11668,611,732 - 68,616,967 (+)NCBICHM1_1
Nol3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Celera1932,585,344 - 32,587,011 (+)NCBICelera
Cytogenetic Map19q11NCBI
Nol3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBIChiLan1.0ChiLan1.0
NOL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11666,904,738 - 66,909,956 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01647,516,156 - 47,521,441 (+)NCBIMhudiblu_PPA_v0panPan3
Nol3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647517,644,299 - 17,648,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,281,492 - 60,286,865 (-)NCBI

Position Markers
AI426165  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388105,280,621 - 105,280,721UniSTSGRCm38
MGSCv378107,804,521 - 107,804,621UniSTSGRCm37
Celera8109,503,770 - 109,503,870UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map8D1UniSTS
cM Map851.0UniSTS
Whitehead/MRC_RH81227.21UniSTS
RH143966  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388105,280,428 - 105,280,570UniSTSGRCm38
MGSCv378107,804,328 - 107,804,470UniSTSGRCm37
Celera8109,503,577 - 109,503,719UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map8D1UniSTS
cM Map851.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8101759576110923404Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8101759576115298718Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA20525879
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA22235332
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA22159222
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA21297663
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA19696787
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA20525879
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA20525879
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA20525879
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA20309945
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA20525879
Mir135a-2mmu-miR-135a-5pOncomiRDBexternal_infoNANA23176581
Mir135a-1mmu-miR-135a-5pOncomiRDBexternal_infoNANA23176581
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA20525879
Mir429mmu-miR-429-5pOncomiRDBexternal_infoNANA21684154
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA20525879
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA20525879
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA20525879
Mir212mmu-miR-212-3pOncomiRDBexternal_infoNANA21053104
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA20525879

Predicted Target Of
Summary Value
Count of predictions:895
Count of miRNA genes:500
Interacting mature miRNAs:586
Transcripts:ENSMUST00000014920
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000014920   ⟹   ENSMUSP00000014920
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)Ensembl
RefSeq Acc Id: NM_030152   ⟹   NP_084428
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398106,003,079 - 106,008,571 (+)NCBI
GRCm388105,276,447 - 105,281,939 (+)NCBI
MGSCv378107,800,347 - 107,805,839 (+)RGD
Celera8109,499,596 - 109,505,088 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531503   ⟹   XP_006531566
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398106,002,777 - 106,006,699 (+)NCBI
GRCm388105,276,145 - 105,280,067 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_084428   ⟸   NM_030152
- UniProtKB: Q9D1X0 (UniProtKB/Swiss-Prot),   Q53YU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531566   ⟸   XM_006531503
- Peptide Label: isoform X1
- UniProtKB: Q9D1X0 (UniProtKB/Swiss-Prot),   Q53YU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000014920   ⟸   ENSMUST00000014920
Protein Domains
CARD

Promoters
RGD ID:8668065
Promoter ID:EPDNEW_M12064
Type:initiation region
Name:Nol3_1
Description:Mus musculus nucleolar protein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388105,276,460 - 105,276,520EPDNEW
RGD ID:6843558
Promoter ID:MM_KWN:55535
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_030152
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368107,800,069 - 107,800,569 (+)MPROMDB
RGD ID:6849257
Promoter ID:MM_XEF:7200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_001083688,   NM_003946,   NM_053516
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368107,802,876 - 107,803,376 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925938 AgrOrtholog
Ensembl Genes ENSMUSG00000014776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000014920 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000014920 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78688 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1925938 ENTREZGENE
NCBI Gene 78688 ENTREZGENE
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nol3 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.475715 ENTREZGENE
UniProt NOL3_MOUSE UniProtKB/Swiss-Prot
  Q53YU5 ENTREZGENE, UniProtKB/TrEMBL
  Q8C550_MOUSE UniProtKB/TrEMBL
  Q8R2S3_MOUSE UniProtKB/TrEMBL
  Q9D1X0 ENTREZGENE