Grk2 (G protein-coupled receptor kinase 2) - Rat Genome Database

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Gene: Grk2 (G protein-coupled receptor kinase 2) Mus musculus
Analyze
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
RGD ID: 10111
MGI Page MGI
Description: Enables G protein-coupled receptor kinase activity. Involved in negative regulation of relaxation of smooth muscle. Acts upstream of or within several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart contraction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrb; Adrbk; Adrbk-1; Adrbk1; adrenergic receptor kinase, beta 1; Bark; Bark-1; beta ARK; beta ARK1; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase-1; beta-AR kinase-1; beta-ARK-1; betaA; betaARK1; G-protein-coupled receptor kinase 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,336,029 - 4,356,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,336,029 - 4,356,250 (-)EnsemblGRCm39 Ensembl
GRCm38194,285,999 - 4,306,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,286,001 - 4,306,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,286,001 - 4,305,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,286,001 - 4,305,955 (-)NCBIMGSCv36mm8
Celera194,157,228 - 4,177,197 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle contraction  (IEA,ISO)
cellular response to catecholamine stimulus  (ISO)
cellular response to chemokine  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to rapamycin  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IBA,IGI,IMP,ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IBA,IDA,ISO)
heart development  (IMP)
maintenance of protein location in nucleus  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of D-glucose import  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of relaxation of smooth muscle  (IMP,ISO)
negative regulation of striated muscle contraction  (IEA,ISO)
negative regulation of the force of heart contraction by chemical signal  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
peptidyl-serine phosphorylation  (IDA)
peptidyl-threonine phosphorylation  (IDA)
positive regulation of catecholamine secretion  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (ISO)
protein modification process  (ISO)
protein phosphorylation  (IDA)
receptor internalization  (IEA,ISO)
regulation of inositol trisphosphate biosynthetic process  (ISO)
regulation of the force of heart contraction  (IBA,IGI)
response to caloric restriction  (ISO)
response to hydrogen peroxide  (ISO)
response to leptin  (ISO)
response to muscle activity  (ISO)
response to oxidative stress  (ISO)
symbiont entry into host cell  (IEA,ISO)
tachykinin receptor signaling pathway  (IEA,ISO)
vasodilation  (ISO)
viral genome replication  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell physiology  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal T cell physiology  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased T cell number  (IAGP)
dilated heart right atrium  (IAGP)
disorganized myocardium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
fetal growth retardation  (IAGP)
heart atrium hypoplasia  (IAGP)
heart hypoplasia  (IAGP)
impaired leukocyte tethering or rolling  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased follicular B cell number  (IAGP)
increased marginal zone B cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
pericardial edema  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricular hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. Anderson KM, etal., Hypertension. 1999 Jan;33(1 Pt 2):402-7.
3. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Arraes SM, etal., Blood. 2006 Nov 1;108(9):2906-13. Epub 2006 Jul 18.
4. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55.
5. Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization. Basu D, etal., PLoS One. 2013 Aug 6;8(8):e70736. doi: 10.1371/journal.pone.0070736. Print 2013.
6. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. ß1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Cannavo A, etal., Circulation. 2013 Oct 8;128(15):1612-22. doi: 10.1161/CIRCULATIONAHA.113.002659. Epub 2013 Aug 22.
8. ß Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves ß2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia. Cannavo A, etal., J Pharmacol Exp Ther. 2016 Feb;356(2):503-13. doi: 10.1124/jpet.115.228411. Epub 2015 Nov 24.
9. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Chen M, etal., Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6.
10. Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to norepinephrine in the mesenteric arteries of cirrhotic patients and rats. Chen W, etal., Hepatobiliary Pancreat Dis Int. 2013 Jun;12(3):295-304.
11. G protein coupled receptor kinase-2 upregulation causes ¿-opioid receptor desensitization in diabetic heart. Chen X, etal., Biochem Biophys Res Commun. 2017 Jan 22;482(4):658-664. doi: 10.1016/j.bbrc.2016.11.090. Epub 2016 Nov 16.
12. Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia. Dong J, etal., Auton Neurosci. 2015 Jan;187:76-83. doi: 10.1016/j.autneu.2014.10.024. Epub 2014 Nov 1.
13. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
14. Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats. Du QH, etal., World J Gastroenterol. 2014 Nov 28;20(44):16674-82. doi: 10.3748/wjg.v20.i44.16674.
15. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
16. Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Ferrari LF, etal., Neuroscience. 2012 Oct 11;222:392-403. doi: 10.1016/j.neuroscience.2012.07.004. Epub 2012 Jul 13.
17. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
18. ß-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly. Gatto F, etal., Endocrinology. 2013 Dec;154(12):4715-25. doi: 10.1210/en.2013-1672. Epub 2013 Oct 29.
19. G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Gros R, etal., Hypertension. 2000 Jan;35(1 Pt 1):38-42.
20. Biventricular differences in ß-adrenergic receptor signaling following burn injury. Guillory AN, etal., PLoS One. 2017 Dec 12;12(12):e0189527. doi: 10.1371/journal.pone.0189527. eCollection 2017.
21. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
22. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Harding VB, etal., Proc Natl Acad Sci U S A 2001 May 8;98(10):5809-14. Epub 2001 May 1.
23. Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28.
24. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg M, etal., Hepatology. 2007 Feb;45(2):495-506.
25. Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Huang ZM, etal., Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.
26. G protein-coupled receptor kinase (GRK)2 is a key negative regulator of itch: L-glutamine attenuates itch via a rapid induction of GRK2 in an ERK-dependent way. Im YN, etal., J Invest Dermatol. 2018 Mar 9. pii: S0022-202X(18)30220-3. doi: 10.1016/j.jid.2018.02.036.
27. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Jaber M, etal., Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9.
28. Small molecule disruption of G protein ß¿ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. Karuppagounder V, etal., PLoS One. 2018 Jul 19;13(7):e0200697. doi: 10.1371/journal.pone.0200697. eCollection 2018.
29. Parathyroid hormone signaling in bone and kidney. Lee M and Partridge NC, Curr Opin Nephrol Hypertens. 2009 Jul;18(4):298-302. doi: 10.1097/MNH.0b013e32832c2264.
30. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Liu H, etal., Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29.
31. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Liu S, etal., Nat Med. 2005 Sep;11(9):952-8. Epub 2005 Sep 4.
32. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
33. A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2. Lu C, etal., Cell Mol Neurobiol. 2017 Jan;37(1):101-109. doi: 10.1007/s10571-016-0349-0. Epub 2016 Mar 2.
34. Tempol reduces oxidative stress and restores renal dopamine D1-like receptor- G protein coupling and function in hyperglycemic rats. Marwaha A and Lokhandwala MF, Am J Physiol Renal Physiol. 2006 Jul;291(1):F58-66. Epub 2006 Feb 14.
35. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
36. MGDs mouse GO annotations MGD data from the GO Consortium
37. MGD IEA MGD IEA
38. beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
39. Hypertensive left ventricular hypertrophy: relation to beta-adrenergic receptor kinase-1 (betaARK1) in peripheral lymphocytes. Park SJ, etal., J Hypertens. 2004 May;22(5):1025-32.
40. Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects. Perianes-Cachero A, etal., Neurochem Int. 2012 Dec;61(8):1385-96. doi: 10.1016/j.neuint.2012.09.019. Epub 2012 Oct 13.
41. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
42. GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Piao L, etal., Circulation. 2012 Dec 11;126(24):2859-69. doi: 10.1161/CIRCULATIONAHA.112.109868. Epub 2012 Nov 2.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Polhemus DJ, etal., Circ Res. 2016 Jul 22;119(3):470-80. doi: 10.1161/CIRCRESAHA.115.308278. Epub 2016 Jun 13.
46. Mouse MP Annotation Import Pipeline RGD automated import pipeline
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Rockman HA, etal., Proc Natl Acad Sci U S A 1998 Jun 9;95(12):7000-5.
49. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. Schlegel P, etal., PLoS One. 2017 Jul 31;12(7):e0182110. doi: 10.1371/journal.pone.0182110. eCollection 2017.
50. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
51. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy. Sorriento D, etal., J Cardiovasc Transl Res. 2015 Nov;8(8):493-502. doi: 10.1007/s12265-015-9646-0. Epub 2015 Jul 30.
52. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
53. Gene expression analysis of TREM1 and GRK2 in polymorphonuclear leukocytes as the surrogate biomarkers of acute bacterial infections. Ubagai T, etal., Int J Med Sci. 2014 Jan 10;11(2):215-21. doi: 10.7150/ijms.7231. eCollection 2014.
54. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Usui I, etal., Mol Endocrinol. 2005 Nov;19(11):2760-8. Epub 2005 Jun 30.
55. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
56. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Wang Q, etal., Sci Rep. 2017 Mar 28;7:45364. doi: 10.1038/srep45364.
57. G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes. Wans ZH, etal., Asian J Androl. 2018 Sep 14. pii: 241306.
58. The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats. Won KA, etal., J Pain. 2014 Mar;15(3):250-61. doi: 10.1016/j.jpain.2013.10.013. Epub 2013 Nov 8.
59. Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury. Woodall MC, etal., Circ Res. 2016 Oct 28;119(10):1116-1127. doi: 10.1161/CIRCRESAHA.116.309538. Epub 2016 Sep 6.
60. Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats. Xing W, etal., Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1111-9. doi: 10.1152/ajpheart.00290.2013. Epub 2013 Aug 2.
61. A Non-Canonical Function of Gbeta as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Zha Z, etal., Mol Cell. 2015 Jun 4;58(5):794-803. doi: 10.1016/j.molcel.2015.04.017. Epub 2015 May 14.
62. (-)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of ß1 adrenoceptor via GRK2 in experimental heart failure. Zhang Q, etal., Inflammopharmacology. 2017 Dec 16. pii: 10.1007/s10787-017-0429-x. doi: 10.1007/s10787-017-0429-x.
63. 2K1C-activated Angiotensin II (Ang II) exacerbates vascular damage in a rat model of arthritis through the ATR/ERK1/2 signaling pathway. Zhang Y, etal., Inflamm Res. 2017 Oct;66(10):881-890. doi: 10.1007/s00011-017-1069-8. Epub 2017 Jun 26.
64. Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats. Zhang ZR, etal., Phytother Res. 2017 Aug;31(8):1249-1256. doi: 10.1002/ptr.5847. Epub 2017 Jun 19.
65. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:1302014   PMID:1869533   PMID:2871555   PMID:7761854   PMID:7972043   PMID:8035170   PMID:8381559   PMID:8638670   PMID:8756570   PMID:8889548   PMID:9187265   PMID:9221785  
PMID:9344655   PMID:9501310   PMID:9660778   PMID:9730611   PMID:9790771   PMID:9826121   PMID:10198406   PMID:10338466   PMID:10349636   PMID:10506199   PMID:10578521   PMID:10922068  
PMID:11042159   PMID:11044616   PMID:11076861   PMID:11087268   PMID:11217851   PMID:11245652   PMID:11489895   PMID:12384166   PMID:12466851   PMID:12477932   PMID:12535942   PMID:12869383  
PMID:14610273   PMID:14654844   PMID:14712229   PMID:14761932   PMID:15218143   PMID:15235770   PMID:15241473   PMID:15489334   PMID:15585587   PMID:15778405   PMID:15782199   PMID:15919661  
PMID:16141072   PMID:16141073   PMID:16183993   PMID:16221891   PMID:16484224   PMID:16602821   PMID:16699071   PMID:16951260   PMID:16980298   PMID:17008600   PMID:17060617   PMID:17088245  
PMID:17322894   PMID:17408432   PMID:17420248   PMID:17482545   PMID:17517892   PMID:17544362   PMID:17869478   PMID:17873012   PMID:17971124   PMID:18056263   PMID:18180038   PMID:18287559  
PMID:18367599   PMID:18369319   PMID:18448421   PMID:18635825   PMID:18723764   PMID:18799693   PMID:19279269   PMID:19564331   PMID:19796012   PMID:19932746   PMID:20080565   PMID:20147541  
PMID:20351116   PMID:20530803   PMID:20609517   PMID:20717897   PMID:20807772   PMID:20861385   PMID:21081496   PMID:21111235   PMID:21267068   PMID:21473908   PMID:21518983   PMID:21520257  
PMID:21571071   PMID:21572010   PMID:21659505   PMID:21873635   PMID:21960637   PMID:21983013   PMID:22193721   PMID:22496128   PMID:22516294   PMID:22581458   PMID:22688330   PMID:22794259  
PMID:22869904   PMID:22895728   PMID:22925038   PMID:23047899   PMID:23313319   PMID:23362259   PMID:23729591   PMID:23772028   PMID:23785004   PMID:23805205   PMID:23950144   PMID:23984976  
PMID:24135140   PMID:24191280   PMID:24506537   PMID:24776686   PMID:24904059   PMID:24927997   PMID:25239306   PMID:25561731   PMID:25696921   PMID:26025460   PMID:26069965   PMID:26198359  
PMID:26279567   PMID:26506135   PMID:26929333   PMID:27002170   PMID:27016525   PMID:27113758   PMID:27543854   PMID:27566547   PMID:27832814   PMID:27911814   PMID:28526706   PMID:28572156  
PMID:28814745   PMID:28882814   PMID:29442133   PMID:29500815   PMID:29570431   PMID:29969579   PMID:30061705   PMID:30171848   PMID:30261289   PMID:30284927   PMID:30333137   PMID:30726732  
PMID:30946029   PMID:31548329   PMID:31680450   PMID:31752326   PMID:31818003   PMID:31927610   PMID:31959897   PMID:32216616   PMID:32325033   PMID:32377998   PMID:32554809   PMID:33058732  
PMID:33658023   PMID:33803070   PMID:34045505   PMID:34140358   PMID:34576061   PMID:34622918   PMID:34852209   PMID:34873237   PMID:35074314   PMID:35115050   PMID:35269919   PMID:35272622  
PMID:36063601   PMID:36396948   PMID:36399825   PMID:36417873   PMID:36451830   PMID:36622065   PMID:36801996   PMID:37063868   PMID:37142655   PMID:37173348   PMID:38159884   PMID:38242702  
PMID:39138140  


Genomics

Comparative Map Data
Grk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,336,029 - 4,356,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,336,029 - 4,356,250 (-)EnsemblGRCm39 Ensembl
GRCm38194,285,999 - 4,306,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,286,001 - 4,306,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,286,001 - 4,305,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,286,001 - 4,305,955 (-)NCBIMGSCv36mm8
Celera194,157,228 - 4,177,197 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.98NCBI
GRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,266,473 - 67,286,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,266,473 - 67,286,556 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,033,944 - 67,054,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,790,481 - 66,810,605 (+)NCBINCBI36Build 36hg18NCBI36
Build 341166,790,668 - 66,810,945NCBI
Celera1164,377,313 - 64,386,599 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,362,803 - 63,382,690 (+)NCBIHuRef
CHM1_11166,912,110 - 66,937,037 (+)NCBICHM1_1
T2T-CHM13v2.01167,260,429 - 67,280,532 (+)NCBIT2T-CHM13v2.0
Grk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,010,259 - 211,031,013 (-)NCBIGRCr8
mRatBN7.21201,580,823 - 201,601,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,581,480 - 201,601,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,932,926 - 209,953,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,026,270 - 217,047,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,717,288 - 209,738,044 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,536,220 - 219,544,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,536,220 - 219,544,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,406,333 - 226,414,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,873,002 - 206,892,868 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,026,454 - 207,034,564 (-)NCBI
Celera1199,125,797 - 199,145,728 (-)NCBICelera
RH 3.4 Map11560.2RGD
Cytogenetic Map1q43NCBI
Grk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,170,616 - 18,192,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,173,438 - 18,192,357 (-)NCBIChiLan1.0ChiLan1.0
GRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,493,145 - 68,513,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,535,713 - 69,555,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,624,647 - 62,644,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,939,169 - 65,959,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,939,164 - 65,959,066 (+)Ensemblpanpan1.1panPan2
GRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,148,566 - 50,167,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,148,598 - 50,167,428 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,758,688 - 48,777,641 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,097,619 - 51,116,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,097,625 - 51,116,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,283,520 - 50,302,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,858,001 - 49,876,975 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,652,610 - 50,671,586 (-)NCBIUU_Cfam_GSD_1.0
Grk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,994,712 - 6,013,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,437,032 - 2,456,147 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,437,061 - 2,456,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,209,439 - 5,227,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,209,435 - 5,227,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,992,505 - 4,000,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,975,202 - 6,995,369 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,975,002 - 6,995,259 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,263,440 - 104,283,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,210,965 - 19,231,082 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,212,218 - 19,231,218 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grk2
488 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3241
Count of miRNA genes:782
Interacting mature miRNAs:1021
Transcripts:ENSMUST00000025791, ENSMUST00000088737, ENSMUST00000113837, ENSMUST00000164427, ENSMUST00000165954, ENSMUST00000167172, ENSMUST00000167511, ENSMUST00000168594, ENSMUST00000169991, ENSMUST00000171123
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse

Markers in Region
RH94463  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,286,660 - 4,286,821UniSTSGRCm38
MGSCv37194,286,660 - 4,286,821UniSTSGRCm37
Celera194,157,887 - 4,158,048UniSTS
Cytogenetic Map19AUniSTS
cM Map193.0UniSTS
Adrbk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,286,218 - 4,287,398UniSTSGRCm38
MGSCv37194,286,218 - 4,287,398UniSTSGRCm37
Celera194,157,445 - 4,158,625UniSTS
Cytogenetic Map19AUniSTS
cM Map193.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025791   ⟹   ENSMUSP00000025791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,336,029 - 4,355,983 (-)Ensembl
GRCm38.p6 Ensembl194,286,001 - 4,305,955 (-)Ensembl
Ensembl Acc Id: ENSMUST00000088737   ⟹   ENSMUSP00000086114
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,336,030 - 4,356,250 (-)Ensembl
GRCm38.p6 Ensembl194,286,002 - 4,306,222 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113837
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,336,029 - 4,356,058 (-)Ensembl
GRCm38.p6 Ensembl194,286,001 - 4,306,030 (-)Ensembl
Ensembl Acc Id: ENSMUST00000164427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,338,170 - 4,339,431 (-)Ensembl
GRCm38.p6 Ensembl194,288,142 - 4,289,403 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165954   ⟹   ENSMUSP00000128177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,338,454 - 4,340,511 (-)Ensembl
GRCm38.p6 Ensembl194,288,426 - 4,290,483 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167511   ⟹   ENSMUSP00000129839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,342,595 - 4,355,236 (-)Ensembl
GRCm38.p6 Ensembl194,292,567 - 4,305,208 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168594   ⟹   ENSMUSP00000126025
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,338,424 - 4,339,422 (-)Ensembl
GRCm38.p6 Ensembl194,288,396 - 4,289,394 (-)Ensembl
Ensembl Acc Id: ENSMUST00000169991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,340,490 - 4,341,839 (-)Ensembl
GRCm38.p6 Ensembl194,290,462 - 4,291,811 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235681   ⟹   ENSMUSP00000157639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,336,647 - 4,337,877 (-)Ensembl
GRCm38.p6 Ensembl194,286,619 - 4,287,849 (-)Ensembl
RefSeq Acc Id: NM_001290818   ⟹   NP_001277747
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,336,029 - 4,356,356 (-)NCBI
GRCm38194,285,999 - 4,306,222 (-)NCBI
Celera194,157,226 - 4,177,339 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001425877   ⟹   NP_001412806
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,336,029 - 4,356,356 (-)NCBI
RefSeq Acc Id: NM_130863   ⟹   NP_570933
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,336,029 - 4,356,356 (-)NCBI
GRCm38194,285,999 - 4,306,222 (-)NCBI
MGSCv37194,286,001 - 4,305,955 (-)RGD
Celera194,157,226 - 4,177,339 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_570933   ⟸   NM_130863
- Peptide Label: isoform 2
- UniProtKB: Q7TS64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277747   ⟸   NM_001290818
- Peptide Label: isoform 1
- UniProtKB: Q99MK8 (UniProtKB/Swiss-Prot),   Q99LL8 (UniProtKB/Swiss-Prot),   Q3U1V3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000086114   ⟸   ENSMUST00000088737
Ensembl Acc Id: ENSMUSP00000128177   ⟸   ENSMUST00000165954
Ensembl Acc Id: ENSMUSP00000126025   ⟸   ENSMUST00000168594
Ensembl Acc Id: ENSMUSP00000129839   ⟸   ENSMUST00000167511
Ensembl Acc Id: ENSMUSP00000157639   ⟸   ENSMUST00000235681
Ensembl Acc Id: ENSMUSP00000025791   ⟸   ENSMUST00000025791
RefSeq Acc Id: NP_001412806   ⟸   NM_001425877
- Peptide Label: isoform 3
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MK8-F1-model_v2 AlphaFold Q99MK8 1-689 view protein structure

Promoters
RGD ID:6829778
Promoter ID:MM_KWN:26003
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:UC008FZT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,287,596 - 4,288,317 (-)MPROMDB
RGD ID:6847533
Promoter ID:MM_ACW:25779
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung,   Spleen
Transcripts:ADRBK1.ESEP07,   ADRBK1.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,289,646 - 4,290,277 (-)MPROMDB
RGD ID:6847534
Promoter ID:MM_ACW:25780
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ADRBK1.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,291,096 - 4,291,596 (-)MPROMDB
RGD ID:6829777
Promoter ID:MM_KWN:26004
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:NM_130863,   UC008FZV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,305,731 - 4,306,231 (-)MPROMDB
RGD ID:13678424
Promoter ID:EPDNEW_M23361
Type:initiation region
Name:Grk2_1
Description:Mus musculus G protein-coupled receptor kinase 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,306,319 - 4,306,379EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87940 AgrOrtholog
Ensembl Genes ENSMUSG00000024858 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025791 ENTREZGENE
  ENSMUST00000088737 ENTREZGENE
  ENSMUST00000088737.11 UniProtKB/Swiss-Prot
  ENSMUST00000113837 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:110355 UniProtKB/Swiss-Prot
MGD MGI:87940 ENTREZGENE
NCBI Gene Grk2 ENTREZGENE
PANTHER BETA-ADRENERGIC RECEPTOR KINASE 1 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Grk2 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
SMART RGS UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48097 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A494B9J9_MOUSE UniProtKB/TrEMBL
  ARBK1_MOUSE UniProtKB/Swiss-Prot
  F6QY34_MOUSE UniProtKB/TrEMBL
  F6Y9P3_MOUSE UniProtKB/TrEMBL
  F7AEX1_MOUSE UniProtKB/TrEMBL
  Q3U1V3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U5J8_MOUSE UniProtKB/TrEMBL
  Q7TS64 ENTREZGENE, UniProtKB/TrEMBL
  Q99LL8 ENTREZGENE
  Q99MK8 ENTREZGENE
UniProt Secondary Q99LL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Grk2  G protein-coupled receptor kinase 2  Adrbk1  adrenergic receptor kinase, beta 1  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Adrbk1  adrenergic receptor kinase, beta 1  Grk2  G protein-coupled receptor kinase 2  Symbol and/or name change 5135510 APPROVED
2016-09-20 Grk2  G protein-coupled receptor kinase 2  Adrbk1  adrenergic receptor kinase, beta 1  Symbol and/or name change 5135510 APPROVED