Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | affects expression | EXP | | 6480464 | ethylene dichloride affects the expression of ZFP46 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZFP46 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP46 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZFP46 mRNA | CTD | PMID:33956508 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZFP46 mRNA | CTD | PMID:32109520 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZFP46 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ZFP46 promoter] | CTD | PMID:19654925 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZNF436 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | ZNF436 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of ZNF436 gene | CTD | PMID:31601247 | 6-propyl-2-thiouracil | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of ZFP46 mRNA | CTD | PMID:30047161 | 8-Br-cAMP | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ZNF436 mRNA | CTD | PMID:22079614 | acrylamide | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of ZNF436 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | ZNF436 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ZNF436 gene | CTD | PMID:27153756 | amitrole | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of ZFP46 mRNA | CTD | PMID:30047161 | arsane | affects methylation | ISO | ZNF436 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ZNF436 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | ZNF436 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ZNF436 gene | CTD | PMID:25304211 | bisphenol A | affects expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ZNF436 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ZNF436 mRNA | CTD | PMID:36232920 | bisphenol A | increases methylation | ISO | ZNF436 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of ZNF436 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ZFP46 mRNA | CTD | PMID:33221593 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of ZFP46 promoter | CTD | PMID:27312807 | bisphenol A | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ZNF436 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZNF436 mRNA | CTD | PMID:28628672 and PMID:31601247 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ZFP46 promoter | CTD | PMID:27312807 | bisphenol A | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of ZFP46 mRNA | CTD | PMID:30816183 | cadmium dichloride | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of ZFP46 mRNA | CTD | PMID:25993096 | cantharidin | decreases expression | EXP | | 6480464 | Cantharidin results in decreased expression of ZFP46 mRNA | CTD | PMID:36907384 | carbamazepine | affects expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of ZNF436 mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ZNF436 gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of ZFP46 mRNA | CTD | PMID:37019170 | copper(II) sulfate | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of ZNF436 mRNA | CTD | PMID:19549813 | CU-O LINKAGE | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of ZNF436 mRNA | CTD | PMID:22077320 | dexamethasone | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZNF436 mRNA | CTD | PMID:28628672 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ZFP46 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ZNF436 mRNA | CTD | PMID:29803840 | entinostat | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | entinostat results in decreased expression of ZNF436 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF436 mRNA | CTD | PMID:27188386 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of ZFP46 mRNA | CTD | PMID:35436446 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of ZFP46 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of ZNF436 mRNA | CTD | PMID:23649840 | flutamide | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of ZFP46 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZFP46 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of ZNF436 mRNA | CTD | PMID:20655997 | formaldehyde | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of ZNF436 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ZNF436 gene | CTD | PMID:31601247 | gentamycin | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of ZFP46 mRNA | CTD | PMID:33387578 | glafenine | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Glafenine results in increased expression of ZFP46 mRNA | CTD | PMID:24136188 | indometacin | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZNF436 mRNA | CTD | PMID:28628672 | leflunomide | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of ZNF436 mRNA | CTD | PMID:28988120 | metformin | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Metformin results in increased expression of ZFP46 mRNA | CTD | PMID:31324951 | methimazole | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of ZFP46 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of ZNF436 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ZNF436 mRNA | CTD | PMID:28001369 | panobinostat | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF436 mRNA | CTD | PMID:27188386 | panobinostat | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | panobinostat results in decreased expression of ZNF436 mRNA | CTD | PMID:26272509 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of ZFP46 mRNA | CTD | PMID:37995155 | phenylephrine | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Phenylephrine results in decreased expression of ZFP46 mRNA | CTD | PMID:18158353 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of ZFP46 mRNA | CTD | PMID:16985257 | rifampicin | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Rifampin results in decreased expression of ZNF436 mRNA | CTD | PMID:24552687 | SB 431542 | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium dichromate | increases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | sodium bichromate results in increased expression of ZFP46 mRNA | CTD | PMID:25993096 | sulfadimethoxine | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of ZFP46 mRNA | CTD | PMID:30047161 | sunitinib | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ZNF436 mRNA | CTD | PMID:31533062 | torcetrapib | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of ZNF436 mRNA | CTD | PMID:23228038 | triadimefon | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | triadimefon results in decreased expression of ZFP46 mRNA | CTD | PMID:30047161 | trichostatin A | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ZNF436 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF436 mRNA | CTD | PMID:27188386 | triclosan | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of ZNF436 mRNA | CTD | PMID:30510588 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of ZFP46 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Urethane results in increased expression of ZNF436 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ZNF436 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | ZNF436 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF436 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ZNF436 mRNA | CTD | PMID:23179753 more ... | vanadyl sulfate | decreases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | vanadyl sulfate results in decreased expression of ZNF436 mRNA | CTD | PMID:16330358 | vinclozolin | decreases expression | ISO | Zfp46 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of ZFP46 mRNA | CTD | PMID:23034163 | zoledronic acid | increases expression | ISO | ZNF436 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of ZNF436 mRNA | CTD | PMID:20977926 | | 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