Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Mus musculus
Analyze
Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 737538
MGI Page MGI
Description: Enables endothelin receptor activity. Acts upstream of or within several processes, including circulatory system development; neural crest cell development; and regulation of glucose transmembrane transport. Predicted to be located in T-tubule and nuclear membrane. Predicted to colocalize with membrane raft. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AEA0; AEA001; endothelin A receptor; endothelin-1 receptor; ET; ET-; ET-A; ET-AR; ETa; G-protein coupled receptor 10; Gpcr; Gpcr10; Mhdaa; Mhdaaea1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBImm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ambrisentan  (ISO)
aminoguanidine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (EXP,ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bosentan  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
celecoxib  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enrasentan  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glucose  (ISO)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (ISO)
Licochalcone B  (ISO)
losartan  (ISO)
Magnolol  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
nicotine  (ISO)
nitrofen  (EXP,ISO)
ouabain  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phosphoramidon  (ISO)
pirinixic acid  (EXP)
potassium chloride  (EXP)
potassium dichromate  (EXP)
progesterone  (ISO)
Ptaquiloside  (EXP)
quartz  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
steviol  (ISO)
stevioside  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IGI)
aging  (ISO)
artery smooth muscle contraction  (ISO)
branching involved in blood vessel morphogenesis  (IGI)
cellular response to mechanical stimulus  (ISO)
enteric nervous system development  (IEA)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (TAS)
glomerular filtration  (ISO)
head development  (IMP)
heart development  (IGI)
histamine secretion  (ISO)
in utero embryonic development  (IMP)
maternal process involved in parturition  (ISO)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (IMP)
penile erection  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood pressure  (IMP)
regulation of epithelial cell proliferation  (ISO)
regulation of glucose transmembrane transport  (IDA)
respiratory gaseous exchange by respiratory system  (IMP)
response to hypoxia  (IMP)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
Rho protein signal transduction  (ISO)
sensory perception of pain  (ISO)
signal transduction  (IEA)
smooth muscle cell proliferation  (ISO)
vasoconstriction  (IMP,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal alveolar process morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal carotid artery morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal ear shape  (IAGP)
abnormal facial morphology  (IEA)
abnormal facial nerve morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal gonial bone morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal incudomalleolar joint morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal inspiratory capacity  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal mandibular nerve branching  (IAGP)
abnormal mandibular nerve morphology  (IAGP)
abnormal mandibular ramus morphology  (IAGP)
abnormal masseter muscle morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal mouth floor morphology  (IAGP)
abnormal mouth morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal orbit morphology  (IAGP)
abnormal outer ear helix morphology  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal palate morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pterygoid process morphology  (IAGP)
abnormal pulmonary ventilation  (IAGP)
abnormal respiration  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone petrous part morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal temporal bone zygomatic process morphology  (IAGP)
abnormal temporomandibular joint morphology  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal urine osmolality  (IAGP)
abnormal vital capacity  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent gonial bone  (IAGP)
absent incus  (IAGP)
absent incus short process  (IAGP)
absent malleus  (IAGP)
absent Meckel's cartilage  (IAGP)
absent right subclavian artery  (IAGP)
absent salivary gland  (IAGP)
absent stapes  (IAGP)
absent submandibular gland  (IAGP)
absent temporal bone squamous part  (IAGP)
absent temporal bone zygomatic process  (IAGP)
absent tubotympanic recess  (IAGP)
absent tympanic membrane  (IAGP)
absent tympanic ring  (IAGP)
absent vibrissae  (IAGP)
anteriorly rotated ears  (IAGP)
aorta tubular hypoplasia  (IAGP)
cleft chin  (IAGP)
conductive hearing loss  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased lung compliance  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased startle reflex  (IAGP)
decreased total lung capacity  (IAGP)
dilated heart atrium  (IAGP)
double aortic arch  (IAGP)
double outlet right ventricle  (IAGP)
ectopic thymus  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
eyelids open at birth  (IAGP)
facial cleft  (IAGP)
impaired hearing  (IAGP)
increased circulating antidiuretic hormone level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
incudomalleolar fusion  (IAGP)
interrupted aorta  (IAGP)
lower jaw to upper jaw transformation  (IAGP)
lowered ear position  (IAGP)
macrophthalmia  (IAGP)
malocclusion  (IAGP)
mandible hypoplasia  (IAGP)
micrognathia  (IAGP)
no abnormal phenotype detected  (IAGP)
overriding aortic valve  (IAGP)
patent ductus arteriosus  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
persistent right 6th pharyngeal arch artery  (IAGP)
persistent right dorsal aorta  (IAGP)
persistent truncus arteriosis  (IAGP)
prenatal lethality  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prominent cheeks  (IAGP)
round face  (IAGP)
round orbits  (IAGP)
short mandible  (IAGP)
short mandibular coronoid process  (IAGP)
short snout  (IAGP)
short styloid process  (IAGP)
shortened head  (IAGP)
small mandibular condyloid process  (IAGP)
small second pharyngeal arch  (IAGP)
small zygomatic bone  (IAGP)
thymus hypoplasia  (IAGP)
tongue hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
upper jaw to lower jaw transformation  (IAGP)
wide coronal suture  (IAGP)
wide lambdoid suture  (IAGP)
wide sagittal suture  (IAGP)
References

References - curated
1. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
2. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
3. Benjafield AV, etal., Clin Genet. 2003 Nov;64(5):433-8.
4. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
5. Buck D, etal., Sleep Med. 2010 Feb;11(2):213-7. Epub 2010 Jan 18.
6. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
7. Darrah R, etal., Physiol Genomics. 2010 Mar 3;41(1):71-7. Epub 2009 Dec 22.
8. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
9. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
10. Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
11. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
12. Herrmann S, etal., Eur Heart J. 2001 Oct;22(20):1948-53.
13. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
14. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
15. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
17. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
18. MGD and Homologene mouse data transfer
19. MGD data from the GO Consortium
20. MGD IEA
21. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
22. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
23. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
24. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
26. OMIM Disease Annotation Pipeline
27. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Plusczyk T, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G145-53.
29. RGD automated import pipeline
30. RGD automated import pipeline for gene-chemical interactions
31. Richter M, etal., Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):299-308. Epub 2007 Apr 19.
32. Said N, etal., J Clin Invest. 2011 Jan 4;121(1):132-47. doi: 10.1172/JCI42912. Epub 2010 Dec 22.
33. Saleh MA, etal., Diabetologia. 2010 Dec 30.
34. Sampaio AL, etal., J Leukoc Biol. 2004 Jul;76(1):210-6. Epub 2004 Apr 23.
35. Stenman E, etal., Eur J Pharmacol. 2007 Sep 10;570(1-3):142-8. Epub 2007 Jun 9.
36. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
37. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
38. Tzourio C, etal., Neurology 2001 May 22;56(10):1273-7.
39. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
40. Yahiaoui L, etal., Cell Physiol Biochem. 2006;17(1-2):37-46. Epub 2006 Feb 7.
41. Yan LD, etal., J Cardiovasc Pharmacol. 2010 Sep;56(3):246-54.
42. Yanagisawa H, etal., Development 1998 Mar;125(5):825-36.
43. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
44. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:7904485   PMID:8288218   PMID:8548579   PMID:8587354   PMID:9012511   PMID:9449664   PMID:9495516   PMID:9826706   PMID:10194519   PMID:10198387   PMID:10349636   PMID:10479458  
PMID:10625532   PMID:10626068   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11546805   PMID:11688556   PMID:12413905   PMID:12477932   PMID:12763050   PMID:14585980   PMID:14659802  
PMID:14691545   PMID:15226263   PMID:15239958   PMID:15306564   PMID:15327783   PMID:15489334   PMID:15647918   PMID:15664398   PMID:15838254   PMID:15838300   PMID:15838311   PMID:15838332  
PMID:15838353   PMID:15928212   PMID:16141072   PMID:16141073   PMID:16399858   PMID:16602821   PMID:16868309   PMID:16962346   PMID:16984730   PMID:17294360   PMID:17607529   PMID:17616694  
PMID:17660396   PMID:18199583   PMID:18287559   PMID:18401410   PMID:18480165   PMID:18524860   PMID:18635823   PMID:18703610   PMID:18784261   PMID:19017795   PMID:19111534   PMID:19185569  
PMID:19193724   PMID:19213955   PMID:19299580   PMID:19370413   PMID:19879049   PMID:19943105   PMID:20093323   PMID:20357223   PMID:20516397   PMID:20628431   PMID:20929948   PMID:21218036  
PMID:21237142   PMID:21555149   PMID:21565284   PMID:21918182   PMID:21949113   PMID:22287612   PMID:22354888   PMID:22442497   PMID:22483687   PMID:22681550   PMID:23217151   PMID:23592430  
PMID:23698114   PMID:23933587   PMID:24043815   PMID:24194600   PMID:24371298   PMID:24412386   PMID:24722437   PMID:24756152   PMID:24875861   PMID:25050930   PMID:25181417   PMID:25197047  
PMID:25572710   PMID:25772936   PMID:25889273   PMID:25902370   PMID:26089164   PMID:26506449   PMID:26531127   PMID:26637970   PMID:27026367   PMID:27165837   PMID:27671791   PMID:27778057  
PMID:27899487   PMID:28455376   PMID:29272493   PMID:29545351   PMID:29570803   PMID:30031229   PMID:30384975   PMID:30735130   PMID:30905259   PMID:30990108   PMID:31219639   PMID:31402170  
PMID:31923844   PMID:31924792   PMID:32133772   PMID:33416142   PMID:33443158  


Genomics

Comparative Map Data
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBImm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBI
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,233,540 - 30,303,727 (+)NCBI
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0panPan3
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBI
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBI
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBI
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBI
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBI
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBI
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBI
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)Ensembl
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBI
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBI

Position Markers
UniSTS:235933  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,664,302 - 77,664,562UniSTSGRCm38
MGSCv37880,188,201 - 80,188,461UniSTSGRCm37
Celera881,947,729 - 81,947,989UniSTS
Cytogenetic Map8C2UniSTS
UniSTS:235935  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,678,370 - 77,678,583UniSTSGRCm38
MGSCv37880,202,269 - 80,202,482UniSTSGRCm37
Celera881,961,854 - 81,962,067UniSTS
Cytogenetic Map8C2UniSTS
PMC262340P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,667,608 - 77,668,203UniSTSGRCm38
MGSCv37880,191,507 - 80,192,102UniSTSGRCm37
Celera881,951,069 - 81,951,664UniSTS
Cytogenetic Map8C2UniSTS
Ednra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS
cM MapUN UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:936
Count of miRNA genes:520
Interacting mature miRNAs:654
Transcripts:ENSMUST00000034029, ENSMUST00000146561
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034029   ⟹   ENSMUSP00000034029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl877,663,031 - 77,724,436 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146561
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl877,669,694 - 77,724,464 (-)Ensembl
RefSeq Acc Id: NM_010332   ⟹   NP_034462
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39878,389,658 - 78,451,081 (-)NCBI
GRCm38877,663,029 - 77,724,452 (-)ENTREZGENE
MGSCv37880,186,928 - 80,248,351 (-)RGD
Celera881,946,457 - 82,007,225 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034462   ⟸   NM_010332
- Peptide Label: precursor
- UniProtKB: Q61614 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034029   ⟸   ENSMUST00000034029

Promoters
RGD ID:8667527
Promoter ID:EPDNEW_M11795
Type:initiation region
Name:Ednra_1
Description:Mus musculus endothelin receptor type A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38877,724,467 - 77,724,527EPDNEW
RGD ID:6843059
Promoter ID:MM_KWN:54925
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Lung,   MEF_B4,   Spleen
Transcripts:NM_010332,   OTTMUST00000059826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36880,247,886 - 80,248,922 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105923 AgrOrtholog
Ensembl Genes ENSMUSG00000031616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034029 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034029 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:13617 UniProtKB/Swiss-Prot
MGD MGI:105923 ENTREZGENE
NCBI Gene 13617 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ednra PhenoGen
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt EDNRA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BMW4_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54993 UniProtKB/Swiss-Prot
  Q91VV2 UniProtKB/Swiss-Prot