Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Mus musculus
Analyze
Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 737538
MGI Page MGI
Description: Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of D-glucose transmembrane transport. Is active in plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AEA0; AEA001; endothelin A receptor; endothelin-1 receptor; ET; ET-; ET-A; ET-AR; ETa; G-protein coupled receptor 10; Gpcr; Gpcr10; Mhdaa; Mhdaaea1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
EdnraMouseAcute Experimental Pancreatitis treatmentISOEdnra (Rattus norvegicus)1581841 RGD 
EdnraMouseasthma  IMP 4892288 RGD 
EdnraMouseasthma  IMP 4892322 RGD 
EdnraMouseCardiovascular Abnormalities  IMP 734910 RGD 
EdnraMouseDiabetic Nephropathies  ISOEdnra (Rattus norvegicus)4892326associated with Diabetes Mellitus and ExperimentalRGD 
EdnraMouseExperimental Diabetes Mellitus  ISOEdnra (Rattus norvegicus)4892336 RGD 
EdnraMousehyperhomocysteinemia  ISOEdnra (Rattus norvegicus)4892572 RGD 
EdnraMousehypertension  ISOEdnra (Rattus norvegicus)4892284associated with UremiaRGD 
EdnraMousehypertension  ISOEDNRA (Homo sapiens)1580950 RGD 
EdnraMouseimpotence  ISOEdnra (Rattus norvegicus)2292142 RGD 
EdnraMouseInflammation  IMP 4892288 RGD 
EdnraMouselung disease severityISOEDNRA (Homo sapiens)4892286associated with Cystic FibrosisRGD 
EdnraMousemigraine  ISOEDNRA (Homo sapiens)734916DNA:polymorphism:-231A>GRGD 
EdnraMousemyocardial infarction  ISOEdnra (Rattus norvegicus)1580948 RGD 
EdnraMouseMyocardial Ischemia  ISOEDNRA (Homo sapiens)1580946 RGD 
EdnraMouseMyocardial Reperfusion Injury  ISOEdnra (Rattus norvegicus)4892580 RGD 
EdnraMouseNeoplasm Metastasis  IMP 4892282associated with Bladder NeoplasmsRGD 
EdnraMousenephrotic syndrome  ISOEdnra (Rattus norvegicus)7244242mRNA:increased expression:GlomerulusRGD 
EdnraMouseobstructive sleep apnea  ISOEDNRA (Homo sapiens)4892306DNA:polymorphism: :-231G>A (human)RGD 
EdnraMouseobstructive sleep apnea  ISOEdnra (Rattus norvegicus)4145067 RGD 
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Original Reference(s)
EdnraMousegenetic disease  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
EdnraMousemandibulofacial dysostosis with alopecia  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Mandibulofacial dysostosis with alopeciaClinVarPMID:16116593 more ...
EdnraMousemethylmalonic acidemia cblA type  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Methylmalonic aciduria and cblA typeClinVarPMID:15523652 more ...
EdnraMousemigraine  ISOEDNRA (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11376172 more ...
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EdnraMousecongenital heart disease  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9811577
EdnraMousecongestive heart failure  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28095452
EdnraMouseCraniofacial Abnormalities  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9811577 and PMID:17294360
EdnraMouseDiaphragmatic Hernia  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9473106 and PMID:10693666
EdnraMouseDisease Progression  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25194819
EdnraMousehypertension  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12600921
EdnraMouseimpotence  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18823320
EdnraMouseNasopharyngeal Neoplasms  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17032313
EdnraMouseobstructive sleep apnea  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20083432
EdnraMouseOvarian Neoplasms  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25194819
EdnraMouseStroke  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29531354
EdnraMousetype 2 diabetes mellitus  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16387788
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EdnraMousemandibulofacial dysostosis with alopecia  IAGP 13592920OMIM:616367MouseDO 
EdnraMousevelocardiofacial syndrome  IAGP 13592920OMIM:192430MouseDO 
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Original Reference(s)
EdnraMousemandibulofacial dysostosis with alopecia  ISOEDNRA (Homo sapiens)7240710 OMIM 
EdnraMousemigraine  ISOEDNRA (Homo sapiens)7240710 OMIM 

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Original Reference(s)
EdnraMouse(R)-noradrenaline multiple interactionsISOEdnra (Rattus norvegicus)6480464[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to NorepinephrineCTDPMID:15834289
EdnraMouse(S)-nicotine decreases expressionISOEDNRA (Homo sapiens)6480464Nicotine results in decreased expression of EDNRA mRNACTDPMID:18247414
EdnraMouse1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of EDNRA mRNACTDPMID:22206623
EdnraMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EDNRA mRNACTDPMID:22206623
EdnraMouse11-deoxycorticosterone multiple interactionsISOEdnra (Rattus norvegicus)6480464[5-(dimethylamino)-N-(3 more ...CTDPMID:16271043 and PMID:22431579
EdnraMouse11-deoxycorticosterone affects response to substanceISOEdnra (Rattus norvegicus)6480464EDNRA protein affects the susceptibility to DesoxycorticosteroneCTDPMID:12600921
EdnraMouse17beta-estradiol increases expressionISOEDNRA (Homo sapiens)6480464Estradiol results in increased expression of EDNRA mRNACTDPMID:19943105
EdnraMouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of EDNRA mRNACTDPMID:39298647
EdnraMouse17beta-estradiol multiple interactionsISOEDNRA (Homo sapiens)6480464Tamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]CTDPMID:19943105
EdnraMouse2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOEdnra (Rattus norvegicus)64804642 more ...CTDPMID:27291303
EdnraMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of EDNRA mRNACTDPMID:25975270
EdnraMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOEdnra (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of EDNRA mRNACTDPMID:34747641
EdnraMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOEdnra (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of EDNRA mRNACTDPMID:32109520
EdnraMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of EDNRA mRNACTDPMID:26290441
EdnraMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
EdnraMouse2-naphthylamine decreases expressionISOEDNRA (Homo sapiens)64804642-Naphthylamine results in decreased expression of EDNRA mRNACTDPMID:18247414
EdnraMouse3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expressionISOEdnra (Rattus norvegicus)6480464Puromycin Aminonucleoside results in increased expression of EDNRA mRNACTDPMID:12972712
EdnraMouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of EDNRA mRNACTDPMID:30951980
EdnraMouse4,4'-sulfonyldiphenol decreases methylationISOEDNRA (Homo sapiens)6480464bisphenol S results in decreased methylation of EDNRA geneCTDPMID:31601247
EdnraMouse4,4'-sulfonyldiphenol affects expressionEXP 6480464bisphenol S affects the expression of EDNRA mRNACTDPMID:39298647

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Biological Process
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Original Reference(s)
EdnraMouseadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinIGIMGI:881212290270 PMID:15928212MGIPMID:15928212
EdnraMouseangiogenesis involved_inIGIMGI:952842290270 PMID:24043815MGIPMID:24043815
EdnraMouseaorta development involved_inIMPMGI:1857473 and MGI:26873622290270 PMID:31219639MGIPMID:31219639
EdnraMouseaorta development involved_inIMPMGI:26873622290270 PMID:14585980MGIPMID:14585980
EdnraMouseartery smooth muscle contraction involved_inISOUniProtKB:P251012290270 GO_CentralGO_REF:0000119
EdnraMouseartery smooth muscle contraction involved_inIEAUniProtKB:P25101 and ensembl:ENSP000004989692290270 EnsemblGO_REF:0000107
EdnraMouseatrial cardiac muscle tissue development involved_inIMPMGI:3773698 and MGI:48673852290270 PMID:20929948MGIPMID:20929948
EdnraMouseaxon extension involved_inIMP 2290270 PMID:18401410MGIPMID:18401410
EdnraMouseaxon guidance involved_inIMPMGI:18574732290270 PMID:18401410MGIPMID:18401410
EdnraMouseaxon guidance involved_inIMPMGI:1857637 more ...2290270 PMID:30735130MGIPMID:30735130
EdnraMouseaxonogenesis involved in innervation involved_inIMPMGI:26873622290270 PMID:30735130MGIPMID:30735130
EdnraMouseaxonogenesis involved in innervation involved_inIMPMGI:1857473 and MGI:26873622290270 PMID:24875861MGIPMID:24875861
EdnraMouseblood vessel remodeling involved_inIMPMGI:26873622290270 PMID:25197047MGIPMID:25197047
EdnraMousebranching involved in blood vessel morphogenesis involved_inIMPMGI:3773698 and MGI:48673852290270 PMID:23933587MGIPMID:23933587
EdnraMousebranching involved in blood vessel morphogenesis acts_upstream_of_or_withinIGIMGI:13474812290270 PMID:15664398MGIPMID:15664398
EdnraMousecalcium ion transmembrane transport involved_inIDA 2290270 PMID:24722437MGIPMID:24722437
EdnraMousecalcium ion transmembrane transport involved_inIMP 2290270 PMID:24722437MGIPMID:24722437
EdnraMousecalcium ion transmembrane transport involved_inIGIMGI:1027202290270 PMID:24722437MGIPMID:24722437
EdnraMousecAMP/PKA signal transduction involved_inISOUniProtKB:P251012290270 PMID:30990108MGIPMID:30990108
EdnraMousecanonical Wnt signaling pathway involved_inIGIMGI:1027202290270 PMID:24722437MGIPMID:24722437
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Cellular Component

  
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Original Reference(s)
EdnraMousenuclear membrane  ISOEdnra (Rattus norvegicus)9068941 RGDPMID:12756260 and REF_RGD_ID:1581838
EdnraMousenuclear membrane located_inISOEdnra (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
EdnraMouseplasma membrane is_active_inIBAPANTHER:PTN002517505 more ...2290270 GO_CentralGO_REF:0000033
EdnraMouseplasma membrane is_active_inIDA 2290270 PMID:30990108MGIPMID:30990108
EdnraMouseT-tubule  ISOEdnra (Rattus norvegicus)9068941 RGDPMID:12972433 and REF_RGD_ID:1581834
EdnraMouseT-tubule located_inISOEdnra (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096

Molecular Function
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RGD Manual Annotations


  

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
EdnraMouseendothelin signaling pathway  ISOEDNRA (Homo sapiens)6484113 PIDPID:200005
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EdnraMouseaberrant origin of the right subclavian artery  IAGP 5509061 MGIPMID:9649553
EdnraMouseabnormal alisphenoid bone morphology  IAGP 5509061 MGIPMID:15306564
EdnraMouseabnormal alisphenoid bone morphology  IAGP 5509061 MGIPMID:18199583
EdnraMouseabnormal alveolar process morphology  IAGP 5509061 MGIPMID:18199583
EdnraMouseabnormal artery morphology  IAGP 5509061 MGIPMID:9449665
EdnraMouseabnormal artery morphology  IAGP 5509061 MGIPMID:9649553
EdnraMouseabnormal ascending aorta morphology  IAGP 5509061 MGIPMID:9649553
EdnraMouseabnormal basisphenoid bone morphology  IAGP 5509061 MGIPMID:18199583
EdnraMouseabnormal cardiovascular system morphology  IAGP 5509061 MGIPMID:9449664
EdnraMouseabnormal carotid artery morphology  IAGP 5509061 MGIPMID:9449664
EdnraMouseabnormal craniofacial bone morphology  IAGP 5509061 MGIPMID:18199583
EdnraMouseabnormal craniofacial bone morphology  IAGP 5509061 MGIPMID:19185569
EdnraMouseabnormal craniofacial morphology  IAGP 5509061 MGIPMID:19185569
EdnraMouseabnormal cranium morphology  IAGP 5509061 MGIPMID:27671791
EdnraMouseabnormal dorsal aorta morphology  IAGP 5509061 MGIPMID:9449664
EdnraMouseabnormal dorsal aorta morphology  IAGP 5509061 MGIPMID:15664398
EdnraMouseabnormal ear shape  IAGP 5509061 MGIPMID:27671791
EdnraMouseabnormal facial morphology  IEA 5509061 MGI 
EdnraMouseabnormal facial nerve morphology  IAGP 5509061 MGIPMID:9449664
EdnraMouseabnormal first pharyngeal arch morphology  IAGP 5509061 MGIPMID:9449664
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#
Reference Title
Reference Citation
1. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
2. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield AV, etal., Clin Genet. 2003 Nov;64(5):433-8.
4. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
5. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. Buck D, etal., Sleep Med. 2010 Feb;11(2):213-7. Epub 2010 Jan 18.
6. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
7. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. Darrah R, etal., Physiol Genomics. 2010 Mar 3;41(1):71-7. Epub 2009 Dec 22.
8. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
9. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
10. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
11. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
12. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Herrmann S, etal., Eur Heart J. 2001 Oct;22(20):1948-53.
13. Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
14. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
17. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
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PMID:7904485   PMID:8288218   PMID:8548579   PMID:8587354   PMID:9012511   PMID:9449664   PMID:9495516   PMID:9826706   PMID:10194519   PMID:10198387   PMID:10349636   PMID:10479458  
PMID:10625532   PMID:10626068   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11546805   PMID:11688556   PMID:12413905   PMID:12477932   PMID:12763050   PMID:14585980   PMID:14659802  
PMID:14691545   PMID:15226263   PMID:15239958   PMID:15306564   PMID:15327783   PMID:15489334   PMID:15647918   PMID:15664398   PMID:15838254   PMID:15838300   PMID:15838311   PMID:15838332  
PMID:15838353   PMID:15928212   PMID:16141072   PMID:16141073   PMID:16399858   PMID:16602821   PMID:16868309   PMID:16962346   PMID:16984730   PMID:17294360   PMID:17607529   PMID:17616694  
PMID:17660396   PMID:18199583   PMID:18287559   PMID:18401410   PMID:18480165   PMID:18524860   PMID:18635823   PMID:18703610   PMID:18784261   PMID:19017795   PMID:19111534   PMID:19185569  
PMID:19193724   PMID:19213955   PMID:19299580   PMID:19370413   PMID:19879049   PMID:19943105   PMID:20093323   PMID:20357223   PMID:20516397   PMID:20628431   PMID:20929948   PMID:21218036  
PMID:21237142   PMID:21555149   PMID:21565284   PMID:21873635   PMID:21918182   PMID:21949113   PMID:22287612   PMID:22354888   PMID:22442497   PMID:22483687   PMID:22681550   PMID:23217151  
PMID:23592430   PMID:23698114   PMID:23933587   PMID:24043815   PMID:24194600   PMID:24371298   PMID:24412386   PMID:24722437   PMID:24756152   PMID:24875861   PMID:25050930   PMID:25181417  
PMID:25197047   PMID:25572710   PMID:25772936   PMID:25889273   PMID:25902370   PMID:26089164   PMID:26506449   PMID:26531127   PMID:26637970   PMID:27026367   PMID:27165837   PMID:27671791  
PMID:27778057   PMID:27899487   PMID:28455376   PMID:29272493   PMID:29545351   PMID:29570803   PMID:30031229   PMID:30384975   PMID:30735130   PMID:30905259   PMID:30990108   PMID:31219639  
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Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBICelera
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,349,200 - 145,415,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14145,714,744 - 145,780,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,949,941 - 2,005,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ednra
5510 total Variants

Predicted Target Of
Summary Value
Count of predictions:936
Count of miRNA genes:520
Interacting mature miRNAs:654
Transcripts:ENSMUST00000034029, ENSMUST00000146561
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse

1 to 10 of 37 rows
UniSTS:235933  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,664,302 - 77,664,562UniSTSGRCm38
MGSCv37880,188,201 - 80,188,461UniSTSGRCm37
Celera881,947,729 - 81,947,989UniSTS
Cytogenetic Map8C2UniSTS
UniSTS:235935  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,678,370 - 77,678,583UniSTSGRCm38
MGSCv37880,202,269 - 80,202,482UniSTSGRCm37
Celera881,961,854 - 81,962,067UniSTS
Cytogenetic Map8C2UniSTS
PMC262340P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38877,667,608 - 77,668,203UniSTSGRCm38
MGSCv37880,191,507 - 80,192,102UniSTSGRCm37
Celera881,951,069 - 81,951,664UniSTS
Cytogenetic Map8C2UniSTS
Ednra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C2UniSTS
cM MapUN UniSTS
cM Map8 UniSTS







Ensembl Acc Id: ENSMUST00000034029   ⟹   ENSMUSP00000034029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl878,389,660 - 78,451,065 (-)Ensembl
GRCm38.p6 Ensembl877,663,031 - 77,724,436 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl878,396,323 - 78,451,093 (-)Ensembl
GRCm38.p6 Ensembl877,669,694 - 77,724,464 (-)Ensembl
RefSeq Acc Id: NM_010332   ⟹   NP_034462
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39878,389,658 - 78,451,081 (-)NCBI
GRCm38877,663,029 - 77,724,452 (-)ENTREZGENE
MGSCv37880,186,928 - 80,248,351 (-)RGD
Celera881,946,457 - 82,007,225 (-)RGD
cM Map8 ENTREZGENE
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_034462 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16845 (Get FASTA)   NCBI Sequence Viewer  
  AAB96671 (Get FASTA)   NCBI Sequence Viewer  
  AAH08277 (Get FASTA)   NCBI Sequence Viewer  
  BAC25516 (Get FASTA)   NCBI Sequence Viewer  
  BAC31493 (Get FASTA)   NCBI Sequence Viewer  
  EDL10850 (Get FASTA)   NCBI Sequence Viewer  
  EDL10851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034029
  ENSMUSP00000034029.8
GenBank Protein Q61614 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_034462   ⟸   NM_010332
- Peptide Label: precursor
- UniProtKB: Q91VV2 (UniProtKB/Swiss-Prot),   Q61614 (UniProtKB/Swiss-Prot),   O54993 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034029   ⟸   ENSMUST00000034029

Name Modeler Protein Id AA Range Protein Structure
AF-Q61614-F1-model_v2 AlphaFold Q61614 1-427 view protein structure

RGD ID:8667527
Promoter ID:EPDNEW_M11795
Type:initiation region
Name:Ednra_1
Description:Mus musculus endothelin receptor type A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38877,724,467 - 77,724,527EPDNEW
RGD ID:6843059
Promoter ID:MM_KWN:54925
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Lung,   MEF_B4,   Spleen
Transcripts:NM_010332,   OTTMUST00000059826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36880,247,886 - 80,248,922 (-)MPROMDB


1 to 29 of 29 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000031616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034029 ENTREZGENE
  ENSMUST00000034029.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Endthln_rcpt UniProtKB/Swiss-Prot
  ETA_rcpt UniProtKB/Swiss-Prot
  GPCR_endothelin_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:13617 UniProtKB/Swiss-Prot
MGD MGI:105923 ENTREZGENE
NCBI Gene Ednra ENTREZGENE
PANTHER ENDOTHELIN-1 RECEPTOR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ednra PhenoGen
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot
  ENDOTHELINR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt EDNRA_MOUSE UniProtKB/Swiss-Prot
  O54993 ENTREZGENE
  Q61614 ENTREZGENE
  Q8BMW4_MOUSE UniProtKB/TrEMBL
  Q91VV2 ENTREZGENE
UniProt Secondary O54993 UniProtKB/Swiss-Prot
  Q91VV2 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Ednra  endothelin receptor type A  Gpcr10  G-protein coupled receptor 10  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gpcr10  G-protein coupled receptor 10  Ednra  endothelin receptor type A  Symbol and/or name change 5135510 APPROVED