EDNRA (endothelin receptor type A) - Rat Genome Database

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Gene: EDNRA (endothelin receptor type A) Homo sapiens
Analyze
Symbol: EDNRA
Name: endothelin receptor type A
RGD ID: 737537
HGNC Page HGNC:3179
Description: Predicted to enable endothelin receptor activity. Involved in several processes, including artery smooth muscle contraction; cellular calcium ion homeostasis; and protein kinase A signaling. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Biomarker of pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: endothelin A receptor; endothelin ET-A receptor; endothelin receptor subtype A; endothelin receptor, ET1-specific type; endothelin-1 receptor; endothelin-1-specific receptor; ET-A; ETA; ETA-R; ETAR; ETRA; G protein-coupled receptor; hET-AR; MFDA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBI
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-naphthylamine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
agmatine  (EXP)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
ambrisentan  (EXP)
aminoguanidine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (EXP)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrasentan  (EXP,ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (EXP)
celecoxib  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cocaine  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
enrasentan  (EXP)
ethanol  (ISO)
fenvalerate  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
glucose  (EXP)
hexadecanoic acid  (EXP)
hydrogen cyanide  (ISO)
isoprenaline  (ISO)
isoquinoline-1,5-diol  (ISO)
Licochalcone B  (EXP)
losartan  (ISO)
Magnolol  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
mifepristone  (ISO)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
panobinostat  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phosphoramidon  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
Ptaquiloside  (ISO)
quartz  (EXP)
raloxifene  (EXP)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
steviol  (EXP)
stevioside  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (TAS)
activation of phospholipase C activity  (TAS)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
aging  (ISO)
angiogenesis  (IEA)
aorta development  (IEA)
artery smooth muscle contraction  (IMP)
atrial cardiac muscle tissue development  (IEA)
axon extension  (IEA)
axon guidance  (IEA)
axonogenesis involved in innervation  (IEA)
blood circulation  (IEA)
blood vessel remodeling  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
canonical Wnt signaling pathway  (IEA)
cardiac chamber formation  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
cell population proliferation  (TAS)
cellular calcium ion homeostasis  (IDA,IEA)
cellular response to follicle-stimulating hormone stimulus  (IEA)
cellular response to human chorionic gonadotropin stimulus  (IEA)
cellular response to luteinizing hormone stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to organic substance  (IEA)
cellular response to oxidative stress  (IEA)
cranial skeletal system development  (IEA)
developmental pigmentation  (IBA)
embryonic heart tube development  (IEA)
embryonic skeletal system development  (IEA)
endothelin receptor signaling pathway  (IBA,IEA)
endothelin receptor signaling pathway involved in heart process  (IEA)
enteric nervous system development  (IEA)
establishment of endothelial barrier  (IEA)
face development  (IEA)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,NAS)
gene expression  (IEA)
glomerular endothelium development  (IEA)
glomerular filtration  (IEA,ISO)
glomerulus development  (IEA)
head development  (IEA,ISO)
heart development  (IEA,ISO)
heparin metabolic process  (IEA)
histamine secretion  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA)
in utero embryonic development  (IEA,ISO)
intracellular signal transduction  (IEA)
left ventricular cardiac muscle tissue morphogenesis  (IEA)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
mesenchymal cell apoptotic process  (IEA)
middle ear morphogenesis  (IEA)
mitochondrion organization  (IEA)
mitotic cell cycle  (IEA)
multicellular organism aging  (IEA)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (IEA,ISO)
neural crest cell differentiation  (IEA)
neural crest cell fate commitment  (IEA)
neuromuscular process  (IEA)
neuron projection development  (IEA)
neuron remodeling  (IEA)
noradrenergic neuron differentiation  (IEA)
norepinephrine metabolic process  (IEA)
penile erection  (ISO)
pharyngeal arch artery morphogenesis  (IEA)
podocyte apoptotic process  (IEA)
podocyte differentiation  (IEA)
positive regulation of calcium ion transport  (ISO)
positive regulation of cation channel activity  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO,TAS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein kinase A signaling  (IDA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
protein phosphorylation  (IEA)
protein transmembrane transport  (IEA)
regulation of biological quality  (IEA)
regulation of blood pressure  (IEA,ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of heart rate  (IEA)
regulation of protein localization to cell leading edge  (IEA)
renal albumin absorption  (IEA)
renal sodium ion absorption  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO,ISS)
response to acetylcholine  (IEA)
response to amphetamine  (IEA)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (IEA)
response to wounding  (IEA)
Rho protein signal transduction  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA)
sensory perception of pain  (ISO)
signal transduction  (IEA,TAS)
smooth muscle cell proliferation  (ISO)
smooth muscle contraction  (NAS,TAS)
sodium ion homeostasis  (IEA)
sympathetic nervous system development  (IEA)
sympathetic neuron axon guidance  (IEA)
thyroid gland development  (IEA)
vascular associated smooth muscle cell development  (IEA)
vasoconstriction  (IBA,IEA,IMP,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
2. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Benjafield AV, etal., Clin Genet. 2003 Nov;64(5):433-8.
4. Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. Bikhazi AB, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):35-43.
5. Genetic polymorphisms in endothelin-receptor-subtype-a-gene as susceptibility factor for obstructive sleep apnea syndrome. Buck D, etal., Sleep Med. 2010 Feb;11(2):213-7. Epub 2010 Jan 18.
6. Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats. D'Amours M, etal., Clin Exp Hypertens. 2010 Jan;32(1):61-9.
7. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. Darrah R, etal., Physiol Genomics. 2010 Mar 3;41(1):71-7. Epub 2009 Dec 22.
8. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
9. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
10. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
11. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
12. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease. Gormley K, etal., Stroke. 2005 Aug;36(8):1656-60. Epub 2005 Jul 7.
13. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Herrmann S, etal., Eur Heart J. 2001 Oct;22(20):1948-53.
14. Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
15. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Kassuya CA, etal., Peptides. 2008 Aug;29(8):1329-37. Epub 2008 Mar 16.
16. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
17. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
18. Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
19. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Nicaud V, etal., Am J Hypertens. 1999 Mar;12(3):304-10.
20. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Nishida M, etal., J Cardiovasc Pharmacol. 2004 Aug;44(2):187-91.
21. Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Plusczyk T, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G145-53.
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
27. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Richter M, etal., Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):299-308. Epub 2007 Apr 19.
28. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. Said N, etal., J Clin Invest. 2011 Jan 4;121(1):132-47. doi: 10.1172/JCI42912. Epub 2010 Dec 22.
29. Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Saleh MA, etal., Diabetologia. 2010 Dec 30.
30. Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation. Sampaio AL, etal., J Leukoc Biol. 2004 Jul;76(1):210-6. Epub 2004 Apr 23.
31. Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat. Stenman E, etal., Eur J Pharmacol. 2007 Sep 10;570(1-3):142-8. Epub 2007 Jun 9.
32. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
33. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
34. Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. Tzourio C, etal., Neurology 2001 May 22;56(10):1273-7.
35. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Wackenfors A, etal., Eur J Pharmacol. 2004 Jan 19;484(1):103-9.
36. Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Yahiaoui L, etal., Cell Physiol Biochem. 2006;17(1-2):37-46. Epub 2006 Feb 7.
37. Inhibition of endothelin-1 and hypoxia-induced pulmonary pressor responses in the rat by a novel selective endothelin-A receptor antagonist, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe. Yan LD, etal., J Cardiovasc Pharmacol. 2010 Sep;56(3):246-54.
38. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
39. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
Additional References at PubMed
PMID:1291713   PMID:1326535   PMID:1415318   PMID:1652463   PMID:1659806   PMID:1719979   PMID:1849646   PMID:7509919   PMID:7882989   PMID:8114678   PMID:8427579   PMID:8440682  
PMID:8611157   PMID:8702836   PMID:8982507   PMID:9211925   PMID:9284755   PMID:9645692   PMID:10448102   PMID:10770212   PMID:10789830   PMID:11262386   PMID:11382773   PMID:11930911  
PMID:11982704   PMID:12082592   PMID:12477932   PMID:12544508   PMID:12595285   PMID:12629276   PMID:12768436   PMID:12875994   PMID:14519635   PMID:14636059   PMID:15041798   PMID:15047866  
PMID:15073116   PMID:15139053   PMID:15187089   PMID:15213100   PMID:15489334   PMID:15713850   PMID:15838262   PMID:15838285   PMID:15838315   PMID:15838329   PMID:15838364   PMID:15838366  
PMID:15838367   PMID:15851553   PMID:15988412   PMID:16149067   PMID:16208144   PMID:16344560   PMID:16531800   PMID:16567585   PMID:16582543   PMID:16618267   PMID:16648553   PMID:16754659  
PMID:16816835   PMID:16879994   PMID:16947775   PMID:16962346   PMID:16971893   PMID:16984730   PMID:17016617   PMID:17122448   PMID:17198909   PMID:17203161   PMID:17353514   PMID:17437213  
PMID:17468950   PMID:17470272   PMID:17525706   PMID:17575543   PMID:17616673   PMID:17616694   PMID:17706018   PMID:18172451   PMID:18187620   PMID:18212505   PMID:18326801   PMID:18577758  
PMID:18660489   PMID:18678984   PMID:18756291   PMID:18945538   PMID:19202075   PMID:19217622   PMID:19225824   PMID:19247692   PMID:19367425   PMID:19460784   PMID:19479828   PMID:19558538  
PMID:19575782   PMID:19578796   PMID:19593212   PMID:19601701   PMID:19626996   PMID:19653178   PMID:19898645   PMID:19913121   PMID:20034471   PMID:20043107   PMID:20100616   PMID:20150570  
PMID:20346360   PMID:20371740   PMID:20401344   PMID:20485444   PMID:20538960   PMID:20628086   PMID:20725140   PMID:20963824   PMID:20964792   PMID:21057729   PMID:21220476   PMID:21356562  
PMID:21418087   PMID:21424380   PMID:21453125   PMID:21487064   PMID:21498912   PMID:21515378   PMID:21601190   PMID:21773759   PMID:21873635   PMID:21909108   PMID:22106312   PMID:22129540  
PMID:22286173   PMID:22365955   PMID:22480520   PMID:22510270   PMID:22561246   PMID:22580289   PMID:22688668   PMID:22997346   PMID:23058564   PMID:23064961   PMID:23217151   PMID:23233754  
PMID:23251661   PMID:23384184   PMID:23436727   PMID:23515723   PMID:23597562   PMID:23683481   PMID:23754170   PMID:23818293   PMID:23987636   PMID:24064210   PMID:24262325   PMID:24291390  
PMID:24332749   PMID:24570333   PMID:24582810   PMID:24612997   PMID:24627317   PMID:24633486   PMID:24815860   PMID:24856242   PMID:24958810   PMID:25048859   PMID:25056169   PMID:25194819  
PMID:25225183   PMID:25377471   PMID:25381251   PMID:25424718   PMID:25772936   PMID:25801761   PMID:25946671   PMID:26176954   PMID:26186194   PMID:26357964   PMID:26522724   PMID:26675258  
PMID:26773103   PMID:26874031   PMID:27072656   PMID:27367030   PMID:27422754   PMID:27777505   PMID:27876299   PMID:27899487   PMID:28095606   PMID:28249901   PMID:28514442   PMID:28548598  
PMID:28606962   PMID:28732172   PMID:29064794   PMID:29097630   PMID:29272493   PMID:29286062   PMID:29696364   PMID:29849817   PMID:29999581   PMID:30384975   PMID:30411193   PMID:30672385  
PMID:30937921   PMID:30990108   PMID:31106465   PMID:31150867   PMID:31295611   PMID:31661578   PMID:31705661   PMID:32133772   PMID:32431219   PMID:32496159   PMID:32744876   PMID:33961781  
PMID:34165174   PMID:34757123   PMID:35043642  


Genomics

Comparative Map Data
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBI
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBImm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)Ensembl
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0panPan3
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBI
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBI
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBI
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBI
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBI
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBI
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-53255  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,413,516 - 148,413,713UniSTSGRCh37
Build 364148,632,966 - 148,633,163RGDNCBI36
Celera4145,734,651 - 145,734,848RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,140,765 - 144,140,962UniSTS
TNG Radiation Hybrid Map488354.0UniSTS
SHGC-59478  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,463,779 - 148,463,932UniSTSGRCh37
Build 364148,683,229 - 148,683,382RGDNCBI36
Celera4145,784,875 - 145,785,028RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,190,851 - 144,191,004UniSTS
GeneMap99-GB4 RH Map4630.42UniSTS
NCBI RH Map4567.6UniSTS
EDNRA_29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,465,426 - 148,466,194UniSTSGRCh37
Build 364148,684,876 - 148,685,644RGDNCBI36
Celera4145,786,522 - 145,787,290RGD
HuRef4144,192,499 - 144,193,267UniSTS
SHGC-59477  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,453,661 - 148,453,798UniSTSGRCh37
Build 364148,673,111 - 148,673,248RGDNCBI36
Celera4145,774,796 - 145,774,933RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,180,734 - 144,180,871UniSTS
GeneMap99-GB4 RH Map4630.11UniSTS
NCBI RH Map41545.8UniSTS
SHGC-67921  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,402,114 - 148,402,304UniSTSGRCh37
Build 364148,621,564 - 148,621,754RGDNCBI36
Celera4145,723,249 - 145,723,439RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,129,371 - 144,129,561UniSTS
GeneMap99-GB4 RH Map4630.11UniSTS
NCBI RH Map41547.2UniSTS
D18S1266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,464,749 - 148,465,089UniSTSGRCh37
Build 364148,684,199 - 148,684,539RGDNCBI36
Celera4145,785,845 - 145,786,185RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,191,821 - 144,192,162UniSTS
Whitehead-YAC Contig Map18 UniSTS
RH48922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,417,851 - 148,418,037UniSTSGRCh37
Build 364148,637,301 - 148,637,487RGDNCBI36
Celera4145,738,986 - 145,739,172RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,145,099 - 144,145,285UniSTS
GeneMap99-GB4 RH Map4625.78UniSTS
NCBI RH Map41545.8UniSTS
G10643  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374148,465,083 - 148,465,307UniSTSGRCh37
Build 364148,684,533 - 148,684,757RGDNCBI36
Celera4145,786,179 - 145,786,403RGD
Cytogenetic Map4q31.22UniSTS
HuRef4144,192,156 - 144,192,380UniSTS
D4S3266  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q31.22UniSTS
TNG Radiation Hybrid Map488408.0UniSTS
GeneMap99-G3 RH Map48095.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR27Bhsa-miR-27b-3pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI20827281

Predicted Target Of
Summary Value
Count of predictions:3523
Count of miRNA genes:883
Interacting mature miRNAs:1048
Transcripts:ENST00000324300, ENST00000339690, ENST00000358556, ENST00000503721, ENST00000506066, ENST00000510697, ENST00000511804, ENST00000514245
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 410 1745 581 93 116 25 2006 280 646 133 906 1165 70 784 1363 1
Low 1907 485 1068 463 544 368 2287 1904 2862 248 499 305 104 1 420 1422 2 2
Below cutoff 30 531 63 59 771 60 41 6 216 21 29 68 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_013343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF014826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY275462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY422989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ006584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD723797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D11151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA183901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA775295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA956937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S45956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S57498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S63938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S67127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000324300   ⟹   ENSP00000315011
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)Ensembl
RefSeq Acc Id: ENST00000358556   ⟹   ENSP00000351359
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)Ensembl
RefSeq Acc Id: ENST00000503721
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,531,643 - 147,543,980 (+)Ensembl
RefSeq Acc Id: ENST00000506066   ⟹   ENSP00000425281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,485,682 - 147,542,693 (+)Ensembl
RefSeq Acc Id: ENST00000510697   ⟹   ENSP00000427259
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,485,682 - 147,542,693 (+)Ensembl
RefSeq Acc Id: ENST00000511804   ⟹   ENSP00000425354
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,480,932 - 147,542,878 (+)Ensembl
RefSeq Acc Id: ENST00000514245
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,485,834 - 147,532,659 (+)Ensembl
RefSeq Acc Id: ENST00000648866   ⟹   ENSP00000496976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,480,932 - 147,544,954 (+)Ensembl
RefSeq Acc Id: ENST00000651419   ⟹   ENSP00000498969
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4147,481,097 - 147,544,954 (+)Ensembl
RefSeq Acc Id: NM_001166055   ⟹   NP_001159527
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,544,954 (+)NCBI
GRCh374148,402,069 - 148,466,106 (+)ENTREZGENE
HuRef4144,129,326 - 144,193,179 (+)ENTREZGENE
CHM1_14148,380,418 - 148,444,465 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001354797   ⟹   NP_001341726
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,527,550 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,851,680 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001957   ⟹   NP_001948
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,544,954 (+)NCBI
GRCh374148,402,069 - 148,466,106 (+)ENTREZGENE
Build 364148,621,575 - 148,685,555 (+)NCBI Archive
HuRef4144,129,326 - 144,193,179 (+)ENTREZGENE
CHM1_14148,380,418 - 148,444,465 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Sequence:
RefSeq Acc Id: NR_045958
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,544,954 (+)NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBI
CHM1_14148,380,418 - 148,444,465 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Sequence:
RefSeq Acc Id: NR_148963
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,544,954 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Sequence:
RefSeq Acc Id: NR_148964
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,544,954 (+)NCBI
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001159527 (Get FASTA)   NCBI Sequence Viewer  
  NP_001341726 (Get FASTA)   NCBI Sequence Viewer  
  NP_001948 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA58447 (Get FASTA)   NCBI Sequence Viewer  
  AAB20278 (Get FASTA)   NCBI Sequence Viewer  
  AAB20407 (Get FASTA)   NCBI Sequence Viewer  
  AAB23644 (Get FASTA)   NCBI Sequence Viewer  
  AAB25212 (Get FASTA)   NCBI Sequence Viewer  
  AAB25530 (Get FASTA)   NCBI Sequence Viewer  
  AAB36325 (Get FASTA)   NCBI Sequence Viewer  
  AAB36326 (Get FASTA)   NCBI Sequence Viewer  
  AAB36327 (Get FASTA)   NCBI Sequence Viewer  
  AAB94859 (Get FASTA)   NCBI Sequence Viewer  
  AAH22511 (Get FASTA)   NCBI Sequence Viewer  
  AAP32294 (Get FASTA)   NCBI Sequence Viewer  
  AAQ87880 (Get FASTA)   NCBI Sequence Viewer  
  BAA01920 (Get FASTA)   NCBI Sequence Viewer  
  BAA14359 (Get FASTA)   NCBI Sequence Viewer  
  BAG35670 (Get FASTA)   NCBI Sequence Viewer  
  BAG65268 (Get FASTA)   NCBI Sequence Viewer  
  BAH14302 (Get FASTA)   NCBI Sequence Viewer  
  CAA43953 (Get FASTA)   NCBI Sequence Viewer  
  EAX05017 (Get FASTA)   NCBI Sequence Viewer  
  EAX05018 (Get FASTA)   NCBI Sequence Viewer  
  EAX05019 (Get FASTA)   NCBI Sequence Viewer  
  EAX05020 (Get FASTA)   NCBI Sequence Viewer  
  EAX05021 (Get FASTA)   NCBI Sequence Viewer  
  P25101 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001948   ⟸   NM_001957
- Peptide Label: isoform a precursor
- UniProtKB: Q8TBH2 (UniProtKB/Swiss-Prot),   P25101 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001159527   ⟸   NM_001166055
- Peptide Label: isoform b precursor
- UniProtKB: P25101 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001341726   ⟸   NM_001354797
- Peptide Label: isoform d precursor
- Sequence:
RefSeq Acc Id: ENSP00000496976   ⟸   ENST00000648866
RefSeq Acc Id: ENSP00000425281   ⟸   ENST00000506066
RefSeq Acc Id: ENSP00000498969   ⟸   ENST00000651419
RefSeq Acc Id: ENSP00000315011   ⟸   ENST00000324300
RefSeq Acc Id: ENSP00000427259   ⟸   ENST00000510697
RefSeq Acc Id: ENSP00000425354   ⟸   ENST00000511804
RefSeq Acc Id: ENSP00000351359   ⟸   ENST00000358556

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25101-F1-model_v2 AlphaFold P25101 1-427 view protein structure

Promoters
RGD ID:6868624
Promoter ID:EPDNEW_H7477
Type:initiation region
Name:EDNRA_2
Description:endothelin receptor type A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7478  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,480,966 - 147,481,026EPDNEW
RGD ID:6868626
Promoter ID:EPDNEW_H7478
Type:initiation region
Name:EDNRA_1
Description:endothelin receptor type A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7477  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384147,481,097 - 147,481,157EPDNEW
RGD ID:6850196
Promoter ID:EP45002
Type:single initiation site
Name:HS_EDNRA
Description:Endothelin-A receptor, EDNRA or ETRA gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:aorta, lung, atrium > other tissues
Experiment Methods:Primer extension with homologous sequence ladder
Position:
Human AssemblyChrPosition (strand)Source
Build 364148,621,549 - 148,621,609EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001957.4(EDNRA):c.-230G>A single nucleotide variant Migraine, resistance to [RCV000018122] Chr4:147481217 [GRCh38]
Chr4:148402369 [GRCh37]
Chr4:4q31.22
pathogenic|protective
NM_001957.4(EDNRA):c.503C>T (p.Ser168Leu) single nucleotide variant Inborn genetic diseases [RCV000624539] Chr4:147519933 [GRCh38]
Chr4:148441085 [GRCh37]
Chr4:4q31.23
uncertain significance
NM_001957.4(EDNRA):c.907G>A (p.Glu303Lys) single nucleotide variant Mandibulofacial dysostosis with alopecia [RCV000170510] Chr4:147539823 [GRCh38]
Chr4:148460975 [GRCh37]
Chr4:4q31.23
pathogenic
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2
pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2
pathogenic
GRCh38/hg38 4q31.21-31.3(chr4:140876253-152186578)x3 copy number gain See cases [RCV000051787] Chr4:140876253..152186578 [GRCh38]
Chr4:141797407..153107730 [GRCh37]
Chr4:142016857..153327180 [NCBI36]
Chr4:4q31.21-31.3
pathogenic
GRCh38/hg38 4q31.22-34.1(chr4:147317283-173675559)x3 copy number gain See cases [RCV000051788] Chr4:147317283..173675559 [GRCh38]
Chr4:148238435..174596710 [GRCh37]
Chr4:148457885..174833285 [NCBI36]
Chr4:4q31.22-34.1
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
NM_001957.4(EDNRA):c.386A>T (p.Tyr129Phe) single nucleotide variant Mandibulofacial dysostosis with alopecia [RCV000170509] Chr4:147486067 [GRCh38]
Chr4:148407219 [GRCh37]
Chr4:4q31.22
pathogenic
GRCh38/hg38 4q31.22-31.23(chr4:147396786-147788662)x3 copy number gain See cases [RCV000135382] Chr4:147396786..147788662 [GRCh38]
Chr4:148317938..148709813 [GRCh37]
Chr4:148537388..148929263 [NCBI36]
Chr4:4q31.22-31.23
uncertain significance
GRCh38/hg38 4q31.21-35.2(chr4:145042668-189975519)x3 copy number gain See cases [RCV000135845] Chr4:145042668..189975519 [GRCh38]
Chr4:145963820..190828225 [GRCh37]
Chr4:146183270..191133668 [NCBI36]
Chr4:4q31.21-35.2
pathogenic
GRCh38/hg38 4q31.21-31.23(chr4:143588844-148514027)x1 copy number loss See cases [RCV000136520] Chr4:143588844..148514027 [GRCh38]
Chr4:144509997..149435179 [GRCh37]
Chr4:144729447..149654629 [NCBI36]
Chr4:4q31.21-31.23
pathogenic
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3 copy number gain See cases [RCV000136810] Chr4:138510532..189963195 [GRCh38]
Chr4:139431686..190828225 [GRCh37]
Chr4:139651136..191121344 [NCBI36]
Chr4:4q31.1-35.2
pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3 copy number gain See cases [RCV000137721] Chr4:131985253..190095391 [GRCh38]
Chr4:132906408..190828225 [GRCh37]
Chr4:133125858..191250527 [NCBI36]
Chr4:4q28.3-35.2
pathogenic|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3 copy number gain See cases [RCV000138578] Chr4:125432943..185761887 [GRCh38]
Chr4:126354098..186683041 [GRCh37]
Chr4:126573548..186920035 [NCBI36]
Chr4:4q28.1-35.1
pathogenic|likely benign
GRCh38/hg38 4q31.22-31.23(chr4:147172571-147792924)x3 copy number gain See cases [RCV000142022] Chr4:147172571..147792924 [GRCh38]
Chr4:148093723..148714075 [GRCh37]
Chr4:148313173..148933525 [NCBI36]
Chr4:4q31.22-31.23
uncertain significance
GRCh38/hg38 4q31.21-31.23(chr4:144742003-148490914)x1 copy number loss See cases [RCV000142098] Chr4:144742003..148490914 [GRCh38]
Chr4:145663155..149412066 [GRCh37]
Chr4:145882605..149631516 [NCBI36]
Chr4:4q31.21-31.23
likely pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3 copy number gain See cases [RCV000143559] Chr4:134935616..190036318 [GRCh38]
Chr4:135856771..190957473 [GRCh37]
Chr4:136076221..191194467 [NCBI36]
Chr4:4q28.3-35.2
pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3 copy number gain See cases [RCV000240245] Chr4:136912336..184253252 [GRCh37]
Chr4:4q28.3-35.1
pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.22-31.23(chr4:148313009-148950412)x3 copy number gain not provided [RCV000682462] Chr4:148313009..148950412 [GRCh37]
Chr4:4q31.22-31.23
uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001957.4(EDNRA):c.354G>A (p.Leu118=) single nucleotide variant not provided [RCV000895293] Chr4:147486035 [GRCh38]
Chr4:148407187 [GRCh37]
Chr4:4q31.22
likely benign
NM_001957.4(EDNRA):c.*70G>C single nucleotide variant not provided [RCV001724998] Chr4:147542688 [GRCh38]
Chr4:148463840 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.828C>T (p.Thr276=) single nucleotide variant not provided [RCV000903369] Chr4:147535957 [GRCh38]
Chr4:148457109 [GRCh37]
Chr4:4q31.23
likely benign
NM_001957.4(EDNRA):c.748-9A>T single nucleotide variant not provided [RCV000905678] Chr4:147535868 [GRCh38]
Chr4:148457020 [GRCh37]
Chr4:4q31.23
likely benign
NM_001957.4(EDNRA):c.1110T>C (p.Tyr370=) single nucleotide variant not provided [RCV000922381] Chr4:147540452 [GRCh38]
Chr4:148461604 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.243C>T (p.Tyr81=) single nucleotide variant not provided [RCV000921654] Chr4:147485924 [GRCh38]
Chr4:148407076 [GRCh37]
Chr4:4q31.22
likely benign
NM_001957.4(EDNRA):c.1146A>G (p.Ser382=) single nucleotide variant not provided [RCV000882916] Chr4:147542480 [GRCh38]
Chr4:148463632 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.303G>C (p.Leu101=) single nucleotide variant not provided [RCV000925784] Chr4:147485984 [GRCh38]
Chr4:148407136 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.549-10T>C single nucleotide variant not provided [RCV000896708] Chr4:147532496 [GRCh38]
Chr4:148453648 [GRCh37]
Chr4:4q31.23
likely benign
NM_001957.4(EDNRA):c.1142A>C (p.Gln381Pro) single nucleotide variant not provided [RCV000786025] Chr4:147540484 [GRCh38]
Chr4:148461636 [GRCh37]
Chr4:4q31.23
uncertain significance
GRCh37/hg19 4q31.21-31.23(chr4:146118793-150492144)x1 copy number loss not provided [RCV000848033] Chr4:146118793..150492144 [GRCh37]
Chr4:4q31.21-31.23
pathogenic
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3 copy number gain not provided [RCV000849686] Chr4:124873497..185278662 [GRCh37]
Chr4:4q28.1-35.1
pathogenic
NM_001957.4(EDNRA):c.748-11dup duplication not provided [RCV001655983] Chr4:147535853..147535854 [GRCh38]
Chr4:148457005..148457006 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.548+9G>A single nucleotide variant not provided [RCV001613659] Chr4:147519987 [GRCh38]
Chr4:148441139 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.1143+54A>C single nucleotide variant not provided [RCV001530681] Chr4:147540539 [GRCh38]
Chr4:148461691 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.901-179C>G single nucleotide variant not provided [RCV001617027] Chr4:147539638 [GRCh38]
Chr4:148460790 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.748-19_748-18insCT insertion not provided [RCV001673292] Chr4:147535857..147535858 [GRCh38]
Chr4:148457009..148457010 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.-70-231T>C single nucleotide variant not provided [RCV001637178] Chr4:147485381 [GRCh38]
Chr4:148406533 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.900+145T>G single nucleotide variant not provided [RCV001720618] Chr4:147536174 [GRCh38]
Chr4:148457326 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.1035-151G>A single nucleotide variant not provided [RCV001621355] Chr4:147540226 [GRCh38]
Chr4:148461378 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.900+178G>A single nucleotide variant not provided [RCV001527955] Chr4:147536207 [GRCh38]
Chr4:148457359 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.1005G>A (p.Glu335=) single nucleotide variant Mandibulofacial dysostosis with alopecia [RCV001661268]|not provided [RCV001676069] Chr4:147539921 [GRCh38]
Chr4:148461073 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.901-138G>A single nucleotide variant not provided [RCV001683844] Chr4:147539679 [GRCh38]
Chr4:148460831 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.969T>C (p.His323=) single nucleotide variant Mandibulofacial dysostosis with alopecia [RCV001658370]|not provided [RCV001648294] Chr4:147539885 [GRCh38]
Chr4:148461037 [GRCh37]
Chr4:4q31.23
benign
GRCh37/hg19 4q31.22-31.23(chr4:148317938-148933250)x3 copy number gain Global developmental delay [RCV001004822] Chr4:148317938..148933250 [GRCh37]
Chr4:4q31.22-31.23
uncertain significance
GRCh37/hg19 4q31.22-31.23(chr4:147148581-149042791)x3 copy number gain not provided [RCV001259872] Chr4:147148581..149042791 [GRCh37]
Chr4:4q31.22-31.23
uncertain significance
GRCh37/hg19 4q28.3-32.3(chr4:131303317-168722402)x3 copy number gain not provided [RCV001537926] Chr4:131303317..168722402 [GRCh37]
Chr4:4q28.3-32.3
pathogenic
NM_001957.4(EDNRA):c.24A>G (p.Ala8=) single nucleotide variant not provided [RCV001514454] Chr4:147485705 [GRCh38]
Chr4:148406857 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.901-195T>C single nucleotide variant not provided [RCV001675488] Chr4:147539622 [GRCh38]
Chr4:148460774 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.420+26G>A single nucleotide variant not provided [RCV001615734] Chr4:147486127 [GRCh38]
Chr4:148407279 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.1034+52T>C single nucleotide variant not provided [RCV001619504] Chr4:147540002 [GRCh38]
Chr4:148461154 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.748-11del deletion not provided [RCV001644378] Chr4:147535854 [GRCh38]
Chr4:148457006 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.743T>C (p.Met248Thr) single nucleotide variant not specified [RCV002247794] Chr4:147532700 [GRCh38]
Chr4:148453852 [GRCh37]
Chr4:4q31.23
uncertain significance
NC_000004.11:g.(?_146560292)_(149358012_?)del deletion Methylmalonic aciduria, cblA type [RCV001970027] Chr4:146560292..149358012 [GRCh37]
Chr4:4q31.21-31.23
pathogenic
NM_001957.4(EDNRA):c.648G>A (p.Leu216=) single nucleotide variant not provided [RCV001927015] Chr4:147532605 [GRCh38]
Chr4:148453757 [GRCh37]
Chr4:4q31.23
uncertain significance
NM_001957.4(EDNRA):c.244A>C (p.Ile82Leu) single nucleotide variant not provided [RCV001967302] Chr4:147485925 [GRCh38]
Chr4:148407077 [GRCh37]
Chr4:4q31.22
uncertain significance
NM_001957.4(EDNRA):c.1213A>G (p.Ile405Val) single nucleotide variant not provided [RCV001908115] Chr4:147542547 [GRCh38]
Chr4:148463699 [GRCh37]
Chr4:4q31.23
uncertain significance
GRCh37/hg19 4q31.22-31.23(chr4:148378902-148750802) copy number gain not specified [RCV002053461] Chr4:148378902..148750802 [GRCh37]
Chr4:4q31.22-31.23
uncertain significance
GRCh37/hg19 4q31.22-31.23(chr4:148011767-148800454) copy number gain not specified [RCV002053460] Chr4:148011767..148800454 [GRCh37]
Chr4:4q31.22-31.23
uncertain significance
NM_001957.4(EDNRA):c.804G>A (p.Leu268=) single nucleotide variant not provided [RCV002018470] Chr4:147535933 [GRCh38]
Chr4:148457085 [GRCh37]
Chr4:4q31.23
uncertain significance
NM_001957.4(EDNRA):c.397G>A (p.Asp133Asn) single nucleotide variant not provided [RCV001992229] Chr4:147486078 [GRCh38]
Chr4:148407230 [GRCh37]
Chr4:4q31.22
uncertain significance
NM_001957.4(EDNRA):c.673G>A (p.Val225Ile) single nucleotide variant not provided [RCV001997339] Chr4:147532630 [GRCh38]
Chr4:148453782 [GRCh37]
Chr4:4q31.23
uncertain significance
NM_001957.4(EDNRA):c.308G>T (p.Arg103Met) single nucleotide variant not provided [RCV002027406] Chr4:147485989 [GRCh38]
Chr4:148407141 [GRCh37]
Chr4:4q31.22
uncertain significance
NM_001957.4(EDNRA):c.732A>T (p.Thr244=) single nucleotide variant not provided [RCV002088427] Chr4:147532689 [GRCh38]
Chr4:148453841 [GRCh37]
Chr4:4q31.23
likely benign
NM_001957.4(EDNRA):c.189C>T (p.Gly63=) single nucleotide variant not provided [RCV002096552] Chr4:147485870 [GRCh38]
Chr4:148407022 [GRCh37]
Chr4:4q31.22
likely benign
NM_001957.4(EDNRA):c.420+12C>G single nucleotide variant not provided [RCV002112938] Chr4:147486113 [GRCh38]
Chr4:148407265 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.420+13C>T single nucleotide variant not provided [RCV002217831] Chr4:147486114 [GRCh38]
Chr4:148407266 [GRCh37]
Chr4:4q31.22
likely benign
NM_001957.4(EDNRA):c.256A>G (p.Ile86Val) single nucleotide variant not provided [RCV002159486] Chr4:147485937 [GRCh38]
Chr4:148407089 [GRCh37]
Chr4:4q31.22
benign
NM_001957.4(EDNRA):c.1034+19G>A single nucleotide variant not provided [RCV002156289] Chr4:147539969 [GRCh38]
Chr4:148461121 [GRCh37]
Chr4:4q31.23
benign
NM_001957.4(EDNRA):c.1259G>C (p.Ser420Thr) single nucleotide variant not specified [RCV002248100] Chr4:147542593 [GRCh38]
Chr4:148463745 [GRCh37]
Chr4:4q31.23
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3179 AgrOrtholog
COSMIC EDNRA COSMIC
Ensembl Genes ENSG00000151617 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000315011.5 UniProtKB/Swiss-Prot
  ENSP00000351359 ENTREZGENE
  ENSP00000351359.4 UniProtKB/Swiss-Prot
  ENSP00000425281.1 UniProtKB/Swiss-Prot
  ENSP00000425354.1 UniProtKB/Swiss-Prot
  ENSP00000427259.1 UniProtKB/Swiss-Prot
  ENSP00000496976.1 UniProtKB/Swiss-Prot
  ENSP00000498969 ENTREZGENE
  ENSP00000498969.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000324300.10 UniProtKB/Swiss-Prot
  ENST00000358556 ENTREZGENE
  ENST00000358556.8 UniProtKB/Swiss-Prot
  ENST00000506066.1 UniProtKB/Swiss-Prot
  ENST00000510697.5 UniProtKB/Swiss-Prot
  ENST00000511804.5 UniProtKB/Swiss-Prot
  ENST00000648866 ENTREZGENE
  ENST00000648866.1 UniProtKB/Swiss-Prot
  ENST00000651419 ENTREZGENE
  ENST00000651419.1 UniProtKB/Swiss-Prot
GTEx ENSG00000151617 GTEx
HGNC ID HGNC:3179 ENTREZGENE
Human Proteome Map EDNRA Human Proteome Map
InterPro Endthln_rcpt UniProtKB/Swiss-Prot
  ETA_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:1909 UniProtKB/Swiss-Prot
NCBI Gene 1909 ENTREZGENE
OMIM 131243 OMIM
  157300 OMIM
  616367 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA27617 PharmGKB
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot
  ENDOTHELINR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt EDNRA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8TBH2 ENTREZGENE
UniProt Secondary B2R723 UniProtKB/Swiss-Prot
  B4E2V6 UniProtKB/Swiss-Prot
  B7Z9G6 UniProtKB/Swiss-Prot
  D3DP03 UniProtKB/Swiss-Prot
  E7ER36 UniProtKB/Swiss-Prot
  O43441 UniProtKB/Swiss-Prot
  Q16432 UniProtKB/Swiss-Prot
  Q16433 UniProtKB/Swiss-Prot
  Q8TBH2 UniProtKB/Swiss-Prot