RGD Reference Report - Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. - Rat Genome Database

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Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.

Authors: Galie, N  Olschewski, H  Oudiz, RJ  Torres, F  Frost, A  Ghofrani, HA  Badesch, DB  McGoon, MD  McLaughlin, VV  Roecker, EB  Gerber, MJ  Dufton, C  Wiens, BL  Rubin, LJ  Rubin, Lewis J 
Citation: Galie N, etal., Circulation. 2008 Jun 10;117(23):3010-9. Epub 2008 May 27.
RGD ID: 4892320
Pubmed: PMID:18506008   (View Abstract at PubMed)
DOI: DOI:10.1161/CIRCULATIONAHA.107.742510   (Journal Full-text)

BACKGROUND: Ambrisentan is a propanoic acid-based, A-selective endothelin receptor antagonist for the once-daily treatment of pulmonary arterial hypertension. METHODS AND RESULTS: Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Study 1 and 2 (ARIES-1 and ARIES-2) were concurrent, double-blind, placebo-controlled studies that randomized 202 and 192 patients with pulmonary arterial hypertension, respectively, to placebo or ambrisentan (ARIES-1, 5 or 10 mg; ARIES-2, 2.5 or 5 mg) orally once daily for 12 weeks. The primary end point for each study was change in 6-minute walk distance from baseline to week 12. Clinical worsening, World Health Organization functional class, Short Form-36 Health Survey score, Borg dyspnea score, and B-type natriuretic peptide plasma concentrations also were assessed. In addition, a long-term extension study was performed. The 6-minute walk distance increased in all ambrisentan groups; mean placebo-corrected treatment effects were 31 m (P=0.008) and 51 m (P<0.001) in ARIES-1 for 5 and 10 mg ambrisentan, respectively, and 32 m (P=0.022) and 59 m (P<0.001) in ARIES-2 for 2.5 and 5 mg ambrisentan, respectively. Improvements in time to clinical worsening (ARIES-2), World Health Organization functional class (ARIES-1), Short Form-36 score (ARIES-2), Borg dyspnea score (both studies), and B-type natriuretic peptide (both studies) were observed. No patient treated with ambrisentan developed aminotransferase concentrations >3 times the upper limit of normal. In 280 patients completing 48 weeks of treatment with ambrisentan monotherapy, the improvement from baseline in 6-minute walk at 48 weeks was 39 m. CONCLUSIONS: Ambrisentan improves exercise capacity in patients with pulmonary arterial hypertension. Improvements were observed for several secondary end points in each of the studies, although statistical significance was more variable. Ambrisentan is well tolerated and is associated with a low risk of aminotransferase abnormalities.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EDNRAHumanpulmonary hypertension  IMP  RGD 
EdnraRatpulmonary hypertension  ISOEDNRA (Homo sapiens) RGD 
EdnraMousepulmonary hypertension  ISOEDNRA (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ednra  (endothelin receptor type A)

Genes (Mus musculus)
Ednra  (endothelin receptor type A)

Genes (Homo sapiens)
EDNRA  (endothelin receptor type A)


Additional Information