Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Chinchilla lanigera
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Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 8792445
Description: ENCODES a protein that exhibits endothelin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); aging (ortholog); angiogenesis (ortholog); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); asthma (ortholog); Cardiovascular Abnormalities (ortholog); FOUND IN cell periphery (ortholog); membrane (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endothelin-1 receptor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
aging  (ISO)
angiogenesis  (ISO)
aorta development  (ISO)
artery smooth muscle contraction  (ISO)
atrial cardiac muscle tissue development  (ISO)
axon extension  (ISO)
axon guidance  (ISO)
axonogenesis involved in innervation  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
calcium ion transmembrane transport  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac chamber formation  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to human chorionic gonadotropin stimulus  (ISO)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to oxidative stress  (ISO)
cranial skeletal system development  (ISO)
embryonic heart tube development  (ISO)
embryonic skeletal system development  (ISO)
endothelin receptor signaling pathway  (ISO)
endothelin receptor signaling pathway involved in heart process  (ISO)
establishment of endothelial barrier  (ISO)
face development  (ISO)
fibroblast proliferation  (ISO)
gene expression  (ISO)
glomerular endothelium development  (ISO)
glomerular filtration  (ISO)
glomerulus development  (ISO)
head development  (ISO)
heart development  (ISO)
heparin metabolic process  (ISO)
histamine secretion  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
in utero embryonic development  (ISO)
left ventricular cardiac muscle tissue morphogenesis  (ISO)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (ISO)
mesenchymal cell apoptotic process  (ISO)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
mitotic cell cycle  (ISO)
multicellular organism aging  (ISO)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (ISO)
neuromuscular process  (ISO)
neuron projection development  (ISO)
neuron remodeling  (ISO)
noradrenergic neuron differentiation  (ISO)
norepinephrine metabolic process  (ISO)
penile erection  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
podocyte apoptotic process  (ISO)
podocyte differentiation  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein kinase A signaling  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
protein phosphorylation  (ISO)
protein transmembrane transport  (ISO)
regulation of blood pressure  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of glucose transmembrane transport  (ISO)
regulation of heart rate  (ISO)
regulation of protein localization to cell leading edge  (ISO)
renal albumin absorption  (ISO)
renal sodium ion absorption  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to acetylcholine  (ISO)
response to amphetamine  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to wounding  (ISO)
Rho protein signal transduction  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
sensory perception of pain  (ISO)
smooth muscle cell proliferation  (ISO)
sodium ion homeostasis  (ISO)
sympathetic nervous system development  (ISO)
sympathetic neuron axon guidance  (ISO)
thyroid gland development  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasoconstriction  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBICelera
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKY
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008427   ⟹   ENSCLAP00000008300
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)Ensembl
RefSeq Acc Id: XM_005386667   ⟹   XP_005386724
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386724 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005386724   ⟸   XM_005386667
- UniProtKB: A0A8C2V562 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000008300   ⟸   ENSCLAT00000008427
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005819 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000008300 ENTREZGENE
  ENSCLAP00000008300.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008427 ENTREZGENE
  ENSCLAT00000008427.1 UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Ednra ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ENDOTHELINAR UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt A0A8C2V562 ENTREZGENE, UniProtKB/TrEMBL