EDNRA (endothelin receptor type A) - Rat Genome Database

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Pathways
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Gene: EDNRA (endothelin receptor type A) Sus scrofa
Analyze
Symbol: EDNRA
Name: endothelin receptor type A
RGD ID: 13910339
Description: ENCODES a protein that exhibits endothelin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); branching involved in blood vessel morphogenesis (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); asthma (ortholog); Cardiovascular Abnormalities (ortholog); FOUND IN cell periphery (ortholog); nuclear membrane (ortholog); T-tubule (ortholog); INTERACTS WITH ambrisentan
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endothelin A receptor; endothelin receptor subtype A; endothelin-1 receptor; ET-A; ET-AR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ambrisentan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
angiogenesis  (IEA)
aorta development  (IEA)
artery smooth muscle contraction  (IEA)
atrial cardiac muscle tissue development  (IEA)
axon extension  (IEA)
axon guidance  (IEA)
axonogenesis involved in innervation  (IEA)
blood circulation  (IEA)
blood vessel remodeling  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
canonical Wnt signaling pathway  (IEA)
cardiac chamber formation  (IEA)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
cellular response to follicle-stimulating hormone stimulus  (IEA)
cellular response to human chorionic gonadotropin stimulus  (IEA)
cellular response to luteinizing hormone stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to organic substance  (IEA)
cellular response to oxidative stress  (IEA)
cranial skeletal system development  (IEA)
developmental pigmentation  (IBA,IEA)
embryonic heart tube development  (IEA)
embryonic skeletal system development  (IEA)
endothelin receptor signaling pathway  (IBA,IEA)
endothelin receptor signaling pathway involved in heart process  (IEA)
enteric nervous system development  (IEA)
establishment of endothelial barrier  (IEA)
face development  (IEA)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IEA)
glomerular endothelium development  (IEA)
glomerular filtration  (IEA,ISO)
glomerulus development  (IEA)
head development  (IEA,ISO)
heart development  (IEA,ISO)
heart process  (IEA)
heparin metabolic process  (IEA)
histamine secretion  (ISO)
in utero embryonic development  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA)
left ventricular cardiac muscle tissue morphogenesis  (IEA)
maternal process involved in parturition  (ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
mesenchymal cell apoptotic process  (IEA)
middle ear morphogenesis  (IEA)
mitochondrion organization  (IEA)
mitotic cell cycle  (IEA)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (IEA,ISO)
neural crest cell differentiation  (IEA)
neural crest cell fate commitment  (IEA)
neuromuscular process  (IEA)
neuron projection development  (IEA)
neuron remodeling  (IEA)
noradrenergic neuron differentiation  (IEA)
norepinephrine metabolic process  (IEA)
pharyngeal arch artery morphogenesis  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
podocyte apoptotic process  (IEA)
podocyte differentiation  (IEA)
positive regulation of calcium ion transport  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein kinase A signaling  (IEA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
protein transmembrane transport  (IEA)
regulation of biological quality  (IEA)
regulation of blood pressure  (IEA,ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of heart rate  (IEA)
regulation of protein localization to cell leading edge  (IEA)
renal albumin absorption  (IEA)
renal sodium ion absorption  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to acetylcholine  (IEA)
response to amphetamine  (IEA)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to wounding  (IEA)
Rho protein signal transduction  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA)
smooth muscle cell proliferation  (ISO)
sodium ion homeostasis  (IEA)
sympathetic nervous system development  (IEA)
sympathetic neuron axon guidance  (IEA)
thyroid gland development  (IEA)
vascular associated smooth muscle cell development  (IEA)
vasoconstriction  (IBA,IEA,ISO)

Cellular Component
cell periphery  (IEA,ISO)
membrane  (IEA)
nuclear membrane  (ISO)
plasma membrane  (IBA,IEA)
T-tubule  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8564193   PMID:12911546   PMID:14681463   PMID:15240868   PMID:15838252   PMID:15838267   PMID:16709643   PMID:17145712   PMID:18031734   PMID:19783117   PMID:20723731   PMID:21726419  
PMID:21760895   PMID:22301074   PMID:22908974   PMID:24414253   PMID:26211713  


Genomics

Comparative Map Data
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBICelera
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 Ensembl
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.63NCBI
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8
mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,349,200 - 145,415,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14145,714,744 - 145,780,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365351,949,941 - 2,005,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EDNRA
1917 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 2 3 5 2 23 2 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009890   ⟹   ENSSSCP00000009635
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078137   ⟹   ENSSSCP00000064241
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl881,209,327 - 81,272,694 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090593   ⟹   ENSSSCP00000067878
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl881,267,659 - 81,276,764 (-)Ensembl
RefSeq Acc Id: NM_214229   ⟹   NP_999394
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1881,212,690 - 81,272,754 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100475   ⟹   XP_020956134
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1881,210,750 - 81,277,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100476   ⟹   XP_020956135
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020956135   ⟸   XM_021100476
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SGU0 (UniProtKB/TrEMBL),   F1RS70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956134   ⟸   XM_021100475
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SGU0 (UniProtKB/TrEMBL),   F1RS70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999394   ⟸   NM_214229
- Peptide Label: precursor
- UniProtKB: Q29010 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009635   ⟸   ENSSSCT00000009890
RefSeq Acc Id: ENSSSCP00000064241   ⟸   ENSSSCT00000078137
RefSeq Acc Id: ENSSSCP00000067878   ⟸   ENSSSCT00000090593
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009031 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005029450 UniProtKB/Swiss-Prot
  ENSSSCG00015045817 UniProtKB/Swiss-Prot
  ENSSSCG00025044425 UniProtKB/TrEMBL
  ENSSSCG00030017166 UniProtKB/Swiss-Prot
  ENSSSCG00035038732 UniProtKB/TrEMBL
  ENSSSCG00040075833 UniProtKB/Swiss-Prot
  ENSSSCG00045022387 UniProtKB/Swiss-Prot
  ENSSSCG00050026780 UniProtKB/Swiss-Prot
  ENSSSCG00055021336 UniProtKB/Swiss-Prot
  ENSSSCG00060002008 UniProtKB/Swiss-Prot
  ENSSSCG00065013180 UniProtKB/Swiss-Prot
  ENSSSCG00070000854 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009890 ENTREZGENE
  ENSSSCT00000009890.4 UniProtKB/TrEMBL
  ENSSSCT00000078137.1 UniProtKB/TrEMBL
  ENSSSCT00005046976.1 UniProtKB/Swiss-Prot
  ENSSSCT00015061597.1 UniProtKB/Swiss-Prot
  ENSSSCT00025060540.1 UniProtKB/TrEMBL
  ENSSSCT00025060754.1 UniProtKB/TrEMBL
  ENSSSCT00030023764.1 UniProtKB/Swiss-Prot
  ENSSSCT00035051425.1 UniProtKB/TrEMBL
  ENSSSCT00035051429.1 UniProtKB/TrEMBL
  ENSSSCT00040105368.1 UniProtKB/Swiss-Prot
  ENSSSCT00045038265.1 UniProtKB/Swiss-Prot
  ENSSSCT00050036077.1 UniProtKB/Swiss-Prot
  ENSSSCT00055042022.1 UniProtKB/Swiss-Prot
  ENSSSCT00060002446.1 UniProtKB/Swiss-Prot
  ENSSSCT00065017565.1 UniProtKB/Swiss-Prot
  ENSSSCT00070001642.1 UniProtKB/TrEMBL
  ENSSSCT00070001651.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397457 UniProtKB/Swiss-Prot
NCBI Gene EDNRA ENTREZGENE
PANTHER ENDOTHELIN-1 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SGL8_PIG UniProtKB/TrEMBL
  A0A4X1SGU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QII3_PIG UniProtKB/TrEMBL
  EDNRA_PIG UniProtKB/Swiss-Prot
  F1RS70 ENTREZGENE, UniProtKB/TrEMBL
  Q29010 ENTREZGENE
VGNC ID VGNC:87549 ENTREZGENE