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Gene: E2f3 (E2F transcription factor 3) Mus musculus
Symbol: E2f3
Name: E2F transcription factor 3
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in negative regulation of fat cell proliferation; positive regulation of cell population proliferation; and positive regulation of transcription, DNA-templated. Predicted to localize to the RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human E2F3 (E2F transcription factor 3); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-nitroquinoline N-oxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E2F-3; E2f3a; E2F3b; mKIAA0075; transcription factor E2F3
Homo sapiens (human) : E2F3 (E2F transcription factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : E2f3 (E2F transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f3 (E2F transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F3 (E2F transcription factor 3)
Canis lupus familiaris (dog) : E2F3 (E2F transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f3 (E2F transcription factor 3)
Sus scrofa (pig) : E2F3 (E2F transcription factor 3)
Chlorocebus sabaeus (African green monkey) : E2F3 (E2F transcription factor 3)
Heterocephalus glaber (naked mole-rat) : E2f3 (E2F transcription factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1329,906,575 - 29,986,063 (-)Ensembl
GRCm381329,906,575 - 29,986,064 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371329,998,444 - 30,077,932 (-)NCBIGRCm37mm9NCBIm37
MGSCv361329,917,237 - 29,993,528 (-)NCBImm8
Celera1330,125,315 - 30,204,809 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on E2f3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320123
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.