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Gene: Nfatc4 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4) Mus musculus
Symbol: Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of nervous system development; and regulation of transcription by RNA polymerase II. Localizes to the cytosol; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NFATC4 (nuclear factor of activated T cells 4); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; B cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110041H08Rik; AW107667; AW546455; NF-AT3; NF-ATc4; Nfat3; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T-cell transcription factor NFAT3; transcription complex subunit NF-ATc4
Homo sapiens (human) : NFATC4 (nuclear factor of activated T cells 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nfatc4 (nuclear factor of activated T-cells 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfatc4 (nuclear factor of activated T cells 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NFATC4 (nuclear factor of activated T cells 4)
Canis lupus familiaris (dog) : NFATC4 (nuclear factor of activated T cells 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfatc4 (nuclear factor of activated T cells 4)
Sus scrofa (pig) : NFATC4 (nuclear factor of activated T cells 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381455,824,795 - 55,833,943 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371456,443,632 - 56,452,780 (+)NCBIGRCm37mm9NCBIm37
MGSCv361454,779,079 - 54,788,014 (+)NCBImm8
Celera1453,626,552 - 53,635,649 (+)NCBICelera
Cytogenetic Map14 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nfatc4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321837
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.