Trim34a (tripartite motif-containing 34A) - Rat Genome Database

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Gene: Trim34a (tripartite motif-containing 34A) Mus musculus
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Symbol: Trim34a
Name: tripartite motif-containing 34A
RGD ID: 1322063
MGI Page MGI
Description: Predicted to have protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and regulation of viral entry into host cell. Predicted to localize to cytosol and nucleoplasm. Is expressed in testis and ureter. Orthologous to several human genes including TRIM34 (tripartite motif containing 34); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Trim; Trim34; Trim34-1; tripartite motif protein 34; tripartite motif-containing 34; tripartite motif-containing protein 34; tripartite motif-containing protein 34A
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397103,893,657 - 103,911,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl7103,893,664 - 103,911,441 (+)Ensembl
GRCm387104,244,448 - 104,262,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7104,244,457 - 104,262,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv377111,392,971 - 111,410,753 (+)NCBIGRCm37mm9NCBIm37
MGSCv367104,203,167 - 104,210,608 (+)NCBImm8
Celera7104,628,965 - 104,632,673 (+)NCBICelera
Cytogenetic Map7E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18287559   PMID:19147168   PMID:19706712  
PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Trim34a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397103,893,657 - 103,911,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl7103,893,664 - 103,911,441 (+)Ensembl
GRCm387104,244,448 - 104,262,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7104,244,457 - 104,262,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv377111,392,971 - 111,410,753 (+)NCBIGRCm37mm9NCBIm37
MGSCv367104,203,167 - 104,210,608 (+)NCBImm8
Celera7104,628,965 - 104,632,673 (+)NCBICelera
Cytogenetic Map7E3NCBI
TRIM34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,619,764 - 5,644,398 (+)EnsemblGRCh38hg38GRCh38
GRCh38115,619,944 - 5,644,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37115,641,174 - 5,665,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,597,750 - 5,622,204 (+)NCBINCBI36hg18NCBI36
Build 34115,610,086 - 5,619,100NCBI
Celera115,759,992 - 5,784,582 (+)NCBI
Cytogenetic Map11p15.4NCBI
HuRef115,300,832 - 5,325,294 (+)NCBIHuRef
CHM1_1115,640,099 - 5,664,580 (+)NCBICHM1_1
Trim34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21158,707,172 - 158,720,214 (+)NCBI
Rnor_6.0 Ensembl1169,433,539 - 169,445,041 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01169,433,539 - 169,445,041 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01175,573,580 - 175,585,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1156,697,815 - 156,709,208 (+)NCBICelera
Cytogenetic Map1q32NCBI
TRIM34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0115,757,732 - 5,779,455 (+)NCBIMhudiblu_PPA_v0panPan3
LOC100738479
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.194,175,660 - 4,188,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,705,985 - 4,718,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM34
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,104,681 - 61,123,901 (-)NCBI
Vero_WHO_p1.0NW_02366604364,883,405 - 64,902,640 (+)NCBI
Trim34
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248177,086,639 - 7,103,561 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:875
Count of miRNA genes:421
Interacting mature miRNAs:455
Transcripts:ENSMUST00000060315, ENSMUST00000106848, ENSMUST00000106849, ENSMUST00000106854, ENSMUST00000143414
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060315   ⟹   ENSMUSP00000055058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,244,459 - 104,262,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106848   ⟹   ENSMUSP00000102461
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,244,493 - 104,261,742 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106849   ⟹   ENSMUSP00000102462
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7104,244,457 - 104,262,234 (+)Ensembl
RefSeq Acc Id: NM_001357679   ⟹   NP_001344608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,664 - 103,911,446 (+)NCBI
GRCm387104,244,457 - 104,262,239 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030684   ⟹   NP_109609
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,664 - 103,911,446 (+)NCBI
GRCm387104,244,457 - 104,262,239 (+)NCBI
MGSCv377111,392,971 - 111,410,753 (+)RGD
Celera7104,628,965 - 104,632,673 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508368   ⟹   XP_006508431
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,676 - 103,911,446 (+)NCBI
GRCm387104,244,469 - 104,262,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508369   ⟹   XP_006508432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,986 - 103,911,446 (+)NCBI
GRCm387104,244,803 - 104,262,244 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003946603
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,657 - 103,911,446 (+)NCBI
GRCm387104,244,448 - 104,262,244 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004934226
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397103,893,657 - 103,911,446 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_109609   ⟸   NM_030684
- UniProtKB: Q99PP6 (UniProtKB/Swiss-Prot),   E9PYZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508431   ⟸   XM_006508368
- Peptide Label: isoform X1
- UniProtKB: E9PYZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508432   ⟸   XM_006508369
- Peptide Label: isoform X1
- UniProtKB: E9PYZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344608   ⟸   NM_001357679
RefSeq Acc Id: ENSMUSP00000102462   ⟸   ENSMUST00000106849
RefSeq Acc Id: ENSMUSP00000102461   ⟸   ENSMUST00000106848
RefSeq Acc Id: ENSMUSP00000055058   ⟸   ENSMUST00000060315
Protein Domains
B box-type   B30.2/SPRY   RING-type

Promoters
RGD ID:8665069
Promoter ID:EPDNEW_M10566
Type:initiation region
Name:Trim34a_1
Description:Mus musculus tripartite motif-containing 34A , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10567  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387104,244,506 - 104,244,566EPDNEW
RGD ID:8665071
Promoter ID:EPDNEW_M10567
Type:single initiation site
Name:Trim34a_2
Description:Mus musculus tripartite motif-containing 34A , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10566  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387104,244,790 - 104,244,850EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2137359 AgrOrtholog
Ensembl Genes ENSMUSG00000056144 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000055058 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000102461 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000102462 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000060315 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000106848 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000106849 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIM34_PRY/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-RING_LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:94094 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2137359 ENTREZGENE
NCBI Gene 94094 ENTREZGENE
Pfam SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RING_UBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim34a PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PYZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q3TA29_MOUSE UniProtKB/TrEMBL
  Q3TAH7_MOUSE UniProtKB/TrEMBL
  Q99PP3_MOUSE UniProtKB/TrEMBL
  Q99PP6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F8VPK2 UniProtKB/TrEMBL
  Q99PP4 UniProtKB/Swiss-Prot
  Q99PP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Trim34a  tripartite motif-containing 34A  Trim34  tripartite motif-containing 34  Symbol and/or name change 5135510 APPROVED