Tsc2 (TSC complex subunit 2) - Rat Genome Database

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Gene: Tsc2 (TSC complex subunit 2) Mus musculus
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Symbol: Tsc2
Name: TSC complex subunit 2
RGD ID: 11457
MGI Page MGI
Description: Enables 14-3-3 protein binding activity. Involved in anoikis; negative regulation of TORC1 signaling; and positive regulation of autophagy. Acts upstream of or within several processes, including intracellular protein transport; intracellular signal transduction; and negative regulation of intracellular signal transduction. Located in cytoplasm and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; mTOR signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; arsenous acid; benzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Na; Nafld; Tcs2; tube; tuberin; tuberous sclerosis 2; tuberous sclerosis 2 protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,814,790 - 24,851,607 (-)NCBIGRCm39mm39
GRCm39 Ensembl1724,814,790 - 24,851,604 (-)Ensembl
GRCm381724,595,816 - 24,632,676 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,595,816 - 24,632,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,732,882 - 24,769,574 (-)NCBIGRCm37mm9NCBIm37
MGSCv361724,323,537 - 24,360,229 (-)NCBImm8
Celera1725,113,932 - 25,155,030 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model