TSC2 (TSC complex subunit 2) - Rat Genome Database
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Gene: TSC2 (TSC complex subunit 2) Homo sapiens
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Symbol: TSC2
Name: TSC complex subunit 2
RGD ID: 736193
HGNC Page HGNC
Description: Exhibits several functions, including GTPase activator activity; Hsp90 protein binding activity; and enzyme binding activity. Involved in anoikis; negative regulation of TOR signaling; and positive regulation of macroautophagy. Localizes to several cellular components, including TSC1-TSC2 complex; perinuclear region of cytoplasm; and postsynaptic density. Implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Biomarker of several diseases, including Alzheimer's disease; angiomyolipoma; endocrine gland cancer (multiple); leiomyoma; and tuberous sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ43106; LAM; PPP1R160; TSC4; tuberin; tuberous sclerosis 2; tuberous sclerosis 2 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl162,047,967 - 2,089,491 (+)EnsemblGRCh38hg38GRCh38
GRCh38162,047,804 - 2,089,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37162,097,986 - 2,139,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,037,991 - 2,078,714 (+)NCBINCBI36hg18NCBI36
Build 34162,038,599 - 2,078,713NCBI
Celera162,310,097 - 2,350,826 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,022,255 - 2,063,441 (+)NCBIHuRef
CHM1_1162,097,871 - 2,138,636 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model